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51.发明申请公开(公告)号：US20080254195A1
公开(公告)日：2008-10-16
申请号：US12102979
申请日：2008-04-15
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
IPC: A01H5/10 , C07H21/00 , C12N5/14 , C12P7/64 , A23D9/007 , A23D9/02 , A01H5/00 , C11B1/00 , A01H1/00
CPC classification number: C12N9/1029 , A23D9/00 , A23D9/007 , A23K20/158 , A23L33/12 , A23V2002/00 , A23V2250/1862 , A23V2250/187 , A23V2250/1868
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-9 elongases in plants.
Abstract translation: 分离的核酸片段和包含编码Δ-9延伸酶的片段的重组构建物以及制备长链多不饱和脂肪酸（PUFA）的方法并在植物中使用这些δ-9延伸酶。
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52.发明申请公开(公告)号：US20070271632A1
公开(公告)日：2007-11-22
申请号：US11748637
申请日：2007-05-15
Applicant: Howard Glenn Damude , Dana M. Walters Pollak , Zhixiong Xue , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Dana M. Walters Pollak , Zhixiong Xue , Quinn Qun Zhu
CPC classification number: C12N9/0083
Abstract: The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this Δ5 desaturase in oleaginous yeast are disclosed.
Abstract translation: 本发明涉及一种Delta5去饱和酶，其具有将二焦γ-亚麻酸（DGLA; 20：3ω-6）转化为花生四烯酸（ARA; 20：4ω-6）和/或二十碳四烯酸（ ETA; 20：4ω-3）至二十碳五烯酸（EPA; 20：5ω-3）。 公开了分离的核酸片段和包含编码Δ5去饱和酶的片段的重组构建物，以及在含油酵母中使用该Delta5去饱和酶制备长链多不饱和脂肪酸（PUFAs）的方法。
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53.发明授权Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids 有权Delta-9脂肪酸延伸酶基因及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08465787B2
公开(公告)日：2013-06-18
申请号：US13428133
申请日：2012-03-23
Applicant: Brian McGonigle , Anthony J. Kinney , Howard Glenn Damude
Inventor： Brian McGonigle , Anthony J. Kinney , Howard Glenn Damude
CPC classification number: C12N15/8247 , A23D9/00 , C12N9/1029 , C12P7/6427
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding novel delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
Abstract translation: 分离的核酸片段和包含编码新的Δ-9延伸酶的这种片段的重组构建物以及在植物中使用这些δ-9延长酶制备长链多不饱和脂肪酸（PUFA）的方法。
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54.发明申请NOVEL DGAT GENES FOR INCREASED SEED STORAGE LIPID PRODUCTION AND ALTERED FATTY ACID PROFILES IN OILSEED PLANTS 有权新鲜DGAT基因在油菜植物中增加种子储存脂肪生产和改变的脂肪酸分布公开(公告)号：US20120156360A1
公开(公告)日：2012-06-21
申请号：US13329939
申请日：2011-12-19
Applicant: KEITH ROESLER , HOWARD GLENN DAMUDE , CHANGJIANG LI , KNUT MEYER , BO SHEN , ERICKA BERMUDEZ , MITCHELL C. TARCZYNSKI
Inventor： KEITH ROESLER , HOWARD GLENN DAMUDE , CHANGJIANG LI , KNUT MEYER , BO SHEN , ERICKA BERMUDEZ , MITCHELL C. TARCZYNSKI
CPC classification number: C12N15/8247 , A23K10/30 , A23L11/00 , A23V2002/00 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与无分离油籽油的总脂肪酸含量相比，具有总脂肪酸含量增加至少10％和改变的脂肪酸分布的转基因油籽。 新型DGAT基因用于实现种子储存脂质的增加。
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55.发明授权DGAT genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in oilseed plants 有权来自含油生物的DGAT基因用于增加种子储存脂质生产和油籽植物中改变的脂肪酸分布公开(公告)号：US08153859B2
公开(公告)日：2012-04-10
申请号：US12470517
申请日：2009-05-22
Applicant: Knut Meyer , Howard Glenn Damude , Kevin G. Ripp , Kevin L. Stecca
Inventor： Knut Meyer , Howard Glenn Damude , Kevin G. Ripp , Kevin L. Stecca
CPC classification number: C12N15/8247 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from oleaginous organisms are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与非转基因，无偏分离大豆种子的总脂肪酸含量相比，具有至少10％的总脂肪酸含量增加和改变的脂肪酸分布的转基因大豆种子。 来自含油生物的DGAT基因用于实现种子储存脂质的增加。
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Patent Agency Ranking
56.发明授权DGAT genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants 有权DGAT基因用于增加油籽植物中的种子储存脂质生成和改变的脂肪酸分布公开(公告)号：US08101819B2
公开(公告)日：2012-01-24
申请号：US12470569
申请日：2009-05-22
Applicant: Keith Roesler , Knut Meyer , Howard Glenn Damude , Bo Shen , Changjiang Li , Ericka Bermudez , Mitchell C. Tarczynski
Inventor： Keith Roesler , Knut Meyer , Howard Glenn Damude , Bo Shen , Changjiang Li , Ericka Bermudez , Mitchell C. Tarczynski
CPC classification number: C12N15/8247 , A23K10/30 , A23L11/00 , A23V2002/00 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic oilseeds having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of null segregant oilseeds are described. Novel DGAT genes are used to achieve the increase in seed storage lipids.
Abstract translation: 描述了与无分离油籽油的总脂肪酸含量相比，具有总脂肪酸含量增加至少10％和改变的脂肪酸分布的转基因油籽。 新型DGAT基因用于实现种子储存脂质的增加。
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57.发明申请Mutant Delta-8 Desaturase Genes Engineered By Targeted Mutagensis and Their Use In Making Polyunsaturated Fatty Acids 审中-公开突变型Delta-8去饱和酶基因由目标突变体及其用于制备多不饱和脂肪酸公开(公告)号：US20110268864A1
公开(公告)日：2011-11-03
申请号：US13178292
申请日：2011-07-07
Applicant: HOWARD GLENN DAMUDE , HONGXIAN HE , DER-ING LIAO , QUINN QUN ZHU
Inventor： HOWARD GLENN DAMUDE , HONGXIAN HE , DER-ING LIAO , QUINN QUN ZHU
CPC classification number: C12N15/8247 , C12N9/0083
Abstract: The present invention relates to mutant delta-8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 omega-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 omega-3, ETrA] to eicosatetraenoic acid [20:3 omega-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant delta-8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20：2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[...]的能力的突变体δ-8去饱和酶基因[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码δ-8去饱和酶的片段以及使用植物中的这些突变型δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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58.发明授权Delta-9-elongases and their use in making polyunsaturated fatty acids 有权Delta-9-延伸酶及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08049062B2
公开(公告)日：2011-11-01
申请号：US11992899
申请日：2006-11-16
Applicant: Howard Glenn Damude , Brian McGonigle , Quinn Qun Zhu , Zhixiong Xue
Inventor： Howard Glenn Damude , Brian McGonigle , Quinn Qun Zhu , Zhixiong Xue
CPC classification number: C12N15/8247 , C11B1/025 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
Abstract translation: 分离的核酸片段和包含编码Δ-9延伸酶的这种片段的重组构建物以及在植物中使用这些δ-9延长酶制备长链多不饱和脂肪酸（PUFA）的方法。
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59.发明授权Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids 有权突变和Dgr; 8去饱和酶基因通过靶向诱变工程改造，并用于制备多不饱和脂肪酸公开(公告)号：US08026089B2
公开(公告)日：2011-09-27
申请号：US12726390
申请日：2010-03-18
Applicant: Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
IPC: C07K14/00 , C12N9/02 , C12N5/10 , C12N1/15 , C12N5/04 , C12N1/21 , C12P7/64 , C12Q1/26 , C12P21/00
CPC classification number: C12N9/0083
Abstract: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20:2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[ 20：3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码“Dgr”8去饱和酶的片段以及使用这些突变体和Dgr。8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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60.发明申请DELTA-8 DESATURASE AND ITS USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开DELTA-8去饱和酶及其在制备多糖脂肪酸中的用途公开(公告)号：US20110184200A1
公开(公告)日：2011-07-28
申请号：US13080279
申请日：2011-04-05
Applicant: Howard Glenn DAMUDE , Quinn Qun Zhu
Inventor： Howard Glenn DAMUDE , Quinn Qun Zhu
IPC: C07F9/02
CPC classification number: C12N15/8247 , C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast are disclosed.
Abstract translation: 公开了分离的核酸片段和重组构建体，其包含编码Δ-8去饱和酶的片段以及使用该植物中的δ-8去饱和酶和油性酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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