公开(公告)号：US20210364505A1

公开(公告)日：2021-11-25

申请号：US17394512

申请日：2021-08-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew

IPC: G01N33/543 ,  G01N33/574

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11059046B2

公开(公告)日：2021-07-13

申请号：US16227081

申请日：2018-12-20

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: C12Q1/6804 ,  G01N33/68 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6876 ,  B01L3/00

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US10908157B2

公开(公告)日：2021-02-02

申请号：US15440191

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/58

Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.

公开(公告)号：US20200378966A1

公开(公告)日：2020-12-03

申请号：US16836245

申请日：2020-03-31

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  Mikayla Higgins ,  John Kenten ,  George Sigal

IPC: G01N33/564

Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US10712351B2

公开(公告)日：2020-07-14

申请号：US15716743

申请日：2017-09-27

Applicant: Meso Scale Technologies, LLC.

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

公开(公告)号：US20190201906A1

公开(公告)日：2019-07-04

申请号：US16292521

申请日：2019-03-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC: B01L3/00 ,  F16K11/074

CPC classification number: B01L3/567 ,  B01L3/502 ,  B01L3/502738 ,  B01L3/5085 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  F16K11/0743 ,  Y10T436/2575

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US10114015B2

公开(公告)日：2018-10-30

申请号：US14208040

申请日：2014-03-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  John Kenten

IPC: C12Q1/68 ,  G01N33/543 ,  C12Q1/682 ,  C12Q1/6844 ,  C12Q1/6837 ,  C12Q1/6848

Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

公开(公告)号：US20180172595A1

公开(公告)日：2018-06-21

申请号：US15898283

申请日：2018-02-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N21/76 ,  B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  C12Q1/00 ,  G01N27/30 ,  G01N33/543

CPC classification number: G01N21/76 ,  B01J19/0046 ,  B01J2219/00653 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/5029 ,  B01L9/527 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/049 ,  B01L2400/0688 ,  B33Y80/00 ,  C12Q1/001 ,  C40B40/10 ,  G01N27/30 ,  G01N33/5438 ,  G01N2458/30 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.

公开(公告)号：US09891221B2

公开(公告)日：2018-02-13

申请号：US14319167

申请日：2014-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Michael Tsionsky ,  Eli N. Glezer ,  Selen Stromgren ,  George Sigal ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC: C12Q1/68 ,  G01N31/00 ,  G01N33/573 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/58 ,  G01N21/76 ,  G01N33/53

CPC classification number: G01N33/573 ,  C12Q1/485 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N2333/91205 ,  G01N2458/30 ,  G01N2458/40 ,  Y10S435/967 ,  Y10S435/968 ,  Y10T436/10 ,  Y10T436/108331

Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

公开(公告)号：US20180029034A1

公开(公告)日：2018-02-01

申请号：US15784399

申请日：2017-10-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: B01L3/00 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/68

CPC classification number: B01L3/50853 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q2563/131

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.