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72 条记录 (耗时 0.05 秒)

    Use of peptide
    53.
    发明授权
    Use of peptide 失效
    使用肽

    公开(公告)号：US07045497B1

    公开(公告)日：2006-05-16

    申请号：US09868885

    申请日：1999-12-22

    申请人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    发明人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    IPC分类号： A61K38/11 ,  A61K38/16 ,  C07K14/00 ,  C07H21/04

    CPC分类号： A61K38/2257

    摘要： The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserving or treating various diseases related to oxytocin secretion such as uterine inertia, atonic hemorrhage, placental expulsion, subinvolution and the like.

    摘要翻译： 本发明涉及G蛋白偶联受体蛋白识别为配体的肽的用途。 由于本发明的配体多肽对催产素分泌具有刺激作用，因此可用作改善，保存或治疗与催产素分泌相关的各种疾病如子宫惯性，失声性出血，胎盘排出，亚溶解等的药物。

    Polypeptides their production and use
    56.
    发明授权
    Polypeptides their production and use 失效
    多肽的生产和使用

    公开(公告)号：US06228984B1

    公开(公告)日：2001-05-08

    申请号：US08776971

    申请日：1997-02-07

    申请人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    发明人： Shuji Hinuma ,  Yugo Habata ,  Yuji Kawamata ,  Masaki Hosoya ,  Ryo Fujii ,  Shoji Fukusumi ,  Chieko Kitada

    IPC分类号： C07K1447

    CPC分类号： C07H21/04 ,  A61K38/00 ,  C07K14/575 ,  C07K14/705 ,  C07K14/72 ,  C07K16/28

    摘要： The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

    摘要翻译： 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。

    Antibodies to .beta.-amyloids or their derivatives and use thereof
    57.
    发明授权
    Antibodies to .beta.-amyloids or their derivatives and use thereof 失效
    β-淀粉样蛋白或其衍生物的抗体及其用途

    公开(公告)号：US5955317A

    公开(公告)日：1999-09-21

    申请号：US986948

    申请日：1997-12-08

    申请人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

    发明人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  C12P21/04 ,  C07K16/00

    CPC分类号： C07K14/4711 ,  C07K16/18 ,  A61K38/00

    摘要： According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.

    摘要翻译： 根据本发明，获得了对β-淀粉样蛋白或其衍生物具有结合特异性的有用和新颖的抗体，即分别识别β-淀粉样蛋白的N-末端，C-末端或中心部分。 通过组合这些抗体，可以灵敏和具体地确定β淀粉样蛋白的测定方法。 这些测定方法可用于诊断β-淀粉样蛋白或其衍生物相关的疾病（例如阿尔茨海默氏病），本发明的抗体可用于开发阿尔茨海默氏病的预防性治疗组合物。

    Polypeptide having c-AMP-producing activity
    58.
    发明授权
    Polypeptide having c-AMP-producing activity 失效
    具有C-AMP生产活性的多肽

    公开(公告)号：US5208320A

    公开(公告)日：1993-05-04

    申请号：US732059

    申请日：1991-07-18

    申请人： Chieko Kitada ,  Takuya Watanabe

    发明人： Chieko Kitada ,  Takuya Watanabe

    IPC分类号： A61K38/00 ,  C07K14/575

    CPC分类号： C07K14/57563 ,  A61K38/00

    摘要： A polypeptide or a pharmaceutically acceptable salt thereof having c-AMP-producing activity is disclosed, the polypeptide being represented by the following general formula:X-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Y (X-SEQ ID NO:2-Y)wherein X represents any amino acid residue or an acyl group, and Y represents NH.sub.2, OH, Ala-NH.sub.2, Ala-OH, Ala-Ala-NH.sub.2, Ala-Ala-OH, Ala-Ala-Val-NH.sub.2 or Ala-Ala-Val-OH.

    GONADAL FUNCTION IMPROVING AGENTS
    60.
    发明申请
    GONADAL FUNCTION IMPROVING AGENTS 审中-公开
    全功能改善剂

    公开(公告)号：US20110052563A1

    公开(公告)日：2011-03-03

    申请号：US12710864

    申请日：2010-02-23

    申请人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    发明人： Tetsuya Ohtaki ,  Hisanori Matsui ,  Hirokazu Matsumoto ,  Chieko Kitada

    IPC分类号： A61K39/395 ,  A61K38/16 ,  A61K31/7088 ,  A61K31/711 ,  A61P15/08 ,  A61P15/00 ,  A61P5/00

    CPC分类号： G01N33/689 ,  A61K31/00 ,  A61K31/7088 ,  A61K38/1709

    摘要： Metastin, compounds that promote the activity of metastin or its receptors and the like are excellent gonadal function improving agents, ovulation inducers or promoters, gonadotropic hormone secretion promoters, gonadotropic hormone secretion inhibitors, sex hormone secretion promoters, sex hormone secretion inhibitors, etc., and can be used as agents for preventing/treating sterility, hormone-sensitive cancers, endometriosis, etc. Metastin and its receptors are useful for screening for these pharmaceuticals.

    摘要翻译： 促甲状腺激素分泌抑制剂，雌激素分泌促进剂，性激素分泌抑制剂等的促性腺激素分泌抑制剂，促性腺激素分泌促进剂，性激素分泌抑制剂等的优良性腺功能改善剂，排卵诱导剂或促进剂，促性腺激素分泌促进剂， 并且可以用作预防/治疗无菌，激素敏感性癌症，子宫内膜异位症等的药剂.MCastin及其受体可用于筛选这些药物。