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64 条记录 (耗时 0.07 秒)

    Biologically pure culture of Actinoplanes missouriensis
    41.
    发明授权
    Biologically pure culture of Actinoplanes missouriensis 失效
    生物学纯文化的流行性感冒

    公开(公告)号：US4375513A

    公开(公告)日：1983-03-01

    申请号：US309965

    申请日：1981-10-09

    申请人： Manuel Debono ,  Kurt E. Merkel ,  Robert E. Weeks ,  Herald J. Cole

    发明人： Manuel Debono ,  Kurt E. Merkel ,  Robert E. Weeks ,  Herald J. Cole

    IPC分类号： A61K38/00 ,  C07K9/00 ,  C12P1/06 ,  C12R1/045

    CPC分类号： C12R1/045 ,  C07K9/008 ,  A61K38/00 ,  Y10S435/827 ,  Y10S930/19 ,  Y10S930/27

    摘要： Antibiotic A-4696 factors B.sub.1, B.sub.2, B.sub.3, C.sub.1a, C.sub.3, and E.sub.1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at p.sup.H 10.5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.

    摘要翻译： 抗生素A-4696因子B1，B2，B3，C1a，C3和E1从抗生素A-4696中分离，抗生素A-4696是由浸润好氧条件下的培养基中的流行性感冒菌ATCC 31680，ATCC 31682和ATCC 31683产生的 并通过在离子交换树脂上吸收并从pH7.10用氢氧化钠洗脱而从发酵液中分离。 新型因子通过薄层色谱和高压液相色谱分离，并具有抗微生物和生长促进作用。

    Glycoside-hydrolase enzyme inhibitors
    46.
    发明授权
    Glycoside-hydrolase enzyme inhibitors 失效
    甘氨酸 - 水解酶酶抑制剂

    公开(公告)号：US3876766A

    公开(公告)日：1975-04-08

    申请号：US21306671

    申请日：1971-12-28

    申请人： BAYER AG

    发明人： FROMMER WERNER ,  PULS WALTER ,  SCHAFER DIETMAR ,  SCHMIDT DELF

    IPC分类号： C08B37/00 ,  A61K31/715 ,  A61K35/74 ,  A61K38/55 ,  A61P1/04 ,  A61P3/04 ,  A61P3/08 ,  C12N9/26 ,  C12N9/99 ,  C12P1/04 ,  C12P1/06 ,  C12P19/04 ,  C12R1/01 ,  C12R1/04 ,  C12R1/045 ,  C12R1/62 ,  A61K27/00

    CPC分类号： A61K31/70 ,  C12P1/04 ,  C12P1/06 ,  Y10S435/822 ,  Y10S435/896 ,  Y10S435/907

    摘要： This invention relates to inhibitors for glycoside-hydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (atheriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycosidehydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, hyperlipidemia (atheriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.

    Process for the production of an amylase inhibitor
    47.
    发明授权
    Process for the production of an amylase inhibitor 失效
    生产淀粉酶抑制剂的方法

    公开(公告)号：US3855066A

    公开(公告)日：1974-12-17

    申请号：US33668773

    申请日：1973-02-28

    申请人： BAYER AG

    发明人： FROMMER W ,  PULS W ,  SCHMIDT D

    IPC分类号： C12N9/99 ,  A61K38/55 ,  C12N9/26 ,  C12P1/06 ,  C12R1/045 ,  C12D13/02

    CPC分类号： C12P1/06 ,  Y10S435/826 ,  Y10S435/827

    摘要： The invention relates to an amylase inhibitor for glycosidehydrolases derived from a new strain of micro-organism, mutants and variants thereof, of the order Actinomycetales, means for their production comprising cultivation of the new strain of the order Actinomycetales, mutants and variants thereof, in appropriate nutrient solutions under conditions most favorable to growth and production of said amylase inhibitor and recovering an amylase inhibitor from culture broths of said nutrient solutions and said new strain of microorganism, mutants and variants thereof, of the order Actinomycetales as well as the use of said enzyme inhibitor in pharmaceutically acceptable therapeutic compositions suitable for use in the treatment and relief of conditions indicative of obesity, diabetes, pre-diabetes, gastritis, gastric and duodenal ulcers, hyperlipidemia (atheriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes, and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzyme in the presence of a glycoside-hydrolase enzyme inhibitor derived from a new strain, mutants and variants thereof, of the order Actinomycetales. The invention further contemplates the provision of method for the treatment of indications of the group consisting of obesity, hyperlipidemia (atheriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer and dental caries induced by the action of glycoside-hydrolase enzymes and carbohydrates which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a new strain of microorganism of the order Actinomycetales of the family Actinoplanaceae.

    摘要翻译： 本发明涉及一种用于衍生自放线菌纲的微生物，突变体和变体的新菌株的糖苷 - 水解酶的淀粉酶抑制剂，其生产手段包括培养放线菌纲的新菌株，突变体及其变体 在最适于所述淀粉酶抑制剂的生长和产生的条件下，在适当的营养液中回收淀粉酶抑制剂，并从放线菌纲的所述营养液和所述新菌株的微生物，突变体和变体的培养液中回收淀粉酶抑制剂，以及使用 所述酶抑制剂在适用于治疗和缓解指示肥胖症，糖尿病，前期糖尿病，胃炎，胃和十二指肠溃疡，高脂血症（动脉粥样硬化）等）的病症的药学上可接受的治疗组合物中。 本发明还考虑提供通过在存在下进行所述碳水化合物和糖苷 - 水解酶的所述反应来抑制碳水化合物和糖苷 - 水解酶的反应的方法，特别是消除道的碳水化合物 - 裂解糖苷 - 水解酶 的衍生自放线菌纲的新菌株，其突变体和变体的糖苷 - 水解酶抑制剂。 本发明进一步考虑提供用于治疗由糖苷 - 水解酶的作用引起的肥胖，高脂血症（动脉硬化），糖尿病，前期糖尿病，胃炎，胃溃疡，十二指肠溃疡和龋齿的组的适应症的方法 和碳水化合物，其包括使用由抑制剂抑制剂，其由通过放线菌科的放线菌纲的微生物的新菌株产生的糖苷 - 水解酶。