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公开(公告)号：US12077826B2
公开(公告)日：2024-09-03
申请号：US17258420
申请日：2019-07-08
IPC分类号： C12Q1/6886 , C12Q1/6806
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/158
摘要： Disclosed are compositions comprising a first lipid-conjugated oligonucleotide comprising a first lipid moiety, a first hybridization region, and a first primer region; a second lipid-conjugated oligonucleotide comprising a second hybridization region and a second lipid moiety, wherein the second hybridization region is the reverse complement of the first hybridization region; and a third oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region; compositions comprising a lipid-conjugated DNA oligonucleotide comprising a lipid moiety, a barcode region, and a capture sequence; and composition comprising a first lipid-conjugated DNA oligonucleotide comprising a lipid moiety and a first primer region; and a second DNA oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region. Also disclosed are membranes and cells comprising such compositions and uses of such compositions.
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公开(公告)号：US12076332B2
公开(公告)日：2024-09-03
申请号：US17050406
申请日：2019-04-25
发明人： Gal Bitan , Alessandro Fraldi , Irene Sambri , Antonio Monaco
IPC分类号： A61K31/663 , A61K31/10 , A61K31/19 , A61K31/6615 , A61P25/00
CPC分类号： A61K31/663 , A61K31/10 , A61K31/19 , A61K31/6615 , A61P25/00
摘要： In various embodiments methods are provided for the treatment or prophylaxis of liposomal storage diseases. In certain embodiments the methods involve administering to a subject in need thereof one or more molecular tweezers that inhibit protein aggregation.
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公开(公告)号：US20240291558A1
公开(公告)日：2024-08-29
申请号：US18570319
申请日：2022-06-15
发明人： Zak Kassas , Mohammad NEINAVAIE , Joe Khalife
CPC分类号： H04B7/1855 , H04B7/18589 , H04B7/195
摘要： Processes and device configurations are provided for extracting navigation observables and navigation using low earth orbit (LEO) signals. Methods and systems described herein can detect one or more low earth orbit (LEO) satellite downlink signals, and determine carrier phase observables and Doppler observables from the downlink signals in order to determine position estimates. Processes can include determining at least one carrier phase observable from the one or more LEO satellite downlink signals, wherein determining the at least at least one carrier phase observable includes tracking a modified beat carrier phase of a sample of a detected LEO signal by performing an estimation operation for a time period and adaptive updating of measurement noise. Processes can include use of position estimates for navigation and navigation based on carrier phase tracking. Processes are also provided for determination of satellite synchronization signals (SS) from downlink transmissions using subspace detection.
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公开(公告)号：US20240290473A1
公开(公告)日：2024-08-29
申请号：US18572113
申请日：2022-06-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： Aydogan Ozcan , Jingxi Li , Yair Rivenson , Xiaoran Zhang , Philip O. Scumpia , Jason Garfinkel , Gennady Rubinstein
CPC分类号： G16H30/40 , A61B5/0068 , A61B5/0071 , G06T7/0012 , G06T15/08 , G06T2207/20084 , G06T2207/30088
摘要： A deep learning-based system and method is provided that uses a convolutional neural network to rapidly transform in vivo reflectance confocal microscopy (RCM) images of unstained skin into virtually-stained hematoxylin and eosin-like images with microscopic resolution, enabling visualization of epidermis, dermal-epidermal junction, and superficial dermis layers. The network is trained using ex vivo RCM images of excised unstained tissue and microscopic images of the same tissue labeled with acetic acid nuclear contrast staining as the ground truth. The trained neural network can be used to rapidly perform virtual histology of in vivo, label-free RCM images of normal skin structure, basal cell carcinoma and melanocytic nevi with pigmented melanocytes, demonstrating similar histological features of traditional histology from the same excised tissue. The system and method enables more rapid diagnosis of malignant skin neoplasms and reduces invasive skin biopsies.
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公开(公告)号：US20240288701A1
公开(公告)日：2024-08-29
申请号：US18571653
申请日：2022-06-29
发明人： Aydogan Ozcan , Yi Luo , Ege Cetintas , Yair Rivenson
CPC分类号： G02B27/0944 , G02B5/1866 , G02B6/4206
摘要： A computer-free system and method is disclosed that uses an all-optical image reconstruction method to see through random diffusers at the speed of light. Using deep learning, a set of transmissive layers are trained to all-optically reconstruct images of arbitrary objects that are distorted by random phase diffusers. After the training stage, the resulting diffractive layers are fabricated and form a diffractive optical network that is physically positioned between the unknown object and the image plane to all-optically reconstruct the object pattern through an unknown, new phase diffuser. Unlike digital methods, all-optical diffractive reconstructions do not require power except for the illumination light. This diffractive solution to see through diffusive and/or scattering media can be extended to other wavelengths, and can fuel various applications in biomedical imaging, astronomy, atmospheric sciences, oceanography, security, robotics, autonomous vehicles, among many others.
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公开(公告)号：US20240287487A1
公开(公告)日：2024-08-29
申请号：US18568796
申请日：2022-06-10
申请人： The Broad Institute, Inc. , President and Fellows of Harvard College , The Regents of the University of California , Massachusetts Institute of Technology
发明人： Luke W. Koblan , David R. Liu , Mandana Arbab , Max Walt Shen , Andrew Vito Anzalone , Jeffrey Hussmann
CPC分类号： C12N9/22 , C07K14/35 , C12N9/104 , C12N9/1252 , C12N9/78 , C12N15/11 , C12N15/907 , C12Y207/07007 , C12Y305/04005 , A61K38/00 , C07K2319/00 , C12N2310/20 , C12N2800/80
摘要： Aspects of this disclosure provide compositions, strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. Fusion proteins capable of inducing a cytosine (C) to guanine (G) change (i.e., transversion changes) in a nucleic acid (e.g., genomic DNA) are provided. Fusion proteins of a nucleic acid programmable DNA binding protein (e.g., Cas9) and nucleic acid editing proteins or protein domains, e.g., deaminase domains, polymerase domains, base excision enzymes, and/or DNA repair proteins, are also provided. Methods for targeted nucleic acid editing are also provided. Reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of a nucleic acid programmable DNA binding protein (e.g., Cas9), and nucleic acid editing proteins or domains, are further provided in the present disclosure.
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公开(公告)号：US20240287430A1
公开(公告)日：2024-08-29
申请号：US18566324
申请日：2022-06-02
发明人： Sebastian Streichan , Eyal Karzbrun
IPC分类号： C12M1/12 , C12N5/0793
CPC分类号： C12M25/14 , C12N5/0619 , C12N2501/155 , C12N2513/00 , C12N2533/90
摘要： Systems and methods for cellular luminal structure formation are provided. In some instances, a cellular luminal structure is formed utilizing a micropatterned matrix, biological cells in contact with the micropatterned matrix, and suspended matrix in media. In some instances, cellular luminal structure is utilized in conjunction with cellular differentiation.
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公开(公告)号：US20240286113A1
公开(公告)日：2024-08-29
申请号：US18655056
申请日：2024-05-03
发明人： Faik Tezcan , Jake Bailey , Ling Zhang
CPC分类号： B01J20/261 , B01J20/24 , B01J20/28047 , B01J20/3425 , B01J20/345
摘要： Hybrid materials are disclosed including molecular/protein crystals integrated with synthetic polymers. The disclosed materials combine the structural order and periodicity of crystals, the adaptiveness and tunable mechanical properties of polymeric networks, and the chemical versatility of protein building blocks. Some of the properties of the disclosed materials include the following: 1) allows crystals-which are typically rigid and brittle—to expand and contract reversibly; 2) incorporates polymers to increase the mechanical toughness of the crystals and allow self-healing; 3) reversibly expand/contract crystal lattices and mobilize the protein components therein may provide a new means to improve X-ray diffraction quality and explore otherwise inaccessible protein structural states using 3D protein crystallography; 4) creation of chemically and mechanically differentiated domains within single crystals. Some example embodiments combine the properties of hydrogels (flexibility, adaptability, elasticity, self-healing), crystals (structural order) and proteins (chemical and genetic tailorability).
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公开(公告)号：US12070312B2
公开(公告)日：2024-08-27
申请号：US16820388
申请日：2020-03-16
发明人： Soheil Ghiasi , Daniel Fong
IPC分类号： A61B5/1464 , A61B5/00 , A61B5/0205 , A61B5/024 , A61B5/08 , A61B5/1455
CPC分类号： A61B5/1464 , A61B5/0205 , A61B5/14552 , A61B5/7214 , A61B5/725 , A61B5/7257 , A61B5/7278 , A61B5/02411 , A61B5/0816 , A61B5/4356 , A61B2562/0238
摘要： The disclosed system determines a fetal blood oxygenation level. During operation, the system activates two or more light sources, having different wavelengths, which are positioned on the abdomen of a pregnant mammal to direct light into the maternal abdomen toward a fetus. Next, the system receives a set of mixed signals from a set of photodetectors, which are positioned at different locations on the maternal abdomen to receive reflected light that traverses both maternal and fetal tissue. The system then performs a filtering operation that removes signal components associated with a maternal heart rate and a maternal respiration rate from the set of mixed signals to produce a set of fetal signals. Next, the system combines the set of fetal signals to produce a composite fetal signal. Finally, the system determines the fetal blood oxygenation level by performing a pulse-oximetry computation based on the composite fetal signal.
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公开(公告)号：US20240282549A1
公开(公告)日：2024-08-22
申请号：US18634129
申请日：2024-04-12
发明人： Jeremy J. Axelrod , Carter Turnbaugh , Sara Campbell , Osip Schwartz , Robert M. Glaeser , Holger Mueller
IPC分类号： H01J37/22
CPC分类号： H01J37/22 , H01J2237/2482 , H01J2237/2614
摘要： A ponderomotive phase plate, also called a laser phase plate or standing wave optical phase plate, has a first mirror and a second mirror that define an optical cavity. An electron beam passes through a focal spot of the optical cavity. A laser with variable polarization angle of laser light is coupled to the optical cavity. A standing wave of polarized laser light, with an anti-node at the focal spot of the optical cavity, causes variable modulation of the electron beam. The variable modulation of the electron beam is controllable by the variable polarization angle of the laser light. In a transmission electron microscope, an image plane receives the electron beam modulated by the standing wave optical phase plate. An image formed at the image plane is based on the variable polarization angle of the polarized laser light.
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