公开(公告)号：US20070208082A1

公开(公告)日：2007-09-06

申请号：US11463840

申请日：2006-08-10

申请人： Patrick Woster ,  Tracey Boncher ,  Robert Casero

发明人： Patrick Woster ,  Tracey Boncher ,  Robert Casero

IPC分类号： A61K31/165

CPC分类号： C07C279/18 ,  C07C211/09 ,  C07C211/18 ,  C07C211/22 ,  C07C211/36 ,  C07C211/49 ,  C07C215/14 ,  C07C233/38 ,  C07C247/12 ,  C07C279/04 ,  C07C279/12 ,  C07C279/265 ,  C07C323/25 ,  C07C381/00 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2603/20 ,  C07C2603/50 ,  C07F9/3264

摘要： Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1.

摘要翻译： 公开了多胺，多胺/胍基和多胺/双胍化合物。 该化合物可用作抗癌和抗寄生虫治疗。 该化合物也可用作酶赖氨酸特异性脱甲基酶-1的抑制剂。

公开(公告)号：US20040235962A1

公开(公告)日：2004-11-25

申请号：US10873100

申请日：2004-06-21

发明人： Benjamin Frydman ,  Laurence J. Marton ,  Venodhar K. Reddy ,  Aldonia L. Valasinas ,  Andrei V. Blokhin ,  Hirak S. Basu

IPC分类号： C07C211/04 ,  A61K031/13

CPC分类号： C07C211/09 ,  A61K38/00 ,  A61K47/65 ,  C07C45/46 ,  C07C67/343 ,  C07C211/18 ,  C07C211/22 ,  C07C211/23 ,  C07C211/36 ,  C07C215/14 ,  C07C257/18 ,  C07C2601/04 ,  C07C2601/08 ,  C07D207/34 ,  C07D219/10 ,  C07D235/18 ,  C07D295/185 ,  C07D307/79 ,  C07D307/92 ,  C07D311/92 ,  C07D317/70 ,  C07D487/22 ,  C07D493/04 ,  C07K5/1013 ,  C07K7/06 ,  C07C47/575 ,  C07C69/734

摘要： Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of delivering these analogs specifically to tumor cells by covalently attaching polyamine analogs to porphyrin compounds, along with novel polyamine-porphyrin covalent conjugates.

摘要翻译： 提供新颖的构象限制性多胺类似物，以及包含这些新型多胺类似物的组合物。 还提供了将新型多胺类似物用于治疗诸如癌症的疾病的方法。 还提供了通过将多胺类似物共价连接到卟啉化合物以及新型多胺 - 卟啉共价缀合物将这些类似物特异性递送至肿瘤细胞的方法。

公开(公告)号：US20040044176A1

公开(公告)日：2004-03-04

申请号：US10463594

申请日：2003-06-18

发明人： Tetsushi Ichikawa ,  Hisayuki Kuwahara ,  Masatoshi Echigo

IPC分类号： C08G059/50

CPC分类号： C08G59/5026 ,  C07C209/60 ,  C07C211/18 ,  C07C211/27 ,  C07C2601/14 ,  C08G59/5033

摘要： An object of the present invention is to provide an amino composition which provides, when used as a curing agent for epoxy resin, a long pot life and an excellent appearance of a coating film to an epoxy resin composition without deteriorating the reactivity of the composition. The amino composition is obtained by addition reaction of diamine such as metaxylylenediamine and 1,3-bis (aminomethyl) cyclohexane and styrene, wherein the content of the diamine is less than 15% by weight based upon the total weight of the amino composition and the content of 1-addition product of having one phenethyl group is 50 to 100% by weight based upon the total weight of amino compound(s) obtained by the addition reaction.

摘要翻译： 本发明的目的是提供一种氨基组合物，其在用作环氧树脂的固化剂时，其使用寿命长，涂膜对环氧树脂组合物的外观优异，而不会降低组合物的反应性。 氨基组成通过二胺如间苯二甲胺和1,3-双（氨基甲基）环己烷和苯乙烯的加成反应获得，其中二胺的含量基于氨基组合物的总重量小于15重量％ 含有一个苯乙基的1-加成物的含量相对于通过加成反应得到的氨基化合物的总重量为50〜100重量％。

公开(公告)号：US20040006049A1

公开(公告)日：2004-01-08

申请号：US10385224

申请日：2003-03-10

申请人： SLIL Biomedical Corporation

发明人： Benjamin Frydman ,  Laurence J. Marton

IPC分类号： A61K031/665 ,  A61K038/00

CPC分类号： C07D295/185 ,  A61K38/00 ,  A61K47/65 ,  C07C45/46 ,  C07C67/343 ,  C07C211/13 ,  C07C211/18 ,  C07C2601/02 ,  C07D207/34 ,  C07D219/10 ,  C07D235/18 ,  C07D307/79 ,  C07D307/92 ,  C07D311/92 ,  C07D317/70 ,  C07D493/04 ,  C07K5/1013 ,  C07K7/06 ,  C07C47/575 ,  C07C69/734

摘要： Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.

摘要翻译： 提供了其中细胞死亡和细胞生长抑制剂（例如多胺类似物或萘醌）与由诸如前列腺特异性抗原（PSA）和组织蛋白酶B之类的酶识别和切割的多肽缀合的肽缀合物，以及包含这些缀合物的组合物。 还提供了使用这些缀合物治疗前列腺疾病的方法。

公开(公告)号：US20030195377A1

公开(公告)日：2003-10-16

申请号：US10313530

申请日：2002-12-06

申请人： SLIL Biomedical Corporation

发明人： Benjamin Frydman ,  Aldonia L. Valasinas ,  Andrei V. Blokhin ,  Aparajita Sarkar ,  Hirak S. Basu ,  Venodhar K. Reddy ,  Laurence J. Marton ,  Yu Wang

IPC分类号： C07C211/17

CPC分类号： A61K31/132 ,  C07C211/18 ,  C07C2601/02

摘要： Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.

摘要翻译： 公开了可用于治疗由异常细胞增殖表现的癌症和其它疾病的构象限制性多胺化合物。 还公开了合成这些化合物的改进方法。 在本发明的一种方法中，含有含碳或含碳原子的化合物与烯烃化合物的双键反应形成环丙基环作为合成中的第一步。

公开(公告)号：US06429338B1

公开(公告)日：2002-08-06

申请号：US10051934

申请日：2002-01-17

申请人： Juan Jesus Burdeniuc ,  Gamini Ananda Vedage ,  Bradley Heath Cook

发明人： Juan Jesus Burdeniuc ,  Gamini Ananda Vedage ,  Bradley Heath Cook

IPC分类号： C07C20900

CPC分类号： C07C209/72 ,  C07C211/18

摘要： This invention relates to an improved process for the preparation of cyclohexylamines wherein an aromatic amine is contacted with hydrogen in the presence of a hydrogenation catalyst. The improvement resides in utilizing a hydrogenation catalyst comprised of rhodium metal, utilizing a dialkyl ether solvent, and effecting delay addition of the aromatic diamine to the reaction medium.

摘要翻译： 本发明涉及一种制备环己胺的改进方法，其中芳族胺在氢化催化剂存在下与氢接触。 改进在于利用由铑金属组成的氢化催化剂，利用二烷基醚溶剂，并且将芳族二胺延迟加入到反应介质中。

公开(公告)号：US5889061A

公开(公告)日：1999-03-30

申请号：US951015

申请日：1997-10-15

申请人： Benjamin J. Frydman ,  Laurence J. Marton ,  Vendohar K. Reddy ,  Aldonia L. Valasinas ,  Donald T. Witiak

发明人： Benjamin J. Frydman ,  Laurence J. Marton ,  Vendohar K. Reddy ,  Aldonia L. Valasinas ,  Donald T. Witiak

IPC分类号： C07C211/18 ,  C07C211/22 ,  C07C211/36 ,  A61K31/13

CPC分类号： C07C211/18 ,  C07C211/22 ,  C07C211/36 ,  C07C2101/02 ,  C07C2101/04

摘要： Compounds of Formula I:E-NH-D-NH-B-A-B-NH-D-NH-E (I)wherein A is C.sub.2 -C.sub.6 alkene, C.sub.3 -C.sub.6 cycloalkyl, cycloalkenyl, or cycloaryl; B is independently a single bond, C.sub.1 -C.sub.6 alkyl alkenyl; D is independently C.sub.1 -C.sub.6 alkyl or alkenyl, or C.sub.3 -C.sub.6 cycloalkyl, cycloalkenyl, or cycloaryl; and E is independently H, C.sub.1 -C.sub.6 alkyl or alkenyl; and pharmaceutically-suitable salts thereof; a synthetic method therefor, pharmaceutical dosage forms containing one of more of these compounds, and use of these compounds in the treatment of neoplastic cell growth, are disclosed.

摘要翻译： 式Ⅰ化合物：E-NH-D-NH-B-A-B-NH-D-NH-E（Ⅰ）其中A为C2-C6烯烃，C3-C6环烷基，环烯基或环芳基; B独立地是单键，C1-C6烷基烯基; D独立地为C 1 -C 6烷基或链烯基，或C 3 -C 6环烷基，环烯基或环芳基; 且E独立地为H，C 1 -C 6烷基或链烯基; 及其药学上合适的盐; 公开了其合成方法，含有这些化合物中的一种以上的药物剂型，以及这些化合物在治疗肿瘤细胞生长中的用途。

公开(公告)号：US5583261A

公开(公告)日：1996-12-10

申请号：US450337

申请日：1995-05-25

申请人： David J. Robins ,  Dale R. Walters

发明人： David J. Robins ,  Dale R. Walters

IPC分类号： A01N33/04 ,  C07C211/18 ,  C07C211/25 ,  C07C211/15

CPC分类号： C07C211/25 ,  A01N33/04 ,  C07C211/18 ,  C07C2101/10 ,  C07C2101/14 ,  C07C2101/16

摘要： Use of a compound having the general formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which may be the same or different represent hydrogen atoms or alkyl groups of 1-6 carbon atoms, or NR.sup.1 R.sup.2 and/or NR.sup.3 R.sup.4 together represent a heterocyclic group having 5 or 6 ring atoms, x is 0 or 1 and when x is 0, the dashed line represents a double bond, W represents a saturated or ethylenically unsaturated divalent hydrocarbyl group required to complete a cycloalkane, cycloalkene or cycloalkadiene ring of 3 to 6 ring atoms and from 0 to 2 double bonds, in the form of the free base or an acid addition salt tolerable to plants, as a plant fungicide, as a fungicide, especially as a mildewicide.Some of the compounds of formula (1) are new and are claimed per se.

摘要翻译： 使用具有以下通式的化合物：其中可以相同或不同的R1，R2，R3和R4表示1-6个碳原子的氢原子或烷基，或NR1R2和/或NR3R4在一起的化合物 表示具有5或6个环原子的杂环基，x为0或1，当x为0时，虚线表示双键，W表示完成环烷烃，环烯烃或环二烯环所需的饱和或烯属不饱和二价烃基 3至6个环原子和0至2个双键，以游离碱的形式或作为植物杀真菌剂可耐受的酸加成盐，作为杀真菌剂，特别是作为防霉剂。 一些式（1）的化合物是新的，本身就是要求的。

公开(公告)号：US3829490A

公开(公告)日：1974-08-13

申请号：US17224671

申请日：1971-08-16

申请人： MONSANTO CO

发明人： MUELLER W ,  CAMPBELL C

IPC分类号： C07C211/18 ,  C07C67/00 ,  C07C209/00 ,  C07C87/38

CPC分类号： C07C211/18

摘要： THE ISOMER RATIO IN A NON-EQUILIBRATED MIXTURE OF THE CIS AND TRANS ISOMERS OF A C6-C14 CYCLOALKYLANEBIS(METHYLAMINE9 SUCH AS 1,4-CYCLOHEXNEBIS(METHYLAMINE) CAN BE CONVENIENTLY ALTERED BY CONTACTING THE MIXTURE AT 175*290*C. WITH HYDROGEN IN THE PRESENCE OF A HYDROGENATION CATALYST AND AMMONIA. A HIGH YEILD OF ONE OF SUCH ISOMERS CAN BE OBTAINED BY SIMILARLY CONTACTING A MIXTURE OF SUCH ISOMERS WHEREIN THE RATIO OF SAID ONE ISOMER TO THE OTHER OF SAID ISOMERS IS LOWER THAN THE CORRESPONDING EQUILBRIUM RATIO OF SUCH ISOMERS, SELECTIVELY SEPARATING SAID ONE ISOMER FROM THE CONTACTED MIXTURE AND RECYCLING THE RESIDUAL MIXTURE FOR MORE OF SUCH CONTACTING.

公开(公告)号：US20180354890A1

公开(公告)日：2018-12-13

申请号：US15778147

申请日：2016-12-09

申请人： MITSUI CHEMICALS, INC.

发明人： Aya NAKAGAWA ,  Tetsuya HAMADA

IPC分类号： C07C209/68

CPC分类号： C07C209/68 ,  C07B61/00 ,  C07B2200/09 ,  C07C211/18 ,  C07C2601/14

摘要： The method for producing trans-rich-1,4-bis(aminomethyl)cyclohexane includes blending 1,4-bis(aminomethyl)cyclohexane with an alkali metal compound and XDA and heating the mixture to isomerize 1,4-bis(aminomethyl)cyclohexane so that the trans isomer content relative to the cis/trans isomers in total is more than 70 mass %, and purifying the isomerized 1,4-bis(aminomethyl)cyclohexane by distillation after the isomerization step. The alkali metal compound is at least one compound selected from the group consisting of alkali metal hydride, alkali metal amide, and alkyl alkali metal. In the isomerization step, 0.01 mol or more and less than 4 mol of XDA is blended relative to 100 mol of 1,4-bis(aminomethyl)cyclohexane, a dimer produced from one molecular of 1,4-bis(aminomethyl)cyclohexane and one molecular of XDA, and a trimer produced from two molecules of 1,4-bis(aminomethyl)cyclohexane and one molecular of XDA are produced, and the dimer content is 5 mass % or more and less than 75 mass % relative to the dimer and trimer in total.