公开(公告)号：US20110171363A1

公开(公告)日：2011-07-14

申请号：US13052272

申请日：2011-03-21

Applicant: Manabu Komatsu ,  Hiroyuki Hashimoto

Inventor： Manabu Komatsu ,  Hiroyuki Hashimoto

IPC: G01N23/00 ,  G01N1/28 ,  G01N23/22 ,  B05D1/02

CPC classification number: H01J49/10 ,  B01L3/5085 ,  H01J49/40 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A test specimen that has one or more chemical substances fixed to prescribed plural independent positions on a substrate, and the quantities of the chemical substances fixed at the respective prescribed positions are the total of integer multiples of existence quantity units defined for the respective chemical substances in the range from 1 amol to 1 nmol (excluding the case in which the total quantity is zero).

Abstract translation: 将具有固定在基板上规定的多个独立位置的一种以上的化学物质的试样和固定在各规定位置的化学物质的量作为对各化学物质定义的存在量单位的整数倍的总和 范围从1 amol到1 nmol（不包括总量为零的情况）。

公开(公告)号：US07979799B2

公开(公告)日：2011-07-12

申请号：US12071464

申请日：2008-02-21

Applicant: Hiroyuki Hashimoto

Inventor： Hiroyuki Hashimoto

IPC: G06F3/00 ,  G06F3/048 ,  G09F5/00

CPC classification number: G03B21/005

Abstract: A computer connectable image display apparatus for presentation is provided. The image display apparatus has a candidate information obtaining unit, a selection screen display unit, a presentation execution instruction unit, and a drawing screen display unit. The candidate information obtaining unit obtains selection candidate information generated by the computer relating selection candidates for a presentation subject file. The selection screen display unit generates and displays a selection screen for selecting the presentation subject file based on the selection candidate information. The presentation execution instruction unit makes the computer to execute the selected presentation subject file by sending selection results with the selection screen. The drawing screen display unit captures and displays a computer drawing screen drawn by the computer. The image display apparatus displays the selection screen without displaying the computer drawing screen when a connection with the computer is established, and displays the computer drawing screen when drawing by the computer executing the selected presentation subject file is started.

Abstract translation: 提供了一种用于呈现的计算机可连接图像显示装置。 图像显示装置具有候选信息获取单元，选择屏幕显示单元，呈现执行指令单元和绘图屏幕显示单元。 候选信息获取单元获得由计算机产生的选择候选信息，该选择候选信息涉及呈现对象文件的选择候选。 选择画面显示单元根据选择候选信息生成并显示用于选择演示对象文件的选择画面。 呈现执行指令单元使计算机通过选择画面发送选择结果来执行所选择的演示主题文件。 绘图屏幕显示单元捕获并显示计算机绘制的计算机绘图画面。 当与计算机的连接建立时，图像显示装置显示选择屏幕而不显示计算机绘图屏幕，并且当执行所选择的呈现对象文件的计算机开始绘图时，显示计算机画面画面。

公开(公告)号：US20100189832A1

公开(公告)日：2010-07-29

申请号：US12670414

申请日：2008-09-03

Applicant: Hideto Monzen ,  Hiroyuki Hashimoto ,  Takuya Fujikawa ,  Hiroshi Hayashi ,  Tsuneo Imatani

Inventor： Hideto Monzen ,  Hiroyuki Hashimoto ,  Takuya Fujikawa ,  Hiroshi Hayashi ,  Tsuneo Imatani

IPC: B29C43/34

CPC classification number: B29C43/34 ,  B29B11/12 ,  B29B11/14 ,  B29B2911/1402 ,  B29B2911/14026 ,  B29B2911/14033 ,  B29B2911/1404 ,  B29B2911/14106 ,  B29B2911/14213 ,  B29B2911/14326 ,  B29B2911/14333 ,  B29B2911/1444 ,  B29B2911/14466 ,  B29C31/048 ,  B29C43/08 ,  B29C47/0016 ,  B29C47/003 ,  B29C47/0042 ,  B29C2043/3466 ,  B29C2043/3676 ,  B29C2793/009 ,  B29K2067/00 ,  B29K2105/04 ,  B29K2105/258

Abstract: [Problems] To provide an apparatus for feeding molten resin capable of preventing the adhesion of matters on the holding units for holding the molten resin, and of shortening the cycle for cleaning the holding units.[Means for Solution] The apparatus includes holding units 17 having holders 22, 23 that can be opened and closed to hold a molten resin that is discharged from an extruder and is cut by a cutter, and a base portion 21. The holding unit 17 opens the holders 22 and 23 to throw the molten resin down to a female mold in a compression-molding machine. A plurality of longitudinal grooves 18 extending up and down are formed in the inner circumferential surface of the base portion 21.

Abstract translation: [问题]提供一种能够防止物料粘附在用于保持熔融树脂的保持单元上的熔融树脂的装置，并且缩短了用于清洁保持单元的循环。 [解决方案]该装置包括保持单元17，该保持单元17具有能够打开和关闭的保持器22,23，以保持从挤出机排出并由切割器切割的熔融树脂和基部21.保持单元17 打开保持器22和23以将熔融树脂向下压到压模机中的阴模上。 在基部21的内周面形成有上下延伸的多个纵向槽18。

公开(公告)号：US07680286B2

公开(公告)日：2010-03-16

申请号：US10852239

申请日：2004-05-25

Applicant: Hiroyuki Hashimoto ,  Kenichi Terai ,  Koichi Hashimoto ,  Kazue Satoh

Inventor： Hiroyuki Hashimoto ,  Kenichi Terai ,  Koichi Hashimoto ,  Kazue Satoh

IPC: H04B1/00 ,  H04R29/00 ,  H03G3/20 ,  H04R3/00

CPC classification number: H04S7/305 ,  H04R5/02 ,  H04R2499/13 ,  H04S7/301 ,  H04S7/302 ,  H04S7/307

Abstract: A wide frequency range signal from a test sound source is reproduced successively by a plurality of speakers, and the reproduced sound is detected by a plurality of microphones, after which the frequency characteristics are obtained at FFTs, while obtaining the frequency characteristics of the wide frequency range signal at an FFT. A high frequency range level is normalized with a low frequency range level, and a determination section compares the normalized value with a reference value stored in a reference value storage section to determine the number and positions of people in the sound field. The transfer functions between the speakers and the microphones are calculated at transfer function calculators, and impulse responses are obtained at IFFTs, after which a reverberation time calculator calculates the reverberation time based on the impulse responses. An audio signal is adjusted based on the results.

Abstract translation: 来自测试声源的宽频率范围信号由多个扬声器连续再现，并且由多个麦克风检测再现的声音，之后在FFT获得频率特性，同时获得宽频率的频率特性 FFT处的范围信号。 高频范围电平用低频范围电平进行归一化，判定部将归一化值与存储在基准值存储部中的基准值进行比较，以确定声场中的人的数量和位置。 扬声器和麦克风之间的传递函数在传递函数计算器中计算，并且在IFFTs获得脉冲响应，之后混响时间计算器基于脉冲响应计算混响时间。 根据结果​​调整音频信号。

公开(公告)号：US20090236767A1

公开(公告)日：2009-09-24

申请号：US12281037

申请日：2007-02-20

Applicant: Kiyoshi Kawaguchi ,  Masayuki Sasaki ,  Jun Yonesato ,  Hiroyuki Hashimoto

Inventor： Kiyoshi Kawaguchi ,  Masayuki Sasaki ,  Jun Yonesato ,  Hiroyuki Hashimoto

IPC: B29C47/34 ,  B29C47/88

CPC classification number: B29C31/048 ,  B29B11/12 ,  B29C43/08 ,  B29C43/34 ,  B29C47/0016 ,  B29C47/003 ,  B29C47/004 ,  B29C47/0066 ,  B29C47/8815 ,  B29C2043/3433 ,  B29C2043/3461 ,  B29C2043/3472 ,  B29C2793/0027 ,  B29C2793/009 ,  B29K2067/00

Abstract: An apparatus for feeding a molten resin is operated for extended periods of time maintaining stability without permitting volatile components of the molten resin to adhere on the surfaces of conveyer means. An extruder in the apparatus for feeding the molten resin to the compression-forming machine has an extrusion unit which discharges a molten resin through an extrusion opening of an extrusion nozzle. An air injection nozzle for injecting the cooling gas is provided along the outer circumference of the extrusion nozzle, and the cooling gas is blown onto the surface of the molten resin extruded from the extrusion opening to cool the surface of the molten resin.

Abstract translation: 用于进料熔融树脂的设备运行时间较长，保持稳定性，而不允许熔融树脂的挥发性组分粘附在传送装置的表面上。 用于将熔融树脂供给到压缩成形机的装置中的挤出机具有挤出单元，该挤出单元通过挤出喷嘴的挤出口排出熔融树脂。 沿着挤出喷嘴的外周设置有用于喷射冷却气体的空气喷射喷嘴，并且将冷却气体吹送到从挤出口挤出的熔融树脂的表面上以冷却熔融树脂的表面。

公开(公告)号：US07491518B2

公开(公告)日：2009-02-17

申请号：US10362483

申请日：2001-08-08

Applicant: Masamichi Okada ,  Shigeharu Mori ,  Hiroyuki Hashimoto ,  Koki Fujita ,  Kozo Hara

Inventor： Masamichi Okada ,  Shigeharu Mori ,  Hiroyuki Hashimoto ,  Koki Fujita ,  Kozo Hara

IPC: C12P19/14 ,  C12P19/12 ,  C12P19/18

CPC classification number: C12N9/2465 ,  C12P19/14 ,  C12Y302/01022

Abstract: A novel method of very efficiently elevating the yield of oligosacchrides containing α-galactosyl, compared with the conventional methods, which comprises treating galactose or a galactose-containing material with a specific α-galactosidase and thus performing a dehydrocondensation reaction at a high substrate concentration. Anti-candida compositions originating in foods, having a high safety and excellent anti-candida effect and not being restricted in the supply, which contain as the active ingredient oligosacchrides obtained by treating galactose or a galactose-containing material with an α-galactosidase and thus performing a dehydrocondensation.

Abstract translation: 与常规方法相比，非常有效地提高含有α-半乳糖苷的寡糖的产率的新方法，其包括用特定的α-半乳糖苷酶处理半乳糖或含半乳糖的材料，从而以高底物浓度进行脱氢反应。 起始于食物的抗念珠菌组合物，具有高安全性和优异的抗念珠菌作用，不受供体限制，其含有通过用α-半乳糖苷酶处理半乳糖或含半乳糖的物质获得的活性成分的寡糖，因此 进行脱氢。

公开(公告)号：US20090026364A1

公开(公告)日：2009-01-29

申请号：US12239344

申请日：2008-09-26

Applicant: Yohei Murayama ,  Manabu Komatsu ,  Hiroyuki Hashimoto

Inventor： Yohei Murayama ,  Manabu Komatsu ,  Hiroyuki Hashimoto

IPC: B01D59/44

CPC classification number: H01J49/40 ,  H01J49/0004 ,  Y10T436/24

Abstract: In-plane distribution of a target object contained in a sample is measured. The sample dispersedly placed on a substrate is treated to promote ionization of the target object. Then, the mass and flying amount of an ion containing the target object or a component thereof is determined by irradiating an ion beam to the sample and performing time-of-flight secondary ion mass spectrometry of the ion that flies from a portion in the sample where the ion beam is irradiated, and the in-plane distribution of the target object is determined from the mass and flying amount data obtained at plural portions by scanning the beam on the sample plane. The step of treating the sample to promote ionization of the target object includes contacting an aqueous solution of an acid that does not crystallize at ordinary temperature with the sample. A high spatial resolution two-dimensional image can be obtained.

Abstract translation: 测量包含在样本中的目标对象的平面内分布。 处理分散放置在基板上的样品，以促进目标物体的电离。 然后，通过向样品照射离子束并进行从样品的一部分飞出的离子的飞行时间二次离子质谱法来确定含有目标物体或其成分的离子的质量和飞散量 其中照射离子束，并且通过在样品平面上扫描光束从多个部分获得的质量和飞行量数据确定目标物体的面内分布。 处理样品以促进目标物体的电离的步骤包括使常温下不结晶的酸的水溶液与样品接触。 可以获得高空间分辨率的二维图像。

公开(公告)号：US20080290268A1

公开(公告)日：2008-11-27

申请号：US12120512

申请日：2008-05-14

Applicant: Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

Inventor： Manabu Komatsu ,  Hiroyuki Hashimoto ,  Yohei Murayama ,  Kazuhiro Ban

IPC: B01D59/44

CPC classification number: H01J49/145

Abstract: An information obtaining method for obtaining information about a mass of a component of an analyte using a time of flight mass spectrometer and obtaining information about a distribution state of the component based on the obtained information about the mass includes the step of: (1) adding a self-reactive substance to the analyte on a base to facilitate ionization of the component; (2) irradiating the analyte with a primary beam in the presence of the self-reactive substance, thereby ionizing the components and allowing resulting ions to fly; (3) obtaining information about mass of the flying ions using the time of flight mass spectrometer; and (4) obtaining information about the distribution state of the component on the base based on the information about the mass.

Abstract translation: 使用飞行时间质谱仪获取关于分析物的成分的质量的信息的信息获取方法，基于获得的关于质量的信息获得关于部件的分布状态的信息，包括以下步骤：（1）添加 对基底上的分析物的自反应物质，以促进组分的离子化; （2）在存在自反应物质的情况下用主光束照射分析物，从而电离成分并允许所得离子飞行; （3）使用飞行时间质谱仪获取关于飞行离子质量的信息; 和（4）基于关于质量的信息获得关于组件在基础上的分布状态的信息。

公开(公告)号：US20080277576A1

公开(公告)日：2008-11-13

申请号：US12117527

申请日：2008-05-08

Applicant: Manabu Komatsu ,  Hiroyuki Hashimoto

Inventor： Manabu Komatsu ,  Hiroyuki Hashimoto

IPC: H01J49/00

CPC classification number: H01J49/142

Abstract: A time-of-flight secondary ion mass spectrometer comprises an ion source which generates cluster ions each comprised of two or more atoms, a pulsing mechanism which pulses the cluster ions, a selecting mechanism which selects ions having a specific mass number from the pulsed cluster ions and passes the selected ions in an ON state of the selecting mechanism, and, passes the pulsed cluster ions without the selecting in an OFF state of the selecting mechanism, and a time-of-flight mass spectrometric unit which measures a mass spectrum of secondary ions generated from a sample using a difference in time of flight when the sample is irradiated with the ions passed through the selecting mechanism.

Abstract translation: 飞行时间二次离子质谱仪包括产生每个由两个或多个原子构成的簇离子的离子源，脉冲簇离子的脉冲机制，从脉冲簇选择具有特定质量数的离子的选择机制 离子，并将所选择的离子通过选择机构的导通状态，并且在选择机构的O​​FF状态下通过脉冲簇离子而不选择，并且测量飞行时间质谱单位， 当使用通过选择机构的离子照射样品时，使用飞行时间差来自样品产生的二次离子。

公开(公告)号：US20080268497A1

公开(公告)日：2008-10-30

申请号：US12098822

申请日：2008-04-07

Applicant: Hiroyuki Hashimoto ,  Manabu Komatsu ,  Satoru Hatakeyama

Inventor： Hiroyuki Hashimoto ,  Manabu Komatsu ,  Satoru Hatakeyama

IPC: G01N1/30 ,  C12Q1/00

CPC classification number: G01N33/6848 ,  B82Y15/00 ,  G01N33/54313

Abstract: The present invention intends to provide a high sensitivity method for identifying the type of a protein contained in each cell with a diameter of ten to several tens μm and a sample treatment solution required for it. The above is achieved by three steps of (1) treating a slice of a diseased tissue with an aqueous solution containing gold particles and a digestive enzyme, and digesting restrictively a protein of interest, (2) measuring a 2-dimensional distribution of fragmented peptides by TOF-SIMS, and (3) visualizing a 2-dimensional distribution of the target protein in the slice of the diseased tissue using the results of the proteome analysis and by means of a numerical analysis.

Abstract translation: 本发明旨在提供用于鉴定直径为10至数十微米的每个电池中所含的蛋白质的类型的高灵敏度方法和所需的样品处理溶液。 上述通过以下三个步骤实现：（1）用含有金颗粒和消化酶的水溶液处理患病组织的切片，并限制性地消化目的蛋白质，（2）测量片段肽的2维分布 通过TOF-SIMS，以及（3）使用蛋白质组分析的结果并通过数值分析来显现病变组织切片中靶蛋白的二维分布。