公开(公告)号：US08383771B2

公开(公告)日：2013-02-26

申请号：US11663603

申请日：2005-09-22

申请人： Maria del Carmen Dominguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marin ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vázquez Bonachea ,  José Suárez Alba

发明人： Maria del Carmen Dominguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marin ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vázquez Bonachea ,  José Suárez Alba

IPC分类号： C07K14/47 ,  A61K38/16

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。

公开(公告)号：US08283324B2

公开(公告)日：2012-10-09

申请号：US12278990

申请日：2007-02-23

申请人： Maribel Guerra Vallespi ,  Isis del Carmen Torréns Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Gerardo Enrique Guillén Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gómez

发明人： Maribel Guerra Vallespi ,  Isis del Carmen Torréns Madrazo ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Pérez ,  Gerardo Enrique Guillén Nieto ,  Boris Ernesto Acevedo Castro ,  Raimundo Ubieta Gómez

IPC分类号： A61K38/16 ,  C07K14/00

CPC分类号： C07K14/43509 ,  A61K38/00

摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.

摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。

公开(公告)号：US20110064718A1

公开(公告)日：2011-03-17

申请号：US12857194

申请日：2010-08-16

申请人： Jesus Mena Campos ,  Eulogio Pimentel Vazquez ,  Armando Tomas Hernadez Garcia ,  Liuven Veloz Gonzalez ,  Marieta Marin Bruzos ,  Oscar Compte Alberto ,  Marilin Domingo Puente ,  Licette Leon Barreras ,  Merardo Pujol Ferrero ,  Juan Diego Mencho Ponce ,  Carlos Borroto Nordelo

发明人： Jesus Mena Campos ,  Eulogio Pimentel Vazquez ,  Armando Tomas Hernadez Garcia ,  Liuven Veloz Gonzalez ,  Marieta Marin Bruzos ,  Oscar Compte Alberto ,  Marilin Domingo Puente ,  Licette Leon Barreras ,  Merardo Pujol Ferrero ,  Juan Diego Mencho Ponce ,  Carlos Borroto Nordelo

IPC分类号： A61K38/47 ,  A01N59/02 ,  A01P5/00 ,  A61P33/00

CPC分类号： A01N63/00 ,  A01N63/02 ,  A01N2300/00

摘要： This invention relates to pesticide and antiparasitic compositions for the control of pests, diseases and parasites attacking plants and animals. The compositions include, at least one chitinolytic agent or a chitinolytic activity-inducing agent, and sulfide or a sulfide-producing agent from microorganisms or chemical compounds, wherein the chitinolytic agent or the chitinolytic activity-inducing agent and sulfur or a sulfur-producing agent obtaining from microorganisms or chemical compounds are concurrently applied at a range significantly lower than any of the above-mentioned compounds, when they are individually to attain effective control.

摘要翻译： 本发明涉及用于防治害虫，疾病和寄生虫攻击植物和动物的农药和抗寄生虫剂组合物。 所述组合物包括至少一种chitinotictic试剂或chitinolytic活性诱导剂，以及来自微生物或化学化合物的硫化物或硫化物生成剂，其中所述chitinolytic试剂或所述chitinolytic活性诱导剂和硫或硫产生剂 当微生物或化合物单独获得有效控制时，从微生物或化合物获得的同时应用于显着低于任何上述化合物的范围。

公开(公告)号：US07790173B2

公开(公告)日：2010-09-07

申请号：US12067129

申请日：2006-09-18

申请人： Laura Lazo Vázquez ,  Lisset Hermida Cruz ,  Carlos López Abarrategui ,  Beatriz de la Caridad Sierra Vázquez ,  Susana Vázquez Ramundo ,  Iris Valdez Prado ,  Gerardo Enrique Guillen Nieto ,  Maria Guadalupe Guzmán Tirado ,  Aida Zulueta Morales

发明人： Laura Lazo Vázquez ,  Lisset Hermida Cruz ,  Carlos López Abarrategui ,  Beatriz de la Caridad Sierra Vázquez ,  Susana Vázquez Ramundo ,  Iris Valdez Prado ,  Gerardo Enrique Guillen Nieto ,  Maria Guadalupe Guzmán Tirado ,  Aida Zulueta Morales

IPC分类号： A61K39/00 ,  A61K39/12

CPC分类号： A61K39/12 ,  A61K2039/55505 ,  A61K2039/55566 ,  C07K14/005 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386

摘要： This invention describes a pharmaceutical compound which has the capsid protein of Dengue virus and which is capable of inducing, in the receptor, a protective immune response before the viral challenge, without inducing the Ab-dependent enhancement phenomenon.

摘要翻译： 本发明描述了具有登革热病毒衣壳蛋白的能够在病毒攻击之前在受体中诱导保护性免疫应答而不诱导依赖于Ab的增强现象的药物化合物。

公开(公告)号：US07736638B2

公开(公告)日：2010-06-15

申请号：US11662844

申请日：2005-09-16

申请人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/20 ,  C12N15/06 ,  C07K14/54 ,  C12N5/02 ,  C12P21/02

CPC分类号： C07K14/5443 ,  A61K38/00 ,  A61K39/00 ,  C07K16/244

摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.

摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示肽结合IL15受体a亚基（IL15Rα）和TNFα介导的细胞凋亡后，抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的几种病症的用途。

公开(公告)号：US20100047265A1

公开(公告)日：2010-02-25

申请号：US12612455

申请日：2009-11-04

申请人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vásquez Blomquist

发明人： Mónica Bequet Romero ,  Boris Ernesto Acevedo Castro ,  Jorge Victor Gavilondo Cowley ,  Luis Enrique Fernández Molina ,  Omar Lopez Ocejo ,  Ricardo de la Caridad Silva Rodriguez ,  Alexis Musachio Lasa ,  Ernesto Galban Rodriguez ,  Dania Marcia Vásquez Blomquist

IPC分类号： A61K39/00 ,  A61K31/7088 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07K14/715 ,  A61K38/1858 ,  A61K38/1866 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55594 ,  C07K14/515 ,  C07K14/52 ,  C07K14/71

摘要： Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis.These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.

摘要翻译： 血管通透性因子（VPF）家族的分子的寡核苷酸和多肽序列在病理实体的主动免疫治疗中的应用及其修饰，其中该过程与增加相关 血管生成。 这些方法可以用于治疗癌症及其转移，急性和慢性炎症过程，感染性疾病，自身免疫性疾病，糖尿病和新生儿视网膜病变，器官移植排斥，黄斑变性，新生血管性青光眼，血管瘤和 血管纤维瘤等。

公开(公告)号：US20090304633A1

公开(公告)日：2009-12-10

申请号：US12280055

申请日：2007-02-28

申请人： Jorge Roberto Toledo Alonso ,  Oliberto Sánchez Ramos ,  Maritza Isidra Barrera Valle ,  Nancy Elena Figueroa Baile ,  Yanet Prieto Carratala ,  Maria Pilar Rodriguez Molto ,  Maria Teresa Frias Lepoureau ,  Carlos Guillermo Borroto Nordelo

发明人： Jorge Roberto Toledo Alonso ,  Oliberto Sánchez Ramos ,  Maritza Isidra Barrera Valle ,  Nancy Elena Figueroa Baile ,  Yanet Prieto Carratala ,  Maria Pilar Rodriguez Molto ,  Maria Teresa Frias Lepoureau ,  Carlos Guillermo Borroto Nordelo

IPC分类号： A61K38/21 ,  A61P31/12

CPC分类号： C07K14/005 ,  A01K2267/01 ,  A61K39/12 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6031 ,  C07K14/70575 ,  C07K16/1081 ,  C07K2317/76 ,  C07K2319/21 ,  C07K2319/74 ,  C12N2710/10343 ,  C12N2770/24322 ,  C12N2770/24334

摘要： The current invention describes chimeric vaccine antigens against the virus that causes the Classic Swine Fever (CSFV). Such vaccine antigens are based on viral subunits coupled to proteins able to stimulate cellular and humoral immune system. Chimeric antigens can be produced in expression systems that guarantee a correct tertiary structure folding of the chimeric molecules, which constitute the essence of the current invention. The vaccine formulations containing such chimeric antigens induce an early and potent immune response on vaccinated pigs and confer full protection against CSFV. Moreover, the resultant vaccine formulations prevent the viral transmission from sows to their offspring. The chimeric antigens, as well as the resultant vaccine formulations, can be applied in animal health as vaccines for preventive use in swine.

摘要翻译： 本发明描述了针对导致经典猪瘟（CSFV）的病毒的嵌合疫苗抗原。 这种疫苗抗原基于与能够刺激细胞和体液免疫系统的蛋白质偶联的病毒亚基。 嵌合抗原可以在保证构成本发明精华的嵌合分子的正确三级结构折叠的表达系统中产生。 含有这种嵌合抗原的疫苗制剂在接种疫苗的猪上诱导早期有效的免疫应答并赋予对CSFV的完全保护。 此外，所得疫苗制剂防止病毒从母猪传播到其后代。 嵌合抗原以及得到的疫苗制剂可以作为预防用于猪的疫苗用于动物健康。

公开(公告)号：US20090005294A1

公开(公告)日：2009-01-01

申请号：US12099646

申请日：2008-04-08

申请人： Silvio Ernesto Perea Rodriquez ,  Osvaldo Reyes Acosta ,  Nelson Francisco Santiago Vispo ,  Yaquelin Puchades Izaguirre ,  Ricardo Silva Rodriguez ,  Alejandro Moro Soria ,  Alicia Santos Savio ,  Luis Javier Gonzalez Lopez ,  Belkis Gonzalez Barrios

发明人： Silvio Ernesto Perea Rodriquez ,  Osvaldo Reyes Acosta ,  Nelson Francisco Santiago Vispo ,  Yaquelin Puchades Izaguirre ,  Ricardo Silva Rodriguez ,  Alejandro Moro Soria ,  Alicia Santos Savio ,  Luis Javier Gonzalez Lopez ,  Belkis Gonzalez Barrios

IPC分类号： A61K38/12 ,  C07K7/64 ,  C12N15/63 ,  C07K14/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C07K7/06 ,  C07K2319/10 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20032

摘要： This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.

摘要翻译： 本发明涉及分子药理学领域，特别涉及可用于治疗上皮肿瘤和主要与致癌型HPV相关的肽的发展。 本发明的主要目的是鉴定其结构允许通过与这种位点的直接相互作用阻断酪蛋白激酶II（CKII）磷酸化结构域的肽。 在本发明中，显示了11种具有不同氨基酸序列的环肽，其在体外抑制CKII磷酸化，对HPV-16转化细胞（CaSki）表现出细胞毒性，并且还增加了这些细胞对干扰素（IFN）的细胞抑制作用的敏感性， 。 此外，本发明涉及这些肽与其它肽和化合物共轭或融合的用途，这些肽和化合物可以渗入细胞以及使用肽和化学模拟分子。

公开(公告)号：US20080280354A1

公开(公告)日：2008-11-13

申请号：US11486535

申请日：2006-07-14

申请人： Enrique Iglesias Perez ,  Dania M. Vazquez Blomquist ,  Carlos A. Duarte Cano

发明人： Enrique Iglesias Perez ,  Dania M. Vazquez Blomquist ,  Carlos A. Duarte Cano

IPC分类号： C12N15/63 ,  C07H21/04

CPC分类号： C07K14/005 ,  A61K2039/525 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16322

摘要： The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary T cells, which are presented by a wide range of antigens of type Major Histocompatibility Complex (HLA-I). Recombinant poxviruses are obtained from said genes, which are useful for prophylactic and therapeutic vaccination against HIV/AIDS infections, are capable of generating a protective immune cell response in vaccinated laboratory animals and are recognized by the CTL lymphocytes of HIV/AIDS patients.

摘要翻译： 本发明涉及通过所述病毒的不同基因的片段的结合而形成的HIV嵌合基因，其中所述片段含有细胞毒性T细胞（CTL）或HIV-1辅助T细胞的表位，所述表位由广泛的抗原 型主要组织相容性复合物（HLA-I）。 从所述基因获得的重组痘病毒可用于针对HIV / AIDS感染的预防和治疗性疫苗接种，能够在接种疫苗的实验室动物中产生保护性免疫细胞应答，并被HIV / AIDS患者的CTL淋巴细胞识别。

公开(公告)号：US07429384B2

公开(公告)日：2008-09-30

申请号：US10513931

申请日：2003-05-08

申请人： Iraldo Bello Rivero ,  Yeny Torres Ruiz ,  Elizabeth Blanco Garcés ,  Giselle Pentón Roll ,  Pedro López Saura

发明人： Iraldo Bello Rivero ,  Yeny Torres Ruiz ,  Elizabeth Blanco Garcés ,  Giselle Pentón Roll ,  Pedro López Saura

IPC分类号： A61K39/00 ,  A61K45/00 ,  A61K38/21 ,  C07K14/00 ,  A01N37/18

CPC分类号： C07K14/55 ,  A61K38/00 ,  C07K14/7156 ,  C07K2319/00

摘要： A recombinant chimeric antagonist formed by a 60 amino acid fragment of the N-terminal region of human interleukin 2 (IL-2) fused to the N-terminal of the extracellular region of the alpha subunit of the gamma IFN (IFN γ) receptor. In vitro this protein has a T cell growth stimulating activity, it inhibits the growth stimulating activity of IL-2 in T cells, it inhibits the induction of HLA-DR by IFN γ and it inhibits the antiproliferative activity of γ IFN. This invention can be applied in the field of medicine for the treatment of several pathologies such as autoimmune diseases, graft rejections, chronic inflammations, sepsis, ischemia and reperfusion syndrome and atherosclerosis.

摘要翻译： 由IL-2（IL-2）的N-末端区域的60个氨基酸片段与γIFN（IFNγ）受体的α亚基的胞外区域的N-末端融合的重组嵌合拮抗剂。 体外该蛋白具有T细胞生长刺激活性，它抑制T细胞中IL-2的生长刺激活性，其通过IFNγ抑制HLA-DR的诱导，并且其抑制γIFN的抗增殖活性。 本发明可应用于医学领域，用于治疗诸如自身免疫疾病，移植排斥，慢性炎症，败血症，缺血再灌注综合征和动脉粥样硬化等几种病症。