Abstract:
New 3-amino-4-nitrophenols, the process for preparation thereof and their use in dyeing keratinous fibers, and new intermediate 4,5-dinitrophenols.The present invention relates to a 3-amino-4-nitrophenol of formula: ##STR1## where Z denotes --CH.sub.2 --W, W denoting hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 hydroxyalkyl, C.sub.2 -C.sub.6 polyhydroxyalkyl, (C.sub.1 -C.sub.3)alkoxy(C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.3)hydroxyalkoxy(C.sub.1 -C.sub.6)alkyl and R denotes hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 hydroxyalkyl, C.sub.2 -C.sub.6 polyhydroxyalkyl or (C.sub.1 -C.sub.3)alkoxy(C.sub.1 -C.sub.6)alkyl, the process for preparation thereof and the intermediate compound of formula: ##STR2## in which Z' denotes CH.sub.2 --W, W denoting C.sub.1 -C.sub.6 hydroxyalkyl, C.sub.2 -C.sub.6 polyhydroxyalkyl, (C.sub.1 -C.sub.3)alkoxy-(C.sub.1 -C.sub.6)alkyl or (C.sub.1 -C.sub.3)hydroxyalcoxy(C.sub.1 -C.sub.6)alkyl.The dyes (I) are useful in direct dyeing of keratinous fibers, in particular human hair.
Abstract:
In a first stage of a process for the preparation of 6-piperidino-2,4-diaminopyrimidine-3-oxide at least one of the two amino groups of a compound having formula (1): ##STR1## where x represents a halogen atom or OH group, is protected by an addition reaction with an isocyanate having formula:R--N=C=OIn this formula R represents an alkyl group, or one of the amino groups. The resulting urea derivative is then oxidized to produce the corresponding N-oxide which is then reacted with piperidine. The protective group(s) are then eliminated by reaction with an organic or inorganic base.
Abstract translation:在制备具有式(1)的化合物的两个氨基中的至少一个的6-哌啶基-2,4-二氨基嘧啶-3-氧化物的方法的第一阶段:其中x表示 通过与具有下式的异氰酸酯的加成反应来保护卤素原子或OH基团:RN = C = O在该式中,R表示烷基或氨基之一。 然后将所得的脲衍生物氧化以产生相应的N-氧化物,然后与哌啶反应。 然后通过与有机或无机碱反应除去保护基。
Abstract:
An aromatic polycyclic compound has the formula ##STR1## wherein R represents --SO.sub.3 H, SO.sub.2 NHR.sub.3, ##STR2## --SO.sub.2 R.sub.3, --SOR.sub.3 or --SR.sub.3, R.sub.3 represents lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aminoalkyl, carboxyalkyl, aminocarboxyalkyl or alkoxyalkyl,R' represents hydrogen, lower alkyl, lower alkoxy, hydroxy, C.sub.1 -C.sub.4 acyloxy or amino,R" represents hydrogen, lower alkyl or lower alkoxy, orR' and R", taken together, form an oxo, methano or hydroxyimino radical,R.sub.1 represents hydrogen or lower alkyl,n is 0 or 1,when n=1, R.sub.2 represents hydrogen or lower alkyl, or R.sub.1 and R.sub.2, taken together form a vinylene radical, andAr represents an aromatic radical selected from ##STR3## wherein R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 represent hydrogen or lower alkyl, at least one of R.sub.4 and/or R.sub.5 being other than hydrogen, and at least two of R.sub.8 -R.sub.11 being other than hydrogen,A represents methylene or dimethylene substituted or not by lower alkyl; when A represents dimethylene, R.sub.8 and R.sub.10 together can form a methylene or dimethylene radical,and the salts of the compound of formula I as well as their geometric and optical isomers.These compounds are useful in human and veterinary medicines and in cosmetic compositions.
Abstract:
The present invention relates to a cosmetic composition comprising a natural essence containing a phototoxic dose of furocoumarin, and 0.01 to 2% by weight of at least one benzylidenecamphor derivative filtering out UV-A radiation and chosen from among 3-p-oxybenzylidenebornan-2-ones, 3,3'-terephthalylidenedicamphors optionally sulfonated in the 10-position of the camphor, p-(3-methylidenecamphor)-cinnamic acid derivatives, 3,3'-terephthalylidenedicampho-10-sulfonamides or 3,3'-terephthalylidenedicampho-10,10'-disulfonamides.It is also possible to incorporate into the composition a UV-B filter chosen from among: benzylidenecamphor, p-methylbenzylidenecamphor, benzylidenecamphor derivatives containing a quaternary ammonium radical on the benzene nucleus in the para position relative to the bornylidene radical, benzylidenecamphor derivatives sulphonated on the methyl radical in the 10-position of the camphor or in the 3'-position of 4'-position on the benzene nucleus, p-methylbenzylidene-camphor derivatives substituted on the p-methyl group, or other 3-benzylidenecamphor derivatives filtering out UV-B radiation.The effect of the benzylidenecamphor derivative is to deactivate the furocoumarins excited by UV radiation and to reduce their phototoxicity.
Abstract translation:本发明涉及一种化妆品组合物,其包含含有光毒性剂量的呋喃香豆素的天然精华和0.01至2重量%的过滤掉UV-A辐射的至少一种亚苄基猝灭衍生物,并选自3-对 - 氧亚苄基 - 樟脑的10位任选磺化的3,3'-对苯二甲酰脒,对 - (3-甲基en or or or am am am am am am am am am am am am am am am am am am am 10 10 10 10,,,,10 3 10 10 10 10 10 10 10 10 10 10 10 10 ,10'-二磺酰胺。 也可以在组合物中加入选自以下的UV-B过滤器:亚苄基樟脑,对甲基亚苄基樟脑,在相对于甘草基的对位的苯核上含有季铵基的亚苄基or or衍生物,其上磺化的亚苄基am or衍生物 樟脑10位或甲苯4'-位的3'-位上的甲基,对甲基取代的对甲基亚苄基 - 樟脑衍生物或其它3-亚苄基am or衍生物过滤出紫外 -B辐射。 亚苄基脒衍生物的作用是使由紫外线辐射激发的呋喃香豆素失活并降低其光毒性。
Abstract:
A compound having formula: ##STR1## is described, where R.sub.3 and R.sub.4 may be identical or different and represent a hydrogen atom, alkyl, alkenyl, cycloalkyl;or R.sub.3 and R.sub.4 represent aryl aralkyl;or R.sub.3 and R.sub.4 together with the nitrogen atom linked thereto form a heterocycle;R.sub.1 and/or R.sub.2, independent of each other, represent hydrogen or carbanoyl having formula: ##STR2## where R.sub.7 represents alkyl, alkenyl, cycloalkyl, aryl or aralkyl. The compounds of formula (I) can be used in cosmetic or pharmaceutical compositions for the cosmetic treatment of hair, the treatment of alopecia, and also for the treatment of desquamating dermatitis.
Abstract:
A compound of formula (I) ##STR1## its isomers and its salts in which R.sub.1, R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, halogen, C.sub.1 -C.sub.8 acyloxy or hydroxyl;R' is hydrogen or C.sub.1 -C.sub.6 -alkyl;R" is either a polyene chain or a benzene ring are useful in cosmetics and in the treatment of various dermatological and other complaints.
Abstract:
The present invention relates to a process for preparing a N,N'-disubstituted nitro-para-phenylenediamine (I) according to the following scheme: ##STR1## X denoting a halogen and R a lower alkyl, lower mono- or polyhydroxyalkyl, lower alkoxyalkyl or lower aminoalkyl group, in which the amino group can be mono- or disubstituted with a lower alkyl or lower mono- or polyhydroxyalkyl group, the nitrogen atom of said amino group being able to form part of a heterocyclic system.The invention also relates to the intermediate oxazolidones of formulae (II) and (III), and the new nitro-para-phenylenediamines in which R denotes a lower alkoxyalkyl, lower polyhydroxyalkyl or lower aminoalkyl group, as well as the dyeing compositions for keratinous fibres containing these new nitro-para-phenylenediamines.
Abstract:
An aromatic naphthyl compound of the formula ##STR1## wherein n is 0 or 1,R' is hydrogen, OH, acyloxy, alkoxy or NH.sub.2,R" is hydrogen or lower alkoxy, or R' and R" taken together form an oxo, methano or hydroxy-imino radical,R is --CH.sub.2 OH or --COR.sub.8,R.sub.8 is hydrogen, --OR.sub.9 or ##STR2## R.sub.9 is hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, aryl, aralkyl, the residue of a sugar or ##STR3##is 1, 2 or 3,r' and r" each independently represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of amino acid or the residue of aminated sugar, or r' and r" together form a heterocycle,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen, lower alkyl, alkoxy having 1-4 carbon atoms, fluoroalkoxy, CF.sub.3, cycloalkyl, lower acyl, halogen, OH, amino, acylamino or alkoxy carbonyl,R.sub.5, R.sub.6 and R.sub.7 represent hydrogen or methyl or when n=1, R.sub.5 and R.sub.7 taken together can form with the benzene ring a naphthalene ring, and the salts of the compound of formula I or their geometric or optical isomers.These compounds are useful in human and veterinary medicine and in cosmetic compositions.
Abstract:
Cosmetic composition containing hydroxylated chalcone derivatives and its use for protecting the skin and the hair against luminous radiations, new hydroxylated chalcone derivatives employed and process for their preparation.The invention relates to a cosmetic composition for protecting the skin and the hair against UV rays comprising, in a cosmetically acceptable substrate, at least one derivative of 2-hydroxychalcone of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 denote, independently of each other, a hydrogen atom, a straight- or branched-chain C.sub.1 -C.sub.12 alkyl group, a straight- or branched-chain C.sub.1 -C.sub.12 alkyl group or a straight- or branched-chain C.sub.2 -C.sub.20 acyloxy group.The invention also relates to new derivatives of 2-hydroxychalcone and the process for their preparation.
Abstract:
The invention relates to the use, for dyeing keratin fibres, and in particular human hair, of benzoquinone derivatives of the formula: ##STR1## in which R.sub.1 and R.sub.3 independently of one another denote hydrogen, a hydroxyl group, an alkoxy group or an optionally hydroxylated alkyl group, and R.sub.2 and R.sub.4 independently of one another denote hydrogen, hydroxyl, alkoxy, alkyl, or phenyl optionally substituted by OH, these compounds having at most two alkyl or alkoxy groups on the quinone ring; if one of the radicals R.sub.1, R.sub.2, R.sub.3 or R.sub.4 denotes a methyl, hydroxyl or methoxy group, at least one of the other substituents is different from hydrogen, and if two of these substituents R.sub.1, R.sub.2, R.sub.3 or R.sub.4 are identical and located in the para-position relative to one another and denote hydroxyl or methoxy, at least one of the other two substituents is different from hydrogen.