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公开(公告)号:US11717179B2
公开(公告)日:2023-08-08
申请号:US17855865
申请日:2022-07-01
Applicant: Medtronic MiniMed, Inc.
Inventor: Andrea Varsavsky , Fei Yu , Ning Yang
IPC: A61B5/0537 , A61B5/145 , A61B5/1468 , A61B5/00 , A61M5/158 , A61B5/0538 , A61B5/1473 , A61B5/1495 , A61B5/1486 , G01N27/02 , A61M5/172 , A61M5/142
CPC classification number: A61B5/0537 , A61B5/0538 , A61B5/1468 , A61B5/1473 , A61B5/1495 , A61B5/14532 , A61B5/14865 , A61B5/7221 , A61B5/7246 , A61M5/1582 , G01N27/026 , A61B5/6849 , A61M5/14244 , A61M5/14276 , A61M2005/1726
Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
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公开(公告)号:US20220378315A1
公开(公告)日:2022-12-01
申请号:US17855865
申请日:2022-07-01
Applicant: Medtronic MiniMed, Inc.
Inventor: Andrea Varsavsky , Fei Yu , Ning Yang
IPC: A61B5/0537 , A61B5/145 , A61B5/1468 , A61B5/00 , A61M5/158 , A61B5/0538 , A61B5/1473 , A61B5/1495 , A61B5/1486 , G01N27/02
Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
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公开(公告)号:US11484651B2
公开(公告)日:2022-11-01
申请号:US16596675
申请日:2019-10-08
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Andrea Varsavsky , Yunfeng Lu , Keith Nogueira , Jeffrey Nishida
IPC: A61M5/172 , G16H40/63 , G16H40/40 , G16H50/20 , G16H10/60 , G16H50/50 , G16H20/17 , A61B5/145 , A61B5/00 , G16H15/00 , A61M5/142 , A61B5/024
Abstract: Medical devices and related patient management systems and parameter modeling methods are provided. An exemplary method of operating a sensing device associated with a patient involves obtaining current operational context information associated with the sensing device, obtaining a parameter model associated with the patient, calculating a current parameter value based on the parameter model and the current operational context information, obtaining one or more signals from a sensing element configured to measure a condition in a body of the patient, and providing an output that is influenced by the calculated current parameter value and the one or more signals.
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公开(公告)号:US11471082B2
公开(公告)日:2022-10-18
申请号:US15840673
申请日:2017-12-13
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Andrea Varsavsky , Jeffrey Nishida , Taly G. Engel , Keith Nogueira , Andy Y. Tsai , Peter Ajemba
IPC: A61B5/1495 , A61B5/1473 , A61B5/145 , A61B5/00 , A61M5/142 , A61M5/172 , A61B5/1486
Abstract: A continuous glucose monitoring system may employ complex redundancy to take operational advantage of disparate characteristics of two or more dissimilar, or non-identical, sensors, including, e.g., characteristics relating to hydration, stabilization, and durability of such sensors. Fusion algorithms, Electrochemical Impedance Spectroscopy (EIS), and advanced Application Specific Integrated Circuits (ASICs) may be used to implement use of such redundant glucose sensors, devices, and sensor systems in such a way as to bridge the gaps between fast start-up, sensor longevity, and accuracy of calibration-free algorithms. Systems, devices, and algorithms are described for achieving a long-wear and reliable sensor which also minimizes, or eliminates, the need for BG calibration, thereby providing a calibration-free, or near calibration-free, sensor.
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55.
公开(公告)号:US11344235B2
公开(公告)日:2022-05-31
申请号:US16117733
申请日:2018-08-30
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Keith Nogueira , Peter Ajemba , Michael E. Miller , Steven C. Jacks , Jeffrey Nishida , Andy Y. Tsai , Andrea Varsavsky
IPC: A61B5/1495 , A61B5/145 , A61B5/1486 , A61B5/00 , G06N5/02 , G16H50/30 , G01N27/02 , G16H20/17 , G16H50/70 , A61B5/1468 , G16H40/40 , A61B5/1455 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/11
Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.
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公开(公告)号:US20200245910A1
公开(公告)日:2020-08-06
申请号:US16773422
申请日:2020-01-27
Applicant: MEDTRONIC MINIMED, INC
Inventor: Georgios Mallas , Andrea Varsavsky , Peter Ajemba , Jeffrey Nishida , Keith Nogueira , Elaine Gee , Leonardo Nava-Guerra , Jing Liu , Sadaf S. Seleh , Taly G, Engel , Benyamin Grosman , Steven Lai , Luis A. Torres , Chi A. Tran , David M. Sniecinski
IPC: A61B5/145 , A61B5/1468
Abstract: A continuous glucose monitoring system may utilize electrode current (Isig) signals, Electrochemical Impedance Spectroscopy (EIS), and Vcntr values to optimize sensor glucose (SG) calculation in such a way as to enable reduction of the need for blood glucose (BG) calibration requests from users.
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公开(公告)号:US10321844B2
公开(公告)日:2019-06-18
申请号:US14466138
申请日:2014-08-22
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Andrea Varsavsky , Fei Yu , Michael E. Miller , Ning Yang
IPC: A61B5/1495 , A61B5/053 , A61B5/145 , A61B5/1468 , A61B5/00 , A61B5/1473 , A61B5/1486 , G01N27/02 , A61M5/158 , A61M5/172 , A61M5/142
Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.
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公开(公告)号:US20190175080A1
公开(公告)日:2019-06-13
申请号:US15840673
申请日:2017-12-13
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Andrea Varsavsky , Jeffrey Nishida , Taly G. Engel , Keith Nogueira , Andy Y. Tsai , Peter Ajemba
IPC: A61B5/1495 , A61B5/145 , A61B5/1473 , A61B5/00 , A61M5/142 , A61M5/172
Abstract: A continuous glucose monitoring system may employ complex redundancy to take operational advantage of disparate characteristics of two or more dissimilar, or non-identical, sensors, including, e.g., characteristics relating to hydration, stabilization, and durability of such sensors. Fusion algorithms, Electrochemical Impedance Spectroscopy (EIS), and advanced Application Specific Integrated Circuits (ASICs) may be used to implement use of such redundant glucose sensors, devices, and sensor systems in such a way as to bridge the gaps between fast start-up, sensor longevity, and accuracy of calibration-free algorithms. Systems, devices, and algorithms are described for achieving a long-wear and reliable sensor which also minimizes, or eliminates, the need for BG calibration, thereby providing a calibration-free, or near calibration-free, sensor.
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公开(公告)号:US10258264B2
公开(公告)日:2019-04-16
申请号:US15483404
申请日:2017-04-10
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Andrea Varsavsky , Xiaolong Li , Mike C. Liu , Yuxiang Zhong , Ning Yang
IPC: A61B5/00 , A61B5/145 , A61M5/142 , A61M5/172 , A61B5/1455 , A61B5/1459 , A61B5/1468 , A61B5/1473 , A61B5/1495 , C12Q1/00 , G01N21/00 , G01N21/59 , G01N21/84 , G01N27/27 , G01N33/49 , G01N33/66 , G01N27/327 , G01N27/416
Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.
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60.
公开(公告)号:US20190076070A1
公开(公告)日:2019-03-14
申请号:US16117733
申请日:2018-08-30
Applicant: MEDTRONIC MINIMED, INC.
Inventor: Keith Nogueira , Peter Ajemba , Michael E. Miller , Steven C. Jacks , Jeffrey Nishida , Andy Y. Tsai , Andrea Varsavsky
IPC: A61B5/145 , A61B5/1495 , A61B5/1486
Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free, or near calibration-free, sensor.
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