公开(公告)号：US06613872B1

公开(公告)日：2003-09-02

申请号：US09159812

申请日：1998-09-23

申请人： Jiangchun Xu ,  Davin C. Dillon

发明人： Jiangchun Xu ,  Davin C. Dillon

IPC分类号： C07K500

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  C07K14/705 ,  C07K2319/00

摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

公开(公告)号：US06432707B1

公开(公告)日：2002-08-13

申请号：US09602877

申请日：2000-06-22

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

IPC分类号： C12H502

CPC分类号： C07K14/82 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2317/21 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于癌症的治疗和诊断的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US20060269532A1

公开(公告)日：2006-11-30

申请号：US11344932

申请日：2006-02-01

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20060024301A1

公开(公告)日：2006-02-02

申请号：US11234786

申请日：2005-09-23

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Steven Reed ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Steven Reed ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K16/30 ,  C07K14/82 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/3069 ,  C07K2317/34 ,  C07K2317/80 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。 组合物可以包含一种或多种前列腺特异性蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达前列腺特异性蛋白质的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如前列腺癌的疾病。 还提供了基于检测样品中前列腺特异性蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US20050260177A1

公开(公告)日：2005-11-24

申请号：US11108172

申请日：2005-04-15

申请人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

发明人： Jiangchun Xu ,  Michael Lodes ,  Heather Secrist ,  Darin Benson ,  Madeleine Meagher ,  John Stolk ,  Tongtong Wang ,  Yuqiu Jiang ,  Carole Smith ,  Gordon King ,  Aijun Wang ,  Jonathan Clapper ,  Yasir Skeiky ,  Gary Fanger ,  Thomas Vedvick ,  Darrick Carter

IPC分类号： A61K31/7088 ,  A61K45/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/30 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57419 ,  A61K31/7088 ,  C07K14/47 ,  C07K16/3046 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：US20080317755A1

公开(公告)日：2008-12-25

申请号：US11768101

申请日：2007-06-25

申请人： Gordon E. King ,  Madeleine Joy Braun ,  Jiangchun Xu ,  Heather Secrist

发明人： Gordon E. King ,  Madeleine Joy Braun ,  Jiangchun Xu ,  Heather Secrist

IPC分类号： A61K39/395 ,  C07H21/00 ,  C07K2/00 ,  C12N15/63 ,  C12N5/00 ,  A61K35/12 ,  A61K31/7052 ,  A61P35/00 ,  A61K38/02 ,  A61K38/16 ,  C07K16/00 ,  G01N33/574 ,  C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。 示例性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。 公开的组合物可用于例如疾病，特别是结肠癌的诊断，预防和/或治疗。

公开(公告)号：US20080233139A1

公开(公告)日：2008-09-25

申请号：US11928375

申请日：2007-10-30

申请人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

发明人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

IPC分类号： A61K39/00 ,  C07K2/00 ,  C07H21/04 ,  C12N5/06 ,  C12Q1/68 ,  A61K35/12 ,  C07K16/00 ,  G01N33/574

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06623923B1

公开(公告)日：2003-09-23

申请号：US09401064

申请日：1999-09-22

申请人： Jiangchun Xu ,  Michael J. Lodes ,  Heather Secrist ,  Madeleine Joy Meagher ,  John Stolk ,  Darin R. Benson ,  Tongtong Wang

发明人： Jiangchun Xu ,  Michael J. Lodes ,  Heather Secrist ,  Madeleine Joy Meagher ,  John Stolk ,  Darin R. Benson ,  Tongtong Wang

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US20080226620A1

公开(公告)日：2008-09-18

申请号：US11929396

申请日：2007-10-30

申请人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

发明人： Jiangchun Xu ,  John A. Stolk ,  Michael D. Kalos

IPC分类号： A61K39/395 ,  C07K7/00 ,  C07K11/00 ,  C12N15/64 ,  C12N5/08 ,  C07K16/00 ,  G01N33/53 ,  C07K19/00 ,  A61K45/00 ,  C07H21/04 ,  C12Q1/68 ,  C12Q1/02 ,  A61K38/04 ,  A61K38/16 ,  A61K31/7088 ,  A61P37/02 ,  A61P35/00

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20050147615A1

公开(公告)日：2005-07-07

申请号：US10961527

申请日：2004-10-07

申请人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist

发明人： Gordon King ,  Madeleine Meagher ,  Jiangchun Xu ,  Heather Secrist

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  A61K39/395 ,  A61K48/00 ,  C07H21/04 ,  C07K16/30 ,  C12N5/08

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。 示例性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是结肠癌的诊断，预防和/或治疗。