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41.发明授权Corn plant and seed corresponding to transgenic event MON89034 and methods for detection and use thereof 有权对应于转基因事件MON89034的玉米种子和种子及其检测和使用方法公开(公告)号：US08062840B2
公开(公告)日：2011-11-22
申请号：US11753574
申请日：2007-05-25
申请人： Heather M. Anderson , Jennifer R. Allen , Jeanna R. Groat , Scott C. Johnson , Rebecca A. Kelly , John Korte , James F. Rice
发明人： Heather M. Anderson , Jennifer R. Allen , Jeanna R. Groat , Scott C. Johnson , Rebecca A. Kelly , John Korte , James F. Rice
CPC分类号： C12N15/8286 , A01H5/10 , C07K14/325 , C12Q1/6895 , C12Q2600/158 , Y02A40/162
摘要： The present invention provides a transgenic corn event MON89034, and cells, seeds, and plants comprising DNA diagnostic for the corn event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said corn event in a sample, methods for detecting the presence of said corn event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said corn event in a sample, growing the seeds of such corn event into corn plants, and breeding to produce corn plants comprising DNA diagnostic for the corn event.
摘要翻译： 本发明提供了一种转基因玉米事件MON89034，以及包含对玉米事件诊断的DNA的细胞，种子和植物。 本发明还提供了包含对样品中的所述玉米事件进行诊断的核苷酸序列的组合物，用于检测样品中所述玉米事件核苷酸序列的存在的方法，用于检测诊断存在的核苷酸序列的探针和引物 在样品中表示玉米事件，将这种玉米事件的种子种植成玉米植物，并育种以生产包含玉米事件的DNA诊断的玉米植物。
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42.发明授权公开(公告)号：US08030346B2
公开(公告)日：2011-10-04
申请号：US12150675
申请日：2008-04-29
申请人： Jennifer R. Allen , Roland Burli , Michael J. Frohn , Randall W. Hungate , Susana C. Neira , Anthony B. Reed
发明人： Jennifer R. Allen , Roland Burli , Michael J. Frohn , Randall W. Hungate , Susana C. Neira , Anthony B. Reed
IPC分类号： A61K31/385 , A01N43/42 , A01N43/78 , C07D221/22 , C07D515/02
CPC分类号： A61K31/4365 , A61K31/437 , C07D495/04 , C07D513/04
摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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43.发明授权Quinolone based compounds exhibiting, prolyl hydroxylase inhibitory activity, and compositions, and uses thereof 有权喹诺酮类化合物，表现出脯氨酰羟化酶抑制活性，组合物及其用途公开(公告)号：US08017626B2
公开(公告)日：2011-09-13
申请号：US12703496
申请日：2010-02-10
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
IPC分类号： A61K31/4704 , C07D215/56
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要翻译： 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
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44.发明授权Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof 有权具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途公开(公告)号：US08012968B2
公开(公告)日：2011-09-06
申请号：US12703716
申请日：2010-02-10
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
IPC分类号： A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4704
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要翻译： 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
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公开(公告)号：US20110160182A1
公开(公告)日：2011-06-30
申请号：US13042410
申请日：2011-03-07
申请人： Jennifer R. Allen , Matthew P. Bourbeau , Ning Chen , Essa Hu , Roxanne Kunz , Shannon Rumfelt
发明人： Jennifer R. Allen , Matthew P. Bourbeau , Ning Chen , Essa Hu , Roxanne Kunz , Shannon Rumfelt
IPC分类号： A61K31/497 , C07D413/14 , A61K31/5377 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/553 , C07D471/04 , C07D471/10 , C07D487/04 , A61K31/4985 , C07D417/14 , C07D417/12 , C07D491/113 , C07D409/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/00 , A61P25/14 , A61P25/24 , A61P25/30
CPC分类号： C07D403/12 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 吡嗪化合物和含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
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公开(公告)号：US20100137278A1
公开(公告)日：2010-06-03
申请号：US12619574
申请日：2009-11-16
申请人： Jennifer R. Allen , Matthew P. Bourbeau , Ning Chen , Essa Hu , Roxanne Kunz , Shannon Rumfelt
发明人： Jennifer R. Allen , Matthew P. Bourbeau , Ning Chen , Essa Hu , Roxanne Kunz , Shannon Rumfelt
IPC分类号： A61K31/497 , C07D413/14 , C07D401/14 , C07D417/14 , A61K31/5377 , A61K31/541 , A61K31/397 , A61P25/28 , A61P25/24
CPC分类号： C07D403/12 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
摘要翻译： 吡嗪化合物和含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相情感障碍，强迫症等。
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47.发明申请NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF 有权萘磺隆化合物展示丙烯酸羟化酶抑制活性，组合物及其用途公开(公告)号：US20100048572A1
公开(公告)日：2010-02-25
申请号：US12612465
申请日：2009-11-04
申请人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号： A61K31/535 , A61K31/435 , A61K31/438 , A61K31/35 , A61K31/34 , A61K31/195
CPC分类号： C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要： Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译： 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：US07569726B2
公开(公告)日：2009-08-04
申请号：US12082263
申请日：2008-04-09
IPC分类号： C07C257/00 , C07C229/00 , A61K31/195
CPC分类号： C07D213/16 , C07D213/56 , C07D309/04 , C07D309/06 , C07D333/10 , C07D333/24
摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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