公开(公告)号：US2999119A

公开(公告)日：1961-09-05

申请号：US55391455

申请日：1955-12-19

Applicant: COLLIER CARBON & CHEMICAL CO

Inventor： MCKINNIS ART C

IPC: C06B25/00 ,  C07C45/54 ,  C07C201/14

CPC classification number: C07C201/14 ,  C06B25/00 ,  C07C205/02

公开(公告)号：US11008358B2

公开(公告)日：2021-05-18

申请号：US16724654

申请日：2019-12-23

Applicant: President and Fellows of Harvard College

Inventor： Andrew G. Myers ,  Ziyang Zhang

IPC: C07H15/12 ,  C07H17/02 ,  C07H11/02 ,  C07H15/18 ,  C07C201/12 ,  C07C201/14 ,  C07H1/00

Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US10544182B2

公开(公告)日：2020-01-28

申请号：US15558910

申请日：2016-03-25

Applicant: President and Fellows of Harvard College

Inventor： Andrew G. Myers ,  Ziyang Zhang

IPC: C07H15/12 ,  C07H17/02 ,  C07H11/02 ,  C07H15/18 ,  C07H1/00 ,  C07C201/12 ,  C07C201/14

Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US09758468B2

公开(公告)日：2017-09-12

申请号：US15293507

申请日：2016-10-14

Applicant: Nippon Soda Co., Ltd.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C209/74 ,  C07C17/12 ,  C07C17/00 ,  C07C201/14 ,  C07C209/32 ,  C07C205/12 ,  C07C211/52 ,  C07C17/06 ,  C07C201/08

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

公开(公告)号：US09656256B2

公开(公告)日：2017-05-23

申请号：US14910456

申请日：2014-05-28

Applicant: Shanghai Research Institute of Chemical Industry

Inventor： An Shen ,  Yucai Cao ,  Xiangyang Wu ,  Xiaofeng Ye ,  Chen Ni ,  Yongqing Li

IPC: B01J31/08 ,  B01J31/10 ,  B01J35/08 ,  B01J21/18 ,  C07C201/14 ,  C07D301/12 ,  C01B31/02 ,  B01J31/22 ,  B01J31/28 ,  C07C67/343 ,  C07D333/16 ,  C07C45/68 ,  C07C49/67 ,  C07C49/784 ,  C07D295/096 ,  C07D307/36 ,  C07F15/00 ,  C07C209/10 ,  C07C1/26 ,  C07C1/32 ,  C07C213/08 ,  C07D213/16 ,  C07D265/30 ,  C07D333/10

CPC classification number: B01J31/2273 ,  B01J31/1805 ,  B01J31/2226 ,  B01J31/28 ,  B01J2231/4205 ,  B01J2231/4277 ,  B01J2531/824 ,  C07C1/26 ,  C07C1/321 ,  C07C1/325 ,  C07C1/326 ,  C07C45/68 ,  C07C49/67 ,  C07C49/784 ,  C07C67/343 ,  C07C209/10 ,  C07C213/08 ,  C07C2531/22 ,  C07C2601/14 ,  C07D213/16 ,  C07D265/30 ,  C07D295/096 ,  C07D307/36 ,  C07D333/10 ,  C07D333/16 ,  C07F15/006 ,  C07C69/734 ,  C07C69/618

Abstract: The present invention relates to an n-heterocyclic carbene (NHC) type palladium catalyst and its preparation method as well as applications. Its preparation process is as below: select glyoxal as the raw material to synthesize glyoxaldiimine in the presence of Lewis acid or Bronsted acid, and then react with paraformaldehyde to get the NHC type ligand. Use palladium(II) to react with the compound containing carbon-nitrogen double bonds to get palladium(II) cyclic dimer; make the palladium cyclic dimer and the NHC type ligand coordinated to get the NHC type palladium catalyst. The palladium catalyst with a brand new structure according to the present invention, boasts high activity and multi-purpose. In addition, it shows excellent reaction activity in a lot of catalytic-coupling reactions including Suzuki-Miyaura, Heck, Buchwald-Hartwig, Kumada-Tamao-Corriu, Sonogashira, Negishi and α-ketone arylation reactions, and some reactions even can be carried out with the presence of an extremely low concentration of catalyst, exhibiting favorable industrialization prospect.

公开(公告)号：US09346780B2

公开(公告)日：2016-05-24

申请号：US14431945

申请日：2013-10-10

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Pandurang V. Chouthaiwale ,  Fujie Tanaka

IPC: A61K31/35 ,  C07D309/16 ,  C07D309/28 ,  C07D309/30 ,  C07D317/30 ,  C07C201/14 ,  C07D407/04 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07C205/55

CPC classification number: C07D309/28 ,  C07C201/14 ,  C07C205/55 ,  C07C2601/14 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04

Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.

Abstract translation: 公开了制备式I的二氢-2H-吡喃衍生物的方法：其中R 1和R 2在本文中定义。 本发明的方法在简单的级联反应中和一锅中提供式I化合物。 通过本发明方法制备的式I化合物及其进一步转化的衍生物可用于制备用于治疗增殖性疾病的药物组合物。

公开(公告)号：US06924396B2

公开(公告)日：2005-08-02

申请号：US10664123

申请日：2003-09-17

Applicant: Dennis P. Phillion

Inventor： Dennis P. Phillion

IPC: C07C17/16 ,  C07C17/18 ,  C07C19/01 ,  C07C23/08 ,  C07C51/56 ,  C07C53/40 ,  C07C53/42 ,  C07C63/10 ,  C07C65/03 ,  C07C65/05 ,  C07C201/14 ,  C07C205/57 ,  C07C209/00 ,  C07C209/74 ,  C07C211/24 ,  C07C211/29 ,  C07C269/06 ,  C07C271/22 ,  C07C303/02 ,  C07C303/38 ,  C07C309/86 ,  C07C311/16 ,  C07D207/34 ,  C07D207/416 ,  C07D233/90 ,  C07D307/68 ,  C07D309/10 ,  C07D403/14 ,  C07F7/12 ,  C07F7/18 ,  C07F9/12 ,  C07F9/14 ,  C07F9/40 ,  C07F9/42 ,  C07F9/44 ,  C08F8/30 ,  C00C211/15

CPC classification number: C07D403/14 ,  C07B2200/11 ,  C07C17/16 ,  C07C205/57 ,  C07C209/74 ,  C07C269/06 ,  C07C303/02 ,  C07D207/34 ,  C07D233/90 ,  C07D307/68 ,  C07F9/12 ,  C07F9/1406 ,  C07F9/4015 ,  C07F9/4075 ,  C07F9/42 ,  C07F9/4465 ,  C08F8/30 ,  C07C211/24 ,  C07C271/22 ,  C07C309/86

Abstract: The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use.

Abstract translation: 本发明描述了固定的卤代胺试剂，固定的叔酰胺，其制备方法和使用方法。

公开(公告)号：US5545768A

公开(公告)日：1996-08-13

申请号：US958107

申请日：1992-12-22

Applicant: Theodor Papenfhus ,  Andreas Kanschik-Conradsen ,  Wilfried Pressler

Inventor： Theodor Papenfhus ,  Andreas Kanschik-Conradsen ,  Wilfried Pressler

IPC: B01J31/02 ,  C07B61/00 ,  C07C201/12 ,  C07C201/14 ,  C07C205/12

CPC classification number: C07C201/12

Abstract: A process for the preparation of chlorofluoronitrobenzenes and difluoronitrobenzenes, which comprises heating dichloronitrobenzene to not more than 200.degree. C. in excess with an alkali metal fluoride having a total water content of about 0.2 to about 2.5% by weight in the presence of a quaternary ammonium and/or phosphonium salt, crown ether and/or polyethylene glycol dimethyl ether as catalyst in the absence of a solvent.

Abstract translation: PCT No.PCT / EP92 / 01079 Sec。 371日期1992年12月22日 102（e）日期1992年12月22日PCT Filed 1991年6月8日PCT公布。 公开号WO91 / 00270 日期1992年1月9日一种氯氟硝基苯和二氟硝基苯的制备方法，其包括在二氯硝基苯与总含水量为约0.2至约2.5重量％的碱金属氟化物中将二氯硝基苯过量加热至不超过200℃ 在不存在溶剂的情况下存在季铵和/或鏻盐，冠醚和/或聚乙二醇二甲醚作为催化剂。

公开(公告)号：US5292966A

公开(公告)日：1994-03-08

申请号：US33110

申请日：1993-03-16

Applicant: Michael Meier ,  Heinz-Georg Kautz

Inventor： Michael Meier ,  Heinz-Georg Kautz

IPC: C07C201/08 ,  C07C201/14 ,  C07C205/26 ,  C07C205/20

CPC classification number: C07C201/08

Abstract: 2-Nitro-3,6-dichlorophenol is prepared by sulfonation of 2,5-dichlorophenol and subsequent nitration and desulfonation, in which the nitration is carried out by metering in a nitrating acid composed of 98 to 100% strength nitric acid and 96 to 100% strength sulfuric acid at temperatures from -15.degree. to 35.degree. C. and a metering time of at least 1 hour.

Abstract translation: 2-硝基-3,6-二氯苯酚是通过2,5-二氯苯酚的磺化和随后的硝化和脱磺酸制备的，其中硝化是通过计量在由98至100％的强度硝酸组成的硝酸中进行的，而96- 在-15度至35摄氏度的温度下，100％强度的硫酸和至少1小时的计量时间。

公开(公告)号：US4992603A

公开(公告)日：1991-02-12

申请号：US363735

申请日：1989-06-09

Applicant: Roger Mari ,  Jacques Quibel

Inventor： Roger Mari ,  Jacques Quibel

IPC: C07C201/06 ,  C07C201/14 ,  C07C205/02

CPC classification number: C07C201/06

Abstract: Nitromethane is preparaed from a nitriding agent comprising an oxygenated nitrogen compound and a carbon compound containing two carbon atoms and at least one atom other than carbon and hydrogen.

Abstract translation: 硝基甲烷由包含含氧氮化合物和含有两个碳原子的碳化合物和除碳和氢以外的至少一个原子的氮化剂制备。