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72 条记录 (耗时 0.036 秒)

    2,3-Dihydro-7-chlorothiazolo[3,2-a]benzimidazole and salt
    54.
    发明授权
    2,3-Dihydro-7-chlorothiazolo[3,2-a]benzimidazole and salt 失效
    2,3-二氢-7-氯噻唑并[8 3,2-a {9苯并咪唑和盐

    公开(公告)号：US4017507A

    公开(公告)日：1977-04-12

    申请号：US637978

    申请日：1975-12-05

    申请人： Kalman Hideg ,  Olga Hankovszky ,  Eva Palosi ,  Gyorgy Hajos ,  Laszlo Szporny

    发明人： Kalman Hideg ,  Olga Hankovszky ,  Eva Palosi ,  Gyorgy Hajos ,  Laszlo Szporny

    IPC分类号： C07D513/04

    CPC分类号： C07D513/04

    摘要： New tricyclic fused imidazole derivatives of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##STR2## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a=C-- group, orA stands for a group of the general formula (III), ##STR3## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##STR4## wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##STR5## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(ch.sub.2).sub.m --X VI.in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen. The reaction is carried out optionally in the presence of a base. The compounds of the general formula (I) can be converted into their acid addition salts.The compounds of the general formula (I) as well as their acid addition salts exert antipyretic and antiphlogistic activities, inhibit the reproduction of viruses, and exert a protecting effect against albumine shock.

    摘要翻译： 通式（I）的新型三环稠合咪唑衍生物，其中R1代表氢或羟基，N等于零或一，M等于零，一或二，A代表一个基团 的通式（II），其中R 2表示氢或羟基，R 3表示氢或氨基，或Q和Z各自代表氮或a = C-基团，或A表示一个 通式（III），其中R 4和R 5各自代表氢，甲基，氯或硝基，通过反应通用化合物（IV）化合物（IV）制备其中A和n各自 具有与上述定义相同的含有通式（Ⅴ）的化合物，其中X代表卤素，R6代表氢，R7代表通式（Ⅵ）的基团， （CH2）mX VI。

    Tricyclic imidazole derivatives
    56.
    发明授权
    Tricyclic imidazole derivatives 失效
    三环咪唑衍生物

    公开(公告)号：US3932395A

    公开(公告)日：1976-01-13

    申请号：US473184

    申请日：1974-05-24

    申请人： Kalman Hideg ,  Olga Hankovszky ,  Eva Palosi ,  Gyorgy Hajos ,  Laszlo Szporny

    发明人： Kalman Hideg ,  Olga Hankovszky ,  Eva Palosi ,  Gyorgy Hajos ,  Laszlo Szporny

    IPC分类号： C07D513/16 ,  C07D513/04 ,  C07D513/14 ,  C07D279/08 ,  C07D279/14

    CPC分类号： C07D513/04 ,  C07D513/14 ,  Y10S514/916

    摘要： New tricyclic fused imidazole derivatives of the general formula (I), ##SPC1##whereinR.sub.1 stands for hydrogen or hydroxy,n is equal to zero or one,m is equal to zero, one or two,A stands for a group of the general formula (II), ##EQU1## wherein R.sub.2 represents hydrogen or hydroxy,R.sub.3 represents hydrogen or amino, orQ and Z each stand for nitrogen or a =C-- group, orA stands for a group of the general formula (III), ##EQU2## wherein R.sub.4 and R.sub.5 each represent hydrogen, methyl, chlorine or nitro,Were prepared by reacting a compound of the general formula (IV) ##SPC2##wherein A and n each have the same meanings as defined above, with a compound of the general formula (V), ##EQU3## wherein X stands for halogen, R.sub.6 stands for hydrogen and R.sub.7 stands for a group of the general formula (VI),--(CH.sub.2).sub.m --X (VI)in which m and X each have the same meanings as defined above, or R.sub.6 and R.sub.7 together stand for oxygen. The reaction is carried out optionally in the presence of a base. The compounds of the general formula (I) can be converted into their acid addition salts.The compounds of the general formula (I) as well as their acid addition salts exert antipyretic and antiphlogistic activities, inhibit the reproduction of viruses, and exert a protecting effect against albumine shock.

    摘要翻译： 新的通式（I）的三环稠合咪唑衍生物，其中R1代表氢或羟基，N等于零或一，M等于零，一或二，A代表通式（II ），-C = QC = Z- |（II）R2R3其中R2表示氢或羟基，R3表示氢或氨基，或Q和Z各自代表氮或a = C-基团，或A表示 通式（III）-CH = C-C = CH- |（III）R4R5其中R4和R5各自表示氢，甲基，氯或硝基，通过反应通用化合物（IV）的化合物制备， 其中A和n各自具有与上述相同的含义，与通式（V）的化合物，X-CH 2 -CH-CH 2 ||（V）R 6 R 7，其中X代表卤素，R6代表氢，R7 代表通式（VI）， - （CH 2）m X（VI）的基团，其中m和X各自具有与上述相同的含义，或者R6和R7一起代表氧。 任选地在碱的存在下进行反应。 通式（I）的化合物可以转化成它们的酸加成盐。