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公开(公告)号：US06852526B2
公开(公告)日：2005-02-08
申请号：US10282505
申请日：2002-10-28
申请人： Michael J. Cima , Hongming Chen , J. Richard Gyory
发明人： Michael J. Cima , Hongming Chen , J. Richard Gyory
CPC分类号： G01N33/5088 , B01L3/50255 , G01N13/00 , G01N33/5008 , G01N33/5044 , G01N2500/00
摘要： The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a surface of the second member. Each sample surface is substantially the same size as each opening. The transdermal assay apparatus also includes a magnetic clamp configured to clamp a tissue specimen between the sample surface and the opening. The magnetic clamp preferably includes a magnet having a strength that is selected based on the clamping force required between the first member and the second member. The invention also provides a method for using a transdermal assay apparatus.
摘要翻译： 透皮测定装置包括第一，第二和第三构件。 第一构件具有一个或多个样品表面，每个样品表面被配置为在其上接收样品。 第二构件限定一个或多个储存器，每个储存器在第二构件的表面上具有开口。 每个样品表面的大小与每个开口大致相同。 透皮测定装置还包括构造成在样品表面和开口之间夹持组织样本的磁性夹具。 磁夹具优选地包括具有基于第一构件和第二构件之间所需的夹紧力选择的强度的磁体。 本发明还提供了一种使用透皮测定装置的方法。
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52.发明授权Microchip devices for delivery of molecules and methods of fabrication thereof 有权用于递送分子的Microchip器件及其制造方法公开(公告)号：US06808522B2
公开(公告)日：2004-10-26
申请号：US09727858
申请日：2000-12-01
IPC分类号： A16K922
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , Y10T436/25
摘要： Methods of manufacturing microchip devices are provided for controlled release of molecules, such as drugs. Methods include compression molding and casting, alone or in combination with microfabrication techniques. In preferred embodiments, devices are made by (1) filling a die with a polymer powder; (2) compressing the powder to form a polymer preform; (3) thermal compression molding the preform to form a substrate in a mold having a plurality of protrusions that form reservoirs in the substrate; and (4) filling the reservoirs with a release system comprising the molecules to be released. Alternatively, ceramic devices are formed by casting the substrate from a ceramic powder or a slurry using a mold having protrusions that form reservoirs in the substrate. Control over the release rate and time of the molecules from the reservoirs of the microchip device is provided by incorporating release systems and/or reservoir caps.
摘要翻译： 提供制造微芯片器件的方法用于控制释放诸如药物之类的分子。 方法包括压塑和铸造，单独或与微细加工技术组合。 在优选实施例中，装置通过（1）用聚合物粉末填充模具制成; （2）压缩粉末以形成聚合物预成型体; （3）热压缩成型预成型件以在具有在基板中形成储存器的多个突起的模具中形成基板; 和（4）用包含要释放的分子的释放系统填充储存器。 或者，通过使用具有在基板中形成储存器的突起的模具从陶瓷粉末或浆料浇铸基材来形成陶瓷装置。 通过结合释放系统和/或储存器盖来控制来自微芯片装置的储存器的分子的释放速率和时间。
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公开(公告)号：US06686207B2
公开(公告)日：2004-02-03
申请号：US09976835
申请日：2001-10-12
IPC分类号： G01N100
CPC分类号： G01N35/10 , B01D17/04 , B01D17/06 , B01D21/0009 , B01J2219/00274 , B01J2219/00315 , B01J2219/00387 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5085 , B03C5/026 , B03C5/028 , C40B30/08 , C40B40/10 , C40B40/14 , C40B40/18 , C40B60/14 , G01N2035/00188 , G01N2035/00237 , Y10T436/25 , Y10T436/25375
摘要： Micron scale dielectric items are manipulated by methods and apparatus taking advantage of spatially non-uniform field. Such fields give rise to a force on dielectric items, directing them generally toward regions of more concentrated field. The electrode may be elongated, either unitary, with a generally planar counter electrode, or dual, such as parallel pins, loops or plates. If dual, particles are generally attracted to regions of high field concentration, including tips, edges and spaces between electrode conductors. Items can be granular, threadlike, or sheets, and microelectronic parts and other shapes. Items can also be collected directly into a recess of a pharmaceutical material delivery microchip, with a conductive membrane of the microchip acting as a manipulating electrode. Items are attracted without regard to their surface charge, or the polarity of the field, which can be AC or DC. Charging, or knowing the charge of items to be manipulated is not necessary. The amount of material collected can be precisely controlled by varying parameters of collection, such as distance between the electrode and the items, distance between dual conductors, size (diameter, length) of the conductors, any dielectric sheathing thereof, and voltage. Elongated electrodes can be used to manipulate items into and from recesses, such as wells of microtitre trays, microchips, and semiconductor chips. Several recesses can be used to calibrate an array of collecting and depositing electrodes and deposits. Items can be removed from fluids, such as aerosol dispersions, and an air cleaner is also disclosed. Dielectrophoretic forces are exploited. Techniques and apparatus for depositing such items include charged targets and targets with electrodes designed to create a non-uniform field.
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公开(公告)号：US06537256B2
公开(公告)日：2003-03-25
申请号：US10195338
申请日：2002-07-15
申请人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M500
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release. The apparatus and methods provide for active or passive controlled release of the molecules. Embodiments include systems for release of fragrance molecules and beverage additives.
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55.发明授权公开(公告)号：US06514518B2
公开(公告)日：2003-02-04
申请号：US09932245
申请日：2001-08-17
IPC分类号： A61F214
CPC分类号： A61K9/0024 , A61F2/02 , A61F2/28 , A61F2/3094 , A61F2002/009 , A61F2002/30032 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/003 , A61F2250/0067 , A61K9/0051 , A61K9/14 , A61K9/1647 , A61K9/1694 , A61K9/20 , A61K9/2086 , A61K9/2095 , B29C64/00 , B29C64/165 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
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公开(公告)号：US6123861A
公开(公告)日：2000-09-26
申请号：US22322
申请日：1998-02-11
CPC分类号： A61K9/0009 , A61K9/0097 , A61M2205/0244 , A61M37/00
摘要： Fabrication methods are provided for microchips that control both the rate and time of release of multiple chemical substances and allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate. Reservoirs are etched into the substrate using either chemical (wet) etching or plasma (dry) etching techniques well known in the field of microfabrication. Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. A release system, which includes the molecules to be delivered, is inserted into the reservoirs by injection, inkjet printing, or spin coating methods. Exemplary release systems include polymers and polymeric matrices, non-polymeric matrices, and other excipients or diluents. The physical properties of the release system control the rate of release of the molecules. The reservoirs can contain multiple drugs or other molecules in variable dosages. The filled reservoirs can be capped with materials that passively disintegrate, materials that allow the molecules to diffuse passively out of the reservoir over time, or materials that disintegrate upon application of an electric potential. Release from an active device can be controlled by a preprogrammed microprocessor, remote control, or by biosensors.
摘要翻译： 为微芯片提供制造方法，其控制多种化学物质的释放速率和时间，并允许以连续或脉动方式释放多种分子。 在所有优选的实施方案中，将待递送的药物或其它分子和周围流体不可渗透的材料用作基底。 使用在微细加工领域中众所周知的化学（湿）蚀刻或等离子（干）蚀刻技术将储层蚀刻到基底中。 使用这些技术，可以在单个微芯片上制造数百到数千个储层。 包括待输送分子的释放系统通过注射，喷墨印刷或旋涂方法插入储存器中。 示例性的释放系统包括聚合物和聚合物基质，非聚合物基质和其它赋形剂或稀释剂。 释放系统的物理性质控制分子的释放速率。 储层可以含有多种药物或其他可变剂量的分子。 填充的储层可以用被动分解的材料封盖，允许分子随时间被动地扩散出储层的材料，或在施加电势时分解的材料。 从有源设备释放可以由预编程的微处理器，遥控器或生物传感器控制。
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公开(公告)号：US5797898A
公开(公告)日：1998-08-25
申请号：US675375
申请日：1996-07-02
CPC分类号： A61K9/0009 , A61K9/0097 , A61M2205/0244 , A61M37/00
摘要： Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate. Reservoirs are etched into the substrate using either chemical (wet) etching or ion beam (dry) etching techniques well known in the field of microfabrication. Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. The molecules to be delivered are inserted into the reservoirs by injection or spin coating methods in their pure form or in a release system. Exemplary release systems include polymers and polymeric matrices, non-polymeric matrices, and other excipients or diluents. The physical properties of the release system control the rate of release of the molecules. The reservoirs can contain multiple drugs or other molecules in variable dosages. The filled reservoirs can be capped with materials that either degrade or allow the molecules to diffuse passively out of the reservoir over time or materials that oxidize and dissolve upon application of an electric potential. Release from an active device can be controlled by a preprogrammed microprocessor, remote control, or by biosensors.
摘要翻译： 提供微芯片，其控制多种化学物质的释放速率和时间，并且允许以连续或脉动方式释放多种分子。 在所有优选的实施方案中，将待递送的药物或其它分子和周围流体不可渗透的材料用作基底。 使用在微细加工领域熟知的化学（湿）蚀刻或离子束（干）蚀刻技术将储层蚀刻到基底中。 使用这些技术，可以在单个微芯片上制造数百到数千个储层。 通过注射或旋涂方法将要输送的分子以纯形式或释放系统插入储存器中。 示例性的释放系统包括聚合物和聚合物基质，非聚合物基质和其它赋形剂或稀释剂。 释放系统的物理性质控制分子的释放速率。 储层可以含有多种药物或其他可变剂量的分子。 填充的储存器可以被降解的材料封盖，或允许分子随时间被动地扩散到储存器中，或者在施加电势时氧化和溶解的材料。 从有源设备释放可以由预编程的微处理器，遥控器或生物传感器控制。
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公开(公告)号：US10806383B2
公开(公告)日：2020-10-20
申请号：US13643707
申请日：2011-05-04
摘要： A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
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公开(公告)号：US20130046164A1
公开(公告)日：2013-02-21
申请号：US13643707
申请日：2011-05-04
CPC分类号： A61B5/14503 , A61B5/055 , A61B5/415 , A61B5/418 , A61K49/10 , G01R33/448 , G01R33/5601
摘要： A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
摘要翻译： 提供了一种传感器，用于在植入组织部位和离体应用时测量体内溶解氧浓度。 传感器包括通过透氧材料包含保持在可植入物品内的传感介质的制品。 感测介质包括用于氧气的MR造影剂。 该传感器被配置为当经历基于MR的方法时，指示流体的溶解氧浓度，例如在组织部位的体内溶解氧浓度。
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公开(公告)号：US20130020906A1
公开(公告)日：2013-01-24
申请号：US13542179
申请日：2012-07-05
IPC分类号： H01L41/09
CPC分类号： F03G7/005 , H01M10/052
摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example
摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置
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