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80 条记录 (耗时 0.105 秒)

    Polynucleotides encoding a cardiotrophin-like cytokine
    52.
    发明授权
    Polynucleotides encoding a cardiotrophin-like cytokine 失效
    编码心肌营养素样细胞因子的多核苷酸

    公开(公告)号：US6046035A

    公开(公告)日：2000-04-04

    申请号：US106182

    申请日：1998-06-29

    申请人： Yanggu Shi ,  Steven M. Ruben

    发明人： Yanggu Shi ,  Steven M. Ruben

    IPC分类号： C12N15/09 ,  A61K38/00 ,  C07K14/435 ,  C07K14/52 ,  C07K14/54 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/19 ,  C12N15/24 ,  C12P21/04 ,  C12P21/08

    CPC分类号： C07K14/52 ,  A61K38/00

    摘要： The present invention relates to a novel CLC protein which is a member of the IL-6 cytokine family. In particular, isolated nucleic acid molecules are provided encoding the human CLC protein. CLC polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CLC activity. Also provided are diagnostic methods for detecting cardiac and immune system-related disorders and therapeutic methods for treating cardiac and immune system-related disorders.

    摘要翻译： 本发明涉及作为IL-6细胞因子家族成员的新型CLC蛋白。 特别地，提供编码人CLC蛋白的分离的核酸分子。 还提供CLC多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及鉴定CLC活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测心脏和免疫系统相关疾病的诊断方法以及用于治疗心脏和免疫系统相关疾病的治疗方法。

    Interleukin 17 Receptor-Like Protein
    54.
    发明申请
    Interleukin 17 Receptor-Like Protein 失效
    白介素17受体样蛋白

    公开(公告)号：US20070269439A1

    公开(公告)日：2007-11-22

    申请号：US11567524

    申请日：2006-12-06

    申请人： Yanggu Shi ,  Steven M. Ruben

    发明人： Yanggu Shi ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  G01N33/53 ,  C07K14/715 ,  C07K16/28

    CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

    摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

    摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

    Human protein tyrosine phosphatase polynucleotides, polypeptides, and antibodies
    55.
    发明授权
    Human protein tyrosine phosphatase polynucleotides, polypeptides, and antibodies 失效
    人蛋白质酪氨酸磷酸酶多核苷酸，多肽和抗体

    公开(公告)号：US06770466B2

    公开(公告)日：2004-08-03

    申请号：US09906779

    申请日：2001-07-18

    申请人： Yanggu Shi ,  Steven M. Ruben

    发明人： Yanggu Shi ,  Steven M. Ruben

    IPC分类号： C12N912

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The present invention relates to novel human PTPase polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human PTPase polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human PtPase polypeptides.

    摘要翻译： 本发明涉及新的人PTPase多肽和含有编码这些多肽的基因的编码区的分离的核酸。 还提供了用于产生人PTPase多肽的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人PtPase多肽相关的疾病的诊断和治疗方法。

    Antibodies against interleukin 17 receptor-like protein
    60.
    发明授权
    Antibodies against interleukin 17 receptor-like protein 失效
    抗白细胞介素17受体样蛋白的抗体

    公开(公告)号：US07638603B2

    公开(公告)日：2009-12-29

    申请号：US11567524

    申请日：2006-12-06

    申请人： Yanggu Shi ,  Steven M. Ruben

    发明人： Yanggu Shi ,  Steven M. Ruben

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

    摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

    摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。