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公开(公告)号：US10443045B2
公开(公告)日：2019-10-15
申请号：US16374482
申请日：2019-04-03
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US10415060B2
公开(公告)日：2019-09-17
申请号：US15670639
申请日：2017-08-07
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/00 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US09487768B2
公开(公告)日：2016-11-08
申请号：US15156829
申请日：2016-05-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US20230193231A1
公开(公告)日：2023-06-22
申请号：US18045829
申请日：2022-10-11
Applicant: Factor Bioscience Inc.
Inventor： Matthew ANGEL , Franklin KOSTAS , Mitchell KOPACZ , Christopher ROHDE
CPC classification number: C12N9/22 , C12N5/0629
Abstract: The present invention relates in part to nucleic acids encoding gene editing proteins, including novel engineered variants.
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公开(公告)号：US11332758B2
公开(公告)日：2022-05-17
申请号：US16655760
申请日：2019-10-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/63 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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Patent Agency Ranking
公开(公告)号：US10767195B2
公开(公告)日：2020-09-08
申请号：US16655766
申请日：2019-10-17
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/63 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US10752917B2
公开(公告)日：2020-08-25
申请号：US16654536
申请日：2019-10-16
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: C07H21/04 , C12N15/63 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US10369233B2
公开(公告)日：2019-08-06
申请号：US16030675
申请日：2018-07-09
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K48/00 , A61K31/7115 , A61P1/16 , A61P3/06 , A61P11/00 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P3/10 , C07K14/00 , C12N9/22 , A61K9/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US10124042B2
公开(公告)日：2018-11-13
申请号：US15678491
申请日：2017-08-16
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
IPC: A61K48/00 , A61K31/7105 , A61K31/713 , C12N15/00 , C12N15/90 , A61K38/39 , A61K38/38 , C12N15/87 , A61K38/44 , A61K38/45 , A61K45/06 , A61K31/573 , A61K31/575 , A61K31/7068 , A61K31/7072 , A61K31/711 , A61K9/00 , A61K9/127 , A61K47/46 , A61B18/18 , A61M35/00 , A61K8/60 , A61Q19/00 , A61Q19/06 , A61Q19/08 , A61B18/00
Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US09879228B2
公开(公告)日：2018-01-30
申请号：US15605513
申请日：2017-05-25
Applicant: Factor Bioscience Inc.
Inventor： Matthew Angel , Christopher Rohde
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0625 , C12N5/0647 , C12N5/0656 , C12N5/0657 , C12N5/0676 , C12N5/0695 , C12N2500/25 , C12N2500/33 , C12N2500/36 , C12N2500/84 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2501/998 , C12N2506/09 , C12N2506/45
Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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