公开(公告)号：US08357957B2

公开(公告)日：2013-01-22

申请号：US12912191

申请日：2010-10-26

Applicant: Kyu-sang Lee ,  Kyu-tae Yoo ,  Jeo-young Shim ,  Jin-tae Kim ,  Yeon-ja Cho

Inventor： Kyu-sang Lee ,  Kyu-tae Yoo ,  Jeo-young Shim ,  Jin-tae Kim ,  Yeon-ja Cho

IPC: H01L29/78

CPC classification number: G01N33/54373 ,  C12Q1/6825 ,  G01N27/4145

Abstract: Provided are a FET-based sensor for detecting an ionic material, an ionic material detecting device including the FET-based sensor, and a method of detecting an ionic material using the FET-based sensor. The FET-based sensor includes: a sensing chamber including a reference electrode and a plurality of sensing FETs; and a reference chamber including a reference electrode and a plurality of reference FETs. The method includes: flowing a first solution into and out of the sensing chamber and the reference chamber of the FET-based sensor; flowing a second solution expected to contain an ionic material into and out of the sensing chamber while continuously flowing the first solution into and out of the reference chamber; measuring a current in a channel region between the source and drain of each of the sensing and reference FETs; and correcting the current of the sensing FETs.

Abstract translation: 提供了一种用于检测离子材料的基于FET的传感器，包括基于FET的传感器的离子材料检测装置，以及使用基于FET的传感器检测离子材料的方法。 基于FET的传感器包括：感测室，包括参考电极和多个感测FET; 以及包括参考电极和多个参考FET的参考室。 该方法包括：使第一溶液流入和流出基于FET的传感器的感测室和参考室; 使预期含有离子材料的第二溶液流入和流出感测室，同时使第一溶液持续流入和移出参考室; 测量每个感测和参考FET的源极和漏极之间的沟道区域中的电流; 并校正感测FET的电流。

公开(公告)号：US08293591B2

公开(公告)日：2012-10-23

申请号：US11733539

申请日：2007-04-10

Applicant: Jeo-young Shim ,  Kyu-tae Yoo ,  Kyu-sang Lee ,  Won-seok Chung ,  Yeon-ja Cho ,  Chang-eun Yoo

Inventor： Jeo-young Shim ,  Kyu-tae Yoo ,  Kyu-sang Lee ,  Won-seok Chung ,  Yeon-ja Cho ,  Chang-eun Yoo

IPC: H01L31/00

CPC classification number: H01L29/78 ,  G01N27/4145

Abstract: A field effect transistor for detecting an analyte having a thiol group includes a substrate, a source region and a drain region formed apart from each other on the substrate, the source region and the drain region being doped such that a polarity of the source and drain region is opposite to a polarity of the substrate, a channel region disposed between the source region and the drain region, an insulating layer formed of an electrically insulating material and disposed on the channel region, a gold layer disposed on the insulating layer and a reference electrode disposed apart from the gold layer.

Abstract translation: 用于检测具有硫醇基的分析物的场效应晶体管包括在衬底上彼此分开形成的衬底，源极区和漏极区，源极区和漏极区被掺杂，使得源极和漏极的极性 区域与基板的极性相反，设置在源极区域和漏极区域之间的沟道区域，由电绝缘材料形成并设置在沟道区域上的绝缘层，设置在绝缘层上的金层和参考 电极与金层分开设置。

公开(公告)号：US20120077683A1

公开(公告)日：2012-03-29

申请号：US13244055

申请日：2011-09-23

Applicant: Dae-soon SON ,  Kyu-sang LEE ,  Sung-ouk JUNG ,  Sung-min CHI ,  Kyung-hee PARK ,  Won-seok CHUNG ,  Jong-suk CHUNG ,  Dong-hwan KIM ,  Jhin-gook KIM ,  In-suk SOHN ,  Sin-ho JUNG

Inventor： Dae-soon SON ,  Kyu-sang LEE ,  Sung-ouk JUNG ,  Sung-min CHI ,  Kyung-hee PARK ,  Won-seok CHUNG ,  Jong-suk CHUNG ,  Dong-hwan KIM ,  Jhin-gook KIM ,  In-suk SOHN ,  Sin-ho JUNG

IPC: C40B20/00 ,  C40B40/06

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: A kit and method for predicting cytarabine sensitivity of patients having acute myeloid leukemia are disclosed.

Abstract translation: 公开了一种用于预测急性骨髓性白血病患者阿糖胞苷敏感性的试剂盒和方法。

公开(公告)号：US20110295858A1

公开(公告)日：2011-12-01

申请号：US13074860

申请日：2011-03-29

Applicant: Tae-jin AHN ,  Kyu-sang LEE

Inventor： Tae-jin AHN ,  Kyu-sang LEE

IPC: G06F17/30

CPC classification number: G06F17/30985 ,  G06F19/22

Abstract: A method and apparatus for searching compressed nucleic acid sequences are disclosed. In the method, a reference sequence is compared with a subject sequence to be encoded, the subject sequence is compressed, an index is created with respect to the reference sequence and the compressed subject sequence, a position corresponding to a query is searched for in the compressed subject sequence using the index, a character found at the position within the compressed sequence is converted into a sequence, and the sequence is output as the response to the query.

Abstract translation: 公开了一种用于搜索压缩的核酸序列的方法和装置。 在该方法中，将参考序列与要编码的主题序列进行比较，主题序列被压缩，相对于参考序列和压缩主题序列创建索引，在相关于查询的位置搜索与 使用该索引的压缩主题序列，将在压缩序列内的位置处找到的字符转换为序列，并且将该序列作为对该查询的响应输出。

公开(公告)号：US07914996B2

公开(公告)日：2011-03-29

申请号：US12627022

申请日：2009-11-30

Applicant: Kyung-hee Park ,  Kyu-sang Lee ,  Yeon-su Lee ,  Jae-Heup Kim ,  Yeon-a Park ,  Ji-young Cho ,  Ok-kyoung Son ,  Byung-chul Kim ,  Min-sun Kim

Inventor： Kyung-hee Park ,  Kyu-sang Lee ,  Yeon-su Lee ,  Jae-Heup Kim ,  Yeon-a Park ,  Ji-young Cho ,  Ok-kyoung Son ,  Byung-chul Kim ,  Min-sun Kim

IPC: C07H21/04 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.

Abstract translation: 提供了包含选自SEQ ID NO：1-12的核苷酸序列并且包含核苷酸序列的101位的核苷酸的核苷酸序列的至少10个连续核苷酸或其互补多核苷酸的多核苷酸。

公开(公告)号：US20100256002A1

公开(公告)日：2010-10-07

申请号：US12688938

申请日：2010-01-18

Applicant: Dae-soon SON ,  Kyu-sang LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-suk CHUNG

Inventor： Dae-soon SON ,  Kyu-sang LEE ,  Kyung-hee PARK ,  Tae-jin AHN ,  Jong-suk CHUNG

IPC: C40B30/00 ,  C40B60/12

CPC classification number: G06K9/0014 ,  G06T7/73 ,  G06T2207/30072

Abstract: In a method and apparatus for detecting positions of data spots on a microarray, images of the microarray are synthesized with a grid-pattern image to distinguish spots on the microarray and synthesized images are thereby generated, and a synthesized image is selected from the synthesized images based on statistics corresponding to light intensities of fiducial spots included in the synthesized images. Accordingly, the positions of the data spots are accurately detected from the selected synthesized image, and the data of the microarray is thereby analyzed.

Abstract translation: 在用于检测微阵列上的数据点的位置的方法和装置中，利用网格图案合成微阵列的图像，以区分微阵列上的斑点，由此产生合成图像，并从合成图像中选择合成图像 基于对应于合成图像中包含的基准点的光强度的统计量。 因此，从所选择的合成图像中准确地检测数据点的位置，从而分析微阵列的数据。

公开(公告)号：US20090322354A1

公开(公告)日：2009-12-31

申请号：US11695905

申请日：2007-04-03

Applicant: Kyu-tae YOO ,  Kyu-sang LEE ,  Won-seok CHUNG ,  Jeo-young SHIM ,  Yeon-ja CHO

Inventor： Kyu-tae YOO ,  Kyu-sang LEE ,  Won-seok CHUNG ,  Jeo-young SHIM ,  Yeon-ja CHO

IPC: G01R27/08

CPC classification number: G01N33/54373

Abstract: A method of detecting a presence of bio-molecules, or a concentration of the target bio-molecules using a field effect transistor, includes allowing a first sample including a first target bio-molecule to contact a sensing surface of the field effect transistor and measuring a change in an electric signal of the field effect transistor, the field effect transistor including a substrate, a source region and a drain region, the source region and the drain region formed apart from each other on the substrate, the source region and the drain region each doped to having an opposite polarity than a polarity of the substrate, a channel region disposed between the source region and the drain region and an insulating layer including the sensing surface, the insulating layer disposed on the channel region.

Abstract translation: 使用场效应晶体管检测生物分子的存在或靶生物分子的浓度的方法包括允许包含第一靶生物分子的第一样品接触场效应晶体管的感测表面并测量 场效应晶体管的电信号的变化，所述场效应晶体管包括基板，源极区和漏极区，在所述基板上彼此分离形成的所述源极区和漏极区，所述源极区和漏极 每个被掺杂为具有与衬底的极性相反的极性，设置在源区和漏区之间的沟道区和包括感测表面的绝缘层，绝缘层设置在沟道区上。

公开(公告)号：US20090180778A1

公开(公告)日：2009-07-16

申请号：US12347162

申请日：2008-12-31

Applicant: June Koo Rhee ,  Kyu Sang Lee ,  Chan T.D. Thai

Inventor： June Koo Rhee ,  Kyu Sang Lee ,  Chan T.D. Thai

IPC: H04J14/00 ,  H04J11/00

CPC classification number: H04J14/007 ,  H04B10/548 ,  H04B10/67 ,  H04L5/0007 ,  H04L27/2096 ,  H04L27/2637 ,  H04L27/2653

Abstract: Disclosed are a forward discrete/inverse-discrete Fourier transform device and method for optical orthogonal frequency division multiplexing (OFDM) communication and a transmitting and receiving apparatus.The forward inverse-discrete Fourier transform device includes N 1:N splitters for splitting subcarrier signals received from N inputs corresponding to the number of optical frequencies of subcarriers, a phase shift delay array module for shifting phases of the split signals from the 1:N splitters, N N:1 power couplers for coupling signals output from the phase shift delay array module, a time delay array module for performing time delay on optical OFDM symbols from the N:1 power couplers, and an N:1 power coupler for coupling signals output from the time delay array module.

Abstract translation: 公开了一种用于光学正交频分复用（OFDM）通信和发送和接收设备的前向离散/逆离散傅立叶变换设备和方法。正向离散傅里叶变换设备包括用于分离接收的子载波信号的N 1：N个分离器 来自与子载波的光频数对应的N个输入;相移延迟阵列模块，用于移位来自1：N分路器的分离信号的相位; NN：1个用于从相移延迟阵列模块输出的耦合信号的功率耦合器; 用于对来自N：1个功率耦合器的光学OFDM符号执行时间延迟的时间延迟阵列模块和用于耦合从时间延迟阵列模块输出的信号的N：1功率耦合器。

公开(公告)号：US20080166729A1

公开(公告)日：2008-07-10

申请号：US11971585

申请日：2008-01-09

Applicant: Byung-chul KIM ,  Jhin-gook KIM ,  Nam HUR ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK ,  Tae-jin AHN

Inventor： Byung-chul KIM ,  Jhin-gook KIM ,  Nam HUR ,  Kyu-sang LEE ,  Dae-soon SON ,  Kyung-hee PARK ,  Tae-jin AHN

IPC: C12Q1/68 ,  C40B40/06

CPC classification number: C40B40/06 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C40B30/04 ,  Y10S977/792

Abstract: Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample, the marker gene being selected from the group consisting of marker genes of Table 1, 2 or 3, to obtain data for the expression level of the marker gene; and determining whether the expression level of the marker gene corresponds to an expression level of a recurrence group or an expression level of a non-recurrence group.

Abstract translation: 本发明提供一种预测肺癌患者的肺癌复发风险或患者进行肺癌治疗后的方法，该方法包括从肺癌患者获得生物样品; 测定来自生物样品的至少一种标记基因的表达水平，所述标记基因选自表1,2或3的标记基因，以获得标记基因表达水平的数据; 确定标记基因的表达水平是否符合复发组的表达水平或非复发组的表达水平。

公开(公告)号：US20070252176A1

公开(公告)日：2007-11-01

申请号：US11613258

申请日：2006-12-20

Applicant: Jeo-young SHIM ,  Kyu-sang LEE ,  Kyu-tae YOO ,  Won-seok CHUNG

Inventor： Jeo-young SHIM ,  Kyu-sang LEE ,  Kyu-tae YOO ,  Won-seok CHUNG

IPC: H01L29/76

CPC classification number: G01N27/4145

Abstract: A field effect transistor for detecting ionic material and a method of detecting ionic material using the field effect transistor. The field effect transistor for detecting ionic material includes a substrate formed of a semiconductor material, a source region and a drain region spaced apart from each other in the substrate and doped with an opposite conductivity type to that of the substrate, a channel region interposed between the source region and the drain region, an insulating layer disposed on the channel region and formed of an electrically insulating material, a first reference electrode disposed at an edge of the upper portion of the insulating layer and a second reference electrode disposed to be spaced apart from the insulating layer.

Abstract translation: 用于检测离子材料的场效应晶体管和使用场效应晶体管检测离子材料的方法。 用于检测离子材料的场效应晶体管包括由衬底形成的衬底，源极区和漏极区，在衬底中彼此间隔开并且掺杂有与衬底相反的导电类型，沟道区介于 源极区域和漏极区域，设置在沟道区域上并由电绝缘材料形成的绝缘层，设置在绝缘层的上部的边缘处的第一参考电极和设置成间隔开的第二参考电极 从绝缘层。