公开(公告)号：US09865892B2

公开(公告)日：2018-01-09

申请号：US13262131

申请日：2010-03-09

申请人： Yoshikazu Tanaka ,  Kiyoshi Taguchi ,  Yoshio Tamura ,  Shigeki Yasuda ,  Hiroaki Kaneko

发明人： Yoshikazu Tanaka ,  Kiyoshi Taguchi ,  Yoshio Tamura ,  Shigeki Yasuda ,  Hiroaki Kaneko

IPC分类号： H01M8/0606 ,  H01M8/04223 ,  H01M8/04955 ,  H01M8/04014 ,  H01M8/0432 ,  H01M8/04701 ,  H01M8/04746

CPC分类号： H01M8/0606 ,  H01M8/04022 ,  H01M8/04223 ,  H01M8/04225 ,  H01M8/04228 ,  H01M8/04302 ,  H01M8/04303 ,  H01M8/04373 ,  H01M8/04738 ,  H01M8/04776 ,  H01M8/04955 ,  H01M2250/10 ,  Y02B90/14

摘要： Provided are a fuel cell system capable of shortening the wait time of an observer who confirms set points of a system interconnection protective device before starting a system interconnection operation, and a method for operating the fuel cell system.A fuel cell system 100 includes: a hydrogen generating unit 16 configured to generate a hydrogen-containing gas by using a raw material; a heater 18 configured to heat the hydrogen generating unit; an electric power generation start command unit 32 configured to receive a command of start of an electric power generating operation of the fuel cell system, the command being input by a manual operation of an operator, the electric power generating operation being interconnected with an electric power system; and a controller 28 configured to: execute electric power generation stand-by, in which the fuel cell system stands by for the start of the electric power generating operation interconnected with the electric power system, while executing a temperature maintaining process of the hydrogen generating unit by the heater after completion of a temperature increasing process of the hydrogen generating unit by the heater; and when the electric power generation start command unit receives the command of the start of the electric power generating operation, stop the electric power generation stand-by and start the electric power generating operation interconnected with the electric power system.

公开(公告)号：US08748409B2

公开(公告)日：2014-06-10

申请号：US13263929

申请日：2010-04-19

申请人： Hiroaki Kaneko ,  Masaya Ito

发明人： Hiroaki Kaneko ,  Masaya Ito

IPC分类号： A61K31/70 ,  C07H5/04

CPC分类号： A61L27/52 ,  A61K9/0024 ,  A61K47/36 ,  A61L27/20 ,  A61L31/042 ,  A61L31/145 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

摘要： Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R2, with R2 being a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into a predetermined location with an injection device such as a syringe, and thus can be advantageously used as a medical gel or an adhesion barrier.

摘要翻译： 公开了通过用-NH-X-CO-Y-Z取代羧基多糖的一些羧基得到的多糖衍生物; 及其水凝胶。 这里，X是C 1-10烃基，Y是在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R2，R2是C1-23烃基。 水凝胶具有优异的粘弹性，并且可以通过诸如注射器的注射装置注射到预定位置，因此可以有利地用作医用凝胶或粘合屏障。

公开(公告)号：US20130137803A1

公开(公告)日：2013-05-30

申请号：US13816058

申请日：2011-08-12

申请人： Yukako Kageyama ,  Susumu Honda ,  Makoto Satake ,  Hiroaki Kaneko

发明人： Yukako Kageyama ,  Susumu Honda ,  Makoto Satake ,  Hiroaki Kaneko

IPC分类号： D01F8/14

CPC分类号： D01F8/14 ,  C08K5/521 ,  D01D5/0007 ,  D01F1/09 ,  D01F6/625 ,  D01F6/92 ,  D04H1/4326 ,  D04H1/435 ,  D04H1/728

摘要： An object to be achieved by the invention is to provide a biodegradable low-charging fiber. The prevent inventors have found that when a specific amount of a specific phospholipid that is not known to have antistatic properties is added to a biodegradable polymer, and the resulting mixture is formed into a fiber having a smooth surface, low-charging properties are developed. The invention has thus been accomplished. The invention is a fiber having an average surface porosity of less than 3% and made of a biodegradable polymer that contains a specific amount of a specific phospholipid.

摘要翻译： 本发明要实现的目的是提供一种可生物降解的低充电纤维。 防止发明人已经发现，将特定量的不知道具有抗静电特性的特定磷脂加入可生物降解的聚合物中，并将所得到的混合物形成为具有光滑表面的纤维时，开发了低充电性能。 从而完成了本发明。 本发明是平均表面孔隙率小于3％并由含有特定量的特定磷脂的可生物降解的聚合物制成的纤维。

公开(公告)号：US20120232224A1

公开(公告)日：2012-09-13

申请号：US13508828

申请日：2010-11-10

申请人： Susumu Honda ,  Yukako Kageyama ,  Makoto Satake ,  Hiroaki Kaneko

发明人： Susumu Honda ,  Yukako Kageyama ,  Makoto Satake ,  Hiroaki Kaneko

IPC分类号： C08G63/91 ,  C08F12/08 ,  B29C47/00 ,  C08G64/42

CPC分类号： A61L15/22 ,  A61L15/42 ,  D01D5/0038 ,  D01F1/10

摘要： Disclosed is a fibrous formed article having excellent hydrophilicity, which contains a hydrophobic polymer and amphiphilic molecules and has an average fiber diameter of 0.05 to 50 μm, the amphiphilic molecules segregating to the fiber surface.

摘要翻译： 公开了具有优异的亲水性的纤维状成形体，其含有疏水性聚合物和两亲性分子，并且平均纤维直径为0.05〜50μm，两亲性分子与纤维表面分离。

公开(公告)号：US08137685B2

公开(公告)日：2012-03-20

申请号：US10577154

申请日：2004-10-27

申请人： Eiichi Kitazono ,  Hiroaki Kaneko ,  Masaya Ito ,  Chiaki Fukutomi ,  Saki Tsuzuki ,  Yoshihiko Sumi

发明人： Eiichi Kitazono ,  Hiroaki Kaneko ,  Masaya Ito ,  Chiaki Fukutomi ,  Saki Tsuzuki ,  Yoshihiko Sumi

IPC分类号： C07H11/04 ,  A61K31/715 ,  A61P19/02

CPC分类号： C08B37/0072 ,  A61L27/20 ,  A61L27/52 ,  C08L5/08

摘要： A hyaluronic acid compound which is a reaction product between hyaluronic acid and a phosphatidyl ethanolamine. This compound has biocompatibility and bio-safety, and can be formed into a hydrogel or molded form having a certain shape. Making use of these properties, it is used to treat a knee joint, prevent the accretion of a tissue after an operation and keep a skin wet.

摘要翻译： 透明质酸化合物，其是透明质酸和磷脂酰乙醇胺之间的反应产物。 该化合物具有生物相容性和生物安全性，可以形成为具有一定形状的水凝胶或成型体。 利用这些性质，它用于治疗膝关节，防止手术后组织的积累并保持皮肤湿润。

公开(公告)号：US20120035128A1

公开(公告)日：2012-02-09

申请号：US13263929

申请日：2010-04-19

申请人： Hiroaki Kaneko ,  Masaya Ito

发明人： Hiroaki Kaneko ,  Masaya Ito

IPC分类号： A61K31/726 ,  C08B37/08 ,  A61K31/728 ,  A61K6/00 ,  A61K47/36 ,  C12N1/00 ,  A61L24/08 ,  C08B37/00 ,  A61P41/00

CPC分类号： A61L27/52 ,  A61K9/0024 ,  A61K47/36 ,  A61L27/20 ,  A61L31/042 ,  A61L31/145 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

摘要： Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R2, with R2 being a C1-23 hydrocarbon group. The hydrogel has excellent viscoelasticity and can be injected into a predetermined location with an injection device such as a syringe, and thus can be advantageously used as a medical gel or an adhesion barrier.

摘要翻译： 公开了通过用-NH-X-CO-Y-Z取代羧基多糖的一些羧基得到的多糖衍生物; 及其水凝胶。 这里，X是C 1-10烃基，Y是在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R2，R2是C1-23烃基。 水凝胶具有优异的粘弹性，并且可以通过诸如注射器的注射装置注射到预定位置，因此可以有利地用作医用凝胶或粘合屏障。

公开(公告)号：US20110301121A1

公开(公告)日：2011-12-08

申请号：US13202234

申请日：2009-09-18

申请人： Nobuyuki Endo ,  Masaya Ito ,  Hiroaki Kaneko ,  Hitoshi Hirata ,  Michiro Yamamoto

发明人： Nobuyuki Endo ,  Masaya Ito ,  Hiroaki Kaneko ,  Hitoshi Hirata ,  Michiro Yamamoto

IPC分类号： A61K31/717 ,  A61P25/00 ,  A61P41/00

CPC分类号： A61L31/042 ,  A61K31/715 ,  A61K31/717 ,  A61L31/145 ,  A61L2430/32 ,  C08B15/05

摘要： A nerve dysfunction repairing material including a hydrogel of a polysaccharide derivative that has, in a 0.5 wt % aqueous solution, a complex modulus of 1 to 1000 N/m2 and a loss factor of 0.01 to 2.0 as measured at an angular velocity of 10 rad/sec using a dynamic viscoelasticity measuring apparatus. The nerve dysfunction repairing material can be a hydrogel injectable through a syringe, has excellent retention in the body, and has a restorative effect on the function of damaged or degenerated nerves.

摘要翻译： 一种神经功能障碍修复材料，其包括多糖衍生物的水凝胶，所述多糖衍生物在0.5重量％水溶液中的复数模量为1〜1000N / m 2，损失因子为0.01〜2.0，以角速度为10rad /秒，使用动态粘弹性测量装置。 神经功能障碍修复材料可以是通过注射器注射的水凝胶，在身体中具有优异的保留性，并且对损伤或退化的神经的功能具有恢复性作用。

公开(公告)号：US20110129505A1

公开(公告)日：2011-06-02

申请号：US12808613

申请日：2008-12-17

申请人： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

发明人： Hiroaki Kaneko ,  Nobuyuki Endo ,  Masaya Ito

IPC分类号： C08B11/193 ,  C08B1/00 ,  C08B11/15 ,  C08B11/12 ,  A61K9/00

CPC分类号： A61L27/20 ,  A61L27/52 ,  A61L31/042 ,  A61L31/145 ,  C08B11/12 ,  C08L1/26

摘要： The invention is a cellulose derivative wherein some of the carboxyl groups of the cellulose derivative carboxymethylcellulose are replaced with —CO—NH—X—CO—Y—Z, and a hydrogel of the same. In the formula, X is a C1-10 divalent hydrocarbon group, Y is a divalent group derived from polyalkylene oxide having oxygen atoms at both ends, and Z is a C1-24 hydrocarbon group or —CO—R4, where R4 is a C1-23 hydrocarbon group.The hydrogel has excellent viscoelasticity and can be injected into prescribed sites with injecting devices such as syringes, and it can thus be utilized as a medical gel or adhesion barrier.

摘要翻译： 本发明是纤维素衍生物羧甲基纤维素的一些羧基被-CO-NH-X-CO-Y-Z代替的纤维素衍生物及其水凝胶。 在该式中，X是C 1-10二价烃基，Y是衍生自在两端具有氧原子的聚环氧烷烃，Z是C1-24烃基或-CO-R4的二价基团，其中R4是C1 -23烃基。 水凝胶具有优异的粘弹性，并且可以用诸如注射器的注射装置注射到规定的位置，因此可以用作医用凝胶或粘附屏障。

公开(公告)号：US20100279982A1

公开(公告)日：2010-11-04

申请号：US11997830

申请日：2006-08-03

申请人： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

发明人： Hiroaki Kaneko ,  Eiichi Kitazono ,  Masaya Ito ,  Yoshihiko Sumi

IPC分类号： A61K31/717 ,  C08B15/05 ,  A61P41/00

CPC分类号： C08B11/20 ,  A61L31/042 ,  C08B15/05 ,  C08L1/00

摘要： A cellulose derivative which has a suitable elastic modulus and viscosity when it is dissolved in water and is useful as an adhesion barrier.The cellulose derivative has a molecular weight of 5×103 to 5×106 and is composed of a repeating unit represented by the following formula (1): wherein R1, R2 and R3 are each independently selected from the group consisting of the following formulas (a), (b), (c) and (d) in predetermined amount: (X in the formula (c) is an alkali metal, and R4 and R5 in the formula (d) are each independently an alkyl group or alkenyl group having 10 to 28 carbon atoms).

摘要翻译： 当纤维素衍生物溶于水中时具有合适的弹性模量和粘度并且可用作粘合屏障。 纤维素衍生物的分子量为5×10 3〜5×10 6，由下述式（1）表示的重复单元构成：其中，R 1，R 2，R 3各自独立地选自下述式 a），（b），（c）和（d））：（式（c）中的X是碱金属，式（d）中的R 4和R 5各自独立地为烷基或烯基 具有10至28个碳原子）。

公开(公告)号：US20090076530A1

公开(公告)日：2009-03-19

申请号：US12281923

申请日：2007-03-05

申请人： Chiaki Fukutomi ,  Hiroaki Kaneko ,  Eiichi Kitazono ,  Mika Kayashima ,  Miyuki Nakayama

发明人： Chiaki Fukutomi ,  Hiroaki Kaneko ,  Eiichi Kitazono ,  Mika Kayashima ,  Miyuki Nakayama

IPC分类号： A61B17/08 ,  A61B19/00

CPC分类号： C12N5/0068 ,  A61L27/14 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  C12M25/14 ,  C12N2533/30 ,  C12N2533/40 ,  D01D5/0007 ,  D01F6/04 ,  D01F6/22 ,  D01F6/66 ,  D04H3/07 ,  C08L67/04

摘要： To provide a scaffold having excellent mechanical strength and cell growth capability and is suitable for use as a cell culture medium or a prosthetic material.The present invention relates to a scaffold composed of an assembly of fibers and having a 3-D structure consisting of two end faces and a side face, wherein (1) the fibers are aligned in a plane direction; (2) the fibers have a diameter of 0.05 to 50 μm; (3) the fibers are essentially composed of a biocompatible polymer; and (4) the scaffold has an apparent density of 95 to 350 kg/m3.

摘要翻译： 提供具有优异的机械强度和细胞生长能力的支架，并且适合用作细胞培养基或假体材料。 本发明涉及一种由纤维组合体构成的具有由两个端面和侧面组成的3-D结构的支架，其中（1）纤维沿平面方向排列; （2）纤维的直径为0.05〜50μm; （3）纤维基本上由生物相容性聚合物组成; 和（4）支架具有95至350kg / m 3的表观密度。