公开(公告)号：US5750349A

公开(公告)日：1998-05-12

申请号：US302808

申请日：1994-09-15

申请人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

发明人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/20 ,  C12P21/08 ,  G01N33/53

CPC分类号： C07K14/4711 ,  C07K16/18 ,  A61K38/00

摘要： According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.

摘要翻译： PCT No.PCT / JP94 / 00089 Sec。 371日期1994年9月15日 102（e）1994年9月15日PCT PCT 1994年1月24日PCT公布。 第WO94 / 17197号公报 日期1994年8月4日根据本发明，有用和新颖的抗体，因为它们对β-淀粉样蛋白或其衍生物具有结合特异性，即识别β-淀粉样蛋白的N-末端，C-末端或中心部分， 分别得到。 通过组合这些抗体，可以灵敏和具体地确定β淀粉样蛋白的测定方法。 这些测定方法可用于诊断β-淀粉样蛋白或其衍生物相关的疾病（例如阿尔茨海默氏病），本发明的抗体可用于开发阿尔茨海默氏病的预防性治疗组合物。

公开(公告)号：US5955317A

公开(公告)日：1999-09-21

申请号：US986948

申请日：1997-12-08

申请人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

发明人： Nobuhiro Suzuki ,  Asano Odaka ,  Chieko Kitada

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  C12P21/04 ,  C07K16/00

CPC分类号： C07K14/4711 ,  C07K16/18 ,  A61K38/00

摘要： According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.

摘要翻译： 根据本发明，获得了对β-淀粉样蛋白或其衍生物具有结合特异性的有用和新颖的抗体，即分别识别β-淀粉样蛋白的N-末端，C-末端或中心部分。 通过组合这些抗体，可以灵敏和具体地确定β淀粉样蛋白的测定方法。 这些测定方法可用于诊断β-淀粉样蛋白或其衍生物相关的疾病（例如阿尔茨海默氏病），本发明的抗体可用于开发阿尔茨海默氏病的预防性治疗组合物。

公开(公告)号：US06991908B1

公开(公告)日：2006-01-31

申请号：US09869540

申请日：1999-12-27

申请人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

发明人： Masaaki Mori ,  Yukio Shimomura ,  Shiro Takekawa ,  Tsukasa Sugo ,  Yoshihiro Ishibashi ,  Chieko Kitada ,  Nobuhiro Suzuki

IPC分类号： G01N33/53

CPC分类号： C07K7/08 ,  A61K38/10 ,  G01N33/74 ,  G01N2333/575 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2500/02 ,  Y10S436/808

摘要： The present invention provides a method for screening a compound or its salt that alters the binding property between MCH or its salt and SLC-1 or its salt, characterized by using MCH or its derivative or a salt thereof and SLC-1 or its salt is useful for screening an SLC-1 agonist which can be used not only as an appetite (eating) promoting agent but also as a prophylactic/therapeutic agent for weak pains, atonic bleeding, before and after expulsion, subinvolution of uterus, cesarean section, induced abortion, galactostasis, and the like, and an SLC-1 antagonist which can be used not only as an antiobestic agents (drug), an appetite (eating) modulator, and the like, but also as a prophylactic/therapeutic agent for hyperstimulation, ankylosing uterine contractions, fetal distress, uterine rupture, cervical laceration, preterm delivery, Prader-Wili syndrome and the like.

摘要翻译： 本发明提供一种筛选化合物或其盐的方法，其改变MCH或其盐与SLC-1或其盐之间的结合性质，其特征在于使用MCH或其衍生物或其盐，SLC-1或其盐是 可用于筛选SLC-1激动剂，其不仅可以用作食欲（进食）促进剂，而且可用作弱疼痛，无症状出血，驱除前后，子宫切除，剖宫产，诱导 流产，半乳糖淀粉酶等，以及不仅可以用作抗生素（药物），食欲调节剂等的SLC-1拮抗剂，而且可以用作过度刺激的预防/治疗剂， 强直性子宫收缩，胎儿窘迫，子宫破裂，子宫颈撕裂，早产，Prader-Wili综合征等。

公开(公告)号：US5486472A

公开(公告)日：1996-01-23

申请号：US924054

申请日：1992-09-03

申请人： Nobuhiro Suzuki ,  Chieko Kitada ,  Masao Tsuda

发明人： Nobuhiro Suzuki ,  Chieko Kitada ,  Masao Tsuda

IPC分类号： C07K16/00 ,  C07K14/435 ,  C07K14/575 ,  C07K16/18 ,  C07K16/26 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  C12N5/12

CPC分类号： C07K16/26 ,  C07K14/57563

摘要： Disclosed are a monoclonal antibody having affinity for PACAP, a partial peptide thereof, a precursor thereof or VIP; a hybridoma cell which produces the above monoclonal antibody; and an immunoassay for assaying PACAP by a competitive method or a sandwich method using the above antibody, whereby PACAP can be specifically detected with high sensitivity.

摘要翻译： PCT No.PCT / JP91 / 00354 Sec。 371日期：1992年9月3日 102（e）日期1992年9月3日PCT 1991年3月15日PCT PCT。 WO91 / 14786 PCT公开 日期为1991年10月3日。公开是对PACAP，其部分肽，其前体或VIP具有亲和性的单克隆抗体; 产生上述单克隆抗体的杂交瘤细胞; 以及通过使用上述抗体的竞争性方法或夹心方法测定PACAP的免疫测定法，由此能够以高灵敏度特异性检测PACAP。

公开(公告)号：US08887476B2

公开(公告)日：2014-11-18

申请号：US12929165

申请日：2011-01-05

申请人： Nobuhiro Suzuki ,  Shuichi Iribe ,  Michinori Watanabe ,  Seiichi Akutsu

发明人： Nobuhiro Suzuki ,  Shuichi Iribe ,  Michinori Watanabe ,  Seiichi Akutsu

IPC分类号： B65B5/06

CPC分类号： B65B25/16

摘要： A bread packaging system comprising: a movable member on which a scoop for holding a packaging member to package bread is mounted; a guide member for defining a moving path along which the movable member is moved; a reciprocating motion mechanism having an endless revolving member for reciprocating the movable member along the guide member; and a link member for linking the endless revolving member with the movable member, wherein the bread packaging system is configured to reciprocate the movable member along the guide member by revolving the endless revolving member in one direction.

摘要翻译： 一种面包包装系统，包括：可移动部件，其上安装有用于保持包装部件以包装面包的勺子; 引导构件，用于限定可移动构件沿其移动的移动路径; 往复运动机构，其具有用于使可动构件沿导向件往复运动的环形旋转构件; 以及用于将环形旋转构件与可动构件连接的连杆构件，其中，所述面包包装系统构造成通过使所述环形旋转构件沿一个方向旋转来使所述可动构件沿着所述引导构件往复运动。

公开(公告)号：US08735401B2

公开(公告)日：2014-05-27

申请号：US13242541

申请日：2011-09-23

申请人： Nobuo Cho ,  Takashi Imada ,  Takenori Hitaka ,  Kazuhiro Miwa ,  Masami Kusuka ,  Nobuhiro Suzuki

发明人： Nobuo Cho ,  Takashi Imada ,  Takenori Hitaka ,  Kazuhiro Miwa ,  Masami Kusuka ,  Nobuhiro Suzuki

IPC分类号： A61K31/519 ,  A61P35/04 ,  C07D495/04

CPC分类号： C07D495/04 ,  A61K31/519

摘要： The present invention provides a compound represented by the formula: wherein R1 is a C1-4 alkyl; R2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a hydroxy group, (3′) a C1-4 alkyl and (4′) a C1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a C1-4 alkoxy-C1-4 alkyl, (3′) a mono-C1-4 alkyl-carbamoyl-C1-4 alkyl, (4′) a C1-4 alkoxy and (5′) a mono-C1-4 alkylcarbamoyl-C1-4 alkoxy, or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.

摘要翻译： 本发明提供由下式表示的化合物：其中R1是C1-4烷基; R2是（1）可以具有选自（1'）卤素，（2'）羟基，（3'），C 1〜C 6的取代基的5〜7元含氮杂环基， 4烷基和（4'）C 1-4烷氧基，（2）可具有选自（1'）卤素，（2'）C 1-4烷氧基-C 1-4烷基的取代基的苯基 ，（3'）单-C 1-4烷基 - 氨基甲酰基-C 1-4烷基，（4'）C 1-4烷氧基和（5'）单-C 1-4烷基氨基甲酰基-C 1-4烷氧基等 ; R3是C1-4烷基; R4是C1-4烷氧基等; n为1〜4的整数， 或其盐作为具有促性腺激素释放激素拮抗活性的噻吩并嘧啶化合物。

公开(公告)号：US08435880B2

公开(公告)日：2013-05-07

申请号：US12906217

申请日：2010-10-18

申请人： Akira Ohmae ,  Kota Tokuda ,  Masayuki Arimochi ,  Nobuhiro Suzuki ,  Michinori Shiomi ,  Tomonori Hino ,  Katsunori Yanashima

发明人： Akira Ohmae ,  Kota Tokuda ,  Masayuki Arimochi ,  Nobuhiro Suzuki ,  Michinori Shiomi ,  Tomonori Hino ,  Katsunori Yanashima

IPC分类号： H01L33/00

CPC分类号： H01L33/16 ,  H01L33/007 ,  H01L33/32 ,  H01S5/3013

摘要： In a method for manufacturing a semiconductor device, the method includes the step of growing a nitride-based III-V compound semiconductor layer, which forms a device structure, directly on a substrate without growing a buffer layer, the substrate being made of a material with a hexagonal crystal structure and having a principal surface that is oriented off at an angle of not less than −0.5° and not more than 0° from an R-plane with respect to a direction of a C-axis.

摘要翻译： 在制造半导体器件的方法中，该方法包括以下步骤：在不生长缓冲层的情况下，直接在衬底上生长形成器件结构的氮化物III-V族化合物半导体层，该衬底由材料 具有六边形晶体结构，并且具有相对于C轴方向从R平面以不小于-0.5°且不大于0°的角度取向的主表面。

公开(公告)号：US20100071987A1

公开(公告)日：2010-03-25

申请号：US12516965

申请日：2007-11-30

申请人： Koji Hyodo ,  Tetsuji Tanaka ,  Eiichi Sakai ,  Nobuhiro Suzuki ,  Koji Takano

发明人： Koji Hyodo ,  Tetsuji Tanaka ,  Eiichi Sakai ,  Nobuhiro Suzuki ,  Koji Takano

IPC分类号： F16H61/00 ,  G06F19/00

CPC分类号： F16H61/0213 ,  E02F9/2079 ,  E02F9/2083 ,  E02F9/2253 ,  F16H59/44 ,  F16H59/68 ,  F16H2059/467 ,  Y10T477/60 ,  Y10T477/62427 ,  Y10T477/6934

摘要： A speed change control system for an industrial vehicle includes: a speed ratio detecting unit that detects a speed ratio of speeds of an input shaft and of an output shaft of a torque converter; a torque converter speed ratio-based speed changer that shifts up or shifts down a speed stage of a transmission 3 in response to the detected speed ratio; a vehicle speed detection unit that detects a speed of the vehicle; a mode selection unit that selects any one of an L-mode and an H-mode; and a speed change control unit that permits an upshift provided that the vehicle speed is equal to or higher than a first predetermined value when the L-mode is selected whereas permits the upshift provided that the vehicle speed is higher than another predetermined value which is larger that the predetermined value when the H-mode is selected.

摘要翻译： 一种用于工业车辆的变速控制系统包括：速比检测单元，其检测变矩器的输入轴和输出轴的速度的速度比; 基于变速器速比的变速器，其响应于所检测的速比而向变速器3的转速级向上或向下移动; 车速检测单元，其检测车辆的速度; 模式选择单元，其选择L模式和H模式中的任一个; 以及变速控制单元，其允许升档，条件是当选择L模式时，车速等于或高于第一预定值，而允许升档，只要车速高于另一个较大的预定值 选择H模式时的预定值。

公开(公告)号：US07469991B2

公开(公告)日：2008-12-30

申请号：US11277242

申请日：2006-03-23

申请人： Nobuhiro Suzuki ,  Hirobumi Tabata ,  Akihiko Koshimizu

发明人： Nobuhiro Suzuki ,  Hirobumi Tabata ,  Akihiko Koshimizu

IPC分类号： B41J2/21

CPC分类号： G03G15/5058 ,  G03G15/0131 ,  G03G15/0194 ,  G03G2215/00059 ,  G03G2215/00063 ,  G03G2215/0119 ,  G03G2215/0161

摘要： An image forming apparatus includes a counter that counts the accumulated number of predetermined printed recording sheets and an image correction controller that performs an image correction operation when the accumulated number of recording sheets reaches a predetermined number. The image forming apparatus is configured to advance an execution timing of the image correction operation, depending on its predetermined operating status.

摘要翻译： 图像形成装置包括计数器，其计数预定打印的记录纸张的累积数量，以及当累积的记录纸张数达到预定数量时执行图像校正操作的图像校正控制器。 图像形成装置被配置为根据其预定的操作状态推进图像校正操作的执行定时。

公开(公告)号：US20080108623A1

公开(公告)日：2008-05-08

申请号：US11848939

申请日：2007-08-31

申请人： Nobuo Cho ,  Takashi Imada ,  Takenori Hitaka ,  Kazuhiro Miwa ,  Masami Kusaka ,  Nobuhiro Suzuki

发明人： Nobuo Cho ,  Takashi Imada ,  Takenori Hitaka ,  Kazuhiro Miwa ,  Masami Kusaka ,  Nobuhiro Suzuki

IPC分类号： A61K31/495 ,  A61K31/519 ,  C07D495/04 ,  C07D401/02 ,  A61P5/04

CPC分类号： C07D495/04 ,  A61K31/519

摘要： The present invention provides a compound represented by the formula: wherein R1 is a C1-4 alkyl; R2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a hydroxy group, (3′) a C1-4 alkyl and (4′) a C1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1′) a halogen, (2′) a C1-4 alkoxy-C1-4 alkyl, (3′) a mono-C1-4 alkyl-carbamoyl-C1-4 alkyl, (4′) a C1-4 alkoxy and (5′) a mono-C1-4 alkylcarbamoyl-C1-4 alkoxy, or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy, or the like; n is an integer of 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin-releasing hormone antagonistic activity.

摘要翻译： 本发明提供由下式表示的化合物：其中R 1是C 1-4烷基; R 2是（1）可以具有选自（1'）卤素，（2'）羟基的取代基的5-至7-元含氮杂环基 ，（3'）C 1-4烷基和（4'）C 1-4烷氧基，（2）可以具有选自以下的取代基的苯基： （1'）卤素，（2'），C 1-4烷氧基-C 1-4烷基，（3'）单-C 烷基 - 氨基甲酰基-C 1-4烷基，（4'）C 1-4烷氧基和（5'）单 -C 1-4烷基氨基甲酰基-C 1-4烷氧基等; R 3是C 1-4烷基; R 4是C 1-4烷氧基等; n为1〜4的整数， 或其盐作为具有促性腺激素释放激素拮抗活性的噻吩并嘧啶化合物。