摘要:
The invention concerns a polybenzazole block copolymer suitable for solid polymer electrolyte membranes application comprising: at least one block (B1) comprising recurring units (R), more than 50% of said recurring units comprising at least one benzimidazole group (formula 1a and 1b) and at least one sulfonic acid group (formula 2) [recurring units (R1)]; wherein E in formula 1a can be a substituted or non-substituted carbon atom or nitrogen atom, and Q in formula 1 can be a hydrogen atom or a group comprising a sulfonic acid group; and at least one block (B2) comprising recurring units (R′), more than 50% by moles of said recurring units comprising at least one benzazole group chosen among benzoxazole group (formula 3a and 3b) and benzothiazole group (formula 4a and 4b) [recurring units (R2)], wherein E′ and E″ in formula 3a and 4a, respectively, can be a substituted or non-substituted carbon atom or nitrogen atom, and the block (B2) is free from sulfonic acid groups. The invention also relates to a polybenzazole polymer composition thereof, a solid polymer electrolyte membrane therefrom, a solid polymer electrolyte doped membrane therefrom, and the fuel cell therefrom.
摘要:
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.
摘要:
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.
摘要:
An oxidation-protected brake disk is made of a fiber-reinforced ceramic material. A method of producing such a brake disk comprises applying at least one paint layer to a brake disk. In order to reduce damage to the brake disk under extreme thermal stress, the brake disk is provided with a layer of a highly temperature-stable paint that is viscous at the operating temperature of the brake disk.
摘要:
A brake disk for a motor vehicle, particularly made of a fiber-glass-reinforced material, includes two disk elements with ribs forming air ducts, which can be connected with one another. The ribs of the disk elements have mutually corresponding hook-type connections on opposite front surfaces.
摘要:
The invention relates to benzylidene-quinuclidinone derivatives of the formula I ##STR1## in which R.sup.1 is A;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH; andA is a straight-chain or branched alkyl radical having 1 to 10 C atomsand processes for their preparation and their use in cosmetic and/or pharmaceutical preparations.
摘要:
Alkylbenzenes of the general formula I ##STR1## where R.sup.1 is C.sub.1 -C.sub.4 -alkyl, preferably methyl, and R.sup.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl, preferably methyl, are prepared by catalytic aromatization of the corresponding alkenylcyclohexenes of the general formula II ##STR2## by carrying out the conversion in the gas phase at 150.degree.-400.degree. C. over a catalyst which contains palladium oxide and sulfur and/or selenium or selenium oxide on active carbon.
摘要:
In a travelling wire EDM apparatus the thermal stresses of the electrode wire are substantially reduced by detecting the position of the triggering electrical discharges preceding the machining electrical discharges, and by controlling the supply of the machining electrical discharge current at one end of the machining zone, at the other end of the machining zone or at both ends of the machining zone. When a machining electrical discharge is located between one end of the machining zone and a first reference position, the machining current is applied at that end. When the electrical discharge is located between the other end of the machining zone and a second reference position, machining current is supplied at that second end. When the electrical discharge is located between the two reference positions, the machining current is applied simultaneously at both ends of the machining zone.
摘要:
An arrangement for detecting abnormal concentration of electrical discharges between a travelling wire electrode and a workpiece in a travelling wire EDM apparatus. The abnormal electrical discharge detector of the invention comprises a circuit measuring the voltage across a pair of contacts supplying machining current to the electrode wire. The length of the electrode wire between the two contacts forms a pair of variable resistors connected in a branch of a Wheatstone bridge circuit. The voltage measuring circuit, connected across a diagonal of the bridge, in turn controls some of the machining parameters such as to prevent damages, as for example rupture of the wire electrode, when an abnormal concentration of electrical discharges is detected at a given point of the machining zone between the wire electrode and the workpiece.
摘要:
The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable of eliciting a protective immune response against polyoma virus JC (JCV) are disclosed, which may be used e.g., for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and/or progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS). Individuals in danger of such PML or PML-IRIS may, e.g., be immuno-compromised or immunosuppressed patients or patients having an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions comprising at least one CD4+ epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof.