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51.发明授权Radiation-curable, urethane-acrylate prepolymers and crosslinked polymers 失效可辐射固化，氨基甲酸酯 - 丙烯酸酯预聚物和交联聚合物
公开(公告)号：US5674921A
公开(公告)日：1997-10-07
申请号：US382325
申请日：1995-02-01
申请人： Donald W. Regula , Michael F. Bregen , Stuart L. Cooper , Dennis D. Jamiolkowski , Rao S. Bezwada
发明人： Donald W. Regula , Michael F. Bregen , Stuart L. Cooper , Dennis D. Jamiolkowski , Rao S. Bezwada
IPC分类号： A61L31/06 , A61L31/14 , C08F290/14 , C08G18/67 , A61B17/08 , B29C35/02 , C08L75/16 , G03C5/00
CPC分类号： A61L31/06 , A61L31/148 , C08F290/147 , C08G18/672 , C08G2230/00
摘要： A radiation-curable prepolymer of a polyurethane endtipped with an hydroxy (acrylate or methacrylate) is disclosed. The polyurethane is derived from the reaction of a polyfunctional isocyanate with a hydrolyzable oligomer of an anhydrous cyclic ester of an hydroxy acid. Crosslinked polymers prepared by irradiating the prepolymers are also disclosed. The crosslinked polymers are bioabsorbable and biocompatible with bodily tissue, yet still maintain the outstanding mechanical properties one would expect from a polyurethane. The prepolymers and crosslinked polymers are especially well-suited for the fabrication of surgical devices, particularly wound closure devices such as surgical staples and clips, in a stereolithography apparatus.
摘要翻译： 公开了一种端接有羟基（丙烯酸酯或甲基丙烯酸酯）的聚氨酯的可辐射固化预聚物。 聚氨酯衍生自多官能异氰酸酯与羟基酸的无水环状酯的可水解低聚物的反应。 还公开了通过照射预聚物制备的交联聚合物。 交联聚合物是生物可吸收的并且与身体组织生物相容，但仍然保持着从聚氨酯所期望的突出的机械性能。 预聚物和交联聚合物特别适用于在立体光刻设备中制造手术装置，特别是诸如外科缝钉和夹子的伤口闭合装置。
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公开(公告)号：US5618314A
公开(公告)日：1997-04-08
申请号：US166493
申请日：1993-12-13
申请人： Steven F. Harwin , Anh Le , Izi Bruker , Brian Luscombe , Dennis D. Jamiolkowski , Mark Cofone , John DiGiovanni
发明人： Steven F. Harwin , Anh Le , Izi Bruker , Brian Luscombe , Dennis D. Jamiolkowski , Mark Cofone , John DiGiovanni
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/56 , A61B17/86 , A61B19/00 , A61F2/00 , A61F2/08 , A61L31/04 , A61L31/06 , A61L31/14
CPC分类号： A61L31/048 , A61B17/0401 , A61L31/06 , A61L31/148 , A61B17/86 , A61B2017/00004 , A61B2017/0409 , A61B2017/0414 , A61B2017/044 , A61B2017/06019 , A61B2090/037 , A61F2/0811 , A61F2002/30299 , A61F2230/0093 , Y10S606/916
摘要： A suture anchor having an anchor member, a central shaft and outwardly extending wing members. A suture mounting hole is provided in the suture anchor for receiving a surgical suture. The suture anchor is inserted into a bore hole in a bone as part of an orthopedic surgical procedure wherein soft tissue such as a tendon is attached to the surface of the bone. Optionally, bone tissue may be attached to the surface of the bone. The wings may have cutting edges or piercing points. The suture anchors may have screw threads on their outer surfaces.
摘要翻译： 具有锚固构件，中心轴和向外延伸的翼构件的缝合锚固件。 缝合线安装孔设置在缝合锚中，用于接收外科缝合线。 将缝合锚固件插入到骨中的钻孔中，作为矫形外科手术的一部分，其中诸如腱的软组织附着到骨的表面。 任选地，骨组织可以附着到骨的表面。 机翼可能有切削刃或刺穿点。 缝合锚可在其外表面上具有螺纹。
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53.发明授权
公开(公告)号：US4649921A
公开(公告)日：1987-03-17
申请号：US744833
申请日：1985-06-14
IPC分类号： A61L17/10 , A61L27/18 , C08G63/672 , A61L17/00
CPC分类号： C08G63/672 , A61L17/105 , A61L27/18
摘要： A sterile surgical suture comprising an absorbable, radiation sterilizable, normally solid polymer comprising a copolyester that comprises repeating divalent units of the formulas:(A) --O--CO--CH.sub.2 --O--CH.sub.2 CH.sub.2 --, and(B) --G--, and(C) --O--CO--CHR--O--.sub.m Ph--O--CHR--CO--O--wherein G represents the residue after removal of the hydroxyl groups of a dihydric alcohol, wherein Ph represents 1,2-, 1,3-, or 1,4-phenylene or alkyl- or alkoxy-substituted phenylene, wherein m represents a number having a value of 0 or 1, wherein R represents hydrogen or lower alkyl, and wherein the divalent units (A), (B), and (C) are bonded to each other through ester groups contained in said units.
摘要翻译： 一种无菌外科缝合线，其包含可吸收的，可辐射灭菌的通常为固体的聚合物，其包含共聚酯，所述共聚酯包含重复下式的二价单元：（A）-O-CO-CH 2 -O-CH 2 CH 2 - 和（B）-G-，和 （C）-O-CO-CHR-O-mPh-O-CHR-CO-O-其中G表示除去二元醇的羟基后的残基，其中Ph表示1,2-， 或1,4-亚苯基或烷基或烷氧基取代的亚苯基，其中m表示数值为0或1的数，其中R表示氢或低级烷基，其中二价单元（A），（B）， 和（C）通过所述单元中所含的酯基彼此键合。
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54.发明授权Surgical articles of copolymers of glycolide and .epsilon.-caprolactone and methods of producing the same 失效乙交酯和ε-己内酯共聚物的手术制品及其制备方法
公开(公告)号：US4605730A
公开(公告)日：1986-08-12
申请号：US743117
申请日：1985-06-10
摘要： Novel copolymers of .epsilon.-caprolactone and glycolide useful in making surgical articles and particularly surgical sutures having Young's modulus of less than 250,000 psi. New and improved polymerization methods for producing the novel .epsilon.-caprolactone and glycolide copolymers.
摘要翻译： ε-己内酯和乙交酯的新型共聚物可用于制造外科用品，特别是具有小于250,000psi的杨氏模量的手术缝合线。 用于生产新型ε-己内酯和乙交酯共聚物的新型改进的聚合方法。
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公开(公告)号：US4510295A
公开(公告)日：1985-04-09
申请号：US459428
申请日：1983-01-20
IPC分类号： C08G63/00 , A61L17/00 , A61L17/10 , A61L27/18 , C08G63/181 , C08G63/60 , C08G63/64 , C08G63/66 , C08G63/688 , C08G63/18
CPC分类号： C08G63/688 , A61L17/10 , A61L27/18 , C08G63/60 , C08G63/66
摘要： Absorbable, radiation sterilizable polymers, useful as sutures and other medical and surgical devices, are produced from polyesters of substituted benzoic acid, dihydric alcohols, and glycolide and/or lactide.
摘要翻译： 由可取代的苯甲酸，二元醇和乙交酯和/或丙交酯的聚酯制备可用作辐射消毒的聚合物，用作缝合线和其它医疗和手术装置。
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公开(公告)号：US4205399A
公开(公告)日：1980-06-03
申请号：US910042
申请日：1978-05-26
CPC分类号： D01F6/84 , A61L17/105 , A61L27/18 , C08G63/16 , D01F6/625
摘要： Synthetic filaments composed of homopolymers and copolymers of poly(alkylene oxalates) are absorbable in animal tissue with minimal adverse tissue reaction. Polymers prepared by reacting a dialkyl oxalate with an alkylene diol are melt spun and drawn to obtain oriented fibers having good tensile properties and a high level of flexibility and softness. The filaments are particularly useful in the preparation of surgical prosthesis comprising woven or knitted fabrics and meshes. Other absorbable surgical devices including films and molded items may also be prepared from the disclosed polymer.
摘要翻译： 由聚（亚烷基草酸酯）的均聚物和共聚物组成的合成长丝在动物组织中是可吸收的，具有最小的不利组织反应。 通过使草酸二烷基酯与亚烷基二醇反应制备的聚合物被熔融纺丝并拉伸，得到具有良好拉伸性能和高柔性和柔软度的取向纤维。 长丝在制备包含织造或针织织物和网眼的手术假体中特别有用。 其它可吸收外科装置，包括膜和模制品也可以由所公开的聚合物制备。
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57.发明授权
公开(公告)号：US4130639A
公开(公告)日：1978-12-19
申请号：US837060
申请日：1977-09-28
摘要： Absorbable copolyoxalate polymers having isomorphic sequences are formulated with drugs and introduced into the body to provide a slow, sustained release of the drug over an extended period of time in accordance with the rate of absorption of the polymer. The copolyoxalate polymers are derived from mixtures of cyclic and linear diols, each having the same number of carbon atoms. The polymers are biodegradable in animal tissue and absorb with minimal adverse tissue reaction.
摘要翻译： 具有同构序列的可吸收的共聚草酸酯聚合物与药物配制并引入体内以根据聚合物的吸收速率在延长的时间段内提供缓慢的持续释放药物。 共聚草酸酯聚合物衍生自环状和线性二醇的混合物，每个二醇具有相同数目的碳原子。 聚合物在动物组织中是可生物降解的并以最小的不利组织反应进行吸收。
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58.发明授权Bioabsorbable polymeric compositions, processing methods, and medical devices therefrom 有权生物可吸收聚合物组合物，加工方法和其中的医疗装置公开(公告)号：US09173978B2
公开(公告)日：2015-11-03
申请号：US12887995
申请日：2010-09-22
IPC分类号： A61K47/34 , A61F2/00 , A61F2/82 , A61B17/00 , A61B17/04 , A61B17/08 , A61B17/64 , A61B17/84 , A61B17/86 , C08L67/00 , A61L31/04 , A61B17/064 , C08L67/04 , A61L31/14 , A61L31/16
CPC分类号： C08L67/04 , A61B17/0401 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2017/0647 , A61L31/041 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/442 , C08L2205/025 , C08L2666/18
摘要： Novel bioabsorbable polymeric blends are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is poly(p-dioxanone) polymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel bioabsorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
摘要翻译： 公开了新的生物可吸收聚合物共混物。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）聚合物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新颖的生物可吸收的医疗装置，以及新颖的制造方法。
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59.发明申请RIGID REINFORCING EXOSKELETAL SLEEVE FOR DELIVERY OF FLOWABLE BIOCOMPATIBLE MATERIALS 审中-公开用于输送可流动的生物成分材料的刚性增强弹性套管公开(公告)号：US20140031788A1
公开(公告)日：2014-01-30
申请号：US13556790
申请日：2012-07-24
CPC分类号： A61M5/1414 , A61B17/00491 , A61B17/34 , A61B17/3415 , A61B2017/00331 , A61B2017/00469 , A61B2017/3405 , A61B2017/347 , A61M5/1424 , A61M25/02 , A61M2005/1416
摘要： Exoskeletal devices or sleeves that can be used with the delivery tube of an applicator device to help dispense fluids, typically flowable biocompatible materials such as hemostatic agents, adhesives, or sealants, onto specific sites in the human body for a medical reason are disclosed.The exoskeletal devices or sleeves are rigid, pre-shaped, and snappably or slidably affixed to the delivery tube. The exoskeletal devices or sleeves do not come into contact with the flowable biocompatible fluid being dispensed, and they can be placed at any position along the delivery tube to address different application situations. Once the exoskeletal device or sleeve is in place, it can optionally be locked onto the delivery tube to prevent further sliding under stresses when pushed against tissue. Multiple exoskeletal devices or sleeves can also be used to achieve more complicated shapes for hard-to-reach anatomical sites.
摘要翻译： 公开了可以与敷贴器装置的输送管一起使用的外骨骼装置或套筒，以帮助将液体（通常是可流动的生物相容性材料，例如止血剂，粘合剂或密封剂）分配到人体的特定部位，用于医学原因。 外骨骼装置或套筒是刚性的，预成形的，并且可滑动地或可滑动地固定到输送管。 外骨骼装置或套管不会与正在分配的可流动的生物相容性流体接触，并且它们可以放置在沿输送管的任何位置以解决不同的应用情况。 一旦外骨骼装置或套筒就位，它可以可选地被锁定在输送管上，以防止在压在组织上时在应力下的进一步滑动。 还可以使用多个外骨骼装置或袖子来实现难以到达的解剖部位的更复杂的形状。
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公开(公告)号：US08580307B2
公开(公告)日：2013-11-12
申请号：US11472830
申请日：2006-06-22
IPC分类号： A61K9/14
CPC分类号： A61K8/025 , A61K8/85 , A61K9/1647 , A61K2800/412 , A61L27/18 , A61L27/50 , A61L27/58 , Y10T428/2982 , C08L67/04
摘要： Absorbable microspheres comprising a copolymer formed from greater than 80 to about 99 mole percent D,L-lactide, L(−)-lactide, D(+)-lactide, or meso-lactide and combinations thereof, and about 1 to less than 20 mole percent of a different second monomer selected from the group consisting of p-dioxanone and trimethylene carbonate and combinations thereof, said microspheres having a particle size ranging from about 5 to 2000 microns. Also described herein are formulations comprising such absorbable microspheres.
摘要翻译： 可吸收的微球包含由大于80-约99摩尔％的D，L-丙交酯，L（ - ） - 丙交酯，D（+） - 丙交酯或内消旋丙交酯及其组合形成的共聚物和约1至小于20 摩尔百分比的选自对二恶烷酮和三亚甲基碳酸酯及其组合的不同的第二单体，所述微球具有约5至2000微米的粒度。 本文还描述了包含这种可吸收微球体的制剂。
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