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公开(公告)号：US07674902B2
公开(公告)日：2010-03-09
申请号：US11572920
申请日：2005-08-03
IPC分类号： C07D471/00
CPC分类号： C09K11/06 , A61K49/0013 , C07C237/02 , C07C237/12 , C09K2211/188
摘要： Some embodiments of the present invention may be said to be directed to metal complexes of Formula I, wherein at least one of X1, X2, X3, R1, R2, R3, R4 and R5 is what may be characterized as an antenna capable of providing (e.g., absorbing and/or emitting) an appropriate electromagnetic signal. Some embodiments of the present invention are directed to ligands corresponding to metal complexes of Formula I. Some embodiments of the invention are directed to methods of determining renal function using at least one metal complex of Formula I.
摘要翻译： 可以说本发明的一些实施方案涉及式I的金属络合物，其中X 1，X 2，X 3，R 1，R 2，R 3，R 4和R 5中的至少一个是可以被表征为能够提供 （例如，吸收和/或发射）适当的电磁信号。 本发明的一些实施方案涉及对应于式I的金属配合物的配体。本发明的一些实施方案涉及使用至少一种式I的金属络合物测定肾功能的方法。
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公开(公告)号：US20100047173A1
公开(公告)日：2010-02-25
申请号：US12515294
申请日：2007-11-13
IPC分类号： A61K49/00
CPC分类号： A61K49/0034 , A61K49/0043
摘要： In certain embodiments, the present invention is directed to novel processes for using hepatobiliary cleared optical agents to detect one or more tissues of the biliary tract of a surgical patient. In certain embodiments, the invention is directed to kits that include one or more optical agents and instructions for using the agent(s), for example, in a process of the invention.
摘要翻译： 在某些实施方案中，本发明涉及使用肝胆清除的光学剂来检测手术患者的胆道的一个或多个组织的新方法。 在某些实施方案中，本发明涉及包含一种或多种光学试剂的试剂盒，以及例如在本发明的方法中使用该试剂的说明书。
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53.发明授权Pathological tissue detection and treatment employing targeted benzoindole optical agents 失效使用靶向苯并吲哚光学剂的病理组织检测和治疗公开(公告)号：US07510700B2
公开(公告)日：2009-03-31
申请号：US11388382
申请日：2006-03-24
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
摘要翻译： 公开了新型肿瘤特异性光疗法和光诊断剂。 该化合物包括用于可视化的碳菁染料，用于光动力学治疗的光敏剂和用于将位点特异性递送探针和光毒性剂到患病组织的肿瘤受体 - 鸟苷肽。 这些元素的组合充分利用了每个组件的独特而有效的特性来进行有效的患者护理管理。
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公开(公告)号：US20080233050A1
公开(公告)日：2008-09-25
申请号：US11371572
申请日：2006-03-09
CPC分类号： C07D209/12 , A61K41/0033 , A61K41/0057 , A61K49/0021 , A61K49/0032 , A61K49/0056 , C07D403/06 , C07D403/08 , C07D405/14 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/0075 , C09B23/08 , C09B23/086
摘要： Disclosed herein are compounds that may be characterized by some as cyanine and indocyanine dye bioconjugates. Compounds disclosed herein may be utilized (e.g., in the form of a pharmaceutically acceptable composition) in a number of medical procedures, such as in the visualization and detection of tumors.
摘要翻译： 本文公开的化合物可以被某些特征化为花青和吲哚菁染料生物缀合物。 本文公开的化合物可以在许多医学过程中使用（例如，以药学上可接受的组合物的形式），例如在肿瘤的可视化和检测中。
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公开(公告)号：US07351807B2
公开(公告)日：2008-04-01
申请号：US09898809
申请日：2001-07-03
IPC分类号： C07K1/00 , C07K16/00 , C12P21/08 , C07D401/00 , C07D403/00
CPC分类号： A61K41/0033 , A61K41/0057 , A61K41/0071 , A61K49/0032 , A61K49/0056 , C09B23/083 , C09B47/065 , C09B47/0678 , C09B47/26
摘要： Dye-sulfenate derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds comprise sulfenates having the formula, t,0080where E is selected from the group consisting of somatostatin receptor binding molecules, heat sensitive bacterioendotoxin receptor binding molecules, neurotensin receptor binding molecules, bombesin receptor binding molecules, cholecystekinin receptor binding molecules, steroid receptor binding molecules, and carbohydrate receptor binding molecules, and dihydoxyindolecarboxylic acid; L and X are independently selected from the group consisting of —(R5)NOC—, —(R5)NOCCH2O—, —(R5)NOCCH2CH2O—, —OCN(R5)—, —HNC(═S)NH—, and HNC(═O)NH—; DYE is an aromatic or a heteroaromatic radical derived from the group consisting of cyanines, indocyanines, phthalocyanines, rhodamines, phenoxazines, phenothiazines, phenoselenazines, fluoresceins, porphyrins, benzoporphyrins, squaraines, corrins, croconiums, azo dyes, methine dyes, indolenium dyes, crellins, and hypocrellins; R1 to R5 are independently selected from the group comprising hydrogen, C1-C10 alkyl, C5-C10 aryl, C1-C10 polyhydroxyalkyl, and C1-C10 polyalkoxyalkyl; and Ar is an aromatic or heteroaromatic radical derived from the group consisting of benzenes, naphthalenes, naphthoquinones, diphenylmethanes, fluorenes, anthracenes, anthraquinones, phenanthrenes, tetracenes, naphthacenediones, pyridines, quinolines, isoquinolines, indoles, isoindoles, pyrroles, imidiazoles, oxazoles, thiazoles, pyrazoles, pyrazines, purines, benzimidazoles, furans, benzofurans, dibenzofurans, carbazoles, acridines, acridones, phenanthridines, thiophenes, benzothiophenes, dibenzothiophenes, xanthenes, xanthones, flavones, coumarins, and anthacylines. The compounds are designed to produce both Type 1 and Type 2 phototherapeutic effects at once using a dual wavelength light source that will produce singlet oxygen and free radicals at the lesion of interest.
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56.发明授权公开(公告)号：US07201892B2
公开(公告)日：2007-04-10
申请号：US10847257
申请日：2004-05-17
CPC分类号： C07D417/04 , A61K41/0057 , A61K47/62 , A61K49/0032 , A61K49/0034 , A61K49/0052 , A61K49/0056 , C07D209/60 , C07D417/14 , C09B23/086 , C09B47/00
摘要： Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.
摘要翻译： 公开了新型肿瘤特异性光疗法和光诊断剂。 该化合物包括用于可视化的碳菁染料，用于光动力学治疗的光敏剂和用于将位点特异性递送探针和光毒性剂到患病组织的肿瘤受体 - 鸟苷肽。 这些元素的组合充分利用了每个组件的独特而有效的特性来进行有效的患者护理管理。
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公开(公告)号：US06706254B2
公开(公告)日：2004-03-16
申请号：US09864011
申请日：2001-05-23
IPC分类号： A61B1000
CPC分类号： A61K49/0032 , A61K41/0033 , A61K41/0057 , A61K49/0056 , C09B23/0066 , C09B23/08
摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologes. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1,300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
摘要翻译： 公开了可用于诊断成像和治疗的花青染料生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350至1,300nm的范围内是有用的，精确的范围取决于特定的染料。 使用二甲基亚砜有助于维持化合物的荧光。 本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗。
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58.发明授权Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients 失效亲水性光吸收吲哚化合物，用于确定重症患者的生理功能公开(公告)号：US06669926B1
公开(公告)日：2003-12-30
申请号：US09688943
申请日：2000-10-16
IPC分类号： A61B1000
CPC分类号： C07D209/58 , A61K31/403 , A61K49/0021 , A61K49/0032 , C07D209/08 , C07D209/12 , C07D209/60
摘要： Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
摘要翻译： 公开了在可见光区域吸收和发出荧光的高度亲水的吲哚和苯并吲哚衍生物。 这些化合物可用于生理和器官功能监测。 特别地，本发明的分子可用于肾脏和心脏疾病的光学诊断以及体内血液体积估计。
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公开(公告)号：US06264920B1
公开(公告)日：2001-07-24
申请号：US09637518
申请日：2000-08-10
IPC分类号： A61B1000
CPC分类号： A61K41/0033
摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
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公开(公告)号：US06190641B1
公开(公告)日：2001-02-20
申请号：US09484323
申请日：2000-01-18
IPC分类号： A61B1000
CPC分类号： A61K49/0056 , A61K41/0033 , A61K41/0057 , A61K49/0032
摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发射光的新型吲哚菁染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。
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