专利检索 ap:("Valentina Molteni" OR "Shuli You" OR "Juliet Nabakka" OR "Yi Liu" OR "Xiaolin Li" OR "Donatella Chianelli" OR "Jon Loren" OR "Xiaodong Liu" OR "Shifeng Pan" OR "Donald S. Karanewsky" OR "Pascal Furet" OR "Vito Guagnano") AND inv:"Pascal Furet" 第 5 页

41.

发明申请
Organic Compounds 有权
标题翻译：有机化合物

公开(公告)号：US20100105711A1

公开(公告)日：2010-04-29

申请号：US12556964

申请日：2009-09-10

申请人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach , Giorgio Caravatti , Pascal Furet

发明人： Robin Alec Fairhurst , Vito Guagnano , Patricia Imbach , Giorgio Caravatti , Pascal Furet

IPC分类号： A61K31/4439 , C07D417/14 , A61K31/506 , A61P43/00

CPC分类号： A61K31/4439 , A61K45/06 , C07D417/14

摘要： The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

摘要翻译： 本发明涉及式（I）化合物或其盐，其中取代基如说明书中所定义，化合物在治疗通过抑制磷脂酰肌醇3-激酶而变态化的疾病中的组合物和用途。

42.

发明申请
Phenylacetamides Suitable as Protein Kinase Inhibitors 失效
标题翻译：苯乙酰胺适合作为蛋白激酶抑制剂

公开(公告)号：US20080319005A1

公开(公告)日：2008-12-25

申请号：US11914895

申请日：2006-04-12

申请人： Guido Bold , Pascal Furet , Vito Guagnano , Clive McCarthy , Andrea Vaupel

发明人： Guido Bold , Pascal Furet , Vito Guagnano , Clive McCarthy , Andrea Vaupel

IPC分类号： A61K31/437 , C07D235/06 , A61K31/4164 , C07D471/04

CPC分类号： C07D235/06 , C07D401/12 , C07D403/12 , C07D471/04 , C07D473/00

摘要： The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

摘要翻译： 本发明涉及式（I）化合物，其中部分R 1，R 2，R 3，R 9，R 10和Q和X，Y和Z如说明书中所定义，及其盐，以及它们的用途，用于它们及其合成方法等。这些化合物是蛋白激酶抑制剂，尤其可用于治疗各种增殖性疾病。

43.

发明申请
BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权

公开(公告)号：US20130237519A1

公开(公告)日：2013-09-12

申请号：US13599267

申请日：2012-08-30

申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh

发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingwood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh

IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/5377 , A61K31/496

CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06

摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

44.

发明申请
BICYCLIC HETEROCYCLE DERIVATIVES FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION 有权
标题翻译：用于治疗肺动脉高压的双相异构体衍生物

公开(公告)号：US20150025059A1

公开(公告)日：2015-01-22

申请号：US14511044

申请日：2014-10-09

申请人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingswood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh

发明人： Ian Bruce , Sylvie Chamoin , Stephen Paul Collingswood , Pascal Furet , Vikki Furminger , Diana Janus , Sarah Lewis , Jon Christopher Loren , Valentina Molteni , Alex Michael Saunders , Duncan Shaw , Lilya Sviridenko , Christopher Thomson , Ryan West , Vince Yeh

IPC分类号： C07D471/04

CPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K45/06

摘要： Bicyclic heterocyclic derivatives of formula I useful in inhibiting PDGF receptor mediated biological activity. wherein A is and R1, R1a, R2, R3, R4, R5, R6 and X are as defined herein.

摘要翻译： 式I的双环杂环衍生物可用于抑制PDGF受体介导的生物活性。其中A是且R 1，R 1a，R 2，R 3，R 4，R 5，R 6和X如本文所定义。

45.

发明授权
Methods and compositions as protein kinase inhibitors 有权
标题翻译：方法和组成作为蛋白激酶抑制剂

公开(公告)号：US07189729B2

公开(公告)日：2007-03-13

申请号：US10956412

申请日：2004-09-30

申请人： Greg Chopiuk , Pascal Furet , Nathanael Schiander Gray , Patricia Imbach , Yi Liu , Joseph Schoepfer , Ruo Steensma

发明人： Greg Chopiuk , Pascal Furet , Nathanael Schiander Gray , Patricia Imbach , Yi Liu , Joseph Schoepfer , Ruo Steensma

IPC分类号： C07D239/42 , C07D403/12 , A61K31/506 , A61P19/02 , A61P35/00

CPC分类号： C07D239/26 , A61K31/5377 , C07D239/42 , C07D403/12

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.

摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，EGF-R，c-erbB2激酶（HER-2），CHK2，FGFR3，p70S6K，PKC，PDGF-R，p38，TGFbeta，KDR，c-Kit，b-RAF，c-RAF，FLT1和/或FLT4 激酶。

46.

发明申请
Methods and compositions as protein kinase inhibitors 有权
标题翻译：方法和组合物作为蛋白激酶抑制剂

公开(公告)号：US20050171105A1

公开(公告)日：2005-08-04

申请号：US10956412

申请日：2004-09-30

申请人： Greg Chopiuk , Pascal Furet , Nathanael Gray , Patricia Imbach , Yi Liu , Joseph Schoepfer , Ruo Steensma

发明人： Greg Chopiuk , Pascal Furet , Nathanael Gray , Patricia Imbach , Yi Liu , Joseph Schoepfer , Ruo Steensma

IPC分类号： A61K31/53 , A61P35/00 , C07D239/26 , C07D239/42 , C07D403/12 , C07D43/02

CPC分类号： C07D239/26 , A61K31/5377 , C07D239/42 , C07D403/12

摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGFβ, KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.

摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，EGF-R，c-erbB2激酶（HER-2），CHK2，FGFR3，p70S6K，PKC，PDGF-R，p38，TGFbeta，KDR，c-Kit，b-RAF，c-RAF，FLT1和/或FLT4 激酶。

47.

发明申请
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors 审中-公开
标题翻译：环稠合的双环吡啶基衍生物作为FGFR4抑制剂

公开(公告)号：US20170066766A1

公开(公告)日：2017-03-09

申请号：US15357195

申请日：2016-11-21

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

IPC分类号： C07D471/04 , C07D519/00 , C07D498/04

CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

摘要翻译： 制备所述化合物的方法及其治疗用途。本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。

48.

发明授权
Purine derivatives and their use in the treatment of disease 有权
标题翻译：嘌呤衍生物及其在治疗疾病中的应用

公开(公告)号：US09334271B2

公开(公告)日：2016-05-10

申请号：US14353950

申请日：2012-10-26

申请人： Emmanuelle Briard , Pascal Furet , Andreas Lerchner , Peter Meier , Branko Radetich , David Andrew Sandham , Yanyi Zhu

发明人： Emmanuelle Briard , Pascal Furet , Andreas Lerchner , Peter Meier , Branko Radetich , David Andrew Sandham , Yanyi Zhu

IPC分类号： C07D487/04 , C07D473/16 , C07D519/00 , A61K31/5377 , A61K31/553 , C07D491/048 , C07D491/107

CPC分类号： C07D473/16 , A61K31/5377 , A61K31/553 , C07D487/04 , C07D491/048 , C07D491/107 , C07D519/00

摘要： The invention relates to PI3K inhibitors of the formula (I)• in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.

摘要翻译： 本发明涉及式（I）的PI3K抑制剂，其中所有变量如说明书中所定义，其制备，其医疗用途，特别是其在治疗癌症和神经变性疾病中的用途，以及包括它们的药物。