公开(公告)号：US20230374036A1

公开(公告)日：2023-11-23

申请号：US18303813

申请日：2023-04-20

Applicant: Gilead Sciences, Inc.

Inventor： Chaodi Dai ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Maoqun Tian ,  Vickie H. Tsui ,  William J. Watkins ,  Adam D. Zajdlik ,  Jennifer R. Zhang

IPC: C07D498/22 ,  C07D471/22 ,  C07F7/10

CPC classification number: C07D498/22 ,  C07D471/22 ,  C07F7/10

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US20230203061A1

公开(公告)日：2023-06-29

申请号：US18050650

申请日：2022-10-28

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18 ,  A61P31/18

CPC classification number: C07D498/18 ,  C07D471/18 ,  A61P31/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I):




including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20220218709A1

公开(公告)日：2022-07-14

申请号：US17540563

申请日：2021-12-02

Applicant: GILEAD SCIENCES, INC.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Richard L. Mackman ,  Samuel E. Metobo ,  Michael R. Mish ,  Hyung-Jung Pyun ,  Jeff Zablocki

IPC: A61K31/517 ,  C07D471/04 ,  C07D239/84 ,  C07D401/04

Abstract: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

公开(公告)号：US20210078991A1

公开(公告)日：2021-03-18

申请号：US16914034

申请日：2020-06-26

Applicant: Gilead Sciences, Inc.

Inventor： Zhenhong R. Cai ,  Hongyan Guo ,  Mingzhe Ji ,  Haolun Jin ,  Amy Lee ,  Ryan McFadden ,  Michael L. Mitchell ,  Manuel Munoz ,  Hyung-Jung Pyun ,  Lianhong Xu ,  Hong Yang

IPC: C07D417/14 ,  A61P31/18 ,  A61K31/428 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D417/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04

Abstract: Compounds disclosed herein including compounds of Formula I: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

公开(公告)号：US20210053988A1

公开(公告)日：2021-02-25

申请号：US16868119

申请日：2020-05-06

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: C07D498/14 ,  A61K31/537 ,  C07D471/22 ,  A61K31/529 ,  A61K31/551 ,  A61K31/498 ,  C07D471/18 ,  A61K45/06 ,  C07D498/18 ,  A61K31/4985 ,  C07D487/14 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20200317689A1

公开(公告)日：2020-10-08

申请号：US16825142

申请日：2020-03-20

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US10328053B2

公开(公告)日：2019-06-25

申请号：US15686499

申请日：2017-08-25

Applicant: Gilead Sciences, Inc.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  C07D487/04 ,  C07D519/00 ,  A61K31/38 ,  A61K31/4192

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20180161307A1

公开(公告)日：2018-06-14

申请号：US15686499

申请日：2017-08-25

Applicant: Gilead Sciences, Inc.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  A61K31/16 ,  A61K31/03 ,  A61K31/38 ,  A61K31/4192 ,  A61P31/20

CPC classification number: A61K31/403 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192 ,  A61P31/20 ,  C07D487/04 ,  C07D519/00

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20180153887A1

公开(公告)日：2018-06-07

申请号：US15618464

申请日：2017-06-09

Applicant: Gilead Sciences, Inc.

Inventor： Mingzhe Ji ,  Scott E. Lazerwith ,  Hyung-Jung Pyun

IPC: A61K31/4985 ,  A61K31/537 ,  A61K45/06

CPC classification number: A61K31/4985 ,  A61K31/537 ,  A61K31/553 ,  A61K45/06 ,  C07D471/14 ,  C07D471/18 ,  C07D498/14 ,  C07D498/18

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US09795602B2

公开(公告)日：2017-10-24

申请号：US15349353

申请日：2016-11-11

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Jeromy J. Cottell ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun

IPC: A61K31/4985 ,  C07D491/147 ,  A61K45/06

CPC classification number: A61K31/4985 ,  A61K45/06 ,  C07D471/04 ,  C07D491/147 ,  C07D491/20

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.