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公开(公告)号：US08401610B2
公开(公告)日：2013-03-19
申请号：US12902092
申请日：2010-10-11
IPC分类号： A61B5/05
CPC分类号： A61B1/00163 , A61B1/0011 , A61B1/00172 , A61B5/0066 , A61B5/6852 , Y10T29/49826
摘要： The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.
摘要翻译： 本发明是旋转尖端导管成像探针，其中电磁能量被传送到导管的远端并且使用光驱动装置转换成机械能。 然后机械能用于旋转将固定模式的光重定向在样品上的反射镜。 光驱装置的旋转元件包含叶片，叶片绕轴线转动并且与轴承一起定位以使摩擦力最小化。 腔室包围旋转元件并被设定为真空压力。 可以通过改变输送到叶片的光功率，腔室中的真空压力，或通过施加到旋转元件的制动机构来控制导管尖端的旋转速度。 叶片可以成形为特定的几何形状以增加来自热驱动气流的叶片上的力。
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52.发明授权公开(公告)号：US08352022B2
公开(公告)日：2013-01-08
申请号：US12717735
申请日：2010-03-04
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译： 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射离子涂层。 可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。
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公开(公告)号：US20120013914A1
公开(公告)日：2012-01-19
申请号：US13243399
申请日：2011-09-23
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B5/0066 , A61B5/0073 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02057 , G01B9/02069 , G01B9/02083 , G01B2290/25 , G01M11/3127 , G01M11/3172 , G01N21/4795
摘要： A method and a system for Uniform Frequency Sample Clocking to directly sample the OCT signal with a temporally-non-linear sampling clock derived from a k-space wavemeter on the external sample clock input port of a digitizer.
摘要翻译： 一种用于均匀频率采样时钟的方法和系统，用于从数字转换器的外部采样时钟输入端口上的k空间波长计导出的时间非线性采样时钟直接采样OCT信号。
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公开(公告)号：US20110137124A1
公开(公告)日：2011-06-09
申请号：US12941548
申请日：2010-11-08
IPC分类号： A61B1/06
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B8/12 , A61B8/4461 , A61M25/0052 , A61M2025/0183
摘要： An Optical imaging catheter that balances optical aberrations and allows recording of high quality optical images while relaxing the requirement of a fluid occupying the space between the prism and the inner sheath of the catheter.
摘要翻译： 一种光学成像导管，其平衡光学像差并且允许记录高质量的光学图像，同时放松占据导管的棱镜和内护套之间的空间的流体的需要。
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55.发明申请MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY 有权使用相敏感光学相干反射测量法测量神经功能公开(公告)号：US20100249609A1
公开(公告)日：2010-09-30
申请号：US12717735
申请日：2010-03-04
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B3/102 , A61B3/1225 , A61B5/0066 , G01N21/4795 , G01N2021/1782
摘要： Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
摘要翻译： 公开了用于非侵入性地检测神经元中的瞬时表面位移的光学方法，装置和系统。 提供的方法，设备和系统可以采用相敏光学低相干反射计。 此外，在使用反射反射光的一些实施例中，可以检测由于神经组织中的动作电位传播引起的表面位移。 根据一些实施方案，不需要外源化学品或反射离子涂层。 可以检测到幅度小于1nm，持续时间为1ms的瞬态神经表面位移，并且可能通常与到达光学测量位置的动作电位一致。 系统和方法可以用于各种神经病如视网膜神经病的非侵入性检测。 它们也可用于检测各种药理学试剂的作用。
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公开(公告)号：US20100237258A1
公开(公告)日：2010-09-23
申请号：US12692333
申请日：2010-01-22
IPC分类号： G21K5/00
CPC分类号： F41H13/0056 , F41H13/0087
摘要： Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject.
摘要翻译： 提供了用于改变成像系统的调制传递功能的方法，系统和装置。 所描述的方法，系统和装置可用于临时改变受试者的视力。
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57.发明申请公开(公告)号：US20100220334A1
公开(公告)日：2010-09-02
申请号：US12703603
申请日：2010-02-10
CPC分类号： G02B3/12 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B2562/0233 , A61B2562/028 , A61B2562/0285 , A61B2562/12 , B82Y20/00 , G01B9/02091 , G01B11/02 , G01B2290/65 , G01N21/4795 , G02B3/14 , G02B26/0833 , G02B26/105 , G02B2207/101 , G02B2207/109
摘要： Provided are forward-imaging optical coherence tomography (OCT) systems and probes.
摘要翻译： 提供了前向成像光学相干断层扫描（OCT）系统和探针。
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公开(公告)号：US06942663B2
公开(公告)日：2005-09-13
申请号：US10385195
申请日：2003-03-10
CPC分类号： A61K31/045 , A61B18/203 , A61B2018/00452
摘要： Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion. Blood flow velocity is slowed within the region using the hyperosmotic agent, and the lesion is exposed to laser radiation.
摘要翻译： 治疗皮肤血管病变等疾病的方法。 确定需要血管病变治疗的患者。 向病变附近的区域施用渗透剂。 使用高渗透剂在该区域内血流速度变慢，病变暴露于激光辐射。
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公开(公告)号：US5015096A
公开(公告)日：1991-05-14
申请号：US261144
申请日：1988-10-24
CPC分类号： G01M11/0271 , G01B11/30 , G01M11/005 , G02B6/2861
摘要： A method and apparatus for scanning and testing optical components is disclosed. An incident laser beam is directed at a trihedral retroreflector and is redirected by the trihedral retroreflector onto a test surface. The trihedral retroreflector is movable in X and Y directions over the test surface, in a plane perpendicular to the incident beam, scanning the incident beam over the test surface. The reflected beam from the test surface is redirected by the trihedral retroreflector to measurement instrumentation including a photodetector. If the test surface is planar, the reflected beam retraces the path of the incident beam independent of the translation of the trihedral retroreflector. Irregularities in the test surface cause deflections of the reflected beam. The linear scanning range, in both X and Y direction, of a single trihedral retroreflector of diameter "d" is the value (d times 2). The linear scanning range of a series of "n" trihedral retroreflectors of diameter "d" is the value (d times 2.sup.n).
摘要翻译： 公开了用于扫描和测试光学部件的方法和装置。 入射激光束指向三面体后向反射器，并由三面体后向反射器重定向到测试表面上。 三面体后向反射器可以在垂直于入射光束的平面上在测试表面上沿X和Y方向移动，将入射光束扫过测试表面。 来自测试表面的反射光束被三面体回射器重定向到包括光电检测器的测量仪器。 如果测试表面是平面的，则反射光束将独立于三面体后向反射器的平移来回溯入射光束的路径。 测试表面的不规则性导致反射光束的偏转。 直径“d”的单个三面体后向反射器的X和Y方向的线性扫描范围为（d倍数2）。 直径“d”的一系列“n”型三面体回射器的线性扫描范围是数值（d倍数2n）。
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公开(公告)号：US10219780B2
公开(公告)日：2019-03-05
申请号：US12173004
申请日：2008-07-14
摘要： The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature.
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