利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

71 条记录 (耗时 0.022 秒)

    Reagent kit of global analysis for protein expression and method for qualitative and quantitative proteomic analysis using the same
    51.
    发明授权
    Reagent kit of global analysis for protein expression and method for qualitative and quantitative proteomic analysis using the same 有权
    用于蛋白质表达的全球分析试剂盒和使用该蛋白质定性和定量蛋白质组学分析的方法

    公开(公告)号：US07338806B2

    公开(公告)日：2008-03-04

    申请号：US10909294

    申请日：2004-08-03

    申请人： Shu Hui Chen ,  Jue Liang Hsu ,  Sheng Yu Huang

    发明人： Shu Hui Chen ,  Jue Liang Hsu ,  Sheng Yu Huang

    IPC分类号： G01N23/00

    CPC分类号： G01N33/6842 ,  G01N33/6848

    摘要： The present invention provides a reagent kit of global analysis for protein expression and method for qualitative and quantitative proteomic analysis using the same, characterized in which isotope labeling reagent is utilized to modify enzymatically cleaved peptides in normal or perturbed cells and subsequently tandem mass spectrometry is used to identify protein sequence, and at the same time, accurately measure the protein expression level based on variation in signal intensity.

    摘要翻译： 本发明提供了一种用于蛋白质表达的全局分析的试剂盒和使用其的定性和定量蛋白质组学分析的方法，其特征在于使用同位素标记试剂来修饰正常或扰动细胞中的酶切割肽，随后使用串联质谱法 鉴定蛋白质序列，同时根据信号强度的变化准确测定蛋白质表达水平。

    Computer motherboard with a control chip having specific pin arrangement for fast cache access
    54.
    发明授权
    Computer motherboard with a control chip having specific pin arrangement for fast cache access 有权
    具有控制芯片的计算机主板具有特定的引脚布置，用于快速缓存访问

    公开(公告)号：US6134701A

    公开(公告)日：2000-10-17

    申请号：US159441

    申请日：1998-09-22

    申请人： Shu-Hui Chen ,  Tsai-Sheng Chen ,  Nai-Shung Chang

    发明人： Shu-Hui Chen ,  Tsai-Sheng Chen ,  Nai-Shung Chang

    IPC分类号： G06F12/08 ,  H05K1/18 ,  G06F3/00

    CPC分类号： H05K1/181 ,  G06F12/0893 ,  H05K2201/09227 ,  H05K2201/10689 ,  H05K2201/10734 ,  Y02P70/611

    摘要： The present invention provides a computer motherboard having an Intel P54C compatible processor socket and a control chip having specifically arranged data pins and address pins which allows a short signal path arrangement from the processor socket to a cache tap RAM and a cache data RAM. The computer motherboard comprises a four-layer printed circuit board, a processor socket, a cache data RAM, a cache tag RAM, and a control chip. All these components are connected by using a high-order-bit data bus, a low-order-bit data bus, and an address bus through the top and bottom layers of the circuit board. The cache data RAM is positioned on the right side of the processor socket. The control chip is positioned on the top side of the cache data RAM and on the top-right side of the processor socket. It comprises an address section positioned at a bottom-middle portion of the control chip, a high-order-bit data section positioned at a bottom-right corner of the control chip, and a low-order-bit data section positioned at a bottom-left corner of the control chip. The cache tag RAM is positioned between the processor socket and the cache data RAM.

    摘要翻译： 本发明提供了一种具有Intel P54C兼容处理器插座的计算机主板和具有特别布置的数据引脚和地址引脚的控制芯片，其允许从处理器插槽到高速缓存分接器RAM和高速缓存数据RAM的短信号路径布置。 计算机主板包括四层印刷电路板，处理器插座，高速缓存数据RAM，高速缓存标签RAM和控制芯片。 所有这些组件通过使用高位数据总线，低位数据总线和通过电路板的顶层和底层的地址总线连接。 缓存数据RAM位于处理器插槽的右侧。 控制芯片位于高速缓存数据RAM的顶侧，并位于处理器插槽的右上侧。 它包括位于控制芯片的底部中间部分的地址部分，位于控制芯片的右下角的高位数据部分和位于底部的低位数据部分 - 控制芯片的左角。 高速缓存标签RAM位于处理器插槽和高速缓存数据RAM之间。

    6,7-modified paclitaxels
    56.
    发明授权
    6,7-modified paclitaxels 失效
    6,7修饰紫杉醇

    公开(公告)号：US5380751A

    公开(公告)日：1995-01-10

    申请号：US128619

    申请日：1993-09-28

    申请人： Shu-Hui Chen ,  Vittorio Farina ,  Gregory Roth ,  John Kadow

    发明人： Shu-Hui Chen ,  Vittorio Farina ,  Gregory Roth ,  John Kadow

    IPC分类号： A61K31/337 ,  A61P35/00 ,  C07D305/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07F7/18 ,  A61K31/335

    CPC分类号： C07D407/12 ,  C07D305/14 ,  C07D409/12 ,  C07D413/12 ,  C07F7/1856

    摘要： The present invention provides paclitaxel derivatives of formula I ##STR1## in which R.sup.1 is --COR.sup.z in which R.sup.Z is RO-- or R;R.sup.2 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or a radical of the formula --W--R.sup.x in which W is a bond, C.sub.2-6 alkenediyl, or --(CH.sub.2).sub.t --, in which t is one to six; and R.sup.x is naphthyl, phenyl, or heteroaryl, and furthermore R.sup.x can be optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups;R.sup.a is --OCOR, H, OH, --OR, --OSO.sub.2 R, --OCONR.sup.o R, --OCONHR, --OCOO(CH.sub.2).sub.t R, or --OCOOR;R.sup.b and R.sup.c are both hydroxy or together form a bond with the carbon atoms to which they are attached; andR and R.sup.o are independently C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkynyl, or phenyl, optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups.Also provided by this invention are pharmaceutical formulations (compositions) and a method of treating mammalian tumors with a compound of formula I.

    摘要翻译： 本发明提供式I的紫杉醇衍生物，其中R 1是其中R Z是RO-或R的-CORz; R 2是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或式-W-Rx的基团，其中W是键，C 2-6亚烯基或 - （CH 2）t - 其中t为1至6; 并且Rx是萘基，苯基或杂芳基，此外Rx可任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R a是-OCOR，H，OH，-OR，-OSO 2 R，-OCONRoR，-OCONHR，-OCOO（CH 2）t R或-OCOOR; Rb和Rc都是羟基或与它们所连接的碳原子一起形成键; 并且R和R 4独立地是C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 -CF3组。 本发明还提供了药物制剂（组合物）和用式I化合物治疗哺乳动物肿瘤的方法。

    WHEEL CYLINDER ADJUSTER
    57.
    发明申请
    WHEEL CYLINDER ADJUSTER 审中-公开
    轮式气缸调节器

    公开(公告)号：US20160076608A1

    公开(公告)日：2016-03-17

    申请号：US14484288

    申请日：2014-09-12

    申请人： Shu-Hui CHEN

    发明人： Shu-Hui CHEN

    IPC分类号： F16D65/00

    CPC分类号： F16D65/0043 ,  B25B27/00 ,  B25B27/0035 ,  B60T17/221 ,  Y10T29/53683

    摘要： A wheel cylinder adjuster includes a rotary unit and a driving unit connected with the rotary unit. The rotary unit includes a rotary disk, a fixing member, two positioning members, a resilient ring, a restriction member and a clip. The rotary disk has a guide groove designed in a shape containing two semi-ovals. Two stepped slots are defined through the fixing member and the positioning members extend through the two stepped slots. Each positioning member has a guide tip which is located in the guide groove. The resilient ring is mounted to the positioning members and the tubular portion. The rotary disk is rotated and the guide tips of the positioning members more in the stepped slots so as to adjust the distance between the positioning members so as to be operated to different sizes of the wheel cylinders.

    摘要翻译： 轮缸调节器包括旋转单元和与旋转单元连接的驱动单元。 旋转单元包括旋转盘，固定构件，两个定位构件，弹性环，限制构件和夹子。 旋转盘具有设计成包含两个半椭圆形状的引导槽。 通过固定构件限定两个台阶槽，并且定位构件延伸穿过两个阶梯槽。 每个定位构件具有位于引导槽中的引导尖端。 弹性环安装到定位构件和管状部分。 旋转盘旋转，并且定位构件的引导尖端更多地在台阶槽中，以便调整定位构件之间的距离，以便操作到不同尺寸的轮缸。

    Wheel cylinder adjuster
    58.
    发明授权
    Wheel cylinder adjuster 有权
    轮缸调节器

    公开(公告)号：US08661638B2

    公开(公告)日：2014-03-04

    申请号：US13441005

    申请日：2012-04-06

    申请人： Shu-Hui Chen

    发明人： Shu-Hui Chen

    IPC分类号： B25B27/00 ,  B25B27/14 ,  B25B13/48 ,  F16D65/00

    CPC分类号： B25B27/00 ,  B25B27/0035 ,  F16D65/0043 ,  Y10T29/53683

    摘要： A wheel cylinder adjuster includes plural actuating discs able to match different-sized wheel cylinders, and a driving wrench able to be jointed with the actuating disc. The driving wrench has two ends of its shank respectively provided with right-handed threads and left-handed threads on the surface, having a crosswise insert hole respectively bored at an outer side of the right-handed threads and of the left-handed threads, and the shank has two ends respectively protruding outward to form a positioning rod to be inserted in the insert hole of the actuating disc. Two positioning sleeves are respectively combined with the right-handed threads and the left-handed threads at the two ends of the shank. A holding rod is inserted in either one of the two insert holes at two ends of the driving wrench, and a positioning stop plate is provided to fix one of the two positioning sleeves.

    摘要翻译： 轮缸调节器包括能够匹配不同大小的轮缸的多个致动盘，以及能够与致动盘连接的驱动扳手。 驱动扳手具有其柄部的两端，分别在表面上设有右旋螺纹和左旋螺纹，具有分别在右旋螺纹和左旋螺纹的外侧钻孔的横向插入孔， 并且柄部具有分别向外突出的两个端部，以形成插入致动盘的插入孔中的定位杆。 两个定位套筒分别与柄部两端的右旋螺纹和左旋螺纹结合。 把持杆插入驱动扳手的两端的两个插入孔的任一个中，并且设置有定位挡板来固定两个定位套筒中的一个。