公开(公告)号：US20050164366A1

公开(公告)日：2005-07-28

申请号：US11035988

申请日：2005-01-18

申请人： Paul Moore ,  Steven Ruben ,  Reinhard Ebner

发明人： Paul Moore ,  Steven Ruben ,  Reinhard Ebner

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  C12N1/21 ,  C12N5/10 ,  C12N9/64 ,  C12N15/55 ,  C07H21/04 ,  C07K16/40

CPC分类号： C12N9/6421 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention relates to a novel t-PALP protein which is a member of the serine protease family. In particular, isolated nucleic acid molecules are provided encoding the human t-PALP protein. t-PALP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of t-PALP activity. Also provided are diagnostic methods for detecting circulatory system-related disorders and therapeutic methods for treating circulatory system-related disorders.

摘要翻译： 本发明涉及一种作为丝氨酸蛋白酶家族成员的新型t-PALP蛋白。 特别地，提供编码人t-PALP蛋白的分离的核酸分子。 还提供t-PALP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定t-PALP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测循环系统相关疾病的诊断方法和用于治疗循环系统相关疾病的治疗方法。

公开(公告)号：US20110003383A1

公开(公告)日：2011-01-06

申请号：US12268263

申请日：2008-11-10

申请人： Steven M. Ruben ,  George A. Komatsoulis ,  D. Roxanne Duan ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Reinhard Ebner ,  Henrik S. Olsen ,  Laurie A. Brewer ,  Kimberly A Florence ,  Paul E. Young ,  Michael Mucenski ,  Gregory A. Endress ,  Daniel R. Soppet

发明人： Steven M. Ruben ,  George A. Komatsoulis ,  D. Roxanne Duan ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Reinhard Ebner ,  Henrik S. Olsen ,  Laurie A. Brewer ,  Kimberly A Florence ,  Paul E. Young ,  Michael Mucenski ,  Gregory A. Endress ,  Daniel R. Soppet

IPC分类号： C12N5/07 ,  G01N33/53 ,  C12P21/06 ,  C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/30

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20090253626A1

公开(公告)日：2009-10-08

申请号：US12325800

申请日：2008-12-01

申请人： Paul A. Moore ,  Steven M. Ruben ,  David W. LaFleur ,  Yanggu Shi ,  Craig A. Rosen ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer

发明人： Paul A. Moore ,  Steven M. Ruben ,  David W. LaFleur ,  Yanggu Shi ,  Craig A. Rosen ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  G01N33/53 ,  C07K14/435 ,  C07K16/00 ,  C12P21/06

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US07381800B2

公开(公告)日：2008-06-03

申请号：US10874484

申请日：2004-06-24

申请人： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

发明人： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

IPC分类号： C12N5/10 ,  C12N5/12 ,  C12P21/08

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20090042792A1

公开(公告)日：2009-02-12

申请号：US11962255

申请日：2007-12-21

申请人： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

发明人： Yanggu Shi ,  Paul E. Young ,  Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

IPC分类号： A61K38/00 ,  C12N15/11 ,  C12N15/00 ,  C12N15/87 ,  C12N5/06 ,  C12Q1/02 ,  A61P31/00 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/00 ,  C07K16/18 ,  C12P21/04

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US07459531B2

公开(公告)日：2008-12-02

申请号：US11565909

申请日：2006-12-01

申请人： Paul A. Moore ,  Steven M. Ruben ,  David W. LaFleur ,  Yanggu Shi ,  Craig A. Rosen ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer

发明人： Paul A. Moore ,  Steven M. Ruben ,  David W. LaFleur ,  Yanggu Shi ,  Craig A. Rosen ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer

IPC分类号： C07K14/47

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US07169565B2

公开(公告)日：2007-01-30

申请号：US10960251

申请日：2004-10-08

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Reinhard Ebner ,  Yanggu Shi

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Reinhard Ebner ,  Yanggu Shi

IPC分类号： G01N33/53 ,  C12N5/12 ,  C12N1/20 ,  C12N5/06 ,  C12N5/16 ,  C12N5/22 ,  C07K16/00 ,  C07K16/18 ,  C12P21/08

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893

摘要： The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及87种新的人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20090247482A1

公开(公告)日：2009-10-01

申请号：US12275899

申请日：2008-11-21

申请人： Paul A. Moore ,  Steven M. Ruben ,  David W. LaFleur ,  Yanggu Shi ,  Craig A. Rosen ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer

发明人： Paul A. Moore ,  Steven M. Ruben ,  David W. LaFleur ,  Yanggu Shi ,  Craig A. Rosen ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer

IPC分类号： A61K31/7088 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12N15/87 ,  C12P21/04

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  G01N2800/042

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20080050379A1

公开(公告)日：2008-02-28

申请号：US11881252

申请日：2007-07-26

申请人： Paul Young ,  Meena Augustus ,  Kenneth Carter ,  Reinhard Ebner ,  Gregory Endress ,  Stephen Horrigan ,  Daniel Soppet ,  Zoe Weaver

发明人： Paul Young ,  Meena Augustus ,  Kenneth Carter ,  Reinhard Ebner ,  Gregory Endress ,  Stephen Horrigan ,  Daniel Soppet ,  Zoe Weaver

IPC分类号： A61K39/395 ,  A61K31/00 ,  A61P43/00 ,  C07K16/18 ,  C12Q1/68 ,  C40B30/06 ,  G01N33/566

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/57407

摘要： Processes for assaying potential antitumor agents based on their modulation of the expression of specified genes, or sets, of suspected cancer cell genes are disclosed, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, or sets of genes. Also disclosed are methods for determining functionally related genes, or gene sets, as well as methods for treating cancer based on targeting expression products of such genes, or gene sets, and determining genes involved in the cancerous process.

摘要翻译： 本发明公开了基于对可疑癌细胞基因的特定基因或组的表达调节的潜在抗肿瘤剂的方法，以及用于诊断由于表达的结果而导致的癌性或潜在癌性病症的方法 表达这些基因或一组基因。 还公开了用于确定功能相关基因或基因组的方法，以及基于这些基因或基因组的靶向表达产物以及确定参与癌症过程的基因来治疗癌症的方法。

公开(公告)号：US20050064454A1

公开(公告)日：2005-03-24

申请号：US10843641

申请日：2004-05-11

申请人： Paul Young ,  Meena Augustus ,  Kenneth Carter ,  Reinhard Ebner ,  Gregory Endress ,  Stephen Horrigan ,  Daniel Soppet ,  Zoe Weaver

发明人： Paul Young ,  Meena Augustus ,  Kenneth Carter ,  Reinhard Ebner ,  Gregory Endress ,  Stephen Horrigan ,  Daniel Soppet ,  Zoe Weaver

IPC分类号： C12Q1/68 ,  G01N33/50

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/57407

摘要： Processes for assaying potential antitumor agents based on their modulation of the expression of specified genes, or sets, of suspected cancer cell genes are disclosed, along with methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression, of such genes, or sets of genes. Also disclosed are methods for determining functionally related genes, or gene sets, as well as methods for treating cancer based on targeting expression products of such genes, or gene sets, and determining genes involved in the cancerous process.

摘要翻译： 本发明公开了基于对可疑癌细胞基因的特定基因或组的表达调节的潜在抗肿瘤剂的方法，以及用于诊断由于表达的结果而导致的癌性或潜在癌性病症的方法 表达这些基因或一组基因。 还公开了用于确定功能相关基因或基因组的方法，以及基于这些基因或基因组的靶向表达产物以及确定参与癌症过程的基因来治疗癌症的方法。