公开(公告)号：US20170258431A1

公开(公告)日：2017-09-14

申请号：US15451575

申请日：2017-03-07

申请人： Klaus Klingenbeck ,  Thomas Redel ,  Michael Scheuering ,  Michael Wiets

发明人： Klaus Klingenbeck ,  Thomas Redel ,  Michael Scheuering ,  Michael Wiets

IPC分类号： A61B6/00 ,  G06T7/00 ,  G06T7/11 ,  A61B6/03

CPC分类号： A61B6/507 ,  A61B5/02007 ,  A61B5/02028 ,  A61B6/03 ,  A61B6/481 ,  A61B6/504 ,  A61B6/5217 ,  A61B2034/105 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/10028 ,  G06T2207/10081 ,  G06T2207/30104 ,  G06T2211/404 ,  G16H50/50

摘要： The disclosure relates to a device and a method for ascertaining at least one individual fluid-dynamic characteristic parameter of a stenosis in a vascular segment having a plurality of serial stenoses, wherein angiography image data of the vascular segment is received from an angiography recording device, geometry data of the vascular segment is ascertained by an analysis device based on the angiography image data and combined into a segment model. At least one division point located between two of the stenoses respectively is ascertained by a dividing device in the segment model, the segment model is subdivided into subsegment models at each of the at least one division points, and the respective fluid-dynamic characteristic parameter is ascertained by a simulation device for at least one of the subsegment models based on respective geometry data of the subsegment model.

公开(公告)号：US20160012636A1

公开(公告)日：2016-01-14

申请号：US14789413

申请日：2015-07-01

申请人： Günter Lauritsch ,  Thomas Redel ,  Christopher Rohkohl ,  Michael Scheuering

发明人： Günter Lauritsch ,  Thomas Redel ,  Christopher Rohkohl ,  Michael Scheuering

IPC分类号： G06T17/10 ,  A61B6/03 ,  A61B6/00 ,  G06T11/60

CPC分类号： A61B6/504 ,  A61B6/032 ,  A61B6/4441 ,  A61B6/5205 ,  A61B6/5288 ,  A61B6/5294 ,  G06T11/60 ,  G06T17/00 ,  G06T2200/04 ,  G06T2210/41

摘要： A three-dimensional model dataset of a blood vessel system of a patient including at least one the vessel system is determined from a number of projection images, which have been recorded from different recording angles, of the blood vessel system The projection images are divided up into image areas each containing at least one pixel. A feature vector is determined for each of the image areas. Classification information, which describes how the respective image area belongs or does not belong to a vessel segment of the blood vessel system defined in accordance with anatomical specification data, is defined for each of the image areas by applying a classification function to the feature vector assigned to the image area. The classification function has been trained by training data records annotated with classification information obtained from at least one person other than the patient. The blood vessel system in the projection images is segmented by grouping image areas with the same classification information. The three-dimensional model dataset is calculated as a function of the segmented projection images and the classification information.

摘要翻译： 包括至少一个血管系统的患者的血管系统的三维模型数据集是从血管系统的不同记录角度记录的多个投影图像确定的。将投影图像分割 到每个包含至少一个像素的图像区域中。 为每个图像区域确定特征向量。 通过对分配的特征矢量应用分类函数，对每个图像区域分别描述各个图像区域属于或不属于根据解剖规范数据定义的血管系统的血管段的分类信息 到图像区域。 分类功能已经通过训练用从患者以外的至少一个人获得的分类信息注释的数据记录来训练。 投影图像中的血管系统通过对具有相同分类信息的图像区域进行分组。 三维模型数据集被计算为分段投影图像和分类信息的函数。

公开(公告)号：US20140058715A1

公开(公告)日：2014-02-27

申请号：US14070810

申请日：2013-11-04

申请人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

发明人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

IPC分类号： G06F19/00

CPC分类号： G16B5/00 ,  A61B5/02007 ,  A61B5/1128 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5217 ,  A61B2576/023 ,  G16H50/50

摘要： A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.

摘要翻译： 公开了冠状动脉狭窄非侵入性评估的方法和系统。 从休息状态下获得的患者的医学图像数据中提取冠状动脉的患者特异性解剖学测量。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 使用冠状动脉循环模型和患者特异性充血边界条件模拟冠状动脉至少一个狭窄区域的血流量和压力。 基于模拟的充血血流量和压力计算至少一个狭窄区域的分数流量储备（FFR）。

公开(公告)号：US20130246034A1

公开(公告)日：2013-09-19

申请号：US13794113

申请日：2013-03-11

申请人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

发明人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

IPC分类号： G06F19/12

CPC分类号： G16B5/00 ,  A61B5/02007 ,  A61B5/1128 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5217 ,  A61B2576/023 ,  G16H50/50

摘要： A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.

摘要翻译： 公开了冠状动脉狭窄非侵入性评估的方法和系统。 从休息状态下获得的患者的医学图像数据中提取冠状动脉的患者特异性解剖学测量。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 使用冠状动脉循环模型和患者特异性充血边界条件模拟冠状动脉至少一个狭窄区域的血流量和压力。 基于模拟的充血血流量和压力计算至少一个狭窄区域的分数流量储备（FFR）。

公开(公告)号：US08380287B2

公开(公告)日：2013-02-19

申请号：US12457633

申请日：2009-06-17

申请人： Lutz Gündel ,  Michael Scheuering

发明人： Lutz Gündel ,  Michael Scheuering

IPC分类号： A61B5/05 ,  G06K9/00 ,  G06T15/40

CPC分类号： A61B6/032 ,  A61B1/31 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/745 ,  A61B6/037 ,  G06T15/08 ,  G06T15/50 ,  G06T19/00 ,  G06T2219/021

摘要： A method is disclosed for visualizing bumps of the inner surface of a hollow organ. In at least one embodiment, the method includes acquiring recorded image data of the hollow organ using an imaging system; drawing a cutting edge in the image data along the surface of the hollow organ in the longitudinal direction; preparing the image data to display the surface of the hollow organ along a plane on which the surface is plotted in an opened-up fashion; and changing a viewing angle and/or an illumination angle during a display of the hollow organ, a rotation of the plane along an axis running parallel to the cutting edge and/or along an axis running transversely to the cutting edge being carried out to change the viewing angle. A visualization module, an image processing device with such a visualization module and a tomographic system with such an image processing system.

公开(公告)号：US20130004037A1

公开(公告)日：2013-01-03

申请号：US13531841

申请日：2012-06-25

申请人： Michael Scheuering

发明人： Michael Scheuering

IPC分类号： G06K9/62

CPC分类号： A61B6/5205 ,  A61B6/032 ,  A61B6/468 ,  A61B6/5294 ,  G06F19/00 ,  G06F19/321 ,  G06T11/006 ,  G16H50/20

摘要： In a method for image generation and image evaluation in the medical field, raw data are generated by a selected medical modality, in particular a computed tomography scanner, depending on given modality parameters, and image data are generated from the raw data using an image reconstruction depending on given reconstruction parameters. The image data are evaluated by a given analysis application. Before acquiring the raw data, a secondary application automatically proposes a set of parameter values for the modality parameters and/or for the reconstruction parameters coordinated to the given analysis application and/or given patient information.

摘要翻译： 在医疗领域中用于图像生成和图像评估的方法中，根据给定的模态参数，通过选择的医疗模式，特别是计算机断层扫描仪生成原始数据，并且使用图像重建从原始数据生成图像数据 取决于给定的重建参数。 图像数据由给定的分析应用程序进行评估。 在获取原始数据之前，辅助应用程序自动提出一组模型参数和/或与给定分析应用程序和/或给定患者信息协调的重建参数的参数值。

公开(公告)号：US08116548B2

公开(公告)日：2012-02-14

申请号：US12471761

申请日：2009-05-26

申请人： Yefeng Zheng ,  Bogdan Georgescu ,  Haibin Ling ,  Michael Scheuering ,  Dorin Comaniciu

发明人： Yefeng Zheng ,  Bogdan Georgescu ,  Haibin Ling ,  Michael Scheuering ,  Dorin Comaniciu

IPC分类号： G06K9/00

CPC分类号： G06K9/3233 ,  G06K2209/051 ,  G06T7/75 ,  G06T2207/10081 ,  G06T2207/30004

摘要： A method and apparatus for detecting 3D anatomical objects in medical images using constrained marginal space learning (MSL) is disclosed. A constrained search range is determined for an input medical image volume based on training data. A first trained classifier is used to detect position candidates in the constrained search range. Position-orientation hypotheses are generated from the position candidates using orientation examples in the training data. A second trained classifier is used to detect position-orientation candidates from the position-orientation hypotheses. Similarity transformation hypotheses are generated from the position-orientation candidates based on scale examples in the training data. A third trained classifier is used to detect similarity transformation candidates from the similarity transformation hypotheses, and the similarity transformation candidates define the position, translation, and scale of the 3D anatomic object in the medical image volume.

摘要翻译： 公开了一种使用受限边际空间学习（MSL）检测医学图像中3D解剖学对象的方法和装置。 基于训练数据确定输入医学图像体积的约束搜索范围。 第一训练分类器用于检测约束搜索范围内的位置候选。 使用训练数据中的取向示例从位置候选者生成位置取向假设。 第二训练分类器用于从位置定向假设检测位置方向候选。 基于训练数据中的比例示例，从位置定位候选生成相似度转换假设。 第三训练分类器用于从相似变换假设检测相似变换候选，并且相似变换候选定义医学图像体积中的3D解剖对象的位置，平移和比例。

公开(公告)号：US08098918B2

公开(公告)日：2012-01-17

申请号：US12228911

申请日：2008-08-18

申请人： Yefeng Zheng ,  Bogdan Georgescu ,  Michael Scheuering ,  Dorin Comaniciu

发明人： Yefeng Zheng ,  Bogdan Georgescu ,  Michael Scheuering ,  Dorin Comaniciu

IPC分类号： G06K9/00

CPC分类号： G06T7/62 ,  G06T7/11 ,  G06T2207/10081 ,  G06T2207/30048

摘要： A method and system for measuring the volume of the left ventricle (LV) in a 3D medical image, such as a CT, volume is disclosed. Heart chambers are segmented in the CT volume, including at least the LV endocardium and the LV epicardium. An optimal threshold value is automatically determined based on voxel intensities within the LV endocardium and voxel intensities between the LV endocardium and the LV epicardium. Voxels within the LV endocardium are labeled as blood pool voxels or papillary muscle voxels based on the optimal threshold value. The LV volume can be measured excluding the papillary muscles based on the number of blood pool voxels, and the LV volume can be measured including the papillary muscles based on the total number of voxels within the LV endocardium.

摘要翻译： 公开了一种用于测量3D医学图像（例如CT）体积中的左心室（LV）的体积的方法和系统。 心室在CT体积中分段，至少包括LV心内膜和LV心外膜。 基于LV心内膜内的体素强度和LV心内膜与LV心外膜之间的体素强度自动确定最佳阈值。 基于最佳阈值将LV心内膜内的体素标记为血池体素或乳头肌肉体素。 基于血液池体素的数量可以除去乳头肌之外的LV体积，并且可以基于LV心内膜中的体素总数来测量LV体积，包括乳头肌。

公开(公告)号：US07916919B2

公开(公告)日：2011-03-29

申请号：US11856878

申请日：2007-09-18

申请人： Yefeng Zheng ,  Adrian Barbu ,  Bogdan Georgescu ,  Michael Scheuering ,  Dorin Comaniciu

发明人： Yefeng Zheng ,  Adrian Barbu ,  Bogdan Georgescu ,  Michael Scheuering ,  Dorin Comaniciu

IPC分类号： G06K9/00

CPC分类号： A61B6/503 ,  A61B8/0883 ,  G06K9/6247 ,  G06T7/12 ,  G06T7/149 ,  G06T2207/10081 ,  G06T2207/30048

摘要： A system and method for segmenting chambers of a heart in three dimensional images is disclosed. A set of three dimensional images of a heart is received. The shape of the heart in the three dimensional images is localized. Boundaries of the chambers of the heart in the localized shape are identified using steerable features.

摘要翻译： 公开了一种用于在三维图像中分割心脏腔室的系统和方法。 接收一组心脏的三维图像。 三维图像中心脏的形状是局部化的。 使用可转向特征来识别局部形状的心脏腔室的边界。

公开(公告)号：US20110007953A1

公开(公告)日：2011-01-13

申请号：US12827275

申请日：2010-06-30

申请人： Dominik Bernhardt ,  Michael Scheuering

发明人： Dominik Bernhardt ,  Michael Scheuering

IPC分类号： G06K9/00

CPC分类号： G06T11/206 ,  A61B6/503 ,  A61B6/507

摘要： A method is disclosed for post-processing measured values of a tissue region including at least part of a heart, which measured values were registered by way of an imaging system. In at least one embodiment, the method includes at least: generating an at least three-dimensional data record from the measured values; analyzing the at least three-dimensional data record and generating parameter maps in respect of at least two of the following parameters: thickness and/or change in thickness of a myocardial wall, movement of the myocardial wall, local blood-supply values for defined spatial regions of the heart; automatically generating a results parameter map on the basis of the generated parameter maps according to fixed rules; and outputting the results parameter map. Moreover, at least one embodiment of the invention relates to a correspondingly designed device.

摘要翻译： 公开了一种用于后处理包括至少部分心脏的组织区域的测量值的方法，该测量值通过成像系统登记。 在至少一个实施例中，该方法至少包括：从测量值生成至少三维数据记录; 分析所述至少三维数据记录并针对以下参数中的至少两个生成参数图：心肌壁的厚度和/或厚度变化，心肌壁的运动，用于定义的空间的局部血液供应值 心脏地区 根据固定规则，根据生成的参数图自动生成结果参数图; 并输出结果参数图。 此外，本发明的至少一个实施例涉及相应设计的装置。