公开(公告)号：US20150045291A1

公开(公告)日：2015-02-12

申请号：US14390372

申请日：2013-04-03

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Yechiel Shai ,  Avraham Ashkenazi

IPC: A61K47/48 ,  C07K14/005

CPC classification number: A61K47/543 ,  C07K14/005 ,  C12N2740/16122

Abstract: The invention provides conjugates comprising a short isolated peptide coupled to a sphingolipid, the peptide comprising a sequence derived from the HIV-1 gp41. The sphingolipid-peptide conjugates are suitable for treatment of infections caused by human and non-human retroviruses, especially HIV.

Abstract translation: 本发明提供了包含与鞘脂偶联的短分离肽的缀合物，所述肽包含衍生自HIV-1 gp41的序列。 鞘脂 - 肽缀合物适用于治疗人和非人类逆转录病毒，特别是艾滋病毒引起的感染。

公开(公告)号：US20140335573A1

公开(公告)日：2014-11-13

申请号：US14446957

申请日：2014-07-30

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Edward A. Bayer ,  Gilad Gefen ,  Michael Anbar

IPC: C12N9/42 ,  C07K14/33 ,  C12N9/96

CPC classification number: C12N9/2445 ,  C07K14/33 ,  C07K2319/70 ,  C12N9/2434 ,  C12N9/96

Abstract: Fusion proteins including a type-II cohesin module that are capable of integrating into native and designer cellulosomes. β-glucosidases modified to include a type-II cohesin module and polynucleotides encoding same. Multi-enzyme complexes including the fusion proteins, and methods for biomass degradation utilizing same.

Abstract translation: 融合蛋白，包括能够整合到天然和设计者纤维素酶体的II型粘合素模块。 - 葡糖苷酶被修饰以包括II型粘合素模块和编码它们的多核苷酸。 多酶复合物，包括融合蛋白，以及利用其的生物降解方法。

公开(公告)号：US20140288157A1

公开(公告)日：2014-09-25

申请号：US14354580

申请日：2012-10-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef Shaul ,  Peter Tsvetkov ,  Julia Adler

IPC: C12N15/113 ,  C12Q1/68 ,  C12Q1/02

CPC classification number: C12N15/1137 ,  A61K31/713 ,  C12N15/1135 ,  C12N2310/14 ,  C12Q1/025 ,  C12Q1/68 ,  G01N33/5011 ,  G01N2333/4703 ,  G01N2500/04 ,  G01N2500/10

Abstract: A method of treating cancer is disclosed. The method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising an agent which induces a dissociation of the 26S proteasomal complex into a 20S component and a 19S component to thereby inhibit 26S proteasomal activity, wherein the pharmaceutical agent is devoid of a chemotherapeutic agent.

Abstract translation: 公开了一种治疗癌症的方法。 该方法包括向受试者施用治疗有效量的药物组合物，其包含诱导26S蛋白酶体复合体解离成20S组分和19S组分从而抑制26S蛋白酶体活性的试剂，其中所述药剂没有 化疗剂。

公开(公告)号：US20140237686A1

公开(公告)日：2014-08-21

申请号：US14268314

申请日：2014-05-02

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Mark Safro ,  Liron Klipcan ,  Inbar Maymon ,  Igal Finarov

IPC: C12N15/82

CPC classification number: C12N15/8251 ,  C12N9/93 ,  C12N15/821 ,  C12N15/8274

Abstract: Transgenic plants resistant to bio-herbicides, particularly to phytotoxic non-protein amino acids including the meta-tyrosine (m-tyrosine) amino acid analog and salts thereof, means and methods for producing the transgenic plants.

Abstract translation: 对生物除草剂，特别是对包括间位酪氨酸（m-酪氨酸）氨基酸类似物及其盐的植物毒性非蛋白质氨基酸的转基因植物，是指用于生产转基因植物的手段和方法。

公开(公告)号：US20140229116A1

公开(公告)日：2014-08-14

申请号：US14180374

申请日：2014-02-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eytan DOMANY ,  Michal SHEFFER ,  Shlomo URBACH ,  Yotam DRIER

IPC: G06F19/24

CPC classification number: G16B40/00

Abstract: A system and method for non-linear quantification of pathway deregulation in an individual biological sample for analysis of malignancies.

Abstract translation: 用于非线性量化用于分析恶性肿瘤的个体生物样品中的途径去调节的系统和方法。

公开(公告)号：US20140221269A1

公开(公告)日：2014-08-07

申请号：US14343064

申请日：2012-09-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Noam Sobel ,  Tali Weiss ,  Kobi Snitz ,  Adi Yablonka-Barak ,  Elad Schneidman ,  Rehan Mahmood Khan

IPC: G06F19/00 ,  C11B9/00 ,  C11B9/02

CPC classification number: G06F19/709 ,  C11B9/0015 ,  C11B9/02 ,  G01N33/0001 ,  G01N33/0004 ,  G06F17/30424 ,  G06F19/704 ,  G06F19/705

Abstract: An odorant mixture is disclosed. The odorant mixture comprises N odorant components wherein N equals at least 20. Each odorant component is characterized by a multidimensional vector of attributes. A z score of an average of characteristic distances between vectors corresponding to odorant components in the mixture and vectors corresponding to odorant components in a group of M odorant components but not in the mixture is less than 2.

Abstract translation: 公开了一种加味剂混合物。 加味剂混合物包含N个气味成分，其中N等于至少20.每个气味组分的特征在于多维属性的向量。 对应于混合物中的气味组分的向量之间的特征距离的平均值的z得分和对应于一组M加臭剂组分但不在混合物中的气味组分的向量的z分数小于2。

公开(公告)号：US20140200159A1

公开(公告)日：2014-07-17

申请号：US14210409

申请日：2014-03-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N33/6803 ,  G06F19/18 ,  G06F19/24

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

Abstract translation: 用于聚类的方法，系统和制品，从而鉴定与需要诊断疾病或监测治疗的患者受试者的血清的未确定免疫球蛋白反应的预定义抗原。

公开(公告)号：US20140199675A1

公开(公告)日：2014-07-17

申请号：US14153037

申请日：2014-01-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Daniel ZAJFMAN

IPC: G09B5/00

CPC classification number: G09B5/00

Abstract: A method for enabling users to offer educational support in response to a designation of instructor identifier (ID) tags associated with network accessible learning documents. The method comprises selecting by a first user using a first client terminal a network accessible learning document, associating an instructor ID tag indicative of the first user with the network accessible learning document, instructing a presentation of the instructor ID tag in association with the presentation of the network accessible learning document to a second user accessing the network accessible learning document via a second client terminal, identifying a user selection designating the instructor ID tag and made by the second user, and establishing a tutorial session which is based on an interactive communication connection between the first user and the second user.

Abstract translation: 一种使用户能够响应于与网络可访问学习文档相关联的指导者标识符（ID）标签的指定来提供教育支持的方法。 该方法包括使用第一客户终端选择网络可访问学习文档，将指示第一用户的指导者ID标签与网络可访问学习文档相关联，指示与指导者ID标签的呈现相关联 所述网络可访问学习文档经由第二客户终端访问所述网络可访问学习文档的第二用户，识别指示所述教师ID标签并由所述第二用户进行的用户选择，以及建立基于交互式通信连接的教学会话 在第一用户和第二用户之间。

公开(公告)号：US20140178353A1

公开(公告)日：2014-06-26

申请号：US14140793

申请日：2013-12-26

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Rotem SOREK ,  Hila Sberro ,  Azita Leavitt

IPC: C12N9/22 ,  A61K38/46 ,  A61K38/45 ,  C12N9/12

CPC classification number: A61K38/45 ,  A61K38/00 ,  C07K14/8107 ,  C12N9/1241 ,  C12N9/22 ,  C12Y207/07

Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.

Abstract translation: 公开了分离的多肽，其包含选自SEQ ID NO：2773-5544和11089-11094的氨基酸序列，其中所述多肽具有抗微生物活性。 还公开了其用于治疗微生物感染的用途。

公开(公告)号：US20140005040A1

公开(公告)日：2014-01-02

申请号：US13855258

申请日：2013-04-02

Applicant: Yeda Research and Development Co. Ltd. ,  NDSU Research Foundation

Inventor： Reshef TENNE ,  Yulia TSVERIN ,  Uwe BURGHAUS ,  Mallikharjuna Rao KOMARNENI

IPC: B01J27/049

CPC classification number: B01J27/049 ,  B01D53/8687 ,  B01D2255/20776 ,  B01D2255/802 ,  B01D2257/70 ,  B01J27/02 ,  B01J35/0013 ,  B01J35/004 ,  B01J35/006 ,  B01J35/06 ,  B01J37/0217 ,  B01J37/16 ,  C02F2305/08 ,  C02F2305/10 ,  C10G45/04 ,  C10G2300/202 ,  C10G2300/70 ,  C10G2300/703 ,  Y02W10/37

Abstract: This invention relates to a hybrid component comprising at least one nanoparticle of inorganic layered compound (in the form of fullerene-like structure or nanotube), and at least one metal nanoparticle, uses thereof as a catalyst, (e.g. photocatalysis) and processes for its preparation.

Abstract translation: 本发明涉及包含至少一种无机层状化合物纳米颗粒（呈富勒烯结构或纳米管形式）的纳米颗粒和至少一种金属纳米颗粒，其用途作为催化剂（例如光催化剂）及其工艺 制备。