公开(公告)号：US20090088576A1

公开(公告)日：2009-04-02

申请号：US12223338

申请日：2007-01-29

申请人： Peter Herold ,  Stefan Stutz ,  Robert Mah ,  Aleksandar Stojanovic ,  Isabelle Lyothier ,  Dirk Behnke ,  Felix Spindler ,  Erhard Bappert

发明人： Peter Herold ,  Stefan Stutz ,  Robert Mah ,  Aleksandar Stojanovic ,  Isabelle Lyothier ,  Dirk Behnke ,  Felix Spindler ,  Erhard Bappert

IPC分类号： C07D231/56

CPC分类号： C07D471/04 ,  C07D231/56

摘要： A process for the synthesis of an alcohol of formula (I), using as intermediate a compound of formula (V).

摘要翻译： 用于合成式（I）的醇的方法，使用式（V）化合物作为中间体。

公开(公告)号：US20090043132A1

公开(公告)日：2009-02-12

申请号：US12113582

申请日：2008-05-01

申请人： Wolfgang Hell ,  Markus Kegel ,  Helmut Buschmann ,  Felix Spindler ,  Detlef Heller ,  Hans-Joachin Drexler

发明人： Wolfgang Hell ,  Markus Kegel ,  Helmut Buschmann ,  Felix Spindler ,  Detlef Heller ,  Hans-Joachin Drexler

IPC分类号： C07C211/43

CPC分类号： C07C213/08 ,  B01J31/2409 ,  B01J31/2433 ,  B01J31/2438 ,  B01J31/2457 ,  B01J31/2476 ,  B01J31/249 ,  B01J2231/645 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/0272 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/827 ,  C07C217/62

摘要： Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of R2 and R3 is not a hydrogen atom and the diphosphine ligand is chiral.

摘要翻译： 在由含有选自Rh，Ir和Ru的金属和优选含有二膦配体的金属的金属盐或络合物构成的均匀的催化剂存在下，可将式II化合物氢化为相应的丁烷衍生物，另外， 当R2和R3之一不是氢原子并且二膦配体是手性时，获得了优异的光学收率。

公开(公告)号：US20080026933A1

公开(公告)日：2008-01-31

申请号：US11631608

申请日：2005-07-04

申请人： Benoit Pugin ,  Xiang Dong Feng ,  Felix Spindler

发明人： Benoit Pugin ,  Xiang Dong Feng ,  Felix Spindler

IPC分类号： C07F15/02 ,  B01J31/00 ,  C07D207/08

CPC分类号： C07F17/02

摘要： In ferrocene diphosphines of formula (I), in which R represents, for example, methyl or phenyl, the catalytic properties of corresponding metal complexes can, in many instances, be distinctly influenced by structural changes on one or both of the CP rings, and the catalytic reaction with regard to selected substrates can be optimized and significantly improved. Diphosphine ligands of this type are accessible by using novel production methods.

摘要翻译： 在式（I）的二茂铁二膦中，其中R表示例如甲基或苯基，在许多情况下，相应的金属络合物的催化性能可以明显受到一个或两个CP环上的结构变化的影响， 可以优化并显着改善对所选择的基材的催化反应。 这种二膦配体可以通过使用新的生产方法获得。

公开(公告)号：US06822118B1

公开(公告)日：2004-11-23

申请号：US08926835

申请日：1997-09-10

申请人： Hans-Peter Jalett ,  Felix Spindler ,  Hans-Ulrich Blaser ,  Reinhard Georg Hanreich

发明人： Hans-Peter Jalett ,  Felix Spindler ,  Hans-Ulrich Blaser ,  Reinhard Georg Hanreich

IPC分类号： C07C23305

CPC分类号： B01J31/2404 ,  B01J31/04 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/24 ,  B01J31/2409 ,  B01J31/2452 ,  B01J31/2457 ,  B01J31/2476 ,  B01J31/248 ,  B01J31/26 ,  B01J2231/643 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/827 ,  B01J2531/842 ,  C07C209/26 ,  C07C209/52 ,  C07C213/02 ,  C07C233/02 ,  C07D333/36

摘要： A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts and with or without an inert solvent, wherein the reaction mixture contains an ammonium or metal chloride, bromide or iodide and additionally an acid.

摘要翻译： 在铱催化剂和惰性溶剂存在下，在高压下用氢氢化亚胺的方法，其中反应混合物含有铵或金属氯化物，溴化物或碘化物，另外是酸。

公开(公告)号：US06777567B2

公开(公告)日：2004-08-17

申请号：US10312816

申请日：2002-12-31

申请人： Walter Weissensteiner ,  Thomas Sturm ,  Felix Spindler

发明人： Walter Weissensteiner ,  Thomas Sturm ,  Felix Spindler

IPC分类号： C07F1702

CPC分类号： B01J31/2409 ,  B01J31/2295 ,  B01J31/24 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/31 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/84 ,  C07B53/00 ,  C07C67/31 ,  C07C231/18 ,  C07F17/02 ,  C07C69/68

摘要： Compounds of the formula (I) and (Ia) in the form of racemates, mixtures of diastereomers or in essentially enantiomerically pure form, (I), (Ia), where R is hydrogen, C1-C8alkyl, C5-C12cycloakyl, phenyl or phenyl substituted by from 1 to 3 C1-C4alky or C1-C4alkoxy groups; n is 0 or an integer from 1 to 4 and R1 are identical or different substituents selected from the group consisting of C1-C4alkyl, C1-C4fluoroalkyl and C1-C4alkoxy; X1 and X2 are each, independently of one another, secondary phosphino; T is C6-C20arylene or C3-C16heteroarylene; and X2 is bound in the ortho position relative to the T-cyclopentadienyl bond. The compounds are ligands for complexes of metal selected from transition groups (I) and (VIII) of the Periodic Table of the Elements, and these metal complexes are valuable catalysts for the asymmetric addition of hydrogen, boron hydrides or silanes onto carbon-carbon or carbon-heteroatom multiple bonds in prochiral organic compounds or the asymmetric addition of carbon nucleophiles or amines onto allyl compounds.

摘要翻译： 式（I）和（Ia）化合物为外消旋体形式，非对映异构体混合物或基本上为对映体纯形式的（I），（Ia），其中R为氢，C 1 -C 8烷基，C 5 -C 12环烷基，苯基或 被1至3个C 1 -C 4烷基或C 1 -C 4烷氧基取代的苯基; n为0或1〜4的整数，R 1为相同或不同的选自C1-C4烷基，C1-C4氟烷基和C1-C4烷氧基的取代基。 X1和X2各自独立地为次膦基; T是C 6 -C 20亚芳基或C 3 -C 16亚芳基; 并且X2相对于T环戊二烯基键在邻位结合。 这些化合物是选自元素周期表的转变基团（I）和（VIII）的金属络合物的配体，这些金属络合物是用于将氢，硼氢化物或硅烷不对称加成到碳 - 碳上的有价值的催化剂 前手性有机化合物中的碳 - 杂原子多重键或碳亲核试剂或胺不对称加成到烯丙基化合物上。

公开(公告)号：US5563309A

公开(公告)日：1996-10-08

申请号：US459435

申请日：1995-06-02

申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B35/02 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C45/41 ,  C07C45/64 ,  C07C49/245 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C217/08 ,  C07C231/18 ,  C07C235/16 ,  C07F17/02 ,  C07F19/00 ,  C07C5/02 ,  C07F17/00

CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  C07C209/52 ,  C07C231/18 ,  C07C67/303 ,  C07C67/31 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  Y10S526/943

摘要： Compounds of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl which is substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy groups; R.sub.2 and R.sub.3 are identical and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy,--SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M,--CO.sub.2 M,--PO.sub.3 M,--NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or R.sub.1 and R.sub.3 are different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy,--SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M,--CO.sub.2 M,--PO.sub.3 M.sub.2, --NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or the group --PR.sub.2 R.sub.3 is a radical of formula II ##STR2## and R.sub.4, R.sub.5 and R.sub.6 are each independently of one another C.sub.1 -C.sub.12 alkyl or phenyl, R.sub.7 and R.sub.8 are H, C.sub.1 -C.sub.12 alkyl, phenyl or R.sub.7 and R.sub.8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R.sub.9 is H or C.sub.1 -C.sub.4 alkyl, M is H or an alkali metal, X.sup..crclbar. is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereoisomers or mixtures of diastereoisomers. Rhodium and iridium complexes with these ligands are suitable for use as homogeneous enantioselective catalysts for the hydrogenation of prochiral compounds containing carbon double bonds or carbon/hereto atom double bonds.

摘要翻译： 式I的化合物其中R 1是C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷氧基取代的苯基; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C 1-4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或R 1和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基，苯基或被一至三个相同或不同的成员取代的苯基， C 1 -C 4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M 2，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或基团-PR 2 R 3是式II的基团（II），且R 4，R 5和R 6彼此独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 12烷基，苯基或R 7和R 8 一起是四亚甲基，五亚甲基或3-氧杂-1,5-亚戊基，R9是H或C1-C4烷基，M是H或碱金属，X（ - ）是一元酸的阴离子，*是 其外消旋体和非对映异构体形式的立体碳原子或非对映异构体的混合物。 与这些配位体的铑和铱络合物适合用作含碳双键或碳/原子双键的前手性化合物氢化的均匀对映选择性催化剂。

公开(公告)号：US5463097A

公开(公告)日：1995-10-31

申请号：US292150

申请日：1994-08-17

申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B35/02 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C45/41 ,  C07C45/64 ,  C07C49/245 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C217/08 ,  C07C231/18 ,  C07C235/16 ,  C07F17/02 ,  C07F19/00 ,  C07F15/00

CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  C07C209/52 ,  C07C231/18 ,  C07C67/303 ,  C07C67/31 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  Y10S526/943

摘要： A complex of the formula V or VI,[X.sub.1 M.sub.1 YZ]X.sub.1 M.sub.1 Y].sup..sym. A.sub.1.sup..crclbar.wherein X.sub.1 is two C.sub.2 -C.sub.12 olefins or one C.sub.5 -C.sub.12 diene, Z is Cl, Br or I, A.sub.1.sup..crclbar. is the anion of an oxyacid or complex acid, M.sub.1 is Rh or Ir, and Y is a compound of the formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl which is substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy groups; R.sub.2 and R.sub.3 are identical and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M, --NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or R.sub.2 and R.sub.3 are different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M.sub.2, --NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or the group --PR.sub.2 R.sub.3 is a radical of formula II ##STR2## and R.sub.4, R.sub.5 and R.sub.6 are each independently of one another C.sub.1 -C.sub.12 alkyl or phenyl, R.sub.7 and R.sub.8 are H, C.sub.1 -C.sub.12 alkyl, phenyl or R.sub.7 and R.sub.8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R.sub.9 is H or C.sub.1 -C.sub.4 alkyl, M is H or an alkali metal, X.sup..crclbar. is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereoisomers or mixtures of diastereoisomers.

摘要翻译： 式Ⅴ或Ⅵ的络合物[X1M1YZ] X1M1Y]（+）A1（ - ）其中X1是两个C2-C12烯烃或一个C5-C12二烯，Z是Cl，Br或I，A1（ - ）是 含氧酸或络合酸，M1为Rh或Ir，Y为式Ⅰ化合物其中R 1为C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷基取代的苯基， C4烷氧基; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C 1-4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或R 2和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基，被一至三个相同或不同的成员所取代的苯基或苯基，所述相同或不同的成员选自 C 1 -C 4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M 2，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或基团-PR 2 R 3是式II的基团（II），且R 4，R 5和R 6彼此独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 12烷基，苯基或R 7和R 8 一起是四亚甲基，五亚甲基或3-氧杂-1,5-亚戊基，R9是H或C1-C4烷基，M是H或碱金属，X（ - ）是一元酸的阴离子，*是 其外消旋体和非对映异构体形式的立体碳原子或非对映异构体的混合物。

公开(公告)号：US5371256A

公开(公告)日：1994-12-06

申请号：US037783

申请日：1993-03-26

申请人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

发明人： Antonio Togni ,  Felix Spindler ,  Nadia Zanetti ,  Amina Tijani

IPC分类号： B01J31/22 ,  B01J31/24 ,  C07B35/02 ,  C07B41/02 ,  C07B43/04 ,  C07B53/00 ,  C07B61/00 ,  C07C45/41 ,  C07C45/64 ,  C07C49/245 ,  C07C67/303 ,  C07C67/31 ,  C07C209/52 ,  C07C217/08 ,  C07C231/18 ,  C07C235/16 ,  C07F17/02 ,  C07F19/00

CPC分类号： C07F17/02 ,  B01J31/2291 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2471 ,  C07C209/52 ,  C07C231/18 ,  C07C67/303 ,  C07C67/31 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0286 ,  B01J2531/822 ,  B01J2531/827 ,  B01J2531/842 ,  Y10S526/943

摘要： Compounds of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, phenyl or phenyl which is substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy groups; R.sub.2 and R.sub.3 are identical and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl or C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M,--NR.sub.7 R.sub.8 and --[.sup..sym. NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or R.sub.2 and R.sub.3 are different and are C.sub.1 -C.sub.12 alkyl, C.sub.5 -C.sub.12 cycloalkyl, C.sub.1 -C.sub.4 alkyl- or C.sub.1 -C.sub.4 alkoxy-substituted C.sub.5 -C.sub.12 cycloalkyl, phenyl or phenyl which is substituted by one to three identical or different members selected from the group consisting of C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, --SiR.sub.4 R.sub.5 R.sub.6, halogen, --SO.sub.3 M, --CO.sub.2 M, --PO.sub.3 M.sub.2, --NR.sub.7 R.sub.8 and --[.sup..sym.NR.sub.7 R.sub.8 R.sub.9 ]X.sup..crclbar. ; or the group --PR.sub.2 R.sub.3 is a radical of formula II ##STR2## and R.sub.4, R.sub.5 and R.sub.6 are each independently of one another C.sub.1 -C.sub.12 alkyl or phenyl, R.sub.7 and R.sub.8 are H, C.sub.1 -C.sub.2 alkyl, phenyl or R.sub.7 and R.sub.8, taken together, are tetramethylene, pentamethylene or 3-oxa-1,5-pentylene, R.sub.9 is H or C.sub.1 -C.sub.4 alkyl, M is H or an alkali metal, X.sup..crclbar. is the anion of a monobasic acid, and * is a stereogenic carbon atom, in the form of their racemates and diastereoisomers or mixtures of diastereoisomers. Rhodium and iridium complexes with these ligands are suitable for use as homogeneous enantioselective catalysts for the hydrogenation of prochiral compounds containing carbon double bonds or carbon/hetero atom double bonds.

摘要翻译： 式I的化合物其中R 1是C 1 -C 8烷基，苯基或被1至3个C 1 -C 4烷基或C 1 -C 4烷氧基取代的苯基; R 2和R 3相同，为C 1 -C 12烷基，C 5 -C 12环烷基或C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基或被一至三个相同或不同的选自C1- C 1-4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或R 2和R 3不同，为C 1 -C 12烷基，C 5 -C 12环烷基，C 1 -C 4烷基 - 或C 1 -C 4烷氧基取代的C 5 -C 12环烷基，被一至三个相同或不同的成员所取代的苯基或苯基，所述相同或不同的成员选自 C 1 -C 4烷基，C 1 -C 4烷氧基，-SiR 4 R 5 R 6，卤素，-SO 3 M，-CO 2 M，-PO 3 M 2，-NR 7 R 8和 - [（+）NR 7 R 8 R 9] X（ - ）。 或基团-PR 2 R 3是式II的基团（II），且R 4，R 5和R 6彼此独立地为C 1 -C 12烷基或苯基，R 7和R 8为H，C 1 -C 2烷基，苯基或R 7和R 8 一起是四亚甲基，五亚甲基或3-氧杂-1,5-亚戊基，R9是H或C1-C4烷基，M是H或碱金属，X（ - ）是一元酸的阴离子，*是 其外消旋体和非对映异构体形式的立体碳原子或非对映异构体的混合物。 与这些配体的铑和铱配合物适合用作含碳双键或碳/杂原子双键的前手性化合物氢化的均匀对映选择性催化剂。

公开(公告)号：US5308819A

公开(公告)日：1994-05-03

申请号：US91802

申请日：1993-07-14

申请人： Benoit Pugin ,  Felix Spindler ,  Manfred Muller

发明人： Benoit Pugin ,  Felix Spindler ,  Manfred Muller

IPC分类号： B01J21/08 ,  B01J31/02 ,  B01J31/16 ,  B01J31/22 ,  B01J31/24 ,  B01J31/40 ,  C07B53/00 ,  C07B61/00 ,  C07C213/02 ,  C07C217/08 ,  C07F9/655 ,  C07F15/00 ,  C07F9/28

CPC分类号： C07F15/008 ,  B01J31/0274 ,  B01J31/1633 ,  B01J31/2291 ,  B01J31/2409 ,  B01J31/4023 ,  B01J31/4046 ,  B01J31/4053 ,  B01J31/4092 ,  C07F15/004 ,  C07F9/65515 ,  B01J21/08 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/827 ,  Y02P20/584 ,  Y02P20/588

摘要： Compounds where a solid carrier material which contains diphosphine rhodium or iridium complexes fixed on the surface thereof, of which the carrier material has the formula IV or IVa: ##STR1## wherein Y denotes two monoolefin ligands or a diene ligand, M is Ir(I) or Rh(i), Z is --Cl, --Br or -I, A.crclbar. is the anion of an oxyacid or complex acid, T is a solid carrier material, r is 0, 1 or 2, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined in claim 1. These materials are heterogeneous and separable catalysts for the asymmetrical hydrogenation of prochiral compounds containing carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.

摘要翻译： 在其表面上固定有二膦铑或铱络合物的固体载体材料的化合物，其载体材料在配体或二烯配体中具有式IV或IVa：Ⅳ（Ⅳ），M是Ir（I） 或Rh（i），Z是-Cl，-Br或-I，A（ - ）是含氧酸或络合酸的阴离子，T是固体载体材料，r是0,1或2，R1，R2 R3，R4和R5如权利要求1中所定义。这些材料是用于不对称氢化含有碳双键或碳/杂原子双键的前手性化合物的非均相和可分离的催化剂，例如酮和亚胺。

公开(公告)号：US5306853A

公开(公告)日：1994-04-26

申请号：US78696

申请日：1993-06-17

申请人： Benoit Pugin ,  Manfred Muller ,  Felix Spindler

发明人： Benoit Pugin ,  Manfred Muller ,  Felix Spindler

IPC分类号： B01J31/02 ,  B01J31/16 ,  B01J31/22 ,  B01J31/24 ,  C07C29/145 ,  C07F9/572 ,  C07F15/00 ,  C07C5/10

CPC分类号： C07F15/008 ,  B01J31/1633 ,  B01J31/2291 ,  B01J31/2409 ,  C07F15/004 ,  C07F9/5722 ,  C07F9/5726 ,  B01J2231/643 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/827 ,  Y02P20/588

摘要： Compounds of formula II ##STR1## wherein the groups (R.sub.1).sub.2 P(CH.sub.2).sub.m bzw.n are in o- or m-position to each other and the substituents R.sub.1 are identical or different radicals, m and n are each independently of the other 0 or 1, R.sub.1 is linear or branched C.sub.1 -C.sub.12 alkyl, unsubstituted C.sub.5 -C.sub.6 cycloalkyl or C.sub.5 -C.sub.6 cycloalkyl which is substituted by C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, or is phenyl or benzyl, or both substituents R.sub.1 in a group (R.sub.1).sub.2 P together are o,o'-diphenylene, --R.sub.2 --X-- is a bond or --(C.sub.x H.sub.2x --O).sub.y --, or X-- is O-- and R.sub.2 is C.sub.1 -C.sub.6 alkylene, x is an integer from 2 to 6 and y is an integer from 2 to 6, R.sub.3 is C.sub.2 -C.sub.18 alkylene, phenylene or benzylene, and R.sub.4 is C.sub.1 -C.sub.6 alkyl or phenyl, can be applied to solid carriers, such as silica gel or aerosils, and complexed with rhodium or iridium compounds. These materials are heterogeneous and separable catalysts for the asymmetrical hydrogenation of prochiral compounds containing carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.

摘要翻译： 式（II）化合物其中基团（R 1）2 P（CH 2）m bzw.n彼此是邻位或间位，取代基R 1是相同或不同的基团，m和n各自为 独立于另一个0或1，R 1是被C 1 -C 4烷基或C 1 -C 4烷氧基取代的直链或支链C 1 -C 12烷基，未被取代的C 5 -C 6环烷基或C 5 -C 6环烷基，或者是苯基或苄基，或两个基团中的两个取代基R 1 （R1）2P一起为o，邻二亚苯基，-R2-X-为键或 - （CxH2x-O）y-或X-为O-，R2为C1-C6亚烷基，x为2的整数 至6，y为2至6的整数，R 3为C 2 -C 18亚烷基，亚苯基或亚苯基，且R 4为C 1 -C 6烷基或苯基，可用于固体载体如硅胶或气溶胶，并与铑或 铱化合物。 这些材料是用于不对称氢化含有双键或碳/杂原子双键的前手性化合物的非均相和可分离的催化剂，例如酮和亚胺。