公开(公告)号：US07853327B2

公开(公告)日：2010-12-14

申请号：US11736055

申请日：2007-04-17

申请人： Abhilash Patangay ,  Krzysztof Z. Siejko ,  Gerrard M. Carlson

发明人： Abhilash Patangay ,  Krzysztof Z. Siejko ,  Gerrard M. Carlson

IPC分类号： A61N1/365

CPC分类号： A61B7/04 ,  A61B7/00 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/368

摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.

摘要翻译： 一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。 心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示 来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。 特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。 此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。

公开(公告)号：US07764996B2

公开(公告)日：2010-07-27

申请号：US11554986

申请日：2006-10-31

申请人： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

发明人： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

IPC分类号： A61B5/00

CPC分类号： A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585 ,  G06F19/00

摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

公开(公告)号：US20090018461A1

公开(公告)日：2009-01-15

申请号：US12283760

申请日：2008-09-16

申请人： Krzysztof Z. Siejko ,  Gerrard M. Carlson

发明人： Krzysztof Z. Siejko ,  Gerrard M. Carlson

IPC分类号： A61B5/02

CPC分类号： A61B7/04

摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.

摘要翻译： 心律管理系统包括提供检测第三心音的心音检测器（S3）。 诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。 心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。 然后从S3检测窗口内的声信号检测S3的出现。

公开(公告)号：US07431699B2

公开(公告)日：2008-10-07

申请号：US10746853

申请日：2003-12-24

申请人： Krzysztof Z. Siejko ,  Gerrard M. Carlson

发明人： Krzysztof Z. Siejko ,  Gerrard M. Carlson

IPC分类号： A61B5/02

CPC分类号： A61B7/04

摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.

摘要翻译： 心律管理系统包括用于检测第三心音的心音检测器（S 3）。 诸如加速度计或麦克风的可植入传感器感测到指示包括第二心音（S 2）和S 3的心音的声信号。 心音检测器检测到S 2的发生，并且在检测到的S 2发生之后，在预定延迟之后开始S 3检测窗口。 然后从S 3检测窗口内的声信号检测出S 3的出现。

公开(公告)号：US20080114219A1

公开(公告)日：2008-05-15

申请号：US11554986

申请日：2006-10-31

申请人： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

发明人： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

IPC分类号： A61B5/00

CPC分类号： A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585 ,  G06F19/00

摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

公开(公告)号：US09254100B2

公开(公告)日：2016-02-09

申请号：US11900596

申请日：2007-09-12

申请人： Kenneth Beck ,  Ramesh Wariar ,  Chie Kawahara ,  Gerrard M. Carlson

发明人： Kenneth Beck ,  Ramesh Wariar ,  Chie Kawahara ,  Gerrard M. Carlson

IPC分类号： A61B5/117 ,  A61B5/103 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61B5/1118 ,  A61B5/0002 ,  A61B5/4866

摘要： An implantable activity detector can detect metabolic stress levels, which can be normalized, such as to identify times of activities such as walking and running or to identify trends such as a decrease in metabolic activity. The data can be derived from different sources such as an accelerometer and pedometer. This data can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with other congestive heart failure (CHF) indications. The alert can notify the patient or a caregiver, such as via remote monitoring. Metabolic activity data from one or more of the activity detectors can be used to establish a model of metabolic stress, to which further activity data can be compared for identifying periods of increased or decreased metabolic stress.

公开(公告)号：US08992436B2

公开(公告)日：2015-03-31

申请号：US11514423

申请日：2006-09-01

申请人： Yachuan Pu ,  Yi Zhang ,  Gerrard M. Carlson

发明人： Yachuan Pu ,  Yi Zhang ,  Gerrard M. Carlson

IPC分类号： A61B5/08

CPC分类号： A61B5/0816

摘要： Systems and methods provide for detecting respiration disturbances and changes in respiration disturbances, preferably by detecting variability in one or more respiration parameters. Respiration rate variability is determined for a variety of diagnostic and therapeutic purposes, including disease/disorder detection, diagnosis, treatment, and therapy titration. Systems and methods provide for generating a footprint, such as a two- or three-dimensional histogram, representative of a patient's respiration parameter variability, and generating one or more indices representative of quantitative measurements of the footprint.

摘要翻译： 系统和方法优选地通过检测一个或多个呼吸参数中的可变性来检测呼吸紊乱和呼吸干扰的变化。 确定各种诊断和治疗目的的呼吸率变异性，包括疾病/病症检测，诊断，治疗和治疗滴定。 系统和方法提供用于生成代表患者呼吸参数变异性的足迹（例如二维或三维直方图），以及生成代表足迹的定量测量的一个或多个指数。

公开(公告)号：US08755883B2

公开(公告)日：2014-06-17

申请号：US12634277

申请日：2009-12-09

申请人： Ramesh Wariar ,  Gerrard M. Carlson

发明人： Ramesh Wariar ,  Gerrard M. Carlson

IPC分类号： A61N1/365 ,  A61B5/025

CPC分类号： A61B7/023 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/0456 ,  A61B5/11 ,  A61N1/3627

摘要： A system, method, or device monitor a force-frequency relationship exhibited by a patient's heart. A contractility characteristic, such as a heart sound characteristic of an S1 heart sound, is measured. The contractility characteristic indicates the forcefulness of a contraction of the heart. The frequency at which the heart is contracting is determined. A group of (contractility characteristic, heart rate) pairs is stored in a memory device. The group of pairs defines a force-frequency relationship for the heart. The method may be implemented by an implantable device, or by a system including a implantable device.

摘要翻译： 系统，方法或设备监测患者心脏展示的力 - 频率关系。 测量S1心音的心音特征的收缩特性。 收缩性特征表明心脏收缩的强度。 确定心脏收缩的频率。 一组（收缩特性，心率）对存储在存储器件中。 一组对定义了心脏的力 - 频率关系。 该方法可以由可植入装置或包括可植入装置的系统来实现。

公开(公告)号：US08150509B2

公开(公告)日：2012-04-03

申请号：US10970449

申请日：2004-10-21

申请人： Veerichetty Kadhiresan ,  Marina V. Brockway ,  Gerrard M. Carlson

发明人： Veerichetty Kadhiresan ,  Marina V. Brockway ,  Gerrard M. Carlson

IPC分类号： A61N1/00

CPC分类号： A61M5/142 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2230/04 ,  A61M2230/08 ,  A61M2230/30 ,  A61M2230/50 ,  A61M2230/63 ,  G06F19/00 ,  G06F19/3456 ,  G16H50/50 ,  Y10S128/923

摘要： A system or method including a device configured to measure at least one pharmacological effect of a drug on a patient. The measured pharmacological effect is compared to an expected pharmacodynamic model. The system can allow for real-time monitoring of positive and side-effects of drugs as well as drug resistance to optimize individual therapy. The system can also enable patient compliance monitoring.

摘要翻译： 一种包括被配置为测量药物对患者的至少一种药理作用的装置的系统或方法。 将测量的药理作用与预期的药效学模型进行比较。 该系统可以实时监测药物的阳性和副作用以及耐药性，以优化个体治疗。 该系统还可以实现患者依从性监控。

公开(公告)号：US08065010B2

公开(公告)日：2011-11-22

申请号：US12319642

申请日：2009-01-08

申请人： Marina V. Brockway ,  Donald L. Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth C. Beck

发明人： Marina V. Brockway ,  Donald L. Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth C. Beck

IPC分类号： A61N1/36

CPC分类号： A61B5/087 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521

摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

摘要翻译： 系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。 基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。 如果未检测到心源性肺水肿，则基于由可植入或非可行的肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病， 植入式传感器。 在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。