公开(公告)号：US20220364175A1

公开(公告)日：2022-11-17

申请号：US17846157

申请日：2022-06-22

Applicant: Yeda Research and Development Co. Ltd. ,  UCL Business Ltd

Inventor： Eran HORNSTEIN ,  Iddo MAGEN ,  Nancy-Sarah YACOVZADA ,  Jonathan ROHRER ,  Pietro FRATTA

IPC: C12Q1/6883 ,  G01N33/68

Abstract: A method of diagnosing Frontotemporal dementia (FTD) in a subject in need thereof is provided. The method comprising detecting a level of at least one micro RNA (miR) selected from the group consisting of hsa-miR-361-5p, hsa-miR-629-5p, hsa-miR-628-3p, hsa-miR-379-5p, hsa-miR-1-3p, hsa-miR-26a-5p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-142-5p and hsa-miR-340-5p in a biological sample of the subject, wherein when said level of said at least one micro RNA (miR) is higher than that in a control sample, it is indicative of FTD.

公开(公告)号：US11471504B2

公开(公告)日：2022-10-18

申请号：US16633175

申请日：2018-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena Samuels ,  Rand Arafeh ,  Karen Flores ,  Rony Seger ,  Ehud Wainstein

IPC: A61K38/10 ,  A61P35/00 ,  A61K31/4184 ,  A61K31/519

Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.

公开(公告)号：US20220307008A1

公开(公告)日：2022-09-29

申请号：US17619722

申请日：2020-06-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ido AMIT ,  Ido YOFE ,  Diego JAITIN ,  Yonatan KATZENELENBOGEN ,  Mami LENNIKOV ,  Assaf WEINER ,  Hadas KEREN-SHAUL

IPC: C12N15/10 ,  C12Q1/6806 ,  C12N15/11

Abstract: A method of permeabilizing a cell is disclosed. Kits for permeabilizing cells and analysing RNA contents are also disclosed.

公开(公告)号：US20220306710A1

公开(公告)日：2022-09-29

申请号：US17748212

申请日：2022-05-19

Applicant: Yeda Research and Development Co. Ltd. ,  Ramot at Tel-Aviv University Ltd.

Inventor： Ruth ARNON ,  Ruth MARON ,  Gad ARMONY ,  Michael Menachem TSOORY ,  Meir WILCHEK ,  Dan FRENKEL

IPC: C07K14/47 ,  A61K9/00 ,  A61P25/28

Abstract: A method of treating Alzheimer's Disease (AD) is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which prevents the binding of amyloid precursor protein (APP) to Tau protein.

公开(公告)号：US11446413B2

公开(公告)日：2022-09-20

申请号：US15109822

申请日：2015-01-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Reshef Tenne ,  David Zbaida ,  Racheli Ron ,  Ilan Kafka ,  Ilan Leibovitch

IPC: A61L29/14 ,  A61L31/08 ,  A61L29/10 ,  A61L31/14 ,  A61L29/18 ,  A61L31/18

Abstract: A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.

公开(公告)号：US11411551B2

公开(公告)日：2022-08-09

申请号：US16473630

申请日：2017-12-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.

Inventor： Reshef Tenne ,  Ernesto Joselevich ,  Yiftach Divon ,  Roi Levi ,  Assaf Yaakobovitz ,  Dan Yudilevich

IPC: H03B5/30 ,  H03H9/24 ,  B82B1/00 ,  H03H9/02

Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.

公开(公告)号：US20220217934A1

公开(公告)日：2022-07-14

申请号：US17272685

申请日：2019-09-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Prashant SONAWANE ,  Maxim ITKIN ,  Adam JOZWlAK

IPC: A01H6/82 ,  C12N15/82 ,  C12N9/10

Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

公开(公告)号：US20220175807A1

公开(公告)日：2022-06-09

申请号：US17442198

申请日：2020-03-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rotem SOREK ,  Auda BERNHEIM ,  Adl Jenny MILLMAN DAYAN

IPC: A61K31/708 ,  A61K31/7068 ,  C07K14/195 ,  A61K31/7072 ,  A61P31/12

Abstract: Disclosed herein are prokaryotic homologs of viperin (pVips), and nucleotide and nucleoside analogs produced from pVips. These nucleotide and nucleoside analogs stop nucleotide chain synthesis and provide host cells with resistance to viral infections by targeting actively replicating viral genome. Further, these nucleotide and nucleoside analogs decrease DNA replication in malignant cells. Further disclosed are methods of identifying pVips, and nucleotide and nucleoside analogs produced thereof.

公开(公告)号：US20220133701A1

公开(公告)日：2022-05-05

申请号：US17576954

申请日：2022-01-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michael FAINZILBER ,  Letizia MARVALDI

IPC: A61K31/437 ,  A61K31/496 ,  A61P25/04

Abstract: Methods of treating pain are provided. Accordingly, there is provided a method of treating nociceptive or neuropathic pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agent which binds importin alpha3 or a polynucleotide encoding same and inhibits expression and/or activity of said importin α3.

公开(公告)号：US20220080034A1

公开(公告)日：2022-03-17

申请号：US17531897

申请日：2021-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  C12N5/078 ,  C12N5/0783 ,  A61P31/00 ,  A61P35/04 ,  A61K39/395 ,  C07K16/28

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.