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    Process for the preparation of 6-piperidino-2,4-diamino pyrimidine-3-oxide
    52.
    发明授权
    Process for the preparation of 6-piperidino-2,4-diamino pyrimidine-3-oxide 失效
    6-哌啶基-2,4-二氨基嘧啶-3-氧化物的制备方法

    公开(公告)号：US4985563A

    公开(公告)日：1991-01-15

    申请号：US225819

    申请日：1988-07-29

    Applicant: Jean Maignan ,  Serge Restle ,  Gerard Lang

    Inventor： Jean Maignan ,  Serge Restle ,  Gerard Lang

    IPC: A61K8/00 ,  A61K8/49 ,  A61Q5/00 ,  C07D239/48 ,  C07D239/50 ,  C07D239/52

    CPC classification number: C07D239/48 ,  C07D239/50 ,  Y02P20/55

    Abstract: In a first stage of a process for the preparation of 6-piperidino-2,4-diaminopyrimidine-3-oxide at least one of the two amino groups of a compound having formula (1): ##STR1## where x represents a halogen atom or OH group, is protected by an addition reaction with an isocyanate having formula:R--N=C=OIn this formula R represents an alkyl group, or one of the amino groups. The resulting urea derivative is then oxidized to produce the corresponding N-oxide which is then reacted with piperidine. The protective group(s) are then eliminated by reaction with an organic or inorganic base.

    Abstract translation: 在制备具有式（1）的化合物的两个氨基中的至少一个的6-哌啶基-2,4-二氨基嘧啶-3-氧化物的方法的第一阶段：其中x表示 通过与具有下式的异氰酸酯的加成反应来保护卤素原子或OH基团：RN = C = O在该式中，R表示烷基或氨基之一。 然后将所得的脲衍生物氧化以产生相应的N-氧化物，然后与哌啶反应。 然后通过与有机或无机碱反应除去保护基。

    Cosmetic compositions containing natural essences and benzylidenecamphor derivatives
    54.
    发明授权
    Cosmetic compositions containing natural essences and benzylidenecamphor derivatives 失效
    含有天然精华和亚苄基or or衍生物的化妆品组合物

    公开(公告)号：US4950478A

    公开(公告)日：1990-08-21

    申请号：US573143

    申请日：1984-01-23

    Applicant: Gerard Lang ,  Andre Deflandre ,  Irena Beck

    Inventor： Gerard Lang ,  Andre Deflandre ,  Irena Beck

    IPC: A61K8/35 ,  A61K8/41 ,  A61K8/46 ,  A61K8/92 ,  A61Q17/04

    CPC classification number: A61K8/35 ,  A61K8/416 ,  A61K8/466 ,  A61K8/922 ,  A61Q17/04 ,  Y10S424/05

    Abstract: The present invention relates to a cosmetic composition comprising a natural essence containing a phototoxic dose of furocoumarin, and 0.01 to 2% by weight of at least one benzylidenecamphor derivative filtering out UV-A radiation and chosen from among 3-p-oxybenzylidenebornan-2-ones, 3,3'-terephthalylidenedicamphors optionally sulfonated in the 10-position of the camphor, p-(3-methylidenecamphor)-cinnamic acid derivatives, 3,3'-terephthalylidenedicampho-10-sulfonamides or 3,3'-terephthalylidenedicampho-10,10'-disulfonamides.It is also possible to incorporate into the composition a UV-B filter chosen from among: benzylidenecamphor, p-methylbenzylidenecamphor, benzylidenecamphor derivatives containing a quaternary ammonium radical on the benzene nucleus in the para position relative to the bornylidene radical, benzylidenecamphor derivatives sulphonated on the methyl radical in the 10-position of the camphor or in the 3'-position of 4'-position on the benzene nucleus, p-methylbenzylidene-camphor derivatives substituted on the p-methyl group, or other 3-benzylidenecamphor derivatives filtering out UV-B radiation.The effect of the benzylidenecamphor derivative is to deactivate the furocoumarins excited by UV radiation and to reduce their phototoxicity.

    Abstract translation: 本发明涉及一种化妆品组合物，其包含含有光毒性剂量的呋喃香豆素的天然精华和0.01至2重量％的过滤掉UV-A辐射的至少一种亚苄基猝灭衍生物，并选自3-对 - 氧亚苄基 - 樟脑的10位任选磺化的3,3'-对苯二甲酰脒，对 - （3-甲基en or or or am am am am am am am am am am am am am am am am am am am 10 10 10 10，，，，10 3 10 10 10 10 10 10 10 10 10 10 10 10 ，10'-二磺酰胺。 也可以在组合物中加入选自以下的UV-B过滤器：亚苄基樟脑，对甲基亚苄基樟脑，在相对于甘草基的对位的苯核上含有季铵基的亚苄基or or衍生物，其上磺化的亚苄基am or衍生物 樟脑10位或甲苯4'-位的3'-位上的甲基，对甲基取代的对甲基亚苄基 - 樟脑衍生物或其它3-亚苄基am or衍生物过滤出紫外 -B辐射。 亚苄基脒衍生物的作用是使由紫外线辐射激发的呋喃香豆素失活并降低其光毒性。

    Process for preparing N,N'-disubstituted nitro-para-phenylenediamines, N,N'-disubstituted nitro-para-phenylenediamines, and intermediate oxazolidones
    57.
    发明授权
    Process for preparing N,N'-disubstituted nitro-para-phenylenediamines, N,N'-disubstituted nitro-para-phenylenediamines, and intermediate oxazolidones 失效
    制备N，N'-二取代的硝基对苯二胺，N，N'-二取代的硝基对苯二胺和中间体恶唑烷酮的方法

    公开(公告)号：US4910341A

    公开(公告)日：1990-03-20

    申请号：US240619

    申请日：1988-09-06

    Applicant: Gerard Lang ,  Alex Junino

    Inventor： Gerard Lang ,  Alex Junino

    IPC: A61K8/41 ,  A61Q5/06 ,  A61Q5/10 ,  C07C215/16 ,  C07D263/20 ,  C07D263/22 ,  C09B51/00 ,  D06P1/19 ,  D06P1/32 ,  D06P3/04

    CPC classification number: A61K8/418 ,  A61Q5/065 ,  A61Q5/10 ,  C07D263/22 ,  C09B51/00

    Abstract: The present invention relates to a process for preparing a N,N'-disubstituted nitro-para-phenylenediamine (I) according to the following scheme: ##STR1## X denoting a halogen and R a lower alkyl, lower mono- or polyhydroxyalkyl, lower alkoxyalkyl or lower aminoalkyl group, in which the amino group can be mono- or disubstituted with a lower alkyl or lower mono- or polyhydroxyalkyl group, the nitrogen atom of said amino group being able to form part of a heterocyclic system.The invention also relates to the intermediate oxazolidones of formulae (II) and (III), and the new nitro-para-phenylenediamines in which R denotes a lower alkoxyalkyl, lower polyhydroxyalkyl or lower aminoalkyl group, as well as the dyeing compositions for keratinous fibres containing these new nitro-para-phenylenediamines.

    Abstract translation: 本发明涉及根据以下方案制备N，N'-二取代的硝基对苯二胺（I）的方法：X表示一个 卤素和R a低级烷基，低级单羟基烷基或多羟基烷基，低级烷氧基烷基或低级氨基烷基，其中氨基可以被低级烷基或低级单羟基或多羟基烷基单 - 或二取代，所述氨基的氮原子 能够形成杂环体系的一部分。 本发明还涉及式（II）和（III）的中间体恶唑烷酮，以及其中R表示低级烷氧基烷基，低级多羟基烷基或低级氨基烷基的新的硝基对苯二胺，以及角质纤维的染色组合物 含有这些新的硝基对苯二胺。

    Use of benzoquinones for the direct dyeing of keratin fibres
    60.
    发明授权
    Use of benzoquinones for the direct dyeing of keratin fibres 失效
    使用苯醌直接染色角蛋白纤维

    公开(公告)号：US4867751A

    公开(公告)日：1989-09-19

    申请号：US682475

    申请日：1984-12-17

    Applicant: Gerard Lang ,  Alain Malaval ,  Jean-Francois Grollier ,  Georges Rosenbaum

    Inventor： Gerard Lang ,  Alain Malaval ,  Jean-Francois Grollier ,  Georges Rosenbaum

    IPC: A61K8/00 ,  A61K20060101 ,  A61K8/35 ,  A61K8/73 ,  A61Q5/10 ,  C07C20060101 ,  C07C50/04 ,  C09B20060101 ,  C09B13/00

    CPC classification number: A61Q5/065 ,  A61K8/355 ,  A61K2800/432

    Abstract: The invention relates to the use, for dyeing keratin fibres, and in particular human hair, of benzoquinone derivatives of the formula: ##STR1## in which R.sub.1 and R.sub.3 independently of one another denote hydrogen, a hydroxyl group, an alkoxy group or an optionally hydroxylated alkyl group, and R.sub.2 and R.sub.4 independently of one another denote hydrogen, hydroxyl, alkoxy, alkyl, or phenyl optionally substituted by OH, these compounds having at most two alkyl or alkoxy groups on the quinone ring; if one of the radicals R.sub.1, R.sub.2, R.sub.3 or R.sub.4 denotes a methyl, hydroxyl or methoxy group, at least one of the other substituents is different from hydrogen, and if two of these substituents R.sub.1, R.sub.2, R.sub.3 or R.sub.4 are identical and located in the para-position relative to one another and denote hydroxyl or methoxy, at least one of the other two substituents is different from hydrogen.

    Abstract translation: 本发明涉及用于染色角蛋白纤维，特别是人类头发的下式的苯醌衍生物：其中R 1和R 3彼此独立地表示氢，羟基，烷氧基或任选地 羟基化烷基，R2和R4彼此独立地表示氢，羟基，烷氧基，烷基或任选被OH取代的苯基，这些化合物在醌环上具有至多两个烷基或烷氧基; 如果基团R 1，R 2，R 3或R 4中的一个表示甲基，羟基或甲氧基，其它取代基中的至少一个不同于氢，并且如果这些取代基中的两个取代基R 1，R 2，R 3或R 4相同且位于 在相对于彼此的对位并且表示羟基或甲氧基，其它两个取代基中的至少一个不同于氢。

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