公开(公告)号：US20080311087A1

公开(公告)日：2008-12-18

申请号：US12133792

申请日：2008-06-05

申请人： Anna Gosiewska ,  Agnieszka Seyda ,  Charito S. Buensuceso

发明人： Anna Gosiewska ,  Agnieszka Seyda ,  Charito S. Buensuceso

IPC分类号： A61K35/44 ,  A61P13/00

CPC分类号： A61K35/44 ,  A61K9/0019 ,  A61K47/34

摘要： Compositions for the treatment of incontinence are disclosed. More particularly, compositions of human umbilical tissue-derived cells and a carrier are disclosed. The compositions are useful in the treatment urinary and fecal incontinence.

摘要翻译： 公开了治疗失禁的组合物。 更具体地，公开了人脐带组织衍生细胞和载体的组合物。 该组合物可用于治疗尿失禁和大便失禁。

公开(公告)号：US07413734B2

公开(公告)日：2008-08-19

申请号：US10877541

申请日：2004-06-25

申请人： Sanjay Mistry ,  Darin J. Messina ,  Ian Ross Harris ,  Alexander M. Harmon ,  Agnieszka Seyda ,  Chin-Feng Yi ,  Anna Gosiewska

发明人： Sanjay Mistry ,  Darin J. Messina ,  Ian Ross Harris ,  Alexander M. Harmon ,  Agnieszka Seyda ,  Chin-Feng Yi ,  Anna Gosiewska

IPC分类号： A01N63/00 ,  C12N5/08

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.

摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞再生或修复眼组织的药物组合物，装置和方法。

公开(公告)号：US20060154367A1

公开(公告)日：2006-07-13

申请号：US11322003

申请日：2005-12-29

申请人： Anthony Kihm ,  Agnieszka Seyda ,  Sridevi Dhanaraj ,  Ziwei Wang ,  Alexander Harmon ,  Ian Harris ,  Darin Messina ,  Sanjay Mistry ,  Anna Gosiewska

发明人： Anthony Kihm ,  Agnieszka Seyda ,  Sridevi Dhanaraj ,  Ziwei Wang ,  Alexander Harmon ,  Ian Harris ,  Darin Messina ,  Sanjay Mistry ,  Anna Gosiewska

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

公开(公告)号：US20060153817A1

公开(公告)日：2006-07-13

申请号：US11321863

申请日：2005-12-29

申请人： Anthony Kihm ,  Agnieszka Seyda ,  Alexander Harmon ,  Ian Harris ,  Darin Messina ,  Sanjay Mistry ,  Anna Gosiewska ,  Chin-Feng Yi

发明人： Anthony Kihm ,  Agnieszka Seyda ,  Alexander Harmon ,  Ian Harris ,  Darin Messina ,  Sanjay Mistry ,  Anna Gosiewska ,  Chin-Feng Yi

IPC分类号： A61K35/12 ,  C12N5/08

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

公开(公告)号：US20050187162A1

公开(公告)日：2005-08-25

申请号：US10674516

申请日：2003-09-30

申请人： Sridevi Dhanaraj ,  Anna Gosiewska ,  Ali Rezania ,  George Heavner ,  Xuanhan Lin ,  Chin-Feng Yi

发明人： Sridevi Dhanaraj ,  Anna Gosiewska ,  Ali Rezania ,  George Heavner ,  Xuanhan Lin ,  Chin-Feng Yi

IPC分类号： A61K20060101 ,  A61K38/02 ,  A61K38/08 ,  C07H21/04 ,  C07K2/00 ,  C07K7/06

CPC分类号： A61K38/08 ,  A61K31/375 ,  A61K31/573 ,  A61K31/661 ,  A61K35/32 ,  A61K38/18 ,  A61K45/06 ,  A61L27/227 ,  A61K2300/00

摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.

摘要翻译： 本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。 促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折 。 已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。

公开(公告)号：US20050032209A1

公开(公告)日：2005-02-10

申请号：US10877269

申请日：2004-06-25

申请人： Darin Messina ,  Sanjay Mistry ,  Alexander Harmon ,  Ian Harris ,  Anthony Kihm ,  Agnieszka Seyda ,  Chin-Feng Yi ,  Anna Gosiewska

发明人： Darin Messina ,  Sanjay Mistry ,  Alexander Harmon ,  Ian Harris ,  Anthony Kihm ,  Agnieszka Seyda ,  Chin-Feng Yi ,  Anna Gosiewska

IPC分类号： C12N5/073 ,  C12N5/074 ,  C12N5/08 ,  C12N15/85

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.

摘要翻译： 公开了产自产后脐带和胎盘的细胞。 还公开了使用产后来源细胞进行神经组织再生或修复的药物组合物，装置和方法。

公开(公告)号：US06783953B1

公开(公告)日：2004-08-31

申请号：US09468647

申请日：1999-12-21

申请人： Robert D. Gordon ,  Jörg J. Sprengel ,  Jeffrey R. Yon ,  Josiena J. H. Dijkmans ,  Anna Gosiewska ,  Sridevi N. Dhanaraj ,  Jean Xu

发明人： Robert D. Gordon ,  Jörg J. Sprengel ,  Jeffrey R. Yon ,  Josiena J. H. Dijkmans ,  Anna Gosiewska ,  Sridevi N. Dhanaraj ,  Jean Xu

IPC分类号： C12P2106

CPC分类号： C07K14/52 ,  A01K2217/05 ,  A61K38/00 ,  C07K2319/00

摘要： There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.

摘要翻译： 除了编码它的核酸分子，用所述载体转化的宿主细胞和抑制或增强血管发生的化合物之外，还提供了新颖的血管内皮生长因子，其被称为VEGF-X。 还提供了存在于VEGF-X序列中的CUB结构域本身防止血管生成并用于治疗与不适当血管形成或血管发生相关的疾病的序列。

公开(公告)号：US09504719B2

公开(公告)日：2016-11-29

申请号：US11316104

申请日：2005-12-22

申请人： Laura Brown ,  Alexander M. Harmon ,  Anna Gosiewska

发明人： Laura Brown ,  Alexander M. Harmon ,  Anna Gosiewska

IPC分类号： C12N5/073 ,  A61K35/50 ,  A61K35/51 ,  C12N5/074 ,  A61K45/06 ,  A61K35/12

CPC分类号： A61K35/51 ,  A01N1/0226 ,  A61K35/12 ,  A61K35/50 ,  A61K38/18 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1891 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/27 ,  A61K45/06 ,  C12N5/0605 ,  C12N5/0606 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2509/10 ,  C12N2533/50

摘要： Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.

公开(公告)号：US08361459B2

公开(公告)日：2013-01-29

申请号：US12697081

申请日：2010-01-29

申请人： Darin J. Messina ,  Sanjay K. Mistry ,  L. S. Klaudyne Hong ,  Brian C. Kramer ,  Michael J. Romanko ,  Anna Gosiewska

发明人： Darin J. Messina ,  Sanjay K. Mistry ,  L. S. Klaudyne Hong ,  Brian C. Kramer ,  Michael J. Romanko ,  Anna Gosiewska

IPC分类号： C12N5/00 ,  C12N5/071 ,  C12N5/074 ,  C12N5/077

CPC分类号： A61K35/30 ,  A61K35/12 ,  A61K35/48 ,  C12N5/0605 ,  C12N5/0607 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/44 ,  C12N2500/90 ,  C12N2500/95 ,  C12N2501/12 ,  C12N2501/21 ,  C12N2501/23 ,  C12N2502/02 ,  C12N2506/02 ,  C12N2506/03 ,  C12N2509/00 ,  C12N2533/50 ,  A61K2300/00

摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.

摘要翻译： 公开了衍生自产后组织如脐带和胎盘的细胞，以及用于再生，修复和改善神经组织以及改善中风患者的行为和神经功能的方法。

公开(公告)号：US07482320B2

公开(公告)日：2009-01-27

申请号：US10471221

申请日：2002-03-07

申请人： Jeffrey C. Geesin ,  Anna Gosiewska ,  Jean Xu ,  Robert Gordon ,  Jeff Yon ,  Sridevi Naidu Dhanaraj ,  Ian Harris

发明人： Jeffrey C. Geesin ,  Anna Gosiewska ,  Jean Xu ,  Robert Gordon ,  Jeff Yon ,  Sridevi Naidu Dhanaraj ,  Ian Harris

IPC分类号： A61K38/18 ,  C07K14/475

CPC分类号： G01N33/5061 ,  A61K38/1866 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/5088 ,  G01N33/5091 ,  G01N33/6863 ,  G01N33/6893

摘要： There is provided a novel use for vascular endothelial growth factor, herein designated VEGF-X, and a CUB domain present in the sequence of VEGF-X, which enhance smooth muscle cell proliferation and can be used to treat diseases associated with reduced smooth muscle cell proliferation. VEGF-X, and a CUB domain can also be used in tissue engineering applications to increase the number of smooth muscle cells within specific tissue to restore that tissue function or architecture. Screening methods for identifying inhibitors of VEGF-X biological activity are also disclosed and these inhibitors include neutralizing VEGF-X antibodies, antisense VEGF-X sequences or non-protein antagonists competing with VEGF-X biological activity. Also provided are therapeutic methods for treating disorders associated with smooth muscle cells hyperproliferation and methods of diagnosis a pathological condition or susceptibility to a pathological condition associated with smooth muscle cell hyperproliferation.

摘要翻译： 提供了VEGF-X序列中存在的血管内皮生长因子（称为VEGF-X）和CUB结构域的新型用途，其增强平滑肌细胞增殖并可用于治疗与减少的平滑肌细胞相关的疾病 增殖。 VEGF-X和CUB结构域也可用于组织工程应用中，以增加特定组织内的平滑肌细胞的数量以恢复组织功能或结构。 还公开了用于鉴定VEGF-X生物活性抑制剂的筛选方法，并且这些抑制剂包括与VEGF-X生物活性竞争的中和VEGF-X抗体，反义VEGF-X序列或非蛋白质拮抗剂。 还提供了用于治疗与平滑肌细胞过度增生相关的疾病的治疗方法以及诊断与平滑肌细胞过度增殖相关的病理状况的病理状况或易感性的方法。