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112 条记录 (耗时 0.082 秒)

    Aryloxy piperidinyl derivatives for the treatment of depression
    58.
    发明授权
    Aryloxy piperidinyl derivatives for the treatment of depression 失效
    芳氧基哌啶衍生物用于治疗抑郁症

    公开(公告)号：US06610712B2

    公开(公告)日：2003-08-26

    申请号：US10000642

    申请日：2001-11-15

    申请人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

    发明人： Richard E. Mewshaw ,  Dahui Zhou ,  Ping Zhou

    IPC分类号： C07D40104

    CPC分类号： C07D401/06 ,  C07D405/14

    摘要： This invention provides compounds useful in treating serotonin-related central nervous system disorders, including anxiety, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, sleep disorders, sexual dysfunction, alcohol and drug addiction, Alzheimer's disease, Parkinson's disease, obesity and migraine, the compounds having the general formula: wherein: R1 and R2 may each be H or an alkyl or alkoxy group; or R1 and R2 may be concatenated to form a bicyclic ring system with the phenyl ring to which they are bound; X is selected from hydrogen, halogen, cyano, C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 0, 1 or 2; the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供了可用于治疗血清素相关的中枢神经系统疾病的化合物，包括焦虑，广泛性焦虑症，恐慌症，强迫症，睡眠障碍，性功能障碍，酒精和药物成瘾，阿尔茨海默病，帕金森病，肥胖症和偏头痛 具有以下通式的化合物：其中：R 1和R 2可以各自为H或烷基或烷氧基; 或者R 1和R 2可以连接形成与它们所结合的苯环的双环系统; X选自氢，卤素，氰基，C 1 -C 6烷氧基; Z是（CH 2）n或羰基; n为0,1或2; 虚线表示可选的双键; 或其药学上可接受的盐。

    Method and apparatus for hermetically sealing photonic devices
    59.
    发明授权
    Method and apparatus for hermetically sealing photonic devices 有权
    用于密封光子器件的方法和装置

    公开(公告)号：US06588949B1

    公开(公告)日：2003-07-08

    申请号：US09224210

    申请日：1998-12-30

    申请人： Ping Zhou

    发明人： Ping Zhou

    IPC分类号： G02B636

    CPC分类号： H01S5/02288 ,  H01S5/0222 ,  H01S5/183

    摘要： A hermetically sealed photonic device submount includes a photonic device mounted on a substrate material and sealed in a flexible hermetic seal. In one configuration, the photonic device is configured to emit or to receive light through the substrate material. In this configuration, the photonic device is covered with an adhesive layer and a metal layer deposited onto the adhesive layer. In another configuration, the photonic device is configured to emit or to receive light in a direction substantially vertically upward from the substrate material. In this configuration, a cover is placed over the photonic device, then the cover is hermetically sealed to the substrate material with an adhesive layer and a metal layer depositd onto the adhesive layer. In both configurations, the photonic device submounts are hermetically sealed according to various aspects of the present invention on the substrate material without using a separate package. Accordingly, any number of hermetically sealed photonic device submounts can be mass produced on wafers using the present invention.

    摘要翻译： 密封的光子器件底座包括安装在基底材料上并密封在柔性密封件中的光子器件。 在一种配置中，光子器件被配置为发射或接收穿过衬底材料的光。 在该配置中，光子器件被粘附层和沉积在粘合剂层上的金属层覆盖。 在另一种配置中，光子器件被配置为发射或接收来自基底材料的基本垂直向上的方向的光。 在该配置中，将盖放置在光子器件上方，然后将盖密封到基底材料上，粘合剂层和金属层沉积在粘合剂层上。 在两种配置中，光子器件底座根据本发明的各个方面在衬底材料上气密密封，而不使用单独的封装。 因此，可以使用本发明在晶片上大量生产任何数量的密封的光子器件底座。