公开(公告)号：US20180333299A1

公开(公告)日：2018-11-22

申请号：US15775515

申请日：2016-11-10

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Eliyahu BSHARIM ,  Tova LIFSHITZ ,  Nadav Yaakov BELFAIR

IPC: A61F9/007

CPC classification number: A61F9/00736 ,  A61F9/00745

Abstract: An ophthalmic surgical instrument for fragmenting the lens nucleus of an eye, and method of use thereof. The instrument includes an elongated handle portion, a tubular head portion at the handle portion distal end, at least three prongs with cutting tips, and a holding ring. The prongs are selectively retractable into and deployable from the head portion. The holding ring selectively contracts and expands to adjust the deployment width of the prongs. The instrument is inserted toward the eye lens through a corneal incision, while the head portion is opened to deploy the prongs to slide over and grasp onto the lens nucleus at a posterior position thereof. The instrument is then withdrawn toward the eye lens anterior while the head portion is closed to retract the prongs, such that the prong cutting tips cut along the lens nucleus, so as to fragment the lens nucleus into multiple segments.

公开(公告)号：US20180206754A1

公开(公告)日：2018-07-26

申请号：US15744083

申请日：2016-07-14

Applicant: MOR RESEARCH APPLICATIONS LTD

Inventor： Matan BEN DAVID ,  Amir KRAITZER

IPC: A61B5/053 ,  A61B5/00 ,  A61B17/11

CPC classification number: A61B5/053 ,  A61B5/0538 ,  A61B5/14539 ,  A61B5/4842 ,  A61B5/4851 ,  A61B5/686 ,  A61B5/6871 ,  A61B5/6873 ,  A61B17/1114 ,  A61B2017/00004 ,  A61B2017/00022 ,  A61B2017/0003 ,  A61B2017/00035 ,  A61B2017/00199 ,  A61B2017/1132

Abstract: Embodiments relate to an implantable device for detecting leakage of matter from a mammalian lumen, the device comprising a mesh structure that is attachable to a lumen of a mammalian. The mesh structure comprises a material or a material composition that is electrically conductive and which is measurably responsive in terms of its electrical conductivity when being subjected to leakage of matter from the lumen.

公开(公告)号：US20180185300A1

公开(公告)日：2018-07-05

申请号：US15905050

申请日：2018-02-26

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Moshe YESHURUN

IPC: A61K31/05 ,  A61K31/573 ,  A61K31/519 ,  A61K31/436 ,  A61K45/06 ,  A61K38/13 ,  A61K9/00

CPC classification number: A61K31/05 ,  A61K9/0053 ,  A61K31/436 ,  A61K31/519 ,  A61K31/573 ,  A61K38/13 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods for preventing, ameliorating and treating the acute and chronic forms of graft-versus-host disease (GVHD) by using Cannabidiol compositions.

公开(公告)号：US20180056086A1

公开(公告)日：2018-03-01

申请号：US15558588

申请日：2016-03-17

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Emanuel HARARI

IPC: A61N5/06 ,  A61B17/22 ,  A61M25/10

CPC classification number: A61N5/062 ,  A61B17/22031 ,  A61B2017/22002 ,  A61B2017/22051 ,  A61B2017/22087 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61M25/104 ,  A61M2025/105 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0643 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/067

Abstract: Aspects of disclosed embodiments relate to systems, devices and methods for treating and preventing restenosis by cross-linking collagen fibrils of the vessel wall at the intervention site. The devices described are drug-eluting devices comprising: an expandable member or a balloon; a cross-linking agent; and a photoactivating light source. Upon the inflation of the expandable member or the balloon the cross linking agent is released and photoactivated in a therapeutically effective amount for cross-linking collagen fibrils.

公开(公告)号：US20170354722A1

公开(公告)日：2017-12-14

申请号：US15524380

申请日：2015-11-09

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Dan ABRAMOV

IPC: A61K38/57

CPC classification number: A61K38/57 ,  A61K9/0019 ,  A61K9/0043 ,  A61P7/04

Abstract: Compositions and methods for treating damage inflicted by use of a cardio-pulmonary bypass (CPB) machine, particularly excessive bleeding and multi organ failure, by administering a pharmaceutical composition comprising alpha-1 antitrypsin (AAT-1).

公开(公告)号：US20160331874A1

公开(公告)日：2016-11-17

申请号：US15109822

申请日：2015-01-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  MOR RESEARCH APPLICATIONS LTD.

Inventor： Reshef TENNE ,  David ZBAIDA ,  Racheli RON ,  Ilan KAFKA ,  Ilan LEIBOVITZ

IPC: A61L31/08 ,  A61L29/14 ,  A61L31/14 ,  A61L29/10

CPC classification number: A61L31/088 ,  A61L29/106 ,  A61L29/14 ,  A61L29/18 ,  A61L31/082 ,  A61L31/14 ,  A61L31/18 ,  A61L2400/12 ,  A61L2420/02

Abstract: A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.

Abstract translation: 提出了一种新方法，通过应用纳米颗粒来减少导尿管的结垢。 证明负表面带电的纳米颗粒产生包括远距离域的涂膜，其中纳米颗粒自组装成马赛克状的顺序，显示出相对较小的附聚倾向。

公开(公告)号：US20160103130A1

公开(公告)日：2016-04-14

申请号：US14881728

申请日：2015-10-13

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Shmuel ARIAD ,  Jacob GOPAS ,  Daniel BENHARROCH ,  Irina LAZAREV

IPC: G01N33/574 ,  A61N5/10 ,  A61K45/06 ,  A61K39/165 ,  C12N7/00

CPC classification number: G01N33/57423 ,  A61K39/165 ,  A61K45/06 ,  A61K2039/525 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/57 ,  A61K2039/585 ,  A61N5/10 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/18422 ,  C12N2760/18432 ,  C12N2760/18434 ,  G01N1/30 ,  G01N33/57415 ,  G01N2333/12 ,  G01N2800/52

Abstract: The present invention provides methods for treating specific populations of cancer patients by immunotherapy. The methods comprise administering an immunogenic composition eliciting an immune response to measles virus to patients having measles virus-immunoreactive cancer cells.

Abstract translation: 本发明提供了通过免疫治疗来治疗癌症患者的特定群体的方法。 所述方法包括向具有麻疹病毒免疫反应性癌细胞的患者施用引发针对麻疹病毒的免疫应答的免疫原性组合物。

公开(公告)号：US20160101063A1

公开(公告)日：2016-04-14

申请号：US14787515

申请日：2014-04-29

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Moshe YESHURUN

IPC: A61K31/05 ,  A61K9/00

CPC classification number: A61K31/05 ,  A61K9/0053 ,  A61K31/436 ,  A61K31/519 ,  A61K31/573 ,  A61K38/13 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods for preventing, ameliorating and treating the acute and chronic forms of graft-versus-host disease (GVHD) by using Cannabidiol compositions.

Abstract translation: 本发明提供了通过使用大麻素组合物预防，改善和治疗急性和慢性形式的移植物抗宿主病（GVHD）的方法。

公开(公告)号：US20140316207A1

公开(公告)日：2014-10-23

申请号：US14114692

申请日：2012-05-08

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Moshe Hain

IPC: A61B1/267 ,  A61B1/00

CPC classification number: A61B1/267 ,  A61B1/00073 ,  A61B1/00082 ,  A61B1/00105 ,  A61M16/0459 ,  A61M16/0488

Abstract: A flexible laryngoscope (10) is disclosed, comprising a flexible body with a plurality of longitudinal channels (150) therethrough, an external groove (110) for an intubation tube, and two inflatable zones (120,130). The laryngoscope is adapted to be inserted intra-orally and to sit in place in the upper hypopharynx and oral cavity in a bent fashion. The laryngoscope is used as a platform for microsurgery by passing flexible microsurgery tools through the channels. In preferred embodiments of the invention, the laryngoscope body comprises a flexible corrugated intermediate portion (102) that allows the body to be bent to fit within the patient's hypopharynx and oral cavity. The inflatable zones are adapted to allow the laryngoscope to be fixed in place when they are inflated.

Abstract translation: 公开了一种灵活的喉镜（10），包括具有穿过其中的多个纵向通道（150）的柔性主体，用于插管的外部凹槽（110）和两个可充气区域（120,130）。 喉镜适于插入口腔内，并以弯曲的方式坐在上咽下和口腔中。 通过通过通过灵活的显微外科手术工具，将喉镜用作显微手术的平台。 在本发明的优选实施例中，喉镜主体包括柔性波纹状中间部分（102），其允许身体弯曲以适合患者的下咽和口腔。 充气区域适于使喉镜在充气时固定就位。

公开(公告)号：US20140303233A1

公开(公告)日：2014-10-09

申请号：US14201970

申请日：2014-03-10

Applicant: Ben-Gurion University of the Negev Research and Development Authority ,  Mor Research Applications Ltd.

Inventor： Rachel LEVY

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2320/30 ,  C12Y301/01004

Abstract: Antisense oligonucleotides against cPLA2 are provided, which are capable of inhibiting cPLA2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases.

Abstract translation: 提供了针对cPLA2的反义寡核苷酸，其能够抑制cPLA2表达以及超氧化物的产生，特别是在吞噬细胞中。 这些反义寡核苷酸是用于治疗炎性病症，特别是关节炎以及神经变性疾病的强力药剂。 反义寡核苷酸或包含其的组合物可用于治疗这些疾病的方法中。