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    PYRIMIDINE COMPOUNDS AND MEDICINAL COMPOSITION THEREOF
    41.
    发明申请
    PYRIMIDINE COMPOUNDS AND MEDICINAL COMPOSITION THEREOF 审中-公开
    吡嗪化合物及其药物组合物

    公开(公告)号：US20090030023A1

    公开(公告)日：2009-01-29

    申请号：US12054337

    申请日：2008-03-24

    申请人： Hitoshi Harada ,  Masato Ueda ,  Yoshihiko Kotake ,  Masahiro Yasuda ,  Daisuke Iida ,  Junichi Nagakawa ,  Makoto Nakagawa

    发明人： Hitoshi Harada ,  Masato Ueda ,  Yoshihiko Kotake ,  Masahiro Yasuda ,  Daisuke Iida ,  Junichi Nagakawa ,  Makoto Nakagawa

    IPC分类号： C07D239/42 ,  A61K31/505 ,  C12N5/00 ,  A61P1/00

    CPC分类号： C07D405/14 ,  A61K31/506 ,  C07D401/04 ,  C07D409/14

    摘要： A compound represented by the following formula (I), a salt, or a solvate thereof: wherein, R1 and R2 are the same as or different from each other and each represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, a non-aromatic heterocyclic group, an aromatic hydrocarbon cyclic group, an aromatic heterocyclic group, an acyl group or an alkylsulfonyl group all of which may be substituted and wherein one, or both, of R1 or R2 is an aromatic, or non-aromatic, heterocyclic group which may be substituted; R3 represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group, an alkenyl group, an alkynyl group, an aromatic hydrocarbon cyclic group, an aromatic heterocyclic group, a nitrogen atom, an oxygen atom or a sulfur atom all of which may be substituted if possible; and R4 is a pyridyl group which may be substituted.

    摘要翻译： 由下式（I）表示的化合物，其盐或溶剂化物：其中，R1和R2彼此相同或不同，各自表示氢原子，烷基，烯基，炔基 基团，环烷基，环烯基，非芳族杂环基，芳香族烃环基，芳香族杂环基，酰基或烷基磺酰基，其全部可以被取代，并且其中R1或 或R 2是可以被取代的芳族或非芳族杂环基; R3表示氢原子，卤原子，氰基，烷基，烯基，炔基，芳香族烃环基，芳香族杂环基，氮原子，氧原子或硫原子全部 如果可能的话可以被替代; R4为可被取代的吡啶基。

    Benzimidazole compound
    42.
    发明授权
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US07425634B2

    公开(公告)日：2008-09-16

    申请号：US11520838

    申请日：2006-09-14

    申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： C07D401/12

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability.Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

    Benzimidazole compound
    44.
    发明申请
    Benzimidazole compound 有权
    苯并咪唑化合物

    公开(公告)号：US20070010542A1

    公开(公告)日：2007-01-11

    申请号：US11520838

    申请日：2006-09-14

    申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

    IPC分类号： A61K31/4747 ,  A61K31/4439 ,  C07D405/14

    CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

    摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

    摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

    Pyrimidone compounds and pharmaceutical compositions containing the same
    45.
    发明授权
    Pyrimidone compounds and pharmaceutical compositions containing the same 失效
    嘧啶酮化合物和含有它们的药物组合物

    公开(公告)号：US07160892B2

    公开(公告)日：2007-01-09

    申请号：US10492547

    申请日：2002-10-22

    申请人： Hitoshi Harada ,  Osamu Asano ,  Masato Ueda ,  Shuhei Miyazawa ,  Yoshihiko Kotake ,  Yasuhiro Kabasawa ,  Masahiro Yasuda ,  Nobuyuki Yasuda

    发明人： Hitoshi Harada ,  Osamu Asano ,  Masato Ueda ,  Shuhei Miyazawa ,  Yoshihiko Kotake ,  Yasuhiro Kabasawa ,  Masahiro Yasuda ,  Nobuyuki Yasuda

    IPC分类号： A61K31/5377 ,  A61K31/513 ,  C07D417/02 ,  C07D413/02 ,  C07D43/02

    CPC分类号： C07D239/34 ,  A61K31/513

    摘要： The invention provides novel pyrimidone compounds exhibiting excellent antagonism against adenosine receptors (A1, A2A, and A2B receptors), particularly, compounds represented by the general formula (1), salts thereof, or solvates of both: (1) wherein R1 and R2 are each independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, a 5- to 14-membered nonaromatic heterocyclic group, a C6-14 aromatic hydrocarbon group, a 5- to 14-membered aromatic heterocyclic group, C1-6 acyl, or C1-6 alkylsulfonyl; R3 is hydrogen, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl; R4 is a C6-14 aromatic hydrocarbon group; a 5- to 14-membered aromatic heterocyclic group, or a 5- to 14-membered nonaromatic heterocyclic group having at least one unsaturated bond; and R5 is a C6-14 aromatic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group (with the proviso that every group except hydrogen may be substituted).

    摘要翻译： 本发明提供了对腺苷受体（A 1 SUB，A 2A和A 2B 2受体）表现出优异拮抗作用的新型嘧啶酮化合物，特别是表示的化合物 通式（1）表示的盐，其盐或两者的溶剂合物：（1）其中R 1和R 2各自独立地为氢，C 1〜 C 1-6烷基，C 2-6链烯基，C 2-6炔基，C 3-8环烷基，C 1 -C 6 - 3-8环烯基，5至14元非芳族杂环基，C 6-14芳族烃基，5至14元芳族杂环基，C 1-6酰基或C 1-6烷基磺酰基; R 3是氢，C 1-6烷基，C 2-6链烯基或C 2-6亚烷基， 炔基; R 4是C 6-14芳族烃基; 5至14元芳族杂环基或具有至少一个不饱和键的5至14元非芳族杂环基; 和R 5是C 6-14芳族烃基或5至14元芳族杂环基（条件是除了氢以外的每个基团可以被取代） 。

    Inkjet head
    46.
    发明申请
    Inkjet head 有权
    喷墨头

    公开(公告)号：US20060119675A1

    公开(公告)日：2006-06-08

    申请号：US11286466

    申请日：2005-11-25

    申请人： Masato Ueda

    发明人： Masato Ueda

    IPC分类号： B41J2/175

    CPC分类号： B41J2/175

    摘要： An ink jet head in which a head chip on which a nozzle for jetting ink and an ink supply port that is communicated with the nozzle are formed and a manifold on which an ink channel connecting port and a groove communicating with the ink channel connecting port are formed, are provided, and an ink channel in which a spacer occupying a part of a space in the groove is arranged in the groove is formed by connecting a face on which the ink supply port of the head chip is formed, to a face on which the groove of the manifold is formed. An ink path is formed so as to be capable of being communicated from the ink channel connecting port to the groove through the ink channel.

    摘要翻译： 一种喷墨头，其中形成有用于喷射墨水的喷嘴和与喷嘴连通的供墨口的头部芯片，以及与墨水通道连接口连通的墨水通道连接口和凹槽的歧管 并且在凹槽中布置有占据槽中的空间的一部分的间隔物的墨通道是通过将形成有头磁芯的供墨口的面与其上的面相连而形成的 形成歧管的槽。 油墨通道形成为能够通过墨水通道从墨水通道连接口连通到凹槽。

    Organic electroluminescence device
    48.
    发明授权
    Organic electroluminescence device 失效
    有机电致发光器件

    公开(公告)号：US5958609A

    公开(公告)日：1999-09-28

    申请号：US787353

    申请日：1997-01-22

    申请人： Masato Ueda ,  Fumi Yamaguchi

    发明人： Masato Ueda ,  Fumi Yamaguchi

    IPC分类号： C08G61/00 ,  C09K11/06 ,  H05B33/14

    CPC分类号： C08G61/00 ,  C09K11/06 ,  H05B33/14 ,  Y10S428/917

    摘要： An organic electroluminescence device which has a pair of electrodes, at least one of which is transparent or semitransparent, and at least one organic layer formed between the electrodes. The organic layer contains a hole transporting material and a light emitting material in the same or different layer. The hole transporting material contains at least one polysilane whose main chain skeleton is composed of a repeating unit represented by the general formula (1) and a repeating unit represented by the general formula (2): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently represent a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group, Ar.sub.1 represents a substituted or unsubstituted arylene group and Ar.sub.2 represents a substituted or unsubstituted aryl group. The polysilane satisfies the expression 0.2.ltoreq.z.ltoreq.1 where a ratio of the number of the repeating unit (1) and that of the repeating unit (2) to the total number of the repeating units (1) and (2) are z and 1-z, respectively. The polysilane has a weight average molecular weight of not less than 5000 and a hole drift mobility of 10.sup.-3 -10.sup.-1 cm.sup.2 /v/sec. The organic EL device shows excellent characteristics of higher luminance and higher luminous efficiency at lower driving voltage.

    摘要翻译： 一种有机电致发光器件，其具有至少一个透明或半透明的一对电极和形成在电极之间的至少一个有机层。 有机层包含相同或不同层中的空穴传输材料和发光材料。 空穴传输材料含有至少一个聚硅烷，其主链骨架由通式（1）表示的重复单元和由通式（2）表示的重复单元组成：其中R1，R2，R3和R4独立地表示 取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的芳基或取代或未取代的芳烷基，Ar1表示取代或未取代的亚芳基，Ar2表示取代或未取代的芳基。 聚硅烷满足重复单元（1）的数量与重复单元（2）的重复单元（1）和（2）的重复单元（1）和（2）的总数之比的0.2≤z≤1 ）分别为z和1-z。 聚硅烷的重均分子量不小于5000，空穴漂移迁移率为10-3-10-1cm2 / v / sec。 有机EL器件在较低的驱动电压下显示出更高亮度和更高发光效率的优异特性。