公开(公告)号：USRE36102E

公开(公告)日：1999-02-16

申请号：US891827

申请日：1997-07-14

Applicant: Thomas J. Dougherty

Inventor： Thomas J. Dougherty

IPC: H01M2/24 ,  H01M2/28 ,  H01M2/30

CPC classification number: H01M2/28 ,  H01M2/24 ,  H01M2/305

Abstract: The present invention relates to a unique battery arrangement including battery plates having a pair of spaced apart battery lugs for both the positive and negative plates. While being spaced apart, the lugs are located generally adjacent one top edge of the plates; on opposite sides for the positive and negative plate constructions. The straps used to electrically connect the lugs are lower in height than those used on current battery designs, providing excellent current collection, efficient fusion with smaller lugs and resistance to vibration caused by separation of the lugs from the straps. The present invention also features plates having greater plate surface area, improved current carrying capability and reduced voltage drop. A weld element couples straps of like polarity, and in the preferred embodiment, at least a portion of the weld element is located intermediate the ends of the straps.

公开(公告)号：US5506255A

公开(公告)日：1996-04-09

申请号：US160384

申请日：1993-12-01

Applicant: Kevin M. Smith ,  Ravindra K. Pandey ,  Joseph M. Ryan ,  Nadine Jagerovic ,  Thomas J. Dougherty

Inventor： Kevin M. Smith ,  Ravindra K. Pandey ,  Joseph M. Ryan ,  Nadine Jagerovic ,  Thomas J. Dougherty

IPC: A61K41/00 ,  C07D487/22 ,  A61K31/40

CPC classification number: C07D487/22 ,  A61K41/0071

Abstract: Novel photosensitizers related to rhodoporphyrins and phylloerythrin methyl ester, their preparation and use as photosensitizers for detection and treatment of tumors by photodynamic therapy. The novel photosensitizers accumulate and concentrate preferentially in tumor tissue, have strong light absorption in the 650 to 700 nm region and have reduced skin phototoxicity.

Abstract translation: 与紫罗兰卟啉和叶绿菊酯甲酯相关的新型光敏剂，它们的制备和用作光敏剂用于通过光动力学治疗检测和治疗肿瘤。 新型光敏剂积聚并优先集中在肿瘤组织中，在650〜700nm区域具有强光吸收，降低皮肤光毒性。

公开(公告)号：US5488283A

公开(公告)日：1996-01-30

申请号：US128453

申请日：1993-09-28

Applicant: Thomas J. Dougherty ,  William J. Wruck ,  Richard J. Johnson

Inventor： Thomas J. Dougherty ,  William J. Wruck ,  Richard J. Johnson

IPC: H01M2/30 ,  H01M6/50 ,  H01M10/04 ,  H01M10/12 ,  H01M10/42 ,  H01M10/44 ,  H01M10/48 ,  H02J7/14 ,  B60L1/02 ,  H02J7/34

CPC classification number: H01M10/0413 ,  B60L11/1855 ,  B60L11/1868 ,  H01M10/122 ,  H01M10/425 ,  H01M10/44 ,  H01M10/482 ,  H02J7/1423 ,  B60L2210/20 ,  B60L2240/36 ,  B60L2240/547 ,  B60L2240/549 ,  B60L2240/662 ,  H01M10/0445 ,  H01M2/305 ,  H01M6/5016 ,  Y02E60/126 ,  Y02T10/7016 ,  Y02T10/7066 ,  Y02T10/725 ,  Y02T10/7291 ,  Y02T90/16 ,  Y10T307/625

Abstract: A battery system for a vehicle includes a main battery for energizing the vehicle SLI circuits and an auxiliary battery for energizing the vehicle EHC system, the battery system providing back-up of the auxiliary battery by the main battery under certain conditions and back-up of the main battery by the auxiliary battery under certain other conditions, and the battery system providing opportunity charging of the auxiliary battery once the vehicle engine is running whereby the auxiliary battery shares the charging current with the main battery with the auxiliary battery being gradually connected to the source of charging current for the main battery by increasing the duty cycle of the drive circuit that connects the auxiliary battery to the source of charging current while monitoring the state of charge of the main battery and decreasing the duty cycle of the drive circuit to protect the main battery state of charge. In other embodiments, separate sources of charging current are provided for the auxiliary battery.

Abstract translation: 一种用于车辆的电池系统包括用于对车辆SLI电路通电的主电池和用于为车辆EHC系统通电的辅助电池，该电池系统在一定条件下提供主电池对辅助电池的备用和备用 主电池由辅助电池在某些其他条件下进行，并且一旦车辆发动机运行，电池系统提供辅助电池的充电机会，由此辅助电池与主电池共享充电电流，辅助电池逐渐连接到 通过增加将辅助电池连接到充电电流源的驱动电路的占空比，同时监视主电池的充电状态并减小驱动电路的占空比来保护主电池的充电电流源， 主电池充电状态。 在其他实施例中，为辅助电池提供单独的充电电流源。

公开(公告)号：US5459159A

公开(公告)日：1995-10-17

申请号：US239089

申请日：1994-05-05

Applicant: Ravindra K. Pandey ,  Thomas J. Dougherty

Inventor： Ravindra K. Pandey ,  Thomas J. Dougherty

IPC: A61K31/40 ,  A61K41/00 ,  A61K51/04 ,  A61P31/12 ,  A61P35/00 ,  C07D487/22 ,  C07D519/00

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K51/0485 ,  C07D519/00 ,  A61K2123/00

Abstract: Pyropheophorbide compounds are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compounds are exposed to a particular wavelength of light the compounds become cytotoxic and destroy the tumor or diseased tissue without causing irreversible normal tissue damage. The pyropheophorbide compounds have shown improved results as compared to drugs currently used in photodynamic therapy. Further, they absorb light further in the red, optimizing tissue penetration and are retained in the skin for short time periods relative to other drugs used in photodynamic therapy.

Abstract translation: 将焦磷偏磷酸酯化合物注射到宿主中并在肿瘤组织中积聚到比周围正常组织更高的程度。 当焦偏磷酸酯化合物暴露于特定波长的光时，化合物变成细胞毒性并破坏肿瘤或患病组织而不引起不可逆的正常组织损伤。 与目前在光动力疗法中使用的药物相比，焦偏镁离子化合物显示出改善的结果。 此外，它们进一步吸收红色的光，优化组织穿透，并相对于光动力疗法中使用的其他药物，在短时间内保留在皮肤中。

公开(公告)号：US5316868A

公开(公告)日：1994-05-31

申请号：US917581

申请日：1992-07-21

Applicant: Thomas J. Dougherty ,  John R. Pierson

Inventor： Thomas J. Dougherty ,  John R. Pierson

IPC: F02N11/08 ,  B60R16/02 ,  B60R16/03 ,  H01M10/04 ,  H01M10/42 ,  H02J7/00 ,  H02J7/14

CPC classification number: H01M10/0413 ,  H01M10/4207 ,  H02J7/0063 ,  H02J7/1423 ,  B60R16/03 ,  H01M10/0445 ,  Y02T10/7005

Abstract: A dual-battery switch circuit associated with a load is provided. The switch circuit includes a primary battery, a secondary battery, a circuit disposed to apply energy from the primary battery to the load, and a controller which disposed to sense attempts to apply energy to the load. The controller is configured to couple the secondary battery to the primary battery with respect to the load when a predetermined number of attempts to apply energy to the load occur within a predetermined time period after a first attempt. Alternatively, a controller is provided which couples the secondary battery to the primary battery with respect to the load when an attempt is made to apply energy to the load and the temperature is below a predetermined level.

Abstract translation: 提供与负载相关联的双电池开关电路。 开关电路包括一次电池，二次电池，被设置为将一次电池的能量施加到负载的电路，以及设置用于感测向负载施加能量的尝试的控制器。 控制器被配置为当在第一次尝试之后的预定时间段内发生预定数量的对负载施加能量的尝试时，相对于负载将二次电池耦合到一次电池。 或者，提供一种控制器，当试图对负载施加能量并且温度低于预定水平时，提供将二次电池相对于负载耦合到一次电池的控制器。

公开(公告)号：US5257970A

公开(公告)日：1993-11-02

申请号：US865918

申请日：1992-04-09

Applicant: Thomas J. Dougherty

Inventor： Thomas J. Dougherty

IPC: A61K9/127 ,  A61K31/40 ,  A61K31/50 ,  A61K31/66 ,  A61K41/00 ,  A61N1/30

CPC classification number: A61K9/127 ,  A61K31/40 ,  A61K31/50 ,  A61K31/66 ,  A61K41/0057 ,  A61K41/0071

Abstract: The process of photodynamic therapy (PDT) is conducted by the step of:1) separately encapsulating at least one activation component for said photodynamic therapy process in a liposome;2) injecting a photosensitizer into a human or animal host;3) injecting the liposome encapsulated components systemically into the same human or animal host; and4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components.The mixing of the activation components can result in:a) energy transfer to the previously injected photosensitizer;b) emission of light and absorption of said light by the previously injected photosensitizer; andc) direct formation of at least one cytotoxic species that functions against the tumor.The heating of the site of the tumor is accomplished by one of the following methods: laser, ultra sound, radio-frequency or microwave frequency. Photofrin photosensitizer is a preferred photosensitizer.

Abstract translation: 光动力学治疗（PDT）的过程是通过以下步骤进行的：1）在脂质体中分别封装所述光动力学治疗过程的至少一种活化成分; 2）将光敏剂注入人或动物宿主; 3）将脂质体包封的组分全身注入相同的人或动物宿主中; 和4）加热肿瘤部位以熔化脂质体包封的组分以允许活化组分的混合。 活化组分的混合可导致：a）能量转移到先前注射的光敏剂; b）通过先前注射的光敏剂发射光和吸收所述光; 和c）直接形成对肿瘤起作用的至少一种细胞毒性物质。 通过以下方法之一实现肿瘤部位的加热：激光，超声，射频或微波频率。 Photofrin光敏剂是优选的光敏剂。

公开(公告)号：US5173504A

公开(公告)日：1992-12-22

申请号：US638172

申请日：1991-01-03

Applicant: Thomas J. Dougherty

Inventor： Thomas J. Dougherty

IPC: A61K41/00 ,  C07D487/22

CPC classification number: C07D487/22 ,  A61K41/0071

Abstract: Compounds of formula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg.sup.+2, Sn.sup.+2, and Zn.sup.+2, or represents 2 H.sup.30 each H.sup.+ bonded to one of the N atoms connected by the solid lines;R.sup.1 is a saturated of unsaturated hydrocarbyl residue of 8-25 C.;each R.sup.2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, andX is COOR.sup.3, wherein R.sup.3 is alkyl (1-C);are useful in photodynamic therapy and diagnosis. These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.

Abstract translation: （1）或式（2）的化合物：其中M是选自Mg + 2，Sn + 2和Zn + 2的非顺磁性金属，或表示2 H30每个H +与通过实线连接的N个原子之一键合; R1是饱和的8-25℃的不饱和烃基残基。 每个R 2独立地选自乙烯基，乙基，乙酰基和1-羟乙基，X是COOR 3，其中R 3是烷基（1-C）; 可用于光动力疗法和诊断。 这些化合物对目标生物底物进行光敏照射，用这些敏化剂处理所述底物，然后照射导致生物底物的损伤或破坏。 当全身施用时，这些化合物积聚在不需要的靶生物底物中。 也可以在体外使用这些化合物，例如以破坏用于输血的血液中的感染性细胞或病毒。

公开(公告)号：US5002840A

公开(公告)日：1991-03-26

申请号：US365084

申请日：1989-06-12

Applicant: Alan J. Klebenow ,  Thomas J. Dougherty ,  Edward N. Mrotek ,  David A. Thuerk ,  Maurice G. Michaud

Inventor： Alan J. Klebenow ,  Thomas J. Dougherty ,  Edward N. Mrotek ,  David A. Thuerk ,  Maurice G. Michaud

IPC: H01M2/02 ,  H01M2/20 ,  H01M2/30 ,  H01M2/34 ,  H01M10/12 ,  H01M10/42

CPC classification number: H01M10/4207 ,  H01M10/122 ,  H01M2/0242 ,  H01M2/20 ,  H01M2/305 ,  H01M2/34 ,  Y02E60/126

Abstract: The invention provides a vehicle battery system including a main and a reserve battery disposed within a battery housing (10) having conventional external dimensions and battery terminal locations. An illustrated embodiment includes a main battery, comprising a series of thin, flat cells (38) disposed along a first axis, and a reserve battery, comprising a series of cells (42) diposed along a second axis transverse to the first axis. An electrical circuit facilitates selective communication between the reserve battery and the vehicle starter in accordance with the position of a switch assembly (100). The circuit illustratively includes a diode (110) configured to permit current flow into the reserve battery (104) during recharging, but which prevents reserve battery drain during normal vehicle operation. A variable resistor (112) is disposed in series with the diode to limit the amount of power, and hence the amount of heat, dissipated by the diode. When the main battery becomes drained, switch assembly (100) is actuated to bring the reserve battery (104) into parallel with the main battery (102).

Abstract translation: 本发明提供了一种车辆电池系统，其包括设置在具有常规外部尺寸和电池端子位置的电池壳体（10）内的主电池和备用电池。 所示实施例包括主电池，其包括沿着第一轴设置的一系列薄的扁平电池（38）和备用电池，其包括沿着横向于第一轴线的第二轴线浸入的一系列电池（42）。 电路有助于根据开关组件（100）的位置在储备电池和车辆启动器之间进行选择性通信。 该电路示例性地包括二次管（110），其被配置为在再充电期间允许电流流入备用电池（104），但是这防止在正常车辆操作期间备用电池漏极。 可变电阻器（112）与二极管串联布置以限制二极管消耗的功率量，因此限制热量。 当主电池耗尽时，开关组件（100）被致动以使备用电池（104）与主电池（102）平行。

公开(公告)号：US4775604A

公开(公告)日：1988-10-04

申请号：US80154

申请日：1987-07-29

Applicant: Thomas J. Dougherty ,  Richard A. Hamann ,  Matthias Geibl

Inventor： Thomas J. Dougherty ,  Richard A. Hamann ,  Matthias Geibl

IPC: H01M2/06 ,  H01M2/08 ,  H01M2/02

CPC classification number: H01M2/08 ,  H01M2/06

Abstract: The interface between the plastic cover of a battery container and the lead or other metal terminal post which extends therethrough is sealed with a rubber bushing which is compressed and extruded along the terminal post during installation and locked tightly in its compressed and extruded state. The bushing preferably has a pair of oppositely angled intersecting frustoconical surfaces on its exterior surface which are adapted to cooperate with mating surfaces surrounding the opening in the cover and on a locking retainer. The assembly provides a flexible seal which will accommodate the inevitable vertical movement of the terminal post as a result of battery element expansion. Most importantly, the assembly provides an extremely effective barrier to the migration of electrolyte along the terminal post to prevent outer terminal corrosion. The rubber bushing is preferably impregnated with silicone oil which, when the bushing is installed, fills the surface voids in the cast terminal post which otherwise provide paths for electrolyte migration. The silicone oil also provides a lubricant for the controlled compression and extrusion of the bushing.

Abstract translation: 电池容器的塑料盖和延伸穿过其的导线或其他金属端子柱之间的界面用橡胶衬套密封，橡胶衬套在安装期间沿着端子柱压缩和挤出并且紧密地锁定在其压缩和挤压状态。 套管优选地在其外表面上具有一对相对角度的相交的截头圆锥形表面，其适于与围绕盖中的开口的配合表面和锁定保持器协作。 组件提供了柔性密封，其将适应由于电池元件膨胀而导致的端子柱的不可避免的垂直运动。 最重要的是，该组件为电极沿着端子柱的迁移提供了非常有效的屏障，以防止外部端子腐蚀。 橡胶衬套优选地浸渍有硅油，当安装衬套时，填充铸造端子柱中的表面空隙，否则其提供用于电解质迁移的路径。 硅油还提供润滑剂用于受控压缩和挤压衬套。

公开(公告)号：US4193025A

公开(公告)日：1980-03-11

申请号：US863925

申请日：1977-12-23

Applicant: Charles E. Frailing ,  Thomas J. Dougherty

Inventor： Charles E. Frailing ,  Thomas J. Dougherty

IPC: G01R31/36 ,  G01N27/42

CPC classification number: G01R31/3662 ,  G01R31/3627 ,  G01R31/3668 ,  Y10S320/12

Abstract: Apparatus for automatically testing automotive-type, lead acid storage batteries are disclosed in which three separate tests are made and the results thereof compared to predetermined standards in a specified order to maximize the information obtained about the battery. The three tests measure (1) whether the battery meets its cold cranking rating by drawing a predetermined load current therefrom for a predetermined period of time and determining whether the battery terminal voltage is above a specified level at the end of that period, (2) whether the battery terminal voltage is above another specified level at the end of a predetermined period of time following the completion of the first test, and (3) whether the internal resistance is acceptably low. If the battery passes the first test, it is known to be acceptable. If the battery fails the first test and passes the second test, it is known to be unacceptable. If the battery fails the first and second tests, the third test is performed. If the battery then passes the third test, it is known to be acceptable but to require a recharge, whereas if the battery then fails the third test the acceptability of the battery is then not yet determined and it must be recharged and retested.

Abstract translation: 公开了用于自动测试汽车型铅酸蓄电池的装置，其中进行三次分开的测试，并且其结果以规定的顺序与预定标准进行比较，以最大限度地获得关于电池的信息。 三个测试测量（1）电池是否通过从预定的时间段内抽出预定的负载电流来满足其冷起动额定值，并确定电池端电压是否在该期间结束时高于规定的电平;（2） 电池端子电压是否在第一次测试完成后的预定时间段结束时高于另一个指定电平，以及（3）内部电阻是否可接受地低。 如果电池通过第一次测试，则已知可以接受。 如果电池第一次测试失败并通过第二次测试，则已知不能接受。 如果电池第一次和第二次测试失败，则进行第三次测试。 如果电池通过第三次测试，则已知可以接受但要求充电，而如果电池在第三次测试中失败，则电池的可接受性尚未确定，并且必须重新充电并重新测试。