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153 条记录 (耗时 0.036 秒)

    Versatile hydrophilic dyes
    42.
    发明授权
    Versatile hydrophilic dyes 失效
    多用途亲水染料

    公开(公告)号：US07566444B2

    公开(公告)日：2009-07-28

    申请号：US11126137

    申请日：2005-05-10

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056

    摘要： Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The molecules of the invention are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities and for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了用于诊断成像和治疗的染料 - 肽缀合物。 染料 - 肽缀合物包括具有多种双和四（羧酸）同系物的几种花青染料。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350-1300nm的范围内是有用的，精确的范围取决于特定的染料。 使用二甲基亚砜有助于维持化合物的荧光。 本发明的分子可用于诊断成像和治疗，用于检测肿瘤和其他异常以及用于局部治疗，用于光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗的内窥镜应用中。

    Tumor-targeted optical contrast agents
    43.
    发明授权
    Tumor-targeted optical contrast agents 失效
    肿瘤靶向光学造影剂

    公开(公告)号：US07514069B2

    公开(公告)日：2009-04-07

    申请号：US11682032

    申请日：2007-03-05

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K49/0056 ,  C07D209/14 ,  C07D405/06 ,  C07K1/13 ,  C07K14/655

    摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.

    摘要翻译： 公开了可用于诊断成像和治疗的花青染料生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350至1300nm的范围内是有用的，精确的范围取决于特定的染料。 使用二甲基亚砜有助于维持化合物的荧光。 本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声波荧光肿瘤成像，检测和治疗。

    Tumor-targeted optical contrast agents
    45.
    发明授权
    Tumor-targeted optical contrast agents 失效
    肿瘤靶向光学造影剂

    公开(公告)号：US07198778B2

    公开(公告)日：2007-04-03

    申请号：US10654033

    申请日：2003-09-03

    申请人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel I. Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61B10/00 ,  A61B8/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K49/0056 ,  C07D209/14 ,  C07D405/06 ,  C07K1/13 ,  C07K14/655

    摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.

    摘要翻译： 公开了可用于诊断成像和治疗的花青染料生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350至1300nm的范围内是有用的，精确的范围取决于特定的染料。 使用二甲基亚砜有助于维持化合物的荧光。 本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声波荧光肿瘤成像，检测和治疗。

    Quinoline ligands and metal complexes for diagnosis and therapy
    48.
    发明授权
    Quinoline ligands and metal complexes for diagnosis and therapy 失效
    喹啉配体和金属配合物用于诊断和治疗

    公开(公告)号：US06277841B1

    公开(公告)日：2001-08-21

    申请号：US09517252

    申请日：2000-03-02

    申请人： Raghavan Rajagopalan ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  Samuel I. Achilefu ,  Joseph E. Bugaj ,  Richard B. Dorshow

    IPC分类号： C07F700

    CPC分类号： C07F13/005 ,  C07D215/26

    摘要： The present invention relates to novel ligands for forming metal complexes that absorb or fluoresce in the visible or near-infrared (NIR) region of the electromagnetic spectrum, new complexes incorporating such ligands, process for preparing such complexes, and methods of imaging or therapy using such agents. More particularly, the present invention specifically pertains to novel metal complexes derived from quinoline based heterocyclic N2O3, N3O3, N3O4, N3O5 and N2OS ligands, and are useful as general imaging, diagnostic, or therapeutic agents employing optical, nuclear medicine, or magnetic resonance procedures.

    摘要翻译： 本发明涉及用于形成在电磁光谱的可见光或近红外（NIR）区域中吸收或发出荧光的金属络合物的新配体，包含这种配体的新配合物，制备这种配体的方法，以及使用 这样的代理。 更具体地说，本发明具体涉及衍生自喹啉类杂环N 2 O 3，N 3 O 3，N 3 O 4，N 3 O 5和N 2 OS配体的新型金属络合物，并且可用作使用光学，核医学或磁共振程序的一般成像，诊断或治疗剂 。