公开(公告)号：US20220062236A1

公开(公告)日：2022-03-03

申请号：US17454310

申请日：2021-11-10

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki SUZUKI ,  Hiroaki OKUTSU ,  Takashi YASUKOCHI ,  Yasunori TAKADA

IPC: A61K31/407 ,  A61K31/55 ,  A61M37/00 ,  A61K9/70 ,  A61K47/06 ,  A61K47/12 ,  A61K47/10 ,  A61K47/14

Abstract: A method for suppressing a plasma concentration of an asenapine metabolite includes applying to a subject a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer includes asenapine and/or a pharmaceutically acceptable salt thereof, and an adhesive base agent.

公开(公告)号：US20210369638A1

公开(公告)日：2021-12-02

申请号：US17404571

申请日：2021-08-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Atsushi SONOBE ,  Takashi YASUKOCHI ,  Yasunori TAKADA

IPC: A61K9/70 ,  A61K31/407 ,  A61K47/14 ,  A61K47/10

Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

公开(公告)号：US20210369637A1

公开(公告)日：2021-12-02

申请号：US17281621

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Satoshi Amano

IPC: A61K9/70 ,  A61K31/407

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan δ) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.

公开(公告)号：US11116955B2

公开(公告)日：2021-09-14

申请号：US16488450

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Toru Kobayashi ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Tetsuji Kuwahara

IPC: A61M37/00

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

公开(公告)号：US20210267882A1

公开(公告)日：2021-09-02

申请号：US17253311

申请日：2019-06-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61M37/00 ,  A61K47/36 ,  A61K31/4174

Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.

公开(公告)号：US20210251913A1

公开(公告)日：2021-08-19

申请号：US17244552

申请日：2021-04-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：USD926031S1

公开(公告)日：2021-07-27

申请号：US29723229

申请日：2020-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Kei Nishioka ,  Shigeo Kusumi

公开(公告)号：US10987502B2

公开(公告)日：2021-04-27

申请号：US16061834

申请日：2016-12-06

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryusuke Fudoji ,  Naoki Yamamoto

IPC: A61M37/00 ,  C08L67/04 ,  C08G69/10

Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.

公开(公告)号：US20210077393A1

公开(公告)日：2021-03-18

申请号：US16975171

申请日：2019-02-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Toshihiro NAKANISHI ,  Yuko NAGASE ,  Shinya MATSUMURA ,  Yasuhisa KOSE

IPC: A61K9/06 ,  A61K31/196 ,  A61K47/38 ,  A61K47/22 ,  A61K47/18 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26

Abstract: The present invention provides an emulsified gel composition comprising diclofenac sodium, water, a gelling agent, an antioxidant, and a surfactant having an HLB of 14 or more, in which the gelling agent is a nonionic water-soluble polymer.

公开(公告)号：US10814002B2

公开(公告)日：2020-10-27

申请号：US16209084

申请日：2018-12-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC: A61K47/12 ,  A61K9/70 ,  A61K47/06 ,  A61K47/14 ,  A61K31/55 ,  A61M37/00 ,  A61K31/407 ,  A61K47/10 ,  A61F13/00 ,  A61F13/02

Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.