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    OLIGOMER PROBE ARRAY WITH IMPROVED SIGNAL-TO-NOISE RATIO AND DETECTION SENSITIVITY AND METHOD OF MANUFACTURING THE SAME
    3.
    发明申请
    OLIGOMER PROBE ARRAY WITH IMPROVED SIGNAL-TO-NOISE RATIO AND DETECTION SENSITIVITY AND METHOD OF MANUFACTURING THE SAME 审中-公开
    具有改进的信号噪声比和检测灵敏度的低级探针阵列及其制造方法

    公开(公告)号：US20120208723A1

    公开(公告)日：2012-08-16

    申请号：US13424890

    申请日：2012-03-20

    申请人： Jung-hwan HAH ,  Sung-min CHI ,  Kyoung-seon KIM ,  Won-sun KIM

    发明人： Jung-hwan HAH ,  Sung-min CHI ,  Kyoung-seon KIM ,  Won-sun KIM

    IPC分类号： C40B40/00 ,  C40B50/18

    CPC分类号： B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00605 ,  B01J2219/00662 ,  B01J2219/00722

    摘要： An oligomer probe array with improved signal-to-noise ratio and desired detection sensitivity even when a reduced design rule is employed includes a substrate, a plurality of probe cell active regions formed on or in the substrate, each of the plurality of probe cell active regions having a three-dimensional surface and being coupled with at least one oligomer probe with its own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.

    摘要翻译： 即使采用减少的设计规则，具有改善的信噪比和期望的检测灵敏度的低聚物探针阵列包括衬底，形成在衬底上或衬底中的多个探针单元活性区，多个探针单元中的每个探针单元活性 具有三维表面并与其自身序列的至少一个低聚物探针偶联的区域和限定探针细胞活性区并且不具有用于与表面上的低聚物探针偶联的官能团的探针细胞隔离区。

    BIOCHIP KITS AND METHODS OF TESTING BIOLOGICAL SAMPLES USING THE SAME
    6.
    发明申请
    BIOCHIP KITS AND METHODS OF TESTING BIOLOGICAL SAMPLES USING THE SAME 审中-公开
    生物试剂盒和使用该方法测试生物样品的方法

    公开(公告)号：US20080167200A1

    公开(公告)日：2008-07-10

    申请号：US11959497

    申请日：2007-12-19

    申请人： Jung-hwan Hah ,  Sung-min Chi ,  Kyoung-seon Kim ,  Won-sun Kim ,  Sang-jun Choi

    发明人： Jung-hwan Hah ,  Sung-min Chi ,  Kyoung-seon Kim ,  Won-sun Kim ,  Sang-jun Choi

    IPC分类号： C40B30/04 ,  C40B60/12

    CPC分类号： B01L3/508 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01L2300/041 ,  B01L2300/0636 ,  B01L2300/0822

    摘要： The present invention provides a biochip kit including a first housing; a biochip disposed inside the first housing and configured to include a plurality of molecular probes; and a second housing joined to the first housing and configured to form a reaction space with the first housing and to cover the biochip, wherein the second housing and the first housing are removably joined in a configuration to allow exposure of an upper surface of the biochip. Methods of testing biological samples using the biochip kits are also provided.

    摘要翻译： 本发明提供了一种生物芯片套件，包括：第一壳体; 生物芯片，其设置在所述第一壳体内并且被配置为包括多个分子探针; 以及第二壳体，其被连接到所述第一壳体并且被配置为与所述第一壳体形成反射空间并覆盖所述生物芯片，其中所述第二壳体和所述第一壳体以可配置的方式可移除地接合以允许所述生物芯片的上表面 。 还提供了使用生物芯片试剂盒测试生物样品的方法。

    Method of Manufacturing a Microarray
    7.
    发明申请
    Method of Manufacturing a Microarray 失效
    制造微阵列的方法

    公开(公告)号：US20080076128A1

    公开(公告)日：2008-03-27

    申请号：US11748175

    申请日：2007-05-14

    申请人： Jung-hwan HAH ,  Sung-min Chi ,  Kyoung-seon Kim ,  Won-sun Kim

    发明人： Jung-hwan HAH ,  Sung-min Chi ,  Kyoung-seon Kim ,  Won-sun Kim

    IPC分类号： C12Q1/68

    CPC分类号： B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00432 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  B82Y30/00 ,  C40B50/18

    摘要： A method of manufacturing a microarray includes providing a substrate having a surface that is immobilized with a functional group protected with an acid-labile protecting group and capable of coupling with an oligomer probe, providing a photoacid generator onto the substrate, disposing on the substrate an imprint template comprising a convex region and a plurality of concave regions surrounding the convex region so that the convex region contacts with or is adjacent to an upper surface of the substrate to define a plurality of reaction zones by the upper surface of the substrate and the convex region and the concave regions of the imprint template, exposing one or more of the reaction zones to light so that an acid is generated by the photoacid generator in the one or more exposed reaction zones and a functional group in the one or more exposed reaction zones is deprotected by the acid, and providing an oligomer probe onto the substrate so that the oligomer probe couples with the deprotected functional group.

    摘要翻译： 一种制造微阵列的方法包括提供具有固定有被酸不稳定保护基团保护的官能团并且能够与低聚物探针耦合的表面的基底，在基底上提供光致酸产生剂，在基底上设置 压印模板，其包括凸区域和围绕所述凸区域的多个凹区域，使得所述凸区域与所述衬底的上表面接触或邻近所述衬底的上表面，以通过所述衬底的上表面和所述凸起部分限定多个反应区域 区域和压印模板的凹区域，使一个或多个反应区域曝光，使得在一个或多个暴露的反应区域中的光酸产生剂产生酸，并且在一个或多个暴露的反应区域中的官能团 通过酸脱保护，并在基底上提供低聚物探针，使得寡聚物探针与沉淀物结合 无效的功能组。

    Oligomer Probe Array with Improved Signal-to-Noise Ratio and Detection Sensitivity and Method of Manufacturing the Same
    10.
    发明申请
    Oligomer Probe Array with Improved Signal-to-Noise Ratio and Detection Sensitivity and Method of Manufacturing the Same 审中-公开
    具有改进的信噪比和检测灵敏度的低聚物探针阵列及其制造方法

    公开(公告)号：US20080038712A1

    公开(公告)日：2008-02-14

    申请号：US11686492

    申请日：2007-03-15

    申请人： Jung-hwan Hah ,  Sung-min Chi ,  Kyoung-seon Kim ,  Won-sun Kim

    发明人： Jung-hwan Hah ,  Sung-min Chi ,  Kyoung-seon Kim ,  Won-sun Kim

    IPC分类号： G01N33/53

    CPC分类号： B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00605 ,  B01J2219/00662 ,  B01J2219/00722

    摘要： An oligomer probe array with improved signal-to-noise ratio and desired detection sensitivity ever when a reduced design rule is employed includes a substrate, a plurality of probe cell active regions formed on or in the substrate, each of the plurality of probe cell active regions having a three-dimensional surface and being coupled, with at least one oligomer probe with its own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.

    摘要翻译： 当采用减少的设计规则时，具有改进的信噪比和期望的检测灵敏度的低聚物探针阵列包括：衬底，形成在衬底上或衬底中的多个探针单元有源区，多个探针单元中的每个探针单元活性 具有三维表面并与其自身序列的至少一个低聚物探针偶联的区域和限定探针细胞活性区并且不具有用于与表面上的低聚物探针偶联的官能团的探针细胞隔离区。