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公开(公告)号：US20140371446A1
公开(公告)日：2014-12-18
申请号：US14467625
申请日：2014-08-25
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: C07F9/6571 , C07F9/6584 , C07C41/09 , C07C315/04 , C07C273/18 , C07C1/30 , C07D209/34 , C07F5/02 , C07C15/14 , C07D295/033 , C07C319/18 , C07F9/40 , C07F9/6568 , C07C201/10
CPC classification number: C07F9/657163 , B01J31/189 , B01J31/2423 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/344 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/30 , C07C1/321 , C07C15/14 , C07C17/093 , C07C17/361 , C07C41/09 , C07C45/68 , C07C201/10 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/40 , C07C315/04 , C07C319/14 , C07C319/18 , C07C2523/42 , C07C2523/44 , C07C2523/46 , C07C2523/52 , C07C2523/72 , C07C2523/75 , C07C2523/755 , C07C2527/14 , C07C2531/22 , C07C2531/24 , C07D209/34 , C07D239/54 , C07D295/033 , C07F5/027 , C07F9/40 , C07F9/65031 , C07F9/65515 , C07F9/6552 , C07F9/65683 , C07F9/6571 , C07F9/6584 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784 , C07C25/18
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
Abstract translation: 本公开涉及：（a）磷酸基配体; （b）在成键反应中使用这种磷酸基配体的方法; 和（c）制备磷酸基配体的方法。
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公开(公告)号：US20130217876A1
公开(公告)日：2013-08-22
申请号：US13591117
申请日：2012-08-21
Applicant: Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: B01J31/24 , C07D209/12 , C07D213/76 , C07D265/30 , C07C253/30 , C07C201/10 , C07D209/34 , C07C303/40 , C07D239/54
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
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3.发明授权Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands 失效通过与刚性手性配体的过渡金属配合物催化不对称合成公开(公告)号：US06380416B2
公开(公告)日：2002-04-30
申请号：US09878417
申请日：2001-06-12
Applicant: Xumu Zhang
Inventor： Xumu Zhang
IPC: C07F906
CPC classification number: C07B53/00 , B01J31/0244 , B01J31/185 , B01J31/1875 , B01J31/2414 , B01J31/2457 , B01J31/2466 , B01J31/2476 , B01J31/248 , B01J31/2485 , B01J31/249 , B01J31/26 , B01J2231/32 , B01J2231/643 , B01J2231/645 , B01J2531/0205 , B01J2531/80 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , C07B2200/07 , C07C29/145 , C07C41/26 , C07C45/505 , C07C231/18 , C07F9/46 , C07F9/5027 , C07F9/572 , C07F9/59 , C07F9/6561 , C07F9/65683 , C07F9/65746 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/045 , C07C33/22 , C07C33/20 , C07C43/23 , C07C33/18 , C07C31/125 , C07C31/12 , C07C31/1355
Abstract: This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.
Abstract translation: 本发明是开发用于实际合成重要手性分子的新型过渡金属催化剂。 本发明强调了基于具有环状环结构的手性二齿膦配体的不对称催化作用，其可用于限制配体的构象柔性，从而可以通过配体刚性增强手性转移的效率。
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公开(公告)号：US20010047113A1
公开(公告)日：2001-11-29
申请号：US09878417
申请日：2001-06-12
Applicant: The Penn State Research Foundation
Inventor： Xumu Zhang
IPC: C07F009/28
CPC classification number: C07B53/00 , B01J31/0244 , B01J31/185 , B01J31/1875 , B01J31/2414 , B01J31/2457 , B01J31/2466 , B01J31/2476 , B01J31/248 , B01J31/2485 , B01J31/249 , B01J31/26 , B01J2231/32 , B01J2231/643 , B01J2231/645 , B01J2531/0205 , B01J2531/80 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , C07B2200/07 , C07C29/145 , C07C41/26 , C07C45/505 , C07C231/18 , C07F9/46 , C07F9/5027 , C07F9/572 , C07F9/59 , C07F9/6561 , C07F9/65683 , C07F9/65746 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/045 , C07C33/22 , C07C33/20 , C07C43/23 , C07C33/18 , C07C31/125 , C07C31/12 , C07C31/1355
Abstract: This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.
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公开(公告)号：US20150360215A1
公开(公告)日：2015-12-17
申请号：US14834420
申请日：2015-08-24
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: B01J31/24 , C07D209/42 , C07F9/50 , C07D239/54 , C07F1/02 , C07F9/40 , C07C303/40 , C07D213/76
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
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Patent Agency Ranking
公开(公告)号：US08975443B2
公开(公告)日：2015-03-10
申请号：US13591117
申请日：2012-08-21
Applicant: Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: C07F9/6568 , C07F9/655 , C07D213/76 , C07C201/10 , B01J31/24 , C07C303/40 , C07D209/34 , C07D239/54 , C07D209/12 , C07D265/30 , C07C253/30
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
Abstract translation: 本公开涉及：（a）磷酸基配体; （b）包含磷酸基配体的催化剂组合物; 和（c）在结合形成反应中使用这种磷酸基配体和催化剂组合物的方法。
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7.发明申请公开(公告)号：US20130123516A1
公开(公告)日：2013-05-16
申请号：US13518040
申请日：2010-02-17
Applicant: Petrus Van Leeuwen , Mathieu Tschan , Zoraida Freixa , Henk Hagen
Inventor： Petrus Van Leeuwen , Mathieu Tschan , Zoraida Freixa , Henk Hagen
CPC classification number: C07F19/005 , B01J31/2452 , B01J31/249 , B01J2231/20 , B01J2531/824 , C07C1/20 , C07C1/22 , C07C41/06 , C07C41/20 , C07C11/02 , C07C43/15 , C07C43/04
Abstract: A phosphine-based catalyst composition suitable for the telomerization of butadiene to produce 1-octene includes palladium and one of a class of novel phosphine ligands characterized by two potentially functionalized phenyl rings and a third phenyl group having an alkoxy functionality on one of the ortho-positions, which is part of a 5- or 6-membered ring between this ortho position and the adjacent meta position, this ring not being part of a second aryl group. The catalysts including this class of phosphine ligands may exhibit higher catalytic activity and selectivity, and may be used at lower temperatures, than many other phosphine ligand catalysts, reducing costs. Palladium precipitation may also be reduced.
Abstract translation: 适用于丁二烯调聚以生产1-辛烯的膦基催化剂组合物包括钯和一类新型膦配体之一，其特征在于两个潜在官能化的苯环和在其中一个邻位上具有烷氧基官能团的第三苯基， 位置，其是该邻位和相邻间位之间的5-或6-元环的一部分，该环不是第二芳基的一部分。 包括这类膦配体的催化剂可以表现出更高的催化活性和选择性，并且可以在比许多其它膦配体催化剂更低的温度下使用，降低成本。 钯沉淀也可能降低。
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8.发明申请公开(公告)号：US20030232991A1
公开(公告)日：2003-12-18
申请号：US10410711
申请日：2003-04-10
Applicant: The Penn State Research Foundation
Inventor： Xumu Zhang
IPC: C07F009/547 , C07F009/02 , C07F009/28
CPC classification number: B01J31/2409 , B01J31/1625 , B01J31/1658 , B01J31/24 , B01J31/2414 , B01J31/2457 , B01J31/249 , B01J2231/643 , B01J2231/645 , B01J2531/80 , B01J2531/822 , C07B53/00 , C07C231/18 , C07F9/5027 , C07F9/5537 , C07F9/572 , C07F9/6506 , C07F9/65515 , C07F9/6552 , C07F9/65522 , C07F9/6561 , C07F9/6596 , C07C233/05 , C07C233/13 , C07C233/18
Abstract: Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include (R,S,S,R)-DIOP*. The ruthenium complex reduces enamide to the corresponding amine with up to 99% enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation, hydride transfer, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, hydrocarboxylation, isomerization, allylic alkylation, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition and epoxidation reactions.
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9.发明申请公开(公告)号：US20170334831A1
公开(公告)日：2017-11-23
申请号：US15526763
申请日：2015-08-08
Applicant: Zhejiang Jiuzhou Pharmaceutical Co., Ltd
Inventor： Qilin ZHOU , Jianhua XIE , Xiaohui YANG , Lixin WANG
IPC: C07C69/675 , B01J31/18 , C07D305/06 , C07D211/12 , C07D211/02 , C07B53/00 , C07C31/20 , C07C29/149 , C07D309/06 , B01J31/24 , C07B57/00 , C07D473/06 , C07C67/48
CPC classification number: C07C69/675 , B01J31/181 , B01J31/189 , B01J31/24 , B01J31/249 , B01J2231/646 , B01J2531/827 , C07B53/00 , C07B57/00 , C07B2200/07 , C07C29/149 , C07C31/20 , C07C33/26 , C07C67/48 , C07C69/708 , C07C69/732 , C07D211/02 , C07D211/12 , C07D305/06 , C07D309/06 , C07D309/30 , C07D473/06
Abstract: The present invention relates to kinetic resolution of racemic δ-hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, racemic δ-hydroxyl esters were subjected to asymmetric catalytic hydrogenation to obtain extent optical purity chiral δ-hydroxyl esters and corresponding 1,5-diols. The method is a new, efficient, highly selective, economical, desirably operable and environmentally friendly method suitable for industrial production. An optically active chiral δ-hydroxyl ester and 1,5-diols can be obtained at very high enantioselectivity and yield with relatively low usage of catalyst. The chiral δ-hydroxyl ester and 1,5-diols obtained by using the method can be used as a critical raw material for asymmetric synthesis of chiral drugs (R)-lisofylline and natural drugs (+)-civet, (−)-indolizidine 167B and (−)-coniine.
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公开(公告)号：US09381508B2
公开(公告)日：2016-07-05
申请号：US14834420
申请日：2015-08-24
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: B01J31/18 , B01J31/24 , C07C1/30 , C07C1/32 , C07C17/093 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/18 , C07C303/36 , C07C303/40 , C07C319/14 , C07C41/01 , C07C45/68 , C07C45/71 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/02 , C07F9/40 , C07F9/50 , C07F9/6568
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
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