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公开(公告)号：US20090203635A1
公开(公告)日：2009-08-13
申请号：US11968925
申请日：2008-01-03
申请人： Craig A. Rosen , George A. Komatsoulis , Kevin P. Baker , Michele Fiscella , Paul A. Moore , Ping Wei , D. Roxanne Duan , Yanggu Shi , Ram Gupta
发明人： Craig A. Rosen , George A. Komatsoulis , Kevin P. Baker , Michele Fiscella , Paul A. Moore , Ping Wei , D. Roxanne Duan , Yanggu Shi , Ram Gupta
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20110002888A1
公开(公告)日：2011-01-06
申请号：US12793658
申请日：2010-06-03
申请人： Craig A. Rosen , Adam Bell , Paul A. Moore , Yanggu Shi , David Lafleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
发明人： Craig A. Rosen , Adam Bell , Paul A. Moore , Yanggu Shi , David Lafleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
IPC分类号： A61K38/21 , C07K14/76 , A61K38/38 , C07H21/00 , C12N15/63 , C12N5/10 , A61K38/46 , A61K38/18 , A61K38/22 , A61K39/395 , A61K38/43 , C12N9/96 , A61K39/12 , A61K38/30 , A61P35/00 , A61P3/04 , A61P3/10 , A61P3/00 , A61P37/02 , A61P9/08 , A61P9/00 , A61P9/04 , A61P1/16 , A61P25/30 , A61P31/12 , A61P9/12
CPC分类号： C07K14/58 , C07K14/765 , C07K2319/01
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
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公开(公告)号：US20080051338A1
公开(公告)日：2008-02-28
申请号：US11777133
申请日：2007-07-12
申请人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
IPC分类号： A61K31/70 , A61K38/00 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/11 , C12N15/87 , C12N5/06 , C12P21/04 , C12Q1/68 , G01N33/53
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070020724A1
公开(公告)日：2007-01-25
申请号：US10886642
申请日：2004-07-09
申请人： Steven Ruben , Jian Ni , Craig Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel Soppet , Laurie Brewer , Gregory Endress , Kenneth Carter , Michael Mucenski , Reinhard Ebner , David LaFleur , Henrik Olsen , Yanggu Shi , Paul Moore , George Komatsoulis
发明人： Steven Ruben , Jian Ni , Craig Rosen , Ying-Fei Wei , Paul Young , Kimberly Florence , Daniel Soppet , Laurie Brewer , Gregory Endress , Kenneth Carter , Michael Mucenski , Reinhard Ebner , David LaFleur , Henrik Olsen , Yanggu Shi , Paul Moore , George Komatsoulis
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070014787A1
公开(公告)日：2007-01-18
申请号：US11375555
申请日：2006-03-15
申请人： Steven Ruben , George Komatsoulis , D. Duan , Craig Rosen , Paul Moore , Yanggu Shi , David LaFleur , Reinhard Ebner , Henrik Olsen , Laurie Brewer , Kimberly Florence , Paul Young , Michael Mucenski , Gregory Endress , Daniel Soppet
发明人： Steven Ruben , George Komatsoulis , D. Duan , Craig Rosen , Paul Moore , Yanggu Shi , David LaFleur , Reinhard Ebner , Henrik Olsen , Laurie Brewer , Kimberly Florence , Paul Young , Michael Mucenski , Gregory Endress , Daniel Soppet
IPC分类号： A61K39/395 , C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060079670A1
公开(公告)日：2006-04-13
申请号：US11229769
申请日：2005-09-20
申请人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
发明人： George Komatsoulis , Craig Rosen , Steven Ruben , Roxanne Duan , Paul Moore , Yanggu Shi , David LaFleur , Ying-Fei Wei , Jian Ni , Kimberly Florence , Paul Young , Laurie Brewer , Daniel Soppet , Gregory Endress , Reinhard Ebner , Henrik Olsen , Michael Mucenski
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060036089A1
公开(公告)日：2006-02-16
申请号：US11240769
申请日：2005-10-03
申请人： Daniel Soppet , Paul Moore , Yanggu Shi , Steven Ruben , Craig Rosen , David LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
发明人： Daniel Soppet , Paul Moore , Yanggu Shi , Steven Ruben , Craig Rosen , David LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
IPC分类号： C07H21/04 , C12P21/06 , C07K14/705 , C07K14/47
摘要： The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及33种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US07638603B2
公开(公告)日：2009-12-29
申请号：US11567524
申请日：2006-12-06
申请人： Yanggu Shi , Steven M. Ruben
发明人： Yanggu Shi , Steven M. Ruben
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/54 , C07K16/2866 , C07K2319/30 , C12N2799/026 , G01N2333/715
摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。
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公开(公告)号：US20090042792A1
公开(公告)日：2009-02-12
申请号：US11962255
申请日：2007-12-21
申请人： Yanggu Shi , Paul E. Young , Reinhard Ebner , Daniel R. Soppet , Steven M. Ruben
发明人： Yanggu Shi , Paul E. Young , Reinhard Ebner , Daniel R. Soppet , Steven M. Ruben
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12Q1/02 , A61P31/00 , G01N33/566 , C12Q1/68 , C07K14/00 , C07K16/18 , C12P21/04
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US06849719B2
公开(公告)日：2005-02-01
申请号：US09796844
申请日：2001-03-02
申请人： Yanggu Shi , Steven M. Ruben
发明人： Yanggu Shi , Steven M. Ruben
IPC分类号： A61K38/00 , C07K14/715 , C07K16/28 , C07K16/00
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/54 , C07K16/2866 , C07K2319/30 , C12N2799/026 , G01N2333/715
摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.
摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。
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