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135 条记录 (耗时 0.015 秒)

    Method for the preparation of collagen-glycosaminoglycan composite materials
    43.
    发明授权
    Method for the preparation of collagen-glycosaminoglycan composite materials 失效
    胶原 - 糖胺聚糖复合材料的制备方法

    公开(公告)号：US4448718A

    公开(公告)日：1984-05-15

    申请号：US531804

    申请日：1983-09-13

    申请人： Ioannis V. Yannas ,  James F. Kirk

    发明人： Ioannis V. Yannas ,  James F. Kirk

    IPC分类号： A61L15/22 ,  A61L27/26 ,  C08H1/06 ,  C07G7/00 ,  C08H1/00

    CPC分类号： C08H1/06 ,  A61L15/225 ,  A61L27/26 ,  Y10S128/08 ,  Y10S623/924

    摘要： A process for preparing a crosslinked collagen-glycosaminoglycan composite material which comprises forming an uncrosslinked composite material from collagen and a glycosaminoglycan and contacting the uncrosslinked composite with a gaseous aldehyde until a crosslinked product having an M.sub.c of from about 800 to about 60,000 is disclosed along with composite materials prepared by this process. Artificial skin produced by this process is more stable toward long-term storage than similar materials prepared using other methods of crosslinking.

    摘要翻译： 一种制备交联的胶原 - 糖胺聚糖复合材料的方法，其包括由胶原和糖胺聚糖形成未交联的复合材料，并将未交联的复合材料与气态醛接触直到具有约800至约60,000的Mc的交联产物连同 复合材料通过该工艺制备。 与使用其他交联方法制备的类似材料相比，通过该方法生产的人造皮肤比长期储存更稳定。

    Method of preparing a porous implantable material from polytetrafluoroethylene and carbon fibers
    44.
    发明授权
    Method of preparing a porous implantable material from polytetrafluoroethylene and carbon fibers 失效
    从聚四氟乙烯和碳纤维制备多孔可植入材料的方法

    公开(公告)号：US4129470A

    公开(公告)日：1978-12-12

    申请号：US694056

    申请日：1976-06-07

    申请人： Charles A. Homsy

    发明人： Charles A. Homsy

    IPC分类号： A61L27/44 ,  A61L27/48 ,  B29C43/00 ,  C08J9/26 ,  C08K7/06 ,  B29D27/00 ,  B32B31/00

    CPC分类号： C08J9/26 ,  A61L27/443 ,  A61L27/48 ,  C08K7/06 ,  B29C43/006 ,  C08J2327/18 ,  Y10S264/17 ,  Y10S264/19 ,  Y10S623/924

    摘要： A composition of material suitable for in vivo implantation to provide an environment in which normal tissue growth is fostered which composition is a porous fibrous structure in which the critical surface tension of the fibers is 35 dynes per centimeter or higher. This composition in the preferred form is a porous structure of carbon or graphite fibers bonded together by sintered polytetrafluoroethylene in a manner to expose a maximum amount of fiber surface.Another composition of material suitable for implantation for wear surfaces includes carbon fibers and polytetrafluoroethylene resin and is processed to align the carbon fibers with the wear surfaces. The method of preparing both material includes the step of mixing, filtering, compressing, rolling, sintering and drying. The method of stabilizing appliances or implants includes bonding the ingrowth material to the appliance or implant. Also the combination of the ingrowth material with appliances, tendon replacement elements and wear material are included.

    摘要翻译： 适于体内植入的材料组合物，以提供其中培养正常组织生长的环境，哪种组合物是其中纤维的临界表面张力为35达因/厘米或更高的多孔纤维结构。 优选形式的组合物是通过烧结的聚四氟乙烯以暴露最大量的纤维表面的方式结合在一起的碳或石墨纤维的多孔结构。

    Medical devices including hardened alloys
    47.
    发明授权
    Medical devices including hardened alloys 有权
    医疗器械包括硬化合金

    公开(公告)号：US07780798B2

    公开(公告)日：2010-08-24

    申请号：US11693498

    申请日：2007-03-29

    申请人： Jonathan S. Stinson ,  Matthew Cambronne ,  Richard B. Frank ,  Richard A. Gleixner ,  James E. Heilmann

    发明人： Jonathan S. Stinson ,  Matthew Cambronne ,  Richard B. Frank ,  Richard A. Gleixner ,  James E. Heilmann

    IPC分类号： C22C38/40 ,  C22C38/44 ,  C22C5/04 ,  C22C28/00

    CPC分类号： A61L31/022 ,  Y10S623/924

    摘要： Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The endoprostheses comprise a tubular member capable of maintaining patency of a bodily vessel. The tubular member includes a mixture of at least two compositions, where the presence of the second composition gives the mixture a greater hardness than that of the first composition alone. The first composition includes less than about 25 weight percent chromium, less than about 7 weight percent molybdenum, from about 10 to about 35 weight percent nickel, and iron. The second composition is different from the first and is present from about 0.1 weight percent to about 5 weight percent of the mixture.

    摘要翻译： 公开了诸如内置假体的医疗装置和制造装置的方法。 内置假体包括能够维持身体血管通畅的管状构件。 管状构件包括至少两种组合物的混合物，其中第二组合物的存在给予混合物比单独的第一组合物更大的硬度。 第一组合物包括小于约25重量％的铬，小于约7重量％的钼，约10至约35重量％的镍和铁。 第二组合物与第一组合物不同，并且存在约0.1重量％至约5重量％的混合物。

    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    49.
    发明授权
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 有权
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US06800672B2

    公开(公告)日：2004-10-05

    申请号：US10011570

    申请日：2001-12-04

    申请人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

    发明人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

    IPC分类号： A61K3180

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L为二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。除聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法也是 描述。