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    Balloon catheter with integrated optical sensor for determining balloon diameter
    52.
    发明授权
    Balloon catheter with integrated optical sensor for determining balloon diameter 有权
    气囊导管，集成光学传感器，用于确定气球直径

    公开(公告)号：US08873900B2

    公开(公告)日：2014-10-28

    申请号：US13091319

    申请日：2011-04-21

    申请人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

    发明人： Patricia O'Beirne ,  Aram Jamous ,  John Kelly

    IPC分类号： G02B6/00 ,  A61M29/00 ,  A61M25/10 ,  G01L1/24

    CPC分类号： A61M25/104 ,  A61M2205/3306 ,  G01L1/246

    摘要： An apparatus and method for determining an expanded diameter of a catheter balloon. An optical sensor includes an elongated optical fiber with at least one diffraction grating formed in a core of a distal portion thereof. The fiber distal portion is coupled to the inflatable balloon. Broadband light is transmitted to the diffraction grating by an optical interrogator. A portion of the light is reflected from the diffraction grating and is received by a wavelength detector. The wavelength of the reflected portion of light is dependent on the strain applied to the diffraction grating. The wavelength detector determines the strain in the balloon and correlates the strain to the diameter of the balloon.

    摘要翻译： 一种用于确定导管球囊的扩大直径的装置和方法。 光学传感器包括细长光纤，其中至少一个衍射光栅形成在其远端部分的芯中。 纤维远端部分连接到可充气球囊。 宽光束通过光学询问器传输到衍射光栅。 一部分光从衍射光栅反射并被波长检测器接收。 光的反射部分的波长取决于施加到衍射光栅的应变。 波长检测器确定球囊中的应变并将应变与球囊的直径相关联。

    SPIRAL PERFUSION DILATATION BALLOON FOR USE IN VALVULOPLASTY PROCEDURE
    53.
    发明申请
    SPIRAL PERFUSION DILATATION BALLOON FOR USE IN VALVULOPLASTY PROCEDURE 有权
    螺旋膨胀性浮球用于戊型肝炎手术

    公开(公告)号：US20120245520A1

    公开(公告)日：2012-09-27

    申请号：US13072689

    申请日：2011-03-26

    申请人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

    发明人： John Kelly ,  Brian Kelly ,  Herinaina Rabarimanantsoa-Jamous

    IPC分类号： A61M25/10

    CPC分类号： A61M25/1002 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1084 ,  A61M2025/1097

    摘要： A balloon dilatation catheter for use in a valvuloplasty procedure includes a catheter shaft and a spiral perfusion balloon mounted thereon. The perfusion balloon is formed from an inflatable tube that is in fluid communication with a catheter shaft inflation lumen. The inflatable tube is coiled into a series of windings that in an inflated configuration form a cylindrical or hourglass profile. In the inflated configuration, inner surfaces of the coiled windings of the inflatable tube define a perfusion lumen to allow blood flow through the perfusion balloon. Adjacent windings may be secured together with a flexible adhesive and/or a support weave formed from one or more filaments of material that criss-crosses between the adjacent windings along substantially the entire length of the spiral perfusion balloon.

    摘要翻译： 用于瓣膜成形术的球囊扩张导管包括安装在其上的导管轴和螺旋灌注球囊。 灌注气球由与导管轴膨胀腔流体连通的可充气管形成。 可膨胀管被卷成一系列绕组，其以膨胀构型形成圆柱形或沙漏型。 在充气构造中，可膨胀管的线圈绕组的内表面限定了灌注腔，以允许血液流过灌注球囊。 相邻绕组可以用柔性粘合剂和/或由沿着螺旋形灌注气球的整个长度在相邻绕组之间交叉的一个或多个材料丝构成的支撑织物固定在一起。

    Apparatuses and methods for coupling a signal to and/or from a cable
    54.
    发明授权
    Apparatuses and methods for coupling a signal to and/or from a cable 有权
    用于将信号耦合到电缆和/或从电缆耦合的装置和方法

    公开(公告)号：US08217734B2

    公开(公告)日：2012-07-10

    申请号：US13079722

    申请日：2011-04-04

    申请人： Anthony Peyton ,  John Kelly

    发明人： Anthony Peyton ,  John Kelly

    IPC分类号： H01P5/00 ,  H03H7/42 ,  H01P3/00

    CPC分类号： G01R31/022 ,  G01R31/312 ,  H04Q1/136

    摘要： Apparatuses and methods for coupling a signal to and from a twisted pair cable by non-contact coupling with twisted pairs in the twisted pair cable, such that the signal propagates along the cable between at least two of the twisted pairs. In particular, a coupling unit for coupling a voltage signal to and/or from such a cable, the coupling unit having a first electrode and a second electrode. The electrodes may be electrically isolated from a voltage signal generator and/or a voltage signal processor.

    摘要翻译： 用于通过与双绞线中的双绞线的非接触耦合来将信号耦合到双绞线电缆的装置和方法，使得信号沿着电缆在至少两个双绞线之间传播。 特别地，耦合单元用于将电压信号耦合到和/或来自这种电缆，耦合单元具有第一电极和第二电极。 电极可以与电压信号发生器和/或电压信号处理器电隔离。

    CONDUCTIVE POLYMER ELECTRONIC DEVICES WITH SURFACE MOUNTABLE CONFIGURATION AND METHODS FOR MANUFACTURING SAME
    56.
    发明申请
    CONDUCTIVE POLYMER ELECTRONIC DEVICES WITH SURFACE MOUNTABLE CONFIGURATION AND METHODS FOR MANUFACTURING SAME 有权
    具有表面可配置配置的导电聚合物电子器件及其制造方法

    公开(公告)号：US20110175700A1

    公开(公告)日：2011-07-21

    申请号：US12294675

    申请日：2007-04-16

    申请人： Gordon L. Bourns ,  Stelar Chu ,  Daniel E. Grindell ,  David Huang ,  John Kelly ,  Eric Meijer

    发明人： Gordon L. Bourns ,  Stelar Chu ,  Daniel E. Grindell ,  David Huang ,  John Kelly ,  Eric Meijer

    IPC分类号： H01C7/13 ,  H05K3/10

    CPC分类号： H01C7/021 ,  H01C1/016 ,  H01C1/1406 ,  H01C1/1413 ,  H01C7/005 ,  H01C7/028 ,  H01C7/041 ,  H01C7/049 ,  H01C7/18 ,  H01C17/02 ,  H01C17/281 ,  Y10T29/49165

    摘要： Surface-mountable conductive polymer electronic devices include at least one conductive polymer active layer laminated between upper and lower electrodes. Upper and lower insulation layers, respectively, sandwich the upper and lower electrodes. First and second planar conductive terminals are formed on the lower insulation layer. First and second cross-conductors are provided by plated through-hole vias, whereby the cross-conductors connect each of the electrodes to one of the terminals. Certain embodiments include two or more active layers, arranged in a vertically-stacked configuration and electrically connected by the cross-conductors and electrodes in parallel. Several embodiments include at least one cross-conductor having a chamfered or beveled entry hole through the upper insulation layer to provide enhanced adhesion between the cross-conductor and the insulation layer. Several methods for manufacturing the present surface-mountable conductive polymer electronic devices are also provided.

    摘要翻译： 表面安装导电聚合物电子器件包括层压在上电极和下电极之间的至少一个导电聚合物有源层。 上下绝缘层分别夹着上下电极。 第一和第二平面导电端子形成在下绝缘层上。 第一和第二导体由电镀通孔通孔提供，由此将导体将每个电极连接到其中一个端子。 某些实施方案包括两个或更多个有源层，其被布置成垂直堆叠的构造并且由交叉导体和电极并联电连接。 几个实施例包括至少一个具有通过上绝缘层的倒角或斜面进入孔的交叉导体，以在交叉导体和绝缘层之间提供增强的粘合。 还提供了用于制造本表面安装导电聚合物电子器件的几种方法。

    PROCESS FOR PREPARING TRANSLUCENT PAPER OR FILM FOR USE WITH DIGITAL PRINTERS AND PRODUCT
    57.
    发明申请
    PROCESS FOR PREPARING TRANSLUCENT PAPER OR FILM FOR USE WITH DIGITAL PRINTERS AND PRODUCT 审中-公开
    用于制作数字打印机和产品的透明纸或薄膜的方法

    公开(公告)号：US20100075113A1

    公开(公告)日：2010-03-25

    申请号：US12359548

    申请日：2009-01-26

    申请人： Phil Schumacher ,  Bruce Peterson ,  John Kelly

    发明人： Phil Schumacher ,  Bruce Peterson ,  John Kelly

    IPC分类号： G03G5/00

    CPC分类号： G03G7/00 ,  G03G15/6591 ,  G03G2215/00497 ,  G03G2215/00502 ,  Y10T428/24802

    摘要： A method and system for conditioning transparent or translucent paper or film for use with digital printers includes the application of a primer coat to the paper or film that controls the hygroscopic characteristics of the paper or film followed by the application of a digital primer that enables the reception of ink or toner during printing thereon by a digital printer. Opaque markers, such as opaque strips, may also be formed on the sheet of paper or film to facilitate detection of the transparent or translucent sheet by sensors, such as “electronic eye” of the digital printer.

    摘要翻译： 用于调节与数字打印机一起使用的透明或半透明纸或薄膜的方法和系统包括在纸或薄膜上施加底漆涂层以控制纸或薄膜的吸湿特性，然后应用数字底漆， 在由数字打印机在其上打印期间接收墨水或墨粉。 也可以在纸或薄膜上形成不透明标记，例如不透明条，以便于通过诸如数字打印机的“电子眼”的传感器检测透明或半透明的片。

    Method and system of managing service reminders using mileage estimates
    58.
    发明授权
    Method and system of managing service reminders using mileage estimates 有权
    使用里程估算来管理服务提醒的方法和系统

    公开(公告)号：US07672984B2

    公开(公告)日：2010-03-02

    申请号：US10453904

    申请日：2003-06-02

    申请人： John Kelly ,  John Supra

    发明人： John Kelly ,  John Supra

    IPC分类号： G06F7/00

    CPC分类号： G06Q10/00

    摘要： The present invention provides a method and system for integrating a shop management system with a system for generating and sending service reminders based on the estimated mileage the vehicle. The mileage of the vehicle can be estimated based on the age of the vehicle, or it can be based on the last known mileage of the vehicle and estimating the additional mileage using average vehicle mileage statistics. The mileage of the vehicle may be estimated based on actual vehicle history, and may be adjusted based on the characteristics of the vehicle, the driver, or the geographic location of the vehicle.

    摘要翻译： 本发明提供了一种用于将商店管理系统与用于基于车辆的估计里程生成和发送服务提醒的系统进行集成的方法和系统。 车辆的里程可以根据车辆的年龄估算，或者可以基于车辆的最后已知里程，并使用平均车辆里程数据估计附加里程。 可以基于实际车辆历史来估计车辆的里程，并且可以基于车辆的特性，驾驶员或车辆的地理位置来调整车辆的里程。

    COMPOSITIONS AND METHODS HAVING MT1 RECEPTOR ACTIVITY
    59.
    发明申请
    COMPOSITIONS AND METHODS HAVING MT1 RECEPTOR ACTIVITY 审中-公开
    具有MT1受体活性的组合物和方法

    公开(公告)号：US20090023814A1

    公开(公告)日：2009-01-22

    申请号：US12165836

    申请日：2008-07-01

    申请人： John Devane ,  John Kelly ,  Mary Martin

    发明人： John Devane ,  John Kelly ,  Mary Martin

    IPC分类号： A61K31/137 ,  A61P1/00

    CPC分类号： A61K31/00 ,  A61K31/277 ,  A61K45/06

    摘要： The present invention is directed to compositions and to methods comprising a composition comprising a therapeutically effective amount of a pharmaceutically active agent such as (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats and/or manages at least one condition having MT1 receptor activity and releases the pharmaceutically active agent, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a primary activity on the MT1 receptor such as, exhibiting at least five times more activity on the MT1 receptor compared with the MT2 receptor.

    摘要翻译： 本发明涉及组合物和方法，其包含包含治疗有效量的药物活性剂如（R） - 维拉帕米，其衍生物或其药学上可接受的盐的组合物，其中所述组合物治疗和/或管理 至少一种具有MT1受体活性的病症，并且释放其药物活性剂，其衍生物或其药学上可接受的盐，以在MT1受体上显示出主要活性，例如与MT1受体相比表现出至少五倍的活性 MT2受体。

    Campylobacter glycans and glycopeptides
    60.
    发明申请
    Campylobacter glycans and glycopeptides 有权
    弯曲杆菌聚糖和糖肽

    公开(公告)号：US20060165728A1

    公开(公告)日：2006-07-27

    申请号：US10523459

    申请日：2003-07-30

    申请人： Noel Young ,  Jean-Robert Brisson ,  John Kelly ,  David Watson ,  Christine Szymanski ,  Harold Jarrell

    发明人： Noel Young ,  Jean-Robert Brisson ,  John Kelly ,  David Watson ,  Christine Szymanski ,  Harold Jarrell

    IPC分类号： A61K39/02 ,  C08B37/00 ,  C07K14/205 ,  C12Q1/04

    CPC分类号： G01N33/56922 ,  A61K39/105 ,  C07H3/06 ,  G01N2400/02 ,  Y02A50/47

    摘要： Multiple strains and species of Campylobacter were found to share a common glycan moitie which is present in a plurality of surface-exposed glycoproteins. This glycan has the formula: GalNAc-a1,4-GalNAc-a1,4-[Glc-β1,3]GalNAc-a1,4-GalNAc-a1,4-GalNAc-a1,3-Bac, wherein Bac is 2,4-diacetamido-2,4,6-trideoxy-D-glucopyranose. This glycan and immunologically active fragments of it have use as vaccines against campylobacter infection in humans and animals. As well, antibodies which specifically bind these compounds may be provided. Such antibodies and vaccines may be used to prevent or neutralize campylobacter infections in livestock thereby preventing this pathogen from entering the human food chain. The glycan may be linked to one or more amino acids to form a glycopeptide. As well, a method for determining the glycan structure of an intact glycoprotein consists of subjecting a sample to high resolution magic angle spinning nuclear magnetic resonance (HR-MAS-NMR) spectroscopy.

    摘要翻译： 发现多种菌株和种类的弯曲杆菌分享一种常见的多糖表面暴露糖蛋白中存在的多糖异味。 该聚糖具有下式：GalNAc-a1,4-GalNAc-a1,4 [Glc-β1,3] GalNAc-a1,4-GalNAc-a1,4-GalNAc-a1,3-Bac，其中Bac为2， 4-二乙酰氨基-2,4,6-三脱氧-D-吡喃葡萄糖。 该聚糖及其免疫活性片段可用作针对人和动物中弯曲杆菌感染的疫苗。 同样，可以提供特异性结合这些化合物的抗体。 这样的抗体和疫苗可用于预防或中和家畜中的弯曲杆菌感染，从而防止该病原体进入人类食物链。 聚糖可以连接到一个或多个氨基酸以形成糖肽。 同样，确定完整糖蛋白的聚糖结构的方法包括使样品进行高分辨率魔角旋转核磁共振（HR-MAS-NMR）光谱。