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公开(公告)号：US20090088475A1
公开(公告)日：2009-04-02
申请号：US12082263
申请日：2008-04-09
IPC分类号： A61K31/197 , C07C229/36
CPC分类号： C07D213/16 , C07D213/56 , C07D309/04 , C07D309/06 , C07D333/10 , C07D333/24
摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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公开(公告)号：US07569726B2
公开(公告)日：2009-08-04
申请号：US12082263
申请日：2008-04-09
IPC分类号： C07C257/00 , C07C229/00 , A61K31/195
CPC分类号： C07D213/16 , C07D213/56 , C07D309/04 , C07D309/06 , C07D333/10 , C07D333/24
摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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3.发明授权公开(公告)号：US07728130B2
公开(公告)日：2010-06-01
申请号：US11635683
申请日：2006-12-08
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
IPC分类号： C07D413/00
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要翻译： 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
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4.发明申请QUINOLONE BASED COMPOUNDS EXHIBITING, PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF 有权基于喹啉酮的化合物展示，丙烯酸羟化酶抑制活性及其组合物及其用途公开(公告)号：US20100184763A1
公开(公告)日：2010-07-22
申请号：US12703496
申请日：2010-02-10
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
IPC分类号： A61K31/5377 , C07D215/56 , A61K31/4704 , C07D401/10 , A61K31/506 , C07D413/10 , A61K31/501 , A61P7/06 , A61P9/10 , A61P17/02 , A61P9/12 , A61P3/10 , A61P35/00 , A61P29/00
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HW molecule.
摘要翻译： 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及在HW分子中检测羟脯氨酸残基的测定。
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5.发明授权Quinolone based compounds exhibiting, prolyl hydroxylase inhibitory activity, and compositions, and uses thereof 有权喹诺酮类化合物，表现出脯氨酰羟化酶抑制活性，组合物及其用途公开(公告)号：US08017626B2
公开(公告)日：2011-09-13
申请号：US12703496
申请日：2010-02-10
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
IPC分类号： A61K31/4704 , C07D215/56
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要翻译： 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
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6.发明授权Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof 有权具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途公开(公告)号：US08012968B2
公开(公告)日：2011-09-06
申请号：US12703716
申请日：2010-02-10
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
IPC分类号： A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4704
CPC分类号： C07D215/22 , C07D215/56 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N33/542
摘要： This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
摘要翻译： 本发明涉及显示脯氨酰羟化酶抑制活性的新型喹诺酮类化合物。 本发明还涉及通过向受试者施用至少一种基于喹诺酮的化合物来增加受试者中HIF水平或活性或治疗与受试者中HIF水平或活性相关的病症的方法。 本发明还涉及用于检测HIF分子中的羟脯氨酸残基的测定法。
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7.发明授权Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权显示脯氨酰羟化酶抑制活性的萘环酮化合物，组合物和用途公开(公告)号：US07928139B2
公开(公告)日：2011-04-19
申请号：US12612465
申请日：2009-11-04
申请人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号： A61K31/352 , A61K31/195
CPC分类号： C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要： Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译： 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构：其中本文提供变量的定义。
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8.发明授权Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof 有权显示脯氨酰羟化酶抑制活性的萘环酮化合物，组合物和用途公开(公告)号：US07635715B2
公开(公告)日：2009-12-22
申请号：US12002537
申请日：2007-12-17
申请人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号： A61K31/352 , C07D311/96
CPC分类号： C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要： Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
摘要翻译： 式I和式II的化合物可用作HIF脯氨酰羟化酶的抑制剂。 式I和式II的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：US20090093483A1
公开(公告)日：2009-04-09
申请号：US12002537
申请日：2007-12-17
申请人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
发明人： Jennifer R. Allen , Kaustav Biswas , Marian C. Bryan , Roland Burli , Guo-Qiang Cao , Michael J. Frohn , Jennifer E. Golden , Stephanie Mercede , Susana Neira , Tanya Peterkin , Alexander J. Pickrell , Anthony Reed , Christopher M. Tegley , Xiang Wang
IPC分类号： A61K31/5375 , C07D265/30 , A61K31/352 , C07D311/96 , C07C229/34 , A61K31/197 , A61K31/4418 , C07D213/56 , A61P9/10 , C12N5/06
CPC分类号： C07C255/47 , C07B2200/07 , C07C59/90 , C07C235/82 , C07C237/24 , C07C255/57 , C07C323/62 , C07C2602/10 , C07C2603/94 , C07D213/56 , C07D213/61 , C07D215/48 , C07D217/02 , C07D221/20 , C07D295/13 , C07D307/94 , C07D311/96
摘要： Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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公开(公告)号：US20090099171A1
公开(公告)日：2009-04-16
申请号：US12150998
申请日：2008-05-02
申请人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer E. Golden , Stephanie Mercede , Christopher M. Tegley
发明人： Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer E. Golden , Stephanie Mercede , Christopher M. Tegley
IPC分类号： A61K31/5377 , C07D487/02 , A61K31/5025 , C12N5/00 , A61K31/4985 , A61P37/06 , A61P35/00 , A61P9/00 , A61P29/00 , A61P17/02 , C07D471/02 , A61K31/519 , C07D413/14
CPC分类号： C07D471/04
摘要： Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
摘要翻译： 式I化合物是HIF脯氨酰羟化酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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