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公开(公告)号：US06265215B1
公开(公告)日：2001-07-24
申请号：US08713354
申请日：1996-09-13
IPC分类号： C12N508
CPC分类号： C07K14/4748 , A61K38/00
摘要： This invention involves the identification of peptides which complex with HLA-Cw*16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and therapeutic uses are described.
摘要翻译： 本发明涉及鉴定与HLA-Cw * 16分子复合的肽，然后可以通过溶细胞T细胞引起它们结合的细胞的裂解。 描述诊断和治疗用途。
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52.发明授权Isolated peptides which complex with HLA-Cw*16 molecules, and uses thereof 失效与HLA-Cw * 16分子复合的分离的肽及其用途
公开(公告)号：US5928938A
公开(公告)日：1999-07-27
申请号：US993738
申请日：1997-12-19
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K7/00 , C07K7/06 , C07K14/47 , C12N5/08 , C12N5/10 , C12N15/12 , C12N15/63 , C07H21/04 , C12N15/85
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention involves the identification of peptides which complex with HLA-Cw.sup.* 16 molecules, and which may then provoke lysis of the cells to which they bind, by cytolytic T cells. Diagnostic and therapeutic uses are described.
摘要翻译： 本发明涉及鉴定与HLA-Cw * 16分子复合的肽，然后可以通过溶细胞T细胞引起它们结合的细胞的裂解。 描述诊断和治疗用途。
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公开(公告)号：US5905145A
公开(公告)日：1999-05-18
申请号：US36467
申请日：1998-03-06
IPC分类号： C12N15/09 , A61K38/00 , C07K14/47 , C12N5/10 , C12P21/02 , C12Q1/68 , C07H21/04 , C12N5/06 , C12N15/85
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as TAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as TAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described.
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54.发明授权Isolated peptides derived from the gage tumor rejection antigen precursor and uses thereof 失效衍生自量规肿瘤排斥抗原前体的分离的肽及其用途
公开(公告)号：US5858689A
公开(公告)日：1999-01-12
申请号：US531662
申请日：1995-09-21
IPC分类号： G01N33/48 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/525 , C12N15/09 , C12N15/12 , C12Q1/00 , C07K7/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： A new family of tumor rejection antigen precursors, and the nucleic acid molecules which code for them, are disclosed. These tumor rejection antigen precursors are referred to as GAGE tumor rejection antigen precursors, and the nucleic acid molecules which code for them are referred to as GAGE coding molecules. Various diagnostic and therapeutic uses of the coding sequences and the tumor rejection antigens, and their precursor molecules are described. Tumor rejection antigens are also shown.
摘要翻译： 公开了一种新的肿瘤排斥抗原前体家族及其编码的核酸分子。 这些肿瘤排斥抗原前体被称为GAGE肿瘤排斥抗原前体，编码它们的核酸分子被称为GAGE编码分子。 描述了编码序列和肿瘤排斥抗原及其前体分子的各种诊断和治疗用途。 还显示肿瘤排斥抗原。
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55.发明授权Method for identifying individuals suffering from a cellular abnormality some of whose abnormal cells present complexes of HLA-C-clone 10/MAGE-1 derived peptides, and methods for treating said individuals 失效用于鉴定患有细胞异常的个体的方法，其一些异常细胞呈现HLA-C-克隆10 / MAGE-1衍生肽的复合物，以及用于治疗所述个体的方法
公开(公告)号：US5629166A
公开(公告)日：1997-05-13
申请号：US288977
申请日：1994-08-11
IPC分类号： G01N33/566 , A61K31/70 , A61K35/14 , A61K38/00 , A61K38/17 , A61K39/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07K14/47 , C07K14/74 , C12N5/08 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/04 , G01N33/574
CPC分类号： A61K48/00 , C07K14/4748 , C07K14/70539 , A61K38/00 , A61K39/00
摘要： The invention relates to the identification of complexes of HLA-C-clone 10 and MAGE-1 derived peptides on the surfaces of abnormal cells. The therapeutic and diagnostic ramifications of this observation are the subject of the invention.
摘要翻译： 本发明涉及在异常细胞表面鉴定HLA-C-clone 10和MAGE-1衍生肽的复合物。 该观察的治疗和诊断结果是本发明的主题。
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公开(公告)号：US5554724A
公开(公告)日：1996-09-10
申请号：US217188
申请日：1994-03-24
申请人： Cornelis J. M. Melief , M. J. W. Visseren , W. M. Kast , Pierre van der Bruggen , Thierry Boon-Falleur
发明人： Cornelis J. M. Melief , M. J. W. Visseren , W. M. Kast , Pierre van der Bruggen , Thierry Boon-Falleur
IPC分类号： C12P21/08 , A61K35/26 , A61K38/00 , A61K38/04 , A61K39/00 , A61K39/395 , A61P35/00 , A61P37/00 , C07K5/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/705 , C07K14/74 , C07K16/28 , C12N5/00 , C07K7/00 , A61K38/08
CPC分类号： C07K14/4748 , C07K14/705 , A61K2039/5158 , A61K38/00 , A61K39/00 , Y10S530/828 , Y10S530/868
摘要： The invention describes peptides derived from tumor rejection antigen precursor MAGE-2. These peptides bind with HLA-A2 molecules, thus presenting complexes which provoke cytolytic T cell production. The resulting "CTLs" are specific for complexes of HLA-A2 and the peptide. The complexes can be used to generate monoclonal antibodies. The cytolytic T cells produced may be used in the context of immunotherapy, such as adoptive transfer.
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57.发明授权Monoclonal antibodies which bind to tumor rejection antigen precursor mage-1 失效结合肿瘤排斥抗原前体法师-1的单克隆抗体
公开(公告)号：US5541104A
公开(公告)日：1996-07-30
申请号：US190411
申请日：1994-02-01
申请人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Pierre van der Bruggen , Thierry Boon-Falleur , Lloyd J. Old
发明人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Pierre van der Bruggen , Thierry Boon-Falleur , Lloyd J. Old
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07H21/04 , C07K20060101 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/30 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/574 , C12P21/04 , C07K16/00 , C12N5/00
CPC分类号： C07K14/4748 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
摘要翻译： 本发明涉及与肿瘤排斥抗原前体分子MAGE-1特异性结合的单克隆抗体，产生这些单克隆抗体的杂交瘤及其应用。 还描述了重组形式的MAGE-1，可用作免疫原的肽和含有肽和佐剂的免疫原性组合物。
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公开(公告)号：US06531451B1
公开(公告)日：2003-03-11
申请号：US09289350
申请日：1999-04-09
申请人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen
发明人： Pascal Chaux , Rosalie Luiten , Nathalie Demotte , Marie-Therese Duffour , Christophe Lurquin , Catia Traversari , Vincent Stroobant , Guy Cornelis , Thiery Boon-Falleur , Pierre van der Bruggen
IPC分类号： A61K3800
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for MAGE-1 and MAGE-4, respectively. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to the MAGE-1 and MAGE-4 antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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公开(公告)号：US06488932B1
公开(公告)日：2002-12-03
申请号：US08571263
申请日：1995-12-12
申请人： Thierry Boon , Pierre van der Bruggen , Etienne De Plaen , Christophe Lurquin , Catia Traversari
发明人： Thierry Boon , Pierre van der Bruggen , Etienne De Plaen , Christophe Lurquin , Catia Traversari
IPC分类号： C07K500
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention involves the reception of particular nonapeptides by HLA molecules. The nonapeptides are derived from expression products of the MAGE gene family. The resulting complexes are identified by cytolytic T cells. Such recognition may be used in diagnostics, or therapeutically.
摘要翻译： 本发明涉及由HLA分子接收特定的非肽。 所述非肽源自MAGE基因家族的表达产物。 所得复合物通过溶细胞T细胞鉴定。 这种识别可用于诊断或治疗。
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60.发明授权Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 失效编码肿瘤排斥抗原前体MAGE-1的核苷酸序列
公开(公告)号：US5342774A
公开(公告)日：1994-08-30
申请号：US807043
申请日：1991-12-12
申请人： Thierry Boon , Pierre van der Bruggen , Benoit Van den Eynde , Aline Van Pel , Etienne De Plaen , Christophe Lurquin , Patrick Chomez , Catia Traversari
发明人： Thierry Boon , Pierre van der Bruggen , Benoit Van den Eynde , Aline Van Pel , Etienne De Plaen , Christophe Lurquin , Patrick Chomez , Catia Traversari
IPC分类号： A61K31/70 , A61K9/127 , A61K35/12 , A61K35/14 , A61K35/18 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K7/06 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/525 , C07K14/54 , C07K14/55 , C07K14/705 , C07K16/00 , C07K16/30 , C07K16/42 , C07K17/00 , C12N1/00 , C12N1/20 , C12N1/21 , C12N5/10 , C12N7/00 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/19 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/577 , G01N33/68 , C07H15/12 , C07K3/00 , C12N1/16 , C12N1/18 , C12N5/00 , C12P19/34
CPC分类号： C07K16/30 , C07K14/4748 , A61K38/00 , A61K39/00
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
摘要翻译： 本发明涉及编码由细胞毒性T细胞识别的肿瘤细胞表达的抗原的分离的DNA序列，导致表达肿瘤的裂解。 还描述了由DNA序列转染的细胞，以及由其编码的DNA和抗原的性质产生的各种治疗和诊断用途。
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