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    Cynara scolymus extracts, the use thereof and formulations containing them
    51.
    发明申请
    Cynara scolymus extracts, the use thereof and formulations containing them 审中-公开
    Cynara scolymus提取物，其使用和含有它们的制剂

    公开(公告)号：US20090285911A1

    公开(公告)日：2009-11-19

    申请号：US11988638

    申请日：2006-06-16

    申请人： Ezio Bombardelli ,  Gabriele Fontana ,  Andrea Giori ,  Paolo Morazzoni ,  Massimo Ronchi ,  Sabrina Arpini

    发明人： Ezio Bombardelli ,  Gabriele Fontana ,  Andrea Giori ,  Paolo Morazzoni ,  Massimo Ronchi ,  Sabrina Arpini

    IPC分类号： A61K36/28 ,  A61K31/343 ,  A61P3/00 ,  A61P1/00 ,  A61P9/10

    CPC分类号： A61K36/28 ,  A61K36/185 ,  A61K36/55 ,  A61K2300/00

    摘要： The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in ω-3 and ω-6 acids which enhance the vascular activity.

    摘要翻译： 本发明涉及通过在树脂上分馏获得的Cynara scolymus提取物的制备。 本发明的方法允许以恒定比例从植物Cynara scolymus的地上部分开始，含有三类活性成分，即二茶醛奎宁酸，木犀草素和猕猴桃糖苷。 通过添加精确量的硫酸化氨基酸或合适的硫代衍生物来稳定辛酰丙酸。 这些提取物具有降血脂，消化不良和血管消炎活性。 提取物主要配制在Enothera biennis油或富含ω-3和ω-6酸的油中，从而增强血管活性。

    Formulations of alpha-amylase inhibitors with alpha-glucosidase inhibitors useful in the treatment of diabetes and obesity
    52.
    发明授权
    Formulations of alpha-amylase inhibitors with alpha-glucosidase inhibitors useful in the treatment of diabetes and obesity 有权
    用于治疗糖尿病和肥胖症的α-葡糖苷酶抑制剂的α-淀粉酶抑制剂的制剂

    公开(公告)号：US07553502B2

    公开(公告)日：2009-06-30

    申请号：US12042355

    申请日：2008-03-05

    申请人： Ezio Bombardelli ,  Paolo Morazzoni ,  Cesare Ponzone ,  Massimo Ronchi

    发明人： Ezio Bombardelli ,  Paolo Morazzoni ,  Cesare Ponzone ,  Massimo Ronchi

    IPC分类号： A01N65/00

    CPC分类号： A61K36/37 ,  A61K36/48 ,  A61K2300/00

    摘要： This invention relates to the combination of α-amylase inhibitors prepared from Phaseolus vulgaris with α-glucosidase inhibitors obtained from Salacia oblonga and other species. The α-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with α-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.

    摘要翻译： 本发明涉及从菜豆提取物制备的α-淀粉酶抑制剂与从长颈鹿藻和其他物种获得的α-葡糖苷酶抑制剂的组合。 α-淀粉酶抑制剂伴随着一定量的凝集素，其降低源自饮食中存在的淀粉的葡萄糖的量，并且在重复给药后显着降低食欲。 与α-葡萄糖苷酶抑制剂（如Salacia提取物或其中存在的硫代糖）的组合进一步降低血糖，协同作用，从而减少碳水化合物的脂肪合成。

    FORMULATIONS OF ALPHA-AMYLASE INHIBITORS WITH ALPHA-GLUCOSIDASE INNHIBITORS USEFUL IN THE TREATMENT OF DIABETES AND OBESITY
    53.
    发明申请
    FORMULATIONS OF ALPHA-AMYLASE INHIBITORS WITH ALPHA-GLUCOSIDASE INNHIBITORS USEFUL IN THE TREATMENT OF DIABETES AND OBESITY 有权
    用于治疗糖尿病和肥胖症的ALPHA-葡萄糖苷酶抑制剂的阿尔法 - 淀粉酶抑制剂的配方

    公开(公告)号：US20080220098A1

    公开(公告)日：2008-09-11

    申请号：US12042355

    申请日：2008-03-05

    申请人： Ezio BOMBARDELLI ,  Paolo Morazzoni ,  Cesare Ponzone ,  Massimo Ronchi

    发明人： Ezio BOMBARDELLI ,  Paolo Morazzoni ,  Cesare Ponzone ,  Massimo Ronchi

    IPC分类号： A61K36/00 ,  A61K38/16

    CPC分类号： A61K36/37 ,  A61K36/48 ,  A61K2300/00

    摘要： This invention relates to the combination of α-amylase inhibitors prepared from Phaseolus vulgaris with α-glucosidase inhibitors obtained from Salacia oblonga and other species. The α-amylase inhibitor is accompanied by a quantity of lectins that reduces the amount of glucose originating from the starches present in the diet, and considerably reduces the appetite after repeated administration. The combination with α-glucosidase inhibitors, such as extracts of Salacia or the thiosugars present in it, further reduce the blood glucose, acting synergically, and consequently reduce the synthesis of fats from carbohydrates.

    摘要翻译： 本发明涉及从菜豆提取物制备的α-淀粉酶抑制剂与从长颈鹿藻和其他物种获得的α-葡糖苷酶抑制剂的组合。 α-淀粉酶抑制剂伴随着一定量的凝集素，其降低源自饮食中存在的淀粉的葡萄糖的量，并且在重复给药后显着降低食欲。 与α-葡萄糖苷酶抑制剂（如Salacia提取物或其中存在的硫代糖）的组合进一步降低血糖，协同作用，从而减少碳水化合物的脂肪合成。

    Polysaccharide of echinacea angustifolia
    56.
    发明授权
    Polysaccharide of echinacea angustifolia 失效
    松果菊多糖

    公开(公告)号：US06818761B2

    公开(公告)日：2004-11-16

    申请号：US10302843

    申请日：2002-11-25

    申请人： Andrea Giori ,  Alessandro Anelli ,  Paolo Morazzoni ,  Francesco Di Pierro

    发明人： Andrea Giori ,  Alessandro Anelli ,  Paolo Morazzoni ,  Francesco Di Pierro

    IPC分类号： C08B3700

    CPC分类号： C08B37/006 ,  A23L29/244 ,  A61K31/715 ,  A61K36/28

    摘要： A polysaccharide of Echinacea angustifolia roots, having molecular weight of 1.3×105 Da and including rhamnose, arabinose, galactose and galacturonic acid in ratio 0.5:2.5:1.75:10.25, is recovered from spontaneous or cultivated Echinacea angustifolia roots by means process including the following steps: a) depriving the roots of non polysaccharidic constituents by extraction with solvent; b)extracting the polysaccharidic fraction from the roots as directly obtained from the preceding step; c) isolating the polysaccharide by chromatography of the polysaccharidic fraction. Due to its immune-stimulating properties, the polysaccharide can be used for the preparation of medicaments, food supplements or nutraceutical compositions to administer whenever it is desirable to strenghthen the immune system body defenses.

    摘要翻译： 分子量为1.3×10 5 Da，包括鼠李糖，阿拉伯糖，半乳糖和半乳糖醛酸的比例为0.5:2.5:1.75:10.25的紫锥菊根的多糖通过手段方法从自发或栽培的松果菊根中回收，包括 以下步骤：a）用溶剂萃取除去非多糖成分的根; b）从前述步骤中直接提取来自根的多糖级分; c）通过多糖级分的色谱分离多糖。 由于其免疫刺激性质，多糖可以用于制备药物，食品添加剂或营养药物组合物，以便在需要加强免疫系统身体防御的情况下进行施用。

    Methods for treating and preventing mucositis
    59.
    发明授权
    Methods for treating and preventing mucositis 有权

    公开(公告)号：US09730952B2

    公开(公告)日：2017-08-15

    申请号：US12856786

    申请日：2010-08-16

    申请人： Ezio Bombardelli ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Paolo Morazzoni

    IPC分类号： A61K36/28 ,  A61K36/45 ,  A61K36/66 ,  A61K31/7048 ,  A61K31/352 ,  A61K36/51

    CPC分类号： A61K31/7048 ,  A61K31/352 ,  A61K36/28 ,  A61K36/45 ,  A61K36/51 ,  A61K36/66

    摘要： Methods for treating and preventing mucositis, in particular mucositis following the administration of chemotherapy drugs or a combination of said drugs with radiotherapy, are disclosed herein. More specifically, disclosed herein is the administration of a therapeutically effective amount of at least one of an anthocyanoside, a proanthocyanidin, or an extract containing at least one of an anthocyanoside or a proanthocyanidin for the treatment or prevention of mucositis. The therapeutically effective amount of the anthocyanoside, proanthocyanidin or extract can be administered alone or in combination with a therapeutically effective amount of at least one of an anti-inflammatory agent, immunomodulating agent, analgesic, antimicrobial agent or antifungal agent. Also disclosed herein are pharmaceutical compositions for treating and preventing mucositis.