公开(公告)号：US20070150014A1

公开(公告)日：2007-06-28

申请号：US11315032

申请日：2005-12-22

Applicant: Andrew Kramer ,  Joseph Pastore ,  Jeffrey Stahmann ,  Rodney Salo ,  Jesse Hartley

Inventor： Andrew Kramer ,  Joseph Pastore ,  Jeffrey Stahmann ,  Rodney Salo ,  Jesse Hartley

IPC: A61N1/365

CPC classification number: A61N1/36557 ,  A61B5/6816 ,  A61B5/6826 ,  A61B5/6829 ,  A61B5/6838 ,  A61N1/36114 ,  A61N1/36564

Abstract: A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.

Abstract translation: 心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。 非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。 一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。

公开(公告)号：US20070088214A1

公开(公告)日：2007-04-19

申请号：US11250928

申请日：2005-10-14

Applicant: Allan Shuros ,  Rodney Salo ,  Michael Kane

Inventor： Allan Shuros ,  Rodney Salo ,  Michael Kane

IPC: A61B8/00

CPC classification number: A61B8/065 ,  A61B5/076 ,  A61B5/1076 ,  A61B5/6876 ,  A61B5/6884 ,  A61B8/02 ,  A61B8/06 ,  A61B8/12 ,  A61B8/4483

Abstract: An ultrasonic implantable device includes an ultrasonic sensor having a plurality of transducers. The sensor is configured for mounting to a vessel wall. A first of the transducers directs sound waves in a direction at least partially upstream or downstream in the vessel. A second of the transducers directs sound waves in a radial direction through an interior of the vessel against a sidewall of the vessel. The sensor monitors a change in frequency of the sound waves from the first transducer to determine a fluid velocity in the vessel. The sensor also monitors a reflection time of the sound waves from the second transducer that return from the sidewall to determine an internal diameter of the vessel. The determined fluid velocity and vessel diameter can be used to determine a volumetric flow rate of the fluid in the vessel.

Abstract translation: 超声波可植入装置包括具有多个换能器的超声波传感器。 传感器被配置为安装到血管壁。 换能器中的第一个将声波沿至少部分在容器的上游或下游的方向引导。 传感器中的第二个将声波沿径向引导通过容器的内部抵靠容器的侧壁。 传感器监测来自第一换能器的声波的频率变化以确定容器中的流体速度。 传感器还监测来自第二换能器的声波的反射时间，其从侧壁返回以确定容器的内径。 确定的流体速度和容器直径可用于确定容器中流体的体积流量。

公开(公告)号：US07206637B2

公开(公告)日：2007-04-17

申请号：US10979073

申请日：2004-11-01

Applicant: Rodney Salo

Inventor： Rodney Salo

IPC: A61N1/08

CPC classification number: A61N1/056 ,  A61N1/3627 ,  A61N1/3655 ,  A61N1/36571 ,  A61N2001/0585

Abstract: Methods of cardiac pacing involve sensing left ventricular electrical rhythms, sensing left ventricular blood flow rate, and sensing a coronary vein blood temperature. The methods further involve modifying delivery of synchronized electrical signals to the patient's heart based at least in part on the sensed coronary vein blood temperature and sensed left ventricular flow rate.

公开(公告)号：US20070060959A1

公开(公告)日：2007-03-15

申请号：US11223398

申请日：2005-09-09

Applicant: Rodney Salo ,  Abhijeet Chavan

Inventor： Rodney Salo ,  Abhijeet Chavan

IPC: A61N1/00 ,  A61B5/02

CPC classification number: A61N1/36564 ,  A61N1/3621 ,  A61N1/3925

Abstract: A system and method for administering a therapeutic treatment to the heart includes a pressure sensor positioned in the pulmonary artery, an implantable medical device located remotely from the sensor, and communication means for communicating pressure data from the pressure sensor to the implantable medical device. The system includes a control module operatively coupled to the implantable medical device. The control module is adapted for comparing the pulmonary arterial pressure data to a pre-programmed value, adjusting an operating parameter of the implantable medical device based on the relationship of the pulmonary arterial pressure to the pre-programmed value, and repeating this process until the relationship between the pulmonary arterial pressure data and the pre-programmed value is such that no adjustment is necessary.

Abstract translation: 用于向心脏施用治疗性治疗的系统和方法包括定位在肺动脉中的压力传感器，远离传感器定位的可植入医疗装置，以及用于将来自压力传感器的压力数据传送到可植入医疗装置的连通装置。 该系统包括可操作地耦合到可植入医疗装置的控制模块。 控制模块适于将肺动脉压数据与预编程值进行比较，基于肺动脉压与预编程值的关系来调整可植入医疗装置的操作参数，并重复该过程直到 肺动脉压数据与预编程值之间的关系使得不需要调整。

公开(公告)号：US20070055317A1

公开(公告)日：2007-03-08

申请号：US11220023

申请日：2005-09-06

Applicant: Jeffrey Stahmann ,  Joseph Pastore ,  Andrew Kramer ,  Rodney Salo ,  Jesse Hartley

Inventor： Jeffrey Stahmann ,  Joseph Pastore ,  Andrew Kramer ,  Rodney Salo ,  Jesse Hartley

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36114 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/3684

Abstract: A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an intravascular pressure measurement in order to balance the beneficial effects of stress reduction with hemodynamic compromise.

Abstract translation: 描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。 根据血管内压力测量调节预激发起搏，以平衡应力减少与血液动力学妥协的有益效果。

公开(公告)号：US20070005114A1

公开(公告)日：2007-01-04

申请号：US11169339

申请日：2005-06-29

Applicant: Rodney Salo ,  Joseph Pastore ,  Jeffrey Stahmann ,  Jesse Hartley

Inventor： Rodney Salo ,  Joseph Pastore ,  Jeffrey Stahmann ,  Jesse Hartley

IPC: A61N1/00

CPC classification number: A61N1/36521 ,  A61N1/30

Abstract: A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.

Abstract translation: 一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路 和治疗电路。 控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

公开(公告)号：US20060287683A1

公开(公告)日：2006-12-21

申请号：US11276741

申请日：2006-03-13

Applicant: Joseph Pastore ,  Rodney Salo ,  Jesse Hartley ,  Andrew Kramer ,  Jeffrey Stahmann

Inventor： Joseph Pastore ,  Rodney Salo ,  Jesse Hartley ,  Andrew Kramer ,  Jeffrey Stahmann

IPC: A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/36521 ,  A61N1/3684

Abstract: A method and device for delivering pre-excitation pacing to prevent or reduce cardiac remodeling following a myocardial infarction is described. The pre-excitation pacing is modulated in accordance with an assessment of cardiac function in order to balance the beneficial effects of stress reduction with hemodynamic compromise.

Abstract translation: 描述了用于递送预激发起搏以预防或减少心肌梗塞后的心脏重塑的方法和装置。 根据心脏功能的评估调节预激励起搏，以平衡应力减少与血液动力学妥协的有益效果。

公开(公告)号：US20050102000A1

公开(公告)日：2005-05-12

申请号：US10981019

申请日：2004-11-03

Applicant: Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

Inventor： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

IPC: A61N1/362 ,  A61N1/368 ,  A61N1/36

CPC classification number: A61N1/3627 ,  A61N1/3684

Abstract: A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

Abstract translation: 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

公开(公告)号：US20050043675A1

公开(公告)日：2005-02-24

申请号：US10645823

申请日：2003-08-21

Applicant: Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

Inventor： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

IPC: A61B5/00 ,  A61B5/11 ,  A61M5/142 ,  A61M5/172 ,  A61M31/00 ,  A61N1/362

CPC classification number: A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

Abstract: A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

Abstract translation: 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

公开(公告)号：US06666826B2

公开(公告)日：2003-12-23

申请号：US10038936

申请日：2002-01-04

Applicant: Rodney Salo ,  Angelo Auricchio

Inventor： Rodney Salo ,  Angelo Auricchio

IPC: A61B502

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N2001/0585

Abstract: A body implantable system employs a lead system having at least one electrode and at least one pressure transducer at a distal end. The lead system is implanted within a patient's heart in a coronary vein of the left ventricle. The lead system includes an occlusion device at a distal end to occlude flow in the coronary vein. The pressure transducer is attached to a catheter that is disposed within an open lumen of the lead system. The pressure transducer senses a coronary vein pressure, the coronary vein pressure being proportional to the left ventricular pressure. The sensed coronary vein pressure gives indications of hemodynamic state of the left ventricle, and measured coronary vein pressure can be used to change a signal sent to the electrode to adaptively pace the patient's heart. The body implantable system can further utilize a right ventricular pressure measurement in concert with the left ventricular pressure measurement to modify pacing therapy parameters.

Abstract translation: 身体可植入系统采用在远端具有至少一个电极和至少一个压力换能器的引导系统。 引导系统植入患者的心脏左心室冠状静脉。 引导系统包括在远端处的阻塞装置以阻塞冠状静脉中的流动。 压力传感器连接到设置在引导系统的开口腔内的导管。 压力传感器感测冠状静脉压力，冠状静脉压力与左心室压力成比例。 感测到的冠状静脉压力给出了左心室的血液动力学状态的指示，并且可以使用测量的冠状静脉压力来改变发送到电极的信号，以适应性地调节患者的心脏。 身体可植入系统可以进一步利用与左心室压力测量一致的右心室压力测量来修改起搏治疗参数。