摘要:
An optically active compound having a 13 Beta -carbonsubstituted-17-hydroxy-8,14-secogona-1,3,5(10),9(11),15-pentaen14-one nucleus is produced from a compound having a 13 Beta carbon-substituted-8,14-secogona-1,3,5(10),9(11),15-pentaene14,17-dione nucleus by the action on the latter of the redoxenzyme system obtained by culturing a Candida, Debaryomyces, Kloeckera, Pichia, Rhodotorula, Schizosaccharomyces or Hansenula micro-organism.
摘要:
A method of producing arabitol by continuous fermentation of at least one sugar by micro-organisms producing arabitol, characterised in that arabitol is produced in a first fermentation area including at least one fermenter in such a manner that some of the sugar introduced into the fermentation medium is consumed by said micro-organisms, some of the fermentation medium obtained in this way is transferred into a second fermentation area including at least one fermenter, the volume being maintained constant in the first fermentation area by adding sugar, production of arabitol continues in said second fermentation area in such a manner as to consume the residual sugar of the fermentation medium, the fermentation medium thus obtained from said second fermentation area is separated a continuously into a fraction concentrated in micro-organisms and another, soluble fraction enriched in arabitol, and the arabitol thus obtained is collected.
摘要:
Disclosed is a method for producing folic acid, comprising incubating yeast having the ability to produce folic acid of 0.3 mg or more or incubating bacteria having the ability to produce folic acid of 1 mg or more per liter of the culture, thereby accumulating folic acid in the culture.
摘要:
2-Oxo-4-phenylbutyric acid is treated with a microorganism, which has been optionally treated, capable of asymmetrically reducing 2-oxo-4-phenylbutyric acid into either (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid, and the (R)-2-hydroxy-4-phenylbutyric acid or (S)-2-hydroxy-4-phenylbutyric acid thus produced is recovered to thereby give optically active 2-hydroxy-4-phenylbutyric acid.The optically active 2-hydroxy-4-phenylbutyric acid is an important intermediate in the synthesis of various drugs such as a remedy for hypertension.
摘要:
Methylotrophic yeasts of the genera Pichia, Torulopsis, Candida and Hansenula when grown on methanol, make use of an enzyme, alcohol oxidase, to catalyse the initial oxidation of methanol to formaldehyde. Non-growing whole cells of such methylotrophic yeasts were used in place of purified alcohol oxidase for the production of flavoring aldehydes from their respective alcohols. To reduce end product inhibition a number of amine buffers, which chelate the aldehydes, were studied and an increase in aldehyde production was demonstrated with selected buffers which maintain a weakly alkaline pH.
摘要:
A method of high cellular density yeast fermentation at high mineral salts feed to and maintained in the ferment.Single cell protein (SCP) is produced in an aerobic fermentation process at high yields under high cell density conditions employing media of high mineral salts concentration. Novel Pichia pastoris and Hansenula polymorpha yeasts are disclosed.
摘要:
A process for the preparation of a 15 .alpha.-hydroxyprostaglandin intermediate of the formula ##STR1## wherein R.sub.1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms, andR.sub.2 is hydrogen, acetyl, benzoyl or p-phenylbenzoyl,which comprises stereospecifically microbiologically reducing a corresponding 15-ketone of the formula ##STR2## with a strain of the microorganism Kloeckera, Saccharomyces or Hansenula.
摘要:
Improved apparatus for the continuous aseptic growth of single-cell protein materials, employing an aqueous ethanolic substrate fortified with nutrient elements, preferably under oxygen limited conditions. The fermentation is conducted under conditions which afford effective means of attaining high rates of oxygen transfer and heat removal coupled with intense agitation.
摘要:
Yeast is continuously cultured in a vapor condensate by adding a neutralizing agent and nutritive agents to the vapor condensate produced from the evaporation of spent sulfite liquor; inoculating said vapor condensate with Candida, Pichia or Hansenula yeast; continuously culturing said yeast in said inoculated vapor condensate; and continuously supplying unsterilized vapor condensate to control the sulfurous acid concentration and the pH of said inoculated vapor condensate.